Mus musculus

11 known processes

Psenen

presenilin enhancer 2 homolog (C. elegans)

(Aliases: 1700023M09Rik,MGC102026)

Psenen biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
copper ion transport GO:0006825 10 0.199
regulation of resting membrane potential GO:0060075 3 0.167
modification dependent macromolecule catabolic process GO:0043632 133 0.151
cellular protein catabolic process GO:0044257 155 0.107
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.097
protein maturation GO:0051604 176 0.091
Human
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.083
negative regulation of protein processing GO:0010955 79 0.069
modification dependent protein catabolic process GO:0019941 133 0.068
protein modification by small protein conjugation GO:0032446 187 0.064
macromolecule catabolic process GO:0009057 281 0.063
regulation of cellular amino acid metabolic process GO:0006521 5 0.061
choline transport GO:0015871 3 0.059
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.057
lateral inhibition GO:0046331 1 0.056
protein catabolic process GO:0030163 221 0.054
ubiquitin dependent protein catabolic process GO:0006511 129 0.053
negative regulation of protein metabolic process GO:0051248 282 0.050
negative regulation of cellular protein metabolic process GO:0032269 247 0.049
negative regulation of protein modification process GO:0031400 163 0.044
notch receptor processing GO:0007220 4 0.044
cellular macromolecule catabolic process GO:0044265 206 0.043
transmembrane transport GO:0055085 412 0.042
positive regulation of cell death GO:0010942 224 0.042
regulation of kinase activity GO:0043549 249 0.041
cation transport GO:0006812 399 0.041
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.038
ion transmembrane transport GO:0034220 361 0.037
ribose phosphate metabolic process GO:0019693 291 0.036
cellular amino acid metabolic process GO:0006520 103 0.036
regulation of cellular catabolic process GO:0031329 242 0.036
notch signaling pathway GO:0007219 71 0.036
Worm
protein processing GO:0016485 163 0.036
Human
protein modification by small protein conjugation or removal GO:0070647 207 0.036
regulation of protein processing GO:0070613 96 0.035
regulation of apoptotic signaling pathway GO:2001233 197 0.035
regulation of proteolysis GO:0030162 164 0.035
spermatogenesis GO:0007283 284 0.035
negative regulation of molecular function GO:0044092 258 0.034
embryonic organ morphogenesis GO:0048562 276 0.034
apoptotic signaling pathway GO:0097190 306 0.033
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.033
mitochondrion organization GO:0007005 134 0.032
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.031
protein ubiquitination GO:0016567 171 0.031
regulation of protein maturation GO:1903317 96 0.031
proteasomal protein catabolic process GO:0010498 98 0.030
regulation of neuron differentiation GO:0045664 281 0.029
microtubule based process GO:0007017 236 0.029
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.028
beta amyloid metabolic process GO:0050435 14 0.028
cation transmembrane transport GO:0098655 266 0.028
cellular ketone metabolic process GO:0042180 84 0.028
cellular protein complex assembly GO:0043623 116 0.027
regulation of cellular ketone metabolic process GO:0010565 66 0.027
negative regulation of proteolysis GO:0045861 74 0.027
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.027
transition metal ion transport GO:0000041 38 0.026
negative regulation of protein maturation GO:1903318 79 0.026
regulation of cellular protein catabolic process GO:1903362 61 0.026
inorganic ion transmembrane transport GO:0098660 234 0.025
determination of left right symmetry GO:0007368 80 0.025
organelle fission GO:0048285 170 0.025
positive regulation of apoptotic signaling pathway GO:2001235 95 0.025
endomembrane system organization GO:0010256 147 0.024
cellular divalent inorganic cation homeostasis GO:0072503 127 0.024
positive regulation of proteolysis GO:0045862 85 0.024
cellular amine metabolic process GO:0044106 44 0.024
regulation of hydrolase activity GO:0051336 246 0.023
negative regulation of cellular catabolic process GO:0031330 47 0.023
regulation of cellular component biogenesis GO:0044087 181 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.022
cytoplasmic transport GO:0016482 234 0.022
divalent inorganic cation transport GO:0072511 178 0.022
growth involved in heart morphogenesis GO:0003241 4 0.021
regulation of cellular amine metabolic process GO:0033238 20 0.021
regulation of membrane potential GO:0042391 192 0.021
response to extracellular stimulus GO:0009991 127 0.021
regulation of transferase activity GO:0051338 263 0.021
negative regulation of cell development GO:0010721 169 0.021
regulation of neurotransmitter levels GO:0001505 87 0.020
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.020
epithelial cell proliferation GO:0050673 174 0.020
ossification GO:0001503 216 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.019
membrane lipid biosynthetic process GO:0046467 32 0.019
inorganic cation transmembrane transport GO:0098662 207 0.019
neuron death GO:0070997 154 0.019
Zebrafish
carbohydrate derivative catabolic process GO:1901136 231 0.019
negative regulation of protein phosphorylation GO:0001933 126 0.019
cation homeostasis GO:0055080 212 0.019
neurotransmitter transport GO:0006836 76 0.019
nuclear division GO:0000280 158 0.019
release of cytochrome c from mitochondria GO:0001836 23 0.019
regulation of cell projection organization GO:0031344 206 0.019
interspecies interaction between organisms GO:0044419 83 0.019
nucleoside triphosphate catabolic process GO:0009143 205 0.019
extracellular structure organization GO:0043062 148 0.019
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.019
nitrogen compound transport GO:0071705 271 0.019
t cell activation GO:0042110 289 0.019
negative regulation of cellular protein catabolic process GO:1903363 22 0.018
regulation of protein catabolic process GO:0042176 108 0.018
ras protein signal transduction GO:0007265 77 0.018
amine metabolic process GO:0009308 45 0.018
microtubule based movement GO:0007018 84 0.018
protein localization to membrane GO:0072657 108 0.018
regionalization GO:0003002 337 0.018
regulation of peptidase activity GO:0052547 96 0.018
immune effector process GO:0002252 321 0.018
male gamete generation GO:0048232 285 0.018
negative regulation of kinase activity GO:0033673 81 0.018
positive regulation of transferase activity GO:0051347 167 0.018
regulation of secretion GO:0051046 274 0.018
hematopoietic progenitor cell differentiation GO:0002244 143 0.018
digestive tract development GO:0048565 190 0.018
Worm
negative regulation of neuron differentiation GO:0045665 101 0.018
autophagic vacuole fusion GO:0000046 1 0.017
organelle membrane fusion GO:0090174 1 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.017
cellular chemical homeostasis GO:0055082 215 0.017
negative regulation of protein modification by small protein conjugation or removal GO:1903321 20 0.017
organic hydroxy compound transport GO:0015850 93 0.017
peptidyl amino acid modification GO:0018193 336 0.017
positive regulation of protein phosphorylation GO:0001934 242 0.016
negative regulation of ligase activity GO:0051352 3 0.016
