Mus musculus

10 known processes

Mlkl

mixed lineage kinase domain-like

(Aliases: 9130019I15Rik)

Mlkl biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of innate immune response GO:0045088 91 0.219
immune effector process GO:0002252 321 0.196
defense response to other organism GO:0098542 197 0.195
regulation of cytokine production GO:0001817 266 0.189
cytokine production GO:0001816 319 0.184
regulation of defense response GO:0031347 233 0.157
positive regulation of defense response GO:0031349 124 0.139
cellular response to lipopolysaccharide GO:0071222 77 0.137
innate immune response GO:0045087 157 0.123
response to molecule of bacterial origin GO:0002237 143 0.118
organic cyclic compound catabolic process GO:1901361 295 0.117
pattern recognition receptor signaling pathway GO:0002221 47 0.116
activation of innate immune response GO:0002218 56 0.112
defense response to bacterium GO:0042742 119 0.111
positive regulation of innate immune response GO:0045089 80 0.104
cellular nitrogen compound catabolic process GO:0044270 280 0.102
response to organic cyclic compound GO:0014070 198 0.094
nucleoside phosphate metabolic process GO:0006753 338 0.091
aromatic compound catabolic process GO:0019439 286 0.087
response to lipopolysaccharide GO:0032496 128 0.087
regulation of multi organism process GO:0043900 111 0.081
cellular response to biotic stimulus GO:0071216 92 0.078
leukocyte mediated immunity GO:0002443 174 0.076
immune response activating signal transduction GO:0002757 116 0.076
positive regulation of cytokine production GO:0001819 174 0.070
immune response regulating signaling pathway GO:0002764 125 0.069
apoptotic signaling pathway GO:0097190 306 0.069
interspecies interaction between organisms GO:0044419 83 0.069
leukocyte mediated cytotoxicity GO:0001909 62 0.068
activation of immune response GO:0002253 138 0.067
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.066
mapk cascade GO:0000165 281 0.061
necroptotic process GO:0070266 21 0.060
regulation of lymphocyte activation GO:0051249 240 0.059
i kappab kinase nf kappab signaling GO:0007249 85 0.059
leukocyte proliferation GO:0070661 172 0.057
cell type specific apoptotic process GO:0097285 268 0.057
response to organonitrogen compound GO:0010243 246 0.056
extrinsic apoptotic signaling pathway GO:0097191 126 0.055
positive regulation of immune effector process GO:0002699 107 0.055
heterocycle catabolic process GO:0046700 280 0.054
glycosyl compound catabolic process GO:1901658 206 0.054
regulation of membrane potential GO:0042391 192 0.053
toll like receptor signaling pathway GO:0002224 38 0.052
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.051
leukocyte differentiation GO:0002521 342 0.051
cellular response to cytokine stimulus GO:0071345 189 0.051
inflammatory response GO:0006954 244 0.050
cellular response to lipid GO:0071396 145 0.050
regulation of hydrolase activity GO:0051336 246 0.050
positive regulation of apoptotic signaling pathway GO:2001235 95 0.050
purine nucleotide metabolic process GO:0006163 302 0.050
defense response to virus GO:0051607 68 0.049
regulation of mapk cascade GO:0043408 248 0.049
purine containing compound metabolic process GO:0072521 311 0.048
macromolecule catabolic process GO:0009057 281 0.048
ribonucleoside catabolic process GO:0042454 206 0.048
myeloid leukocyte differentiation GO:0002573 119 0.047
regulation of cellular ketone metabolic process GO:0010565 66 0.047
regulation of protein transport GO:0051223 163 0.046
t cell activation GO:0042110 289 0.046
regulation of homeostatic process GO:0032844 182 0.046
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.045
regulation of cell activation GO:0050865 289 0.045
negative regulation of cellular protein metabolic process GO:0032269 247 0.045
nucleobase containing small molecule metabolic process GO:0055086 352 0.044
leukocyte homeostasis GO:0001776 79 0.044
regulation of transferase activity GO:0051338 263 0.043
negative regulation of multi organism process GO:0043901 68 0.043
lymphocyte proliferation GO:0046651 164 0.042
programmed necrotic cell death GO:0097300 28 0.042
cell activation involved in immune response GO:0002263 126 0.041
positive regulation of apoptotic process GO:0043065 217 0.041
cellular macromolecule catabolic process GO:0044265 206 0.040
protein oligomerization GO:0051259 67 0.040
Human
signal transduction in absence of ligand GO:0038034 55 0.039
