|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
1.000
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.999
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.998
|
Mouse |
|
|
response to interleukin 1
|
GO:0070555 |
11 |
0.997
|
Human Rat |
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.996
|
Mouse |
|
|
cytokine production
|
GO:0001816 |
319 |
0.996
|
Mouse |
|
|
interleukin 18 mediated signaling pathway
|
GO:0035655 |
2 |
0.996
|
Mouse |
|
|
chemokine biosynthetic process
|
GO:0042033 |
8 |
0.992
|
Mouse |
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.986
|
Mouse |
|
|
positive regulation of protein secretion
|
GO:0050714 |
52 |
0.985
|
Mouse |
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.984
|
Mouse |
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.983
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
84 |
0.982
|
Mouse |
|
|
cellular response to interleukin 18
|
GO:0071351 |
3 |
0.973
|
Mouse |
|
|
regulation of interleukin 6 production
|
GO:0032675 |
55 |
0.973
|
Mouse |
|
|
myeloid leukocyte activation
|
GO:0002274 |
83 |
0.972
|
Mouse |
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.972
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.972
|
Mouse |
|
|
acute inflammatory response
|
GO:0002526 |
41 |
0.969
|
Mouse |
|
|
t helper cell differentiation
|
GO:0042093 |
28 |
0.969
|
Mouse |
|
|
alpha beta t cell differentiation involved in immune response
|
GO:0002293 |
30 |
0.968
|
Mouse |
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.960
|
Mouse |
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.959
|
|
|
|
positive regulation of inflammatory response
|
GO:0050729 |
47 |
0.955
|
Mouse |
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.954
|
|
|
|
negative regulation of chemokine production
|
GO:0032682 |
4 |
0.953
|
Mouse |
|
|
cytokine metabolic process
|
GO:0042107 |
71 |
0.952
|
Mouse |
|
|
regulation of acute inflammatory response
|
GO:0002673 |
27 |
0.952
|
|
|
|
chemokine metabolic process
|
GO:0050755 |
10 |
0.951
|
Mouse |
|
|
detection of molecule of bacterial origin
|
GO:0032490 |
2 |
0.949
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.947
|
Mouse |
|
|
t cell activation
|
GO:0042110 |
289 |
0.945
|
Mouse |
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.943
|
Mouse |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.942
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.941
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
71 |
0.939
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.930
|
Mouse |
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
37 |
0.927
|
Mouse |
|
|
negative regulation of reactive oxygen species biosynthetic process
|
GO:1903427 |
0 |
0.916
|
|
|
|
chemokine production
|
GO:0032602 |
34 |
0.915
|
Mouse |
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.913
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.909
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
96 |
0.907
|
|
|
|
inflammatory response to wounding
|
GO:0090594 |
4 |
0.905
|
|
|
|
interleukin 6 production
|
GO:0032635 |
58 |
0.897
|
Mouse |
|
|
interleukin 2 biosynthetic process
|
GO:0042094 |
15 |
0.896
|
Mouse |
|
|
positive regulation of cytokine secretion
|
GO:0050715 |
41 |
0.894
|
Mouse |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.890
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.888
|
Mouse |
|
|
response to peptide hormone
|
GO:0043434 |
127 |
0.888
|
|
|
|
interleukin 2 production
|
GO:0032623 |
33 |
0.886
|
Mouse |
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.885
|
|
|
|
cellular response to peptidoglycan
|
GO:0071224 |
4 |
0.884
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
6 |
0.882
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.874
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
93 |
0.871
|
Mouse |
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
26 |
0.862
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
130 |
0.860
|
Mouse |
|
|
positive regulation of t cell activation
|
GO:0050870 |
101 |
0.857
|
Mouse |
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.854
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.853
|
Mouse |
|
|
positive regulation of response to wounding
|
GO:1903036 |
66 |
0.850
|
Mouse |
|
|
regulation of peptide transport
|
GO:0090087 |
91 |
0.848
|
Mouse |
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.844
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
41 |
0.841
|
Mouse |
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.840
|
Mouse |
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.836
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.835
|
Mouse |
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.829
|
Mouse |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.823
|
|
|
|
granulocyte chemotaxis
|
GO:0071621 |
39 |
0.821
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.819
|
Mouse |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.818
|
|
|
|
regulation of chemokine production
|
GO:0032642 |
30 |
0.814
|
Mouse |
|
|
regulation of chemokine secretion
|
GO:0090196 |
4 |
0.811
|
Mouse |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.806
|
|
|
|
cytokine secretion
|
GO:0050663 |
72 |
0.804
|
Mouse |
|
|
antibacterial peptide production
|
GO:0002778 |
2 |
0.797
|
|
|
|
protein processing
|
GO:0016485 |
163 |
0.796
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.796
|
|
|
|
positive regulation of chemokine production
|
GO:0032722 |
22 |
0.794
|
Mouse |
|
|
protein secretion
|
GO:0009306 |
111 |
0.792
|
Mouse |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.792
|
Mouse |
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.791
|
|
|
|
peptide transport
|
GO:0015833 |
133 |
0.786
|
Mouse |
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.784
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.780
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.776
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.776
|
Mouse |
|
|
mapk cascade
|
GO:0000165 |
281 |
0.775
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
26 |
0.775
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.771
|
Mouse |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.770
|
Mouse |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.761
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.761
|
|
|
|
regulation of natural killer cell differentiation
|
GO:0032823 |
11 |
0.759
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.753
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
36 |
0.753
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.751
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.749
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.749
|
Mouse |
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.746
|
Mouse |
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.744
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.739
|
|
|
|
negative regulation of inflammatory response to antigenic stimulus
|
GO:0002862 |
10 |
0.732
|
|
|
|
regulation of immune complex clearance by monocytes and macrophages
|
GO:0090264 |
2 |
0.731
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.731
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.731
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.730
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.728
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
52 |
0.724
|
Mouse |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.723
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.719
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.717
|
|
|
|
t cell differentiation involved in immune response
|
GO:0002292 |
30 |
0.716
|
Mouse