Mus musculus

42 known processes

Comt

catechol-O-methyltransferase

(Aliases: D16Wsu103e,D330014B15Rik,Comt1)

Comt biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 342 0.278
cellular lipid metabolic process GO:0044255 323 0.137
cellular ketone metabolic process GO:0042180 84 0.093
cellular amino acid metabolic process GO:0006520 103 0.081
cellular amine metabolic process GO:0044106 44 0.078
regulation of cellular ketone metabolic process GO:0010565 66 0.078
response to organic cyclic compound GO:0014070 198 0.076
regulation of cellular amino acid metabolic process GO:0006521 5 0.071
amine metabolic process GO:0009308 45 0.066
monocarboxylic acid metabolic process GO:0032787 191 0.062
lipid biosynthetic process GO:0008610 179 0.056
regulation of cellular amine metabolic process GO:0033238 20 0.055
sulfur compound metabolic process GO:0006790 100 0.054
negative regulation of protein metabolic process GO:0051248 282 0.047
organic anion transport GO:0015711 137 0.045
negative regulation of molecular function GO:0044092 258 0.045
glycerolipid metabolic process GO:0046486 122 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
lipid modification GO:0030258 65 0.043
apoptotic signaling pathway GO:0097190 306 0.042
alcohol metabolic process GO:0006066 116 0.042
maintenance of location GO:0051235 89 0.040
positive regulation of cellular amine metabolic process GO:0033240 5 0.040
cation transport GO:0006812 399 0.039
organonitrogen compound biosynthetic process GO:1901566 192 0.039
regulation of defense response GO:0031347 233 0.039
ion transmembrane transport GO:0034220 361 0.038
cellular lipid catabolic process GO:0044242 52 0.037
transmembrane transport GO:0055085 412 0.037
small molecule catabolic process GO:0044282 71 0.037
small molecule biosynthetic process GO:0044283 132 0.036
negative regulation of cellular protein metabolic process GO:0032269 247 0.035
fatty acid metabolic process GO:0006631 121 0.035
carbohydrate derivative biosynthetic process GO:1901137 183 0.034
organic hydroxy compound metabolic process GO:1901615 203 0.034
regulation of mapk cascade GO:0043408 248 0.032
nucleoside phosphate metabolic process GO:0006753 338 0.032
cofactor metabolic process GO:0051186 80 0.032
response to organonitrogen compound GO:0010243 246 0.032
regulation of cytokine production GO:0001817 266 0.032
regulation of apoptotic signaling pathway GO:2001233 197 0.031
organophosphate biosynthetic process GO:0090407 122 0.031
cell type specific apoptotic process GO:0097285 268 0.031
regulation of cell activation GO:0050865 289 0.030
innate immune response GO:0045087 157 0.030
lipid catabolic process GO:0016042 69 0.030
cellular homeostasis GO:0019725 240 0.030
lipid localization GO:0010876 126 0.030
peptidyl amino acid modification GO:0018193 336 0.029
negative regulation of cell proliferation GO:0008285 296 0.029
protein maturation GO:0051604 176 0.029
nucleobase containing small molecule metabolic process GO:0055086 352 0.029
anion transport GO:0006820 177 0.029
nucleotide metabolic process GO:0009117 332 0.029
nitrogen compound transport GO:0071705 271 0.029
purine containing compound metabolic process GO:0072521 311 0.029
homeostasis of number of cells GO:0048872 210 0.029
inflammatory response GO:0006954 244 0.029
sterol metabolic process GO:0016125 58 0.028
acylglycerol metabolic process GO:0006639 55 0.028
cytoplasmic transport GO:0016482 234 0.028
myeloid cell differentiation GO:0030099 233 0.027
endocytosis GO:0006897 168 0.027
ribose phosphate metabolic process GO:0019693 291 0.026
cytokine production GO:0001816 319 0.026
leukocyte differentiation GO:0002521 342 0.026
regulation of protein localization GO:0032880 231 0.026
response to acid chemical GO:0001101 111 0.026
multicellular organismal homeostasis GO:0048871 164 0.025
mapk cascade GO:0000165 281 0.025
protein processing GO:0016485 163 0.025
cholesterol metabolic process GO:0008203 56 0.025
gland development GO:0048732 330 0.025
organic acid catabolic process GO:0016054 51 0.025
regulation of intracellular transport GO:0032386 159 0.025
regulation of protein kinase activity GO:0045859 232 0.025
cellular modified amino acid metabolic process GO:0006575 63 0.024