positive regulation of necrotic cell death GO:0010940 1 0.039
nucleotide metabolic process GO:0009117 332 0.039
reactive oxygen species metabolic process GO:0072593 84 0.038
oxidation reduction process GO:0055114 342 0.038
adaptive immune response GO:0002250 155 0.038
cellular response to peptidoglycan GO:0071224 4 0.038
purine containing compound catabolic process GO:0072523 213 0.038
innate immune response activating signal transduction GO:0002758 50 0.037
cytokine mediated signaling pathway GO:0019221 115 0.037
regulation of lymphocyte proliferation GO:0050670 117 0.037
regulation of cell killing GO:0031341 40 0.037
purine ribonucleotide catabolic process GO:0009154 208 0.037
regulation of apoptotic signaling pathway GO:2001233 197 0.036
lymphocyte mediated immunity GO:0002449 139 0.036
negative regulation of phosphorylation GO:0042326 166 0.035
regulation of cellular catabolic process GO:0031329 242 0.035
negative regulation of cell proliferation GO:0008285 296 0.035
t cell proliferation GO:0042098 120 0.035
regulation of leukocyte proliferation GO:0070663 121 0.034
nucleoside metabolic process GO:0009116 246 0.034
epidermis development GO:0008544 187 0.034
cellular amine metabolic process GO:0044106 44 0.034
glycosyl compound metabolic process GO:1901657 246 0.034
negative regulation of phosphorus metabolic process GO:0010563 184 0.034
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.034
positive regulation of programmed cell death GO:0043068 218 0.034
negative regulation of molecular function GO:0044092 258 0.034
regulation of reactive oxygen species metabolic process GO:2000377 40 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.033
chemokine production GO:0032602 34 0.033
positive regulation of immature t cell proliferation GO:0033091 4 0.032
regulation of t cell activation GO:0050863 170 0.032
ribose phosphate metabolic process GO:0019693 291 0.032
myeloid cell differentiation GO:0030099 233 0.032
regulation of chemokine production GO:0032642 30 0.032
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.032
cell killing GO:0001906 67 0.032
regulation of interleukin 1 alpha production GO:0032650 4 0.032
regulation of t cell proliferation GO:0042129 92 0.032
cation transport GO:0006812 399 0.032
regulation of cd8 positive alpha beta cytotoxic t cell extravasation GO:2000452 2 0.031
cellular ketone metabolic process GO:0042180 84 0.031
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.031
lymphocyte differentiation GO:0030098 242 0.031
response to interleukin 12 GO:0070671 2 0.031
carbohydrate derivative catabolic process GO:1901136 231 0.031
intrinsic apoptotic signaling pathway GO:0097193 132 0.031
leukocyte apoptotic process GO:0071887 71 0.031
regulation of jnk cascade GO:0046328 62 0.031
epithelial tube morphogenesis GO:0060562 303 0.031
skin development GO:0043588 220 0.031
viral process GO:0016032 41 0.031
negative regulation of immune system process GO:0002683 209 0.030
anion transport GO:0006820 177 0.030
regulation of leukocyte differentiation GO:1902105 159 0.030
lymphocyte apoptotic process GO:0070227 54 0.030
regulation of leukocyte mediated immunity GO:0002703 104 0.030
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.030
negative regulation of phosphate metabolic process GO:0045936 184 0.029
t cell mediated cytotoxicity GO:0001913 26 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.029
negative regulation of viral genome replication GO:0045071 10 0.029
positive regulation of interleukin 6 production GO:0032755 37 0.029
nitrogen compound transport GO:0071705 271 0.029
spleen development GO:0048536 39 0.029
male gamete generation GO:0048232 285 0.029
regulation of protein localization GO:0032880 231 0.029
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.029
regulation of t cell extravasation GO:2000407 3 0.029
regulation of necroptotic process GO:0060544 10 0.029
defense response to gram positive bacterium GO:0050830 50 0.028
regulation of cellular response to stress GO:0080135 159 0.028
lymphocyte homeostasis GO:0002260 64 0.028
regulation of secretion by cell GO:1903530 249 0.028
negative regulation of lymphocyte activation GO:0051250 91 0.028
intracellular receptor signaling pathway GO:0030522 74 0.028
organophosphate catabolic process GO:0046434 232 0.028
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.028
regulation of kinase activity GO:0043549 249 0.028