extrinsic apoptotic signaling pathway GO:0097191 126 0.016
regulation of cell migration GO:0030334 219 0.016
negative regulation of ubiquitin protein transferase activity GO:0051444 3 0.016
regulation of intracellular protein transport GO:0033157 82 0.016
purine containing compound metabolic process GO:0072521 311 0.016
cellular response to extracellular stimulus GO:0031668 81 0.016
mapk cascade GO:0000165 281 0.016
regulation of establishment of protein localization GO:0070201 181 0.016
ribonucleoside metabolic process GO:0009119 245 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
vesicle organization GO:0016050 60 0.016
autophagy GO:0006914 45 0.016
carbohydrate homeostasis GO:0033500 128 0.016
acidic amino acid transport GO:0015800 16 0.016
regulation of organelle organization GO:0033043 289 0.015
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.015
cellular homeostasis GO:0019725 240 0.015
regulation of cytoplasmic transport GO:1903649 112 0.015
intracellular protein transport GO:0006886 204 0.015
divalent metal ion transport GO:0070838 172 0.015
negative regulation of phosphate metabolic process GO:0045936 184 0.015
membrane organization GO:0061024 245 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
synaptic transmission GO:0007268 329 0.015
positive regulation of mapk cascade GO:0043410 170 0.015
regulation of ion transport GO:0043269 215 0.015
regulation of protein localization GO:0032880 231 0.015
myotube differentiation GO:0014902 105 0.015
regulation of protein kinase activity GO:0045859 232 0.015
nucleotide metabolic process GO:0009117 332 0.015
positive regulation of interleukin 8 production GO:0032757 2 0.015
heart morphogenesis GO:0003007 178 0.014
water soluble vitamin biosynthetic process GO:0042364 3 0.014
leukocyte differentiation GO:0002521 342 0.014
respiratory tube development GO:0030323 167 0.014
regulation of cell motility GO:2000145 236 0.014
positive regulation of protein kinase activity GO:0045860 144 0.014
positive regulation of protein modification process GO:0031401 299 0.014
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.014
regulation of protein serine threonine kinase activity GO:0071900 157 0.014
autophagic vacuole assembly GO:0000045 13 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.014
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.014
cellular response to dna damage stimulus GO:0006974 207 0.014
regulation of mapk cascade GO:0043408 248 0.014
regulation of vesicle mediated transport GO:0060627 139 0.014
exocytosis GO:0006887 121 0.014
organelle localization GO:0051640 179 0.014
ribonucleoside triphosphate catabolic process GO:0009203 199 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
negative regulation of cellular component organization GO:0051129 194 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.013
positive regulation of cellular amine metabolic process GO:0033240 5 0.013
somitogenesis GO:0001756 69 0.013
embryonic heart tube morphogenesis GO:0003143 51 0.013
developmental maturation GO:0021700 193 0.013
regulation of map kinase activity GO:0043405 120 0.013
viral budding GO:0046755 1 0.013
negative regulation of nervous system development GO:0051961 156 0.013
regulation of proteasomal protein catabolic process GO:0061136 46 0.013
purine nucleotide catabolic process GO:0006195 211 0.013
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
cellular ion homeostasis GO:0006873 165 0.013
single organism cell adhesion GO:0098602 156 0.013
calcium ion homeostasis GO:0055074 127 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.013
regulation of receptor recycling GO:0001919 8 0.013
mitotic cell cycle GO:0000278 195 0.013
nucleoside phosphate metabolic process GO:0006753 338 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
ameboidal type cell migration GO:0001667 128 0.013
meiotic nuclear division GO:0007126 115 0.013
somite development GO:0061053 81 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
nucleobase containing small molecule metabolic process GO:0055086 352 0.012
organic cyclic compound catabolic process GO:1901361 295 0.012
meiotic cell cycle GO:0051321 122 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
purine nucleoside triphosphate metabolic process GO:0009144 226 0.012
heterocycle catabolic process GO:0046700 280 0.012
locomotory behavior GO:0007626 195 0.012
filopodium assembly GO:0046847 19 0.012
activation of mapkk activity GO:0000186 15 0.012
blood circulation GO:0008015 195 0.012
regulation of epithelial cell proliferation GO:0050678 141 0.012
establishment of organelle localization GO:0051656 122 0.012
establishment of vesicle localization GO:0051650 81 0.012
regulation of secretion by cell GO:1903530 249 0.012
embryonic limb morphogenesis GO:0030326 126 0.012
smoothened signaling pathway GO:0007224 105 0.012
inflammatory response GO:0006954 244 0.012
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.012
negative regulation of transferase activity GO:0051348 85 0.012
cell growth GO:0016049 130 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.011
actin cytoskeleton organization GO:0030036 220 0.011
interleukin 8 production GO:0032637 4 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
regulation of transmembrane transport GO:0034762 128 0.011
nucleotide catabolic process GO:0009166 217 0.011
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 6 0.011
regulation of neuron projection development GO:0010975 169 0.011
negative regulation of erbb signaling pathway GO:1901185 7 0.011
amino acid transport GO:0006865 61 0.011
skeletal system development GO:0001501 356 0.011
regulation of cell activation GO:0050865 289 0.011
lipoprotein metabolic process GO:0042157 43 0.011
glucose homeostasis GO:0042593 128 0.011
striated muscle myosin thick filament assembly GO:0071688 1 0.011
respiratory system development GO:0060541 190 0.011
anatomical structure homeostasis GO:0060249 145 0.011
response to oxidative stress GO:0006979 123 0.011
negative regulation of cell cycle GO:0045786 123 0.011
learning or memory GO:0007611 148 0.011
negative regulation of protein catabolic process GO:0042177 36 0.011
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.011
muscle contraction GO:0006936 101 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
regulation of protein transport GO:0051223 163 0.011
response to nutrient levels GO:0031667 109 0.010
muscle tissue development GO:0060537 308 0.010
metal ion homeostasis GO:0055065 189 0.010
regulation of protein binding GO:0043393 60 0.010
limb development GO:0060173 166 0.010
cellular response to cytokine stimulus GO:0071345 189 0.010
circulatory system process GO:0003013 197 0.010
cellular nitrogen compound catabolic process GO:0044270 280 0.010
organonitrogen compound biosynthetic process GO:1901566 192 0.010
cellular response to lipid GO:0071396 145 0.010
positive regulation of kinase activity GO:0033674 155 0.010
vesicle localization GO:0051648 86 0.010
virion assembly GO:0019068 1 0.010
digestive system development GO:0055123 200 0.010
Worm
limb morphogenesis GO:0035108 149 0.010
response to starvation GO:0042594 65 0.010
neurotransmitter secretion GO:0007269 62 0.010
epithelial tube morphogenesis GO:0060562 303 0.010