ribonucleoside metabolic process GO:0009119 245 0.024
regulation of organelle organization GO:0033043 289 0.023
organic cyclic compound catabolic process GO:1901361 295 0.023
cellular chemical homeostasis GO:0055082 215 0.023
membrane organization GO:0061024 245 0.023
regulation of homeostatic process GO:0032844 182 0.023
cation transmembrane transport GO:0098655 266 0.023
male gamete generation GO:0048232 285 0.023
glycerolipid biosynthetic process GO:0045017 50 0.023
skin development GO:0043588 220 0.023
Mouse
reactive oxygen species metabolic process GO:0072593 84 0.023
carboxylic acid biosynthetic process GO:0046394 86 0.023
metal ion homeostasis GO:0055065 189 0.023
macromolecule catabolic process GO:0009057 281 0.022
immune effector process GO:0002252 321 0.022
regulation of hormone levels GO:0010817 211 0.022
regulation of body fluid levels GO:0050878 162 0.022
amide transport GO:0042886 138 0.022
carboxylic acid catabolic process GO:0046395 51 0.022
peptide metabolic process GO:0006518 46 0.022
purine nucleotide metabolic process GO:0006163 302 0.022
positive regulation of protein phosphorylation GO:0001934 242 0.022
response to inorganic substance GO:0010035 96 0.021
positive regulation of mapk cascade GO:0043410 170 0.021
regulation of hydrolase activity GO:0051336 246 0.021
divalent inorganic cation homeostasis GO:0072507 138 0.021
negative regulation of phosphorylation GO:0042326 166 0.021
positive regulation of protein modification process GO:0031401 299 0.021
purine ribonucleotide metabolic process GO:0009150 290 0.021
glycerophospholipid metabolic process GO:0006650 71 0.021
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.021
regulation of lymphocyte activation GO:0051249 240 0.020
spermatogenesis GO:0007283 284 0.020
regulation of neuron death GO:1901214 134 0.020
response to molecule of bacterial origin GO:0002237 143 0.020
heart contraction GO:0060047 93 0.020
cellular response to organonitrogen compound GO:0071417 145 0.020
inorganic ion transmembrane transport GO:0098660 234 0.020
t cell activation GO:0042110 289 0.020
positive regulation of cell death GO:0010942 224 0.020
transmission of nerve impulse GO:0019226 76 0.019
regulation of cellular response to stress GO:0080135 159 0.019
organic acid transport GO:0015849 101 0.019
intracellular protein transport GO:0006886 204 0.019
regulation of kinase activity GO:0043549 249 0.019
neuronal action potential GO:0019228 54 0.019
regulation of ion transport GO:0043269 215 0.019
regulation of map kinase activity GO:0043405 120 0.019
circulatory system process GO:0003013 197 0.019
defense response to other organism GO:0098542 197 0.019
muscle cell differentiation GO:0042692 261 0.019
negative regulation of phosphorus metabolic process GO:0010563 184 0.019
regulation of plasma lipoprotein particle levels GO:0097006 23 0.019
sensory perception GO:0007600 245 0.019
Mouse
leukocyte migration GO:0050900 124 0.019
negative regulation of immune system process GO:0002683 209 0.019
carbohydrate metabolic process GO:0005975 230 0.018
endomembrane system organization GO:0010256 147 0.018
striated muscle tissue development GO:0014706 293 0.018
forebrain development GO:0030900 302 0.018
regulation of transferase activity GO:0051338 263 0.018
regulation of membrane potential GO:0042391 192 0.018
cellular response to lipid GO:0071396 145 0.018
inter male aggressive behavior GO:0002121 3 0.018
protein localization to organelle GO:0033365 185 0.018
regulation of leukocyte differentiation GO:1902105 159 0.018
lymphocyte differentiation GO:0030098 242 0.018
regulation of lipid metabolic process GO:0019216 118 0.018
blood circulation GO:0008015 195 0.017
epithelial cell development GO:0002064 159 0.017
Mouse
tissue homeostasis GO:0001894 115 0.017
response to oxidative stress GO:0006979 123 0.017
regulation of reactive oxygen species metabolic process GO:2000377 40 0.017
neuron death GO:0070997 154 0.017
extrinsic apoptotic signaling pathway GO:0097191 126 0.017
cation homeostasis GO:0055080 212 0.017
phospholipid metabolic process GO:0006644 87 0.017
ribonucleotide metabolic process GO:0009259 291 0.017