lymphocyte activation involved in immune response GO:0002285 93 0.028
nucleoside phosphate catabolic process GO:1901292 222 0.027
cellular amino acid metabolic process GO:0006520 103 0.027
regulation of protein kinase activity GO:0045859 232 0.027
gland development GO:0048732 330 0.027
regulation of leukocyte apoptotic process GO:2000106 56 0.027
organonitrogen compound biosynthetic process GO:1901566 192 0.027
response to growth factor GO:0070848 198 0.027
regulation of lymphocyte apoptotic process GO:0070228 41 0.027
spermatogenesis GO:0007283 284 0.027
mitochondrion organization GO:0007005 134 0.027
dephosphorylation GO:0016311 129 0.027
purine ribonucleoside metabolic process GO:0046128 241 0.027
regulation of cytoplasmic transport GO:1903649 112 0.026
nucleoside catabolic process GO:0009164 206 0.026
regulation of cellular amine metabolic process GO:0033238 20 0.026
stress activated mapk cascade GO:0051403 80 0.026
regulation of organelle organization GO:0033043 289 0.026
carbohydrate metabolic process GO:0005975 230 0.026
dna metabolic process GO:0006259 303 0.026
cytoplasmic transport GO:0016482 234 0.025
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.025
t cell apoptotic process GO:0070231 39 0.025
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.025
t cell mediated immunity GO:0002456 50 0.025
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.025
cellular response to organonitrogen compound GO:0071417 145 0.025
schwann cell proliferation GO:0014010 2 0.025
cellular chemical homeostasis GO:0055082 215 0.025
t cell extravasation GO:0072683 4 0.025
response to dsrna GO:0043331 30 0.024
negative regulation of protein metabolic process GO:0051248 282 0.024
purine ribonucleotide metabolic process GO:0009150 290 0.024
regulation of cellular amino acid metabolic process GO:0006521 5 0.024
lipid biosynthetic process GO:0008610 179 0.024
cellular homeostasis GO:0019725 240 0.024
regulation of interleukin 6 production GO:0032675 55 0.024
regulation of inflammatory response GO:0050727 147 0.024
nucleoside triphosphate catabolic process GO:0009143 205 0.024
ion transmembrane transport GO:0034220 361 0.024
cellular lipid metabolic process GO:0044255 323 0.024
organophosphate biosynthetic process GO:0090407 122 0.023
regulation of t cell apoptotic process GO:0070232 28 0.023
positive regulation of mapk cascade GO:0043410 170 0.023
jnk cascade GO:0007254 72 0.023
regulation of establishment of protein localization GO:0070201 181 0.023
regulation of interferon gamma production GO:0032649 57 0.023
regulation of secretion GO:0051046 274 0.023
cell adhesion GO:0007155 329 0.023
regulation of defense response to bacterium GO:1900424 3 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
positive regulation of protein modification process GO:0031401 299 0.022
ribonucleotide metabolic process GO:0009259 291 0.022
negative regulation of apoptotic signaling pathway GO:2001234 104 0.022
positive regulation of chemokine production GO:0032722 22 0.022
nucleotide catabolic process GO:0009166 217 0.022
necrotic cell death GO:0070265 30 0.022
protein localization to organelle GO:0033365 185 0.022
compound eye development GO:0048749 1 0.022
regulation of necrotic cell death GO:0010939 13 0.022
regulation of interleukin 1 alpha secretion GO:0050705 3 0.021
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.021
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.021
viral life cycle GO:0019058 36 0.021
regulation of adaptive immune response GO:0002819 90 0.021
b cell activation GO:0042113 161 0.021
positive regulation of lymphocyte activation GO:0051251 140 0.021
type i interferon production GO:0032606 29 0.021
purine ribonucleoside catabolic process GO:0046130 205 0.021
transmembrane transport GO:0055085 412 0.021
membrane organization GO:0061024 245 0.021
positive regulation of kinase activity GO:0033674 155 0.021
organonitrogen compound catabolic process GO:1901565 264 0.021
positive regulation of hydrolase activity GO:0051345 148 0.021
endocytosis GO:0006897 168 0.020
cellular response to organic cyclic compound GO:0071407 87 0.020
maintenance of location GO:0051235 89 0.020
sensory perception GO:0007600 245 0.020
striated muscle tissue development GO:0014706 293 0.020
nucleotide biosynthetic process GO:0009165 78 0.020
negative regulation of immune effector process GO:0002698 55 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