Psenen disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.102
disease of anatomical entity DOID:7 0 0.102
Human
nervous system disease DOID:863 0 0.102
myopathy DOID:423 0 0.057
muscular disease DOID:0080000 0 0.057
musculoskeletal system disease DOID:17 0 0.057
muscle tissue disease DOID:66 0 0.057
heart disease DOID:114 0 0.048
cardiomyopathy DOID:0050700 0 0.048
dilated cardiomyopathy DOID:12930 0 0.048
intrinsic cardiomyopathy DOID:0060036 0 0.048
cardiovascular system disease DOID:1287 0 0.048
neurodegenerative disease DOID:1289 0 0.041
skin disease DOID:37 0 0.030
Human
integumentary system disease DOID:16 0 0.030
Human
disease of mental health DOID:150 0 0.024
cognitive disorder DOID:1561 0 0.024
dementia DOID:1307 0 0.018
alzheimer s disease DOID:10652 0 0.018
tauopathy DOID:680 0 0.018
immune system disease DOID:2914 0 0.017
disease of metabolism DOID:0014667 0 0.015
brain disease DOID:936 0 0.013
aplastic anemia DOID:12449 0 0.010
bone marrow disease DOID:4961 0 0.010
anemia DOID:2355 0 0.010
hematopoietic system disease DOID:74 0 0.010