inorganic cation transmembrane transport GO:0098662 207 0.017
negative regulation of transferase activity GO:0051348 85 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
dna metabolic process GO:0006259 303 0.017
muscle tissue development GO:0060537 308 0.017
sequestering of calcium ion GO:0051208 18 0.017
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
response to lipopolysaccharide GO:0032496 128 0.017
cellular response to hormone stimulus GO:0032870 150 0.017
positive regulation of response to wounding GO:1903036 66 0.017
organonitrogen compound catabolic process GO:1901565 264 0.016
action potential GO:0001508 78 0.016
regulation of t cell activation GO:0050863 170 0.016
regulation of secretion by cell GO:1903530 249 0.016
leukocyte proliferation GO:0070661 172 0.016
g protein coupled receptor signaling pathway GO:0007186 243 0.016
ras protein signal transduction GO:0007265 77 0.016
peptide transport GO:0015833 133 0.016
carboxylic acid transport GO:0046942 100 0.016
t cell differentiation GO:0030217 174 0.016
lung development GO:0030324 164 0.016
cellular nitrogen compound catabolic process GO:0044270 280 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.016
renal system development GO:0072001 225 0.016
peptidyl tyrosine modification GO:0018212 145 0.016
actin cytoskeleton organization GO:0030036 220 0.016
positive regulation of cytokine production GO:0001819 174 0.016
fatty acid oxidation GO:0019395 28 0.016
negative regulation of apoptotic signaling pathway GO:2001234 104 0.016
divalent inorganic cation transport GO:0072511 178 0.016
regulation of secretion GO:0051046 274 0.016
lipid transport GO:0006869 98 0.015
triglyceride metabolic process GO:0006641 51 0.015
rho protein signal transduction GO:0007266 32 0.015
anatomical structure homeostasis GO:0060249 145 0.015
glycoprotein metabolic process GO:0009100 116 0.015
calcium ion homeostasis GO:0055074 127 0.015
chromatin organization GO:0006325 206 0.015
regulation of cellular catabolic process GO:0031329 242 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
epidermis development GO:0008544 187 0.015
Mouse
chemotaxis GO:0006935 247 0.015
regulation of anatomical structure size GO:0090066 178 0.015
glycoprotein biosynthetic process GO:0009101 89 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
respiratory system development GO:0060541 190 0.015
regulation of system process GO:0044057 200 0.015
nuclear transport GO:0051169 139 0.015
regulation of ossification GO:0030278 112 0.015
skeletal system development GO:0001501 356 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
regulation of cell migration GO:0030334 219 0.015
aromatic compound catabolic process GO:0019439 286 0.015
heterocycle catabolic process GO:0046700 280 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
response to monosaccharide GO:0034284 67 0.014
cellular response to molecule of bacterial origin GO:0071219 83 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
defense response to bacterium GO:0042742 119 0.014
regulation of response to wounding GO:1903034 189 0.014
cellular metal ion homeostasis GO:0006875 151 0.014
regulation of vesicle mediated transport GO:0060627 139 0.014
response to light stimulus GO:0009416 135 0.014
camera type eye development GO:0043010 266 0.014
telencephalon development GO:0021537 186 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
sequestering of metal ion GO:0051238 19 0.014
regulation of proteolysis GO:0030162 164 0.014
kidney development GO:0001822 213 0.014
nucleoside metabolic process GO:0009116 246 0.014
organophosphate catabolic process GO:0046434 232 0.014
multicellular organismal signaling GO:0035637 91 0.014
cellular divalent inorganic cation homeostasis GO:0072503 127 0.014
hematopoietic progenitor cell differentiation GO:0002244 143 0.014
blood vessel morphogenesis GO:0048514 285 0.014
nucleotide catabolic process GO:0009166 217 0.014
peptide secretion GO:0002790 114 0.014
cellular ion homeostasis GO:0006873 165 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
lateral inhibition GO:0046331 1 0.014
digestive system development GO:0055123 200 0.014
nucleoside triphosphate metabolic process GO:0009141 230 0.014