cellular response to dna damage stimulus GO:0006974 207 0.020
muscle cell differentiation GO:0042692 261 0.020
homeostasis of number of cells GO:0048872 210 0.020
stress activated protein kinase signaling cascade GO:0031098 81 0.020
protein catabolic process GO:0030163 221 0.020
sequestering of calcium ion GO:0051208 18 0.020
cellularization GO:0007349 1 0.020
regulation of response to biotic stimulus GO:0002831 38 0.019
purine nucleoside metabolic process GO:0042278 241 0.019
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.019
viral genome replication GO:0019079 17 0.019
intracellular protein transport GO:0006886 204 0.019
alpha beta t cell activation GO:0046631 91 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
amine metabolic process GO:0009308 45 0.019
ripoptosome assembly involved in necroptotic process GO:1901026 6 0.019
positive regulation of protein secretion GO:0050714 52 0.019
purine nucleoside catabolic process GO:0006152 205 0.019
protein deacetylation GO:0006476 32 0.019
regulation of hormone levels GO:0010817 211 0.019
organic anion transport GO:0015711 137 0.019
regulation of cell motility GO:2000145 236 0.019
glial cell apoptotic process GO:0034349 3 0.019
regulation of erk1 and erk2 cascade GO:0070372 71 0.019
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.019
regulation of cell migration GO:0030334 219 0.019
positive regulation of leukocyte differentiation GO:1902107 86 0.019
regulation of stress activated mapk cascade GO:0032872 69 0.019
divalent metal ion transport GO:0070838 172 0.018
action potential GO:0001508 78 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.018
cation transmembrane transport GO:0098655 266 0.018
interleukin 6 production GO:0032635 58 0.018
nucleoside triphosphate metabolic process GO:0009141 230 0.018
negative regulation of protein phosphorylation GO:0001933 126 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
protein maturation GO:0051604 176 0.018
peptidyl amino acid modification GO:0018193 336 0.018
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
positive regulation of interferon gamma production GO:0032729 39 0.018
protein import GO:0017038 101 0.018
nuclear transport GO:0051169 139 0.017
purine nucleoside triphosphate catabolic process GO:0009146 203 0.017
apoptotic mitochondrial changes GO:0008637 48 0.017
response to extracellular stimulus GO:0009991 127 0.017
ribonucleoside triphosphate catabolic process GO:0009203 199 0.017
pyrimidine containing compound catabolic process GO:0072529 3 0.017
t cell homeostasis GO:0043029 35 0.017
protein import into nucleus GO:0006606 95 0.017
regulation of interleukin 8 production GO:0032677 3 0.017
regulation of proteolysis GO:0030162 164 0.017
regulation of protein serine threonine kinase activity GO:0071900 157 0.017
protein homooligomerization GO:0051260 43 0.017
Human
purine nucleotide catabolic process GO:0006195 211 0.017
regulation of activated t cell proliferation GO:0046006 16 0.017
regulation of ion transport GO:0043269 215 0.017
regulation of protein secretion GO:0050708 82 0.017
inorganic ion transmembrane transport GO:0098660 234 0.017
blood vessel morphogenesis GO:0048514 285 0.017
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.016
protein modification by small protein conjugation or removal GO:0070647 207 0.016
cellular response to hormone stimulus GO:0032870 150 0.016
mitotic cell cycle process GO:1903047 159 0.016
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.016
peptide transport GO:0015833 133 0.016
cellular protein catabolic process GO:0044257 155 0.016
positive regulation of interferon alpha production GO:0032727 4 0.016
positive regulation of cell death GO:0010942 224 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.016
nucleoside monophosphate metabolic process GO:0009123 85 0.016
protein autophosphorylation GO:0046777 61 0.016
chromatin organization GO:0006325 206 0.016
extracellular structure organization GO:0043062 148 0.016
regulation of type i interferon production GO:0032479 22 0.016
regulation of anatomical structure size GO:0090066 178 0.016
interferon gamma production GO:0032609 67 0.016
cation homeostasis GO:0055080 212 0.016
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.016
interleukin 8 production GO:0032637 4 0.016
sequestering of metal ion GO:0051238 19 0.015
t cell receptor signaling pathway GO:0050852 46 0.015
negative regulation of kinase activity GO:0033673 81 0.015