regulation of protein serine threonine kinase activity GO:0071900 157 0.014
regulation of peptidase activity GO:0052547 96 0.013
response to radiation GO:0009314 165 0.013
plasma membrane organization GO:0007009 90 0.013
skeletal system morphogenesis GO:0048705 203 0.013
small gtpase mediated signal transduction GO:0007264 97 0.013
modification dependent protein catabolic process GO:0019941 133 0.013
heart process GO:0003015 94 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
mitochondrion organization GO:0007005 134 0.013
regulation of multi organism process GO:0043900 111 0.013
rhythmic process GO:0048511 174 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
response to oxygen levels GO:0070482 62 0.013
nucleotide biosynthetic process GO:0009165 78 0.013
urogenital system development GO:0001655 261 0.013
response to extracellular stimulus GO:0009991 127 0.013
ossification GO:0001503 216 0.013
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.013
cellular response to acid chemical GO:0071229 68 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
positive regulation of secretion GO:0051047 130 0.013
lipid oxidation GO:0034440 29 0.013
response to insulin GO:0032868 100 0.013
wound healing GO:0042060 157 0.013
axonogenesis GO:0007409 274 0.013
purine nucleoside triphosphate metabolic process GO:0009144 226 0.013
muscle system process GO:0003012 141 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
neuron apoptotic process GO:0051402 142 0.013
monocarboxylic acid catabolic process GO:0072329 27 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
fat cell differentiation GO:0045444 160 0.013
morphogenesis of a branching structure GO:0001763 203 0.012
heart morphogenesis GO:0003007 178 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
synaptic transmission GO:0007268 329 0.012
protein ubiquitination GO:0016567 171 0.012
wnt signaling pathway GO:0016055 188 0.012
cell adhesion GO:0007155 329 0.012
glucose homeostasis GO:0042593 128 0.012
cellular calcium ion homeostasis GO:0006874 119 0.012
organic hydroxy compound transport GO:0015850 93 0.012
extracellular structure organization GO:0043062 148 0.012
neutral lipid metabolic process GO:0006638 57 0.012
multicellular organism growth GO:0035264 161 0.012
cellular response to peptide GO:1901653 92 0.012
lymphocyte proliferation GO:0046651 164 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
divalent metal ion transport GO:0070838 172 0.012
hair cycle GO:0042633 90 0.012
regulation of cell motility GO:2000145 236 0.012
response to growth factor GO:0070848 198 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
regulation of cell cycle GO:0051726 281 0.012
protein secretion GO:0009306 111 0.012
nuclear import GO:0051170 95 0.012
muscle contraction GO:0006936 101 0.012
sensory organ morphogenesis GO:0090596 242 0.012
cellular protein complex assembly GO:0043623 116 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
ketone catabolic process GO:0042182 3 0.012
glutathione metabolic process GO:0006749 16 0.012
positive regulation of cell motility GO:2000147 116 0.012
establishment of protein localization to organelle GO:0072594 118 0.012
ensheathment of neurons GO:0007272 76 0.012
peptidyl tyrosine phosphorylation GO:0018108 143 0.012
morphogenesis of a branching epithelium GO:0061138 193 0.012
interleukin 8 production GO:0032637 4 0.012
response to vitamin a GO:0033189 1 0.012
respiratory tube development GO:0030323 167 0.012
response to peptide GO:1901652 136 0.011
protein oligomerization GO:0051259 67 0.011
response to steroid hormone GO:0048545 56 0.011
positive regulation of cell activation GO:0050867 158 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.011
negative regulation of protein modification process GO:0031400 163 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
protein catabolic process GO:0030163 221 0.011
connective tissue development GO:0061448 179 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
nucleoside catabolic process GO:0009164 206 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
regulation of lymphocyte differentiation GO:0045619 107 0.011