negative regulation of viral process GO:0048525 23 0.015
alpha beta t cell differentiation GO:0046632 69 0.015
ossification GO:0001503 216 0.015
carbohydrate derivative biosynthetic process GO:1901137 183 0.015
hexose metabolic process GO:0019318 98 0.015
regulation of cell cycle GO:0051726 281 0.015
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.015
regulation of response to wounding GO:1903034 189 0.015
regulation of system process GO:0044057 200 0.015
germ cell development GO:0007281 185 0.015
protein processing GO:0016485 163 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
muscle tissue development GO:0060537 308 0.015
microtubule based process GO:0007017 236 0.015
cofactor metabolic process GO:0051186 80 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.015
angiogenesis GO:0001525 201 0.015
protein targeting GO:0006605 143 0.015
negative regulation of cellular component organization GO:0051129 194 0.015
ribonucleoside monophosphate metabolic process GO:0009161 80 0.015
regulation of interferon beta biosynthetic process GO:0045357 4 0.014
single organism nuclear import GO:1902593 95 0.014
positive regulation of cell activation GO:0050867 158 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.014
neuronal action potential GO:0019228 54 0.014
protein ubiquitination GO:0016567 171 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.014
positive regulation of interleukin 1 alpha secretion GO:0050717 3 0.014
monocarboxylic acid metabolic process GO:0032787 191 0.014
response to oxygen levels GO:0070482 62 0.014
hematopoietic progenitor cell differentiation GO:0002244 143 0.014
modification dependent macromolecule catabolic process GO:0043632 133 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
positive regulation of jnk cascade GO:0046330 46 0.014
divalent inorganic cation transport GO:0072511 178 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
necroptotic signaling pathway GO:0097527 3 0.014
lipid localization GO:0010876 126 0.014
positive regulation of protein kinase activity GO:0045860 144 0.014
fat cell differentiation GO:0045444 160 0.014
multicellular organismal signaling GO:0035637 91 0.014
regulation of neuron differentiation GO:0045664 281 0.014
inorganic cation transmembrane transport GO:0098662 207 0.014
calcium ion transport GO:0006816 159 0.014
exocytosis GO:0006887 121 0.014
negative regulation of cell cycle GO:0045786 123 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.013
alcohol metabolic process GO:0006066 116 0.013
positive regulation of stress activated mapk cascade GO:0032874 48 0.013
lipid transport GO:0006869 98 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
regulation of lymphocyte mediated immunity GO:0002706 84 0.013
regulation of protein targeting GO:1903533 61 0.013
negative regulation of cytokine production GO:0001818 84 0.013
leukocyte migration GO:0050900 124 0.013
cellular response to oxidative stress GO:0034599 76 0.013
rna interference GO:0016246 2 0.013
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.013
positive regulation of secretion GO:0051047 130 0.013
organic acid transport GO:0015849 101 0.013
regulation of response to cytokine stimulus GO:0060759 23 0.013
regulation of cytokine secretion GO:0050707 61 0.013
hormone secretion GO:0046879 128 0.013
camera type eye development GO:0043010 266 0.013
cellular response to external stimulus GO:0071496 88 0.013
glucose metabolic process GO:0006006 92 0.013
glycosylation GO:0070085 62 0.013
cellular ion homeostasis GO:0006873 165 0.013
nucleoside phosphate biosynthetic process GO:1901293 79 0.013
carboxylic acid transport GO:0046942 100 0.013
regulation of intracellular transport GO:0032386 159 0.013
myeloid leukocyte activation GO:0002274 83 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
toll like receptor 7 signaling pathway GO:0034154 4 0.013
erk1 and erk2 cascade GO:0070371 77 0.013
antimicrobial peptide biosynthetic process GO:0002777 2 0.013
dna recombination GO:0006310 92 0.013
regulation of neuron death GO:1901214 134 0.013
response to nutrient levels GO:0031667 109 0.013
antigen receptor mediated signaling pathway GO:0050851 64 0.013
protein glycosylation GO:0006486 55 0.013
multicellular organismal homeostasis GO:0048871 164 0.013
mitotic cell cycle GO:0000278 195 0.012
neuron death GO:0070997 154 0.012
cellular carbohydrate metabolic process GO:0044262 119 0.012