regulation of protein transport GO:0051223 163 0.011
epithelial cell proliferation GO:0050673 174 0.011
leukocyte mediated immunity GO:0002443 174 0.011
cellular response to oxidative stress GO:0034599 76 0.011
regulation of cell adhesion GO:0030155 154 0.011
cofactor transport GO:0051181 4 0.011
regulation of protein catabolic process GO:0042176 108 0.011
positive regulation of defense response GO:0031349 124 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
regulation of cysteine type endopeptidase activity GO:2000116 65 0.011
cellularization GO:0007349 1 0.011
phospholipid biosynthetic process GO:0008654 36 0.011
developmental growth involved in morphogenesis GO:0060560 138 0.011
nadph regeneration GO:0006740 2 0.011
regulation of protein maturation GO:1903317 96 0.011
myeloid cell homeostasis GO:0002262 114 0.011
regulation of neuron projection development GO:0010975 169 0.011
carbohydrate homeostasis GO:0033500 128 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
protein localization to membrane GO:0072657 108 0.011
phagocytosis GO:0006909 66 0.011
locomotory behavior GO:0007626 195 0.011
regulation of interleukin 8 production GO:0032677 3 0.011
methylation GO:0032259 134 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
plasma lipoprotein particle clearance GO:0034381 13 0.011
regulation of transmembrane transport GO:0034762 128 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
positive regulation of secretion by cell GO:1903532 114 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
purine ribonucleotide biosynthetic process GO:0009152 59 0.011
response to nutrient levels GO:0031667 109 0.011
positive regulation of fatty acid oxidation GO:0046321 4 0.011
covalent chromatin modification GO:0016569 163 0.011
negative regulation of neuron apoptotic process GO:0043524 92 0.011
positive regulation of proteolysis GO:0045862 85 0.011
regulation of leukocyte proliferation GO:0070663 121 0.011
response to peptide hormone GO:0043434 127 0.011
protein localization to nucleus GO:0034504 121 0.011
cell activation involved in immune response GO:0002263 126 0.011
purine nucleotide catabolic process GO:0006195 211 0.011
chromatin modification GO:0016568 187 0.011
glycosyl compound metabolic process GO:1901657 246 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.011
germ cell development GO:0007281 185 0.011
protein import GO:0017038 101 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
positive regulation of cell development GO:0010720 237 0.010
embryonic organ morphogenesis GO:0048562 276 0.010
nucleoside monophosphate metabolic process GO:0009123 85 0.010
purine containing compound biosynthetic process GO:0072522 70 0.010
cellular response to lipopolysaccharide GO:0071222 77 0.010
compound eye development GO:0048749 1 0.010
placenta development GO:0001890 140 0.010
positive regulation of kinase activity GO:0033674 155 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
blood coagulation GO:0007596 76 0.010
myelination GO:0042552 74 0.010
cell chemotaxis GO:0060326 81 0.010
hair follicle development GO:0001942 85 0.010
cellular alcohol metabolic process GO:0044107 3 0.010
regulation of inflammatory response GO:0050727 147 0.010
skeletal muscle organ development GO:0060538 163 0.010
organelle fission GO:0048285 170 0.010
angiogenesis GO:0001525 201 0.010
purine nucleoside catabolic process GO:0006152 205 0.010
calcium ion transport GO:0006816 159 0.010
spermatid differentiation GO:0048515 115 0.010
nucleoside phosphate biosynthetic process GO:1901293 79 0.010
erythrocyte differentiation GO:0030218 88 0.010
response to metal ion GO:0010038 47 0.010
purine ribonucleotide catabolic process GO:0009154 208 0.010
hormone secretion GO:0046879 128 0.010

Comt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
disease of metabolism DOID:0014667 0 0.019
sensory system disease DOID:0050155 0 0.015
musculoskeletal system disease DOID:17 0 0.012
connective tissue disease DOID:65 0 0.012
central nervous system disease DOID:331 0 0.011
immune system disease DOID:2914 0 0.011
bone disease DOID:0080001 0 0.011
eye and adnexa disease DOID:1492 0 0.010
hematopoietic system disease DOID:74 0 0.010