protein localization to nucleus GO:0034504 121 0.012
positive regulation of ion transport GO:0043270 65 0.012
purine containing compound biosynthetic process GO:0072522 70 0.012
cellular response to extracellular stimulus GO:0031668 81 0.012
spermatid differentiation GO:0048515 115 0.012
positive regulation of homeostatic process GO:0032846 64 0.012
activation induced cell death of t cells GO:0006924 10 0.012
response to radiation GO:0009314 165 0.012
positive regulation of adaptive immune response GO:0002821 61 0.012
t cell differentiation GO:0030217 174 0.012
regulation of lymphocyte differentiation GO:0045619 107 0.012
transmission of nerve impulse GO:0019226 76 0.012
lymphocyte migration GO:0072676 26 0.012
ras protein signal transduction GO:0007265 77 0.012
atp metabolic process GO:0046034 75 0.012
nuclear import GO:0051170 95 0.012
retrograde transport endosome to golgi GO:0042147 2 0.012
forebrain development GO:0030900 302 0.012
amide transport GO:0042886 138 0.012
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
positive regulation of phosphatase activity GO:0010922 4 0.012
positive regulation of lymphocyte proliferation GO:0050671 70 0.012
negative regulation of protein modification process GO:0031400 163 0.012
developmental maturation GO:0021700 193 0.012
spermatid development GO:0007286 108 0.012
tumor necrosis factor production GO:0032640 50 0.012
regulation of interferon beta production GO:0032648 13 0.012
gene silencing GO:0016458 38 0.012
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.012
tube formation GO:0035148 140 0.012
lung development GO:0030324 164 0.012
skeletal system development GO:0001501 356 0.012
blood circulation GO:0008015 195 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
purine nucleotide biosynthetic process GO:0006164 65 0.012
glycoprotein metabolic process GO:0009100 116 0.012
extracellular matrix organization GO:0030198 147 0.012
positive regulation of secretion by cell GO:1903532 114 0.012
chromatin modification GO:0016568 187 0.012
response to light stimulus GO:0009416 135 0.012
monosaccharide metabolic process GO:0005996 106 0.012
positive regulation of protein transport GO:0051222 93 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
regulation of metal ion transport GO:0010959 106 0.011
endomembrane system organization GO:0010256 147 0.011
regulation of tumor necrosis factor production GO:0032680 49 0.011
carbohydrate homeostasis GO:0033500 128 0.011
positive regulation of leukocyte proliferation GO:0070665 73 0.011
connective tissue development GO:0061448 179 0.011
negative regulation of transferase activity GO:0051348 85 0.011
dna catabolic process endonucleolytic GO:0000737 15 0.011
positive regulation of cell development GO:0010720 237 0.011
cytokine secretion GO:0050663 72 0.011
response to uv GO:0009411 44 0.011
mrna metabolic process GO:0016071 84 0.011
rna processing GO:0006396 105 0.011
production of molecular mediator of immune response GO:0002440 103 0.011
rig i signaling pathway GO:0039529 4 0.011
rho protein signal transduction GO:0007266 32 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
meiotic cell cycle GO:0051321 122 0.011
neuron apoptotic process GO:0051402 142 0.011
sensory perception of sound GO:0007605 97 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
cellular response to molecule of bacterial origin GO:0071219 83 0.011
circulatory system process GO:0003013 197 0.011
organelle fission GO:0048285 170 0.011
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.011
regulation of defense response to fungus GO:1900150 1 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.011
ear development GO:0043583 200 0.011
positive regulation of intracellular transport GO:0032388 70 0.011
regulation of ossification GO:0030278 112 0.011
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.011
regulation of protein import into nucleus GO:0042306 52 0.011
protein secretion GO:0009306 111 0.011
modification by symbiont of host morphology or physiology GO:0044003 4 0.011

Mlkl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.031
disease of cellular proliferation DOID:14566 0 0.031
organ system cancer DOID:0050686 0 0.031
disease of metabolism DOID:0014667 0 0.018
immune system disease DOID:2914 0 0.014
disease of anatomical entity DOID:7 0 0.014
thoracic cancer DOID:5093 0 0.014
nervous system disease DOID:863 0 0.013
gastrointestinal system cancer DOID:3119 0 0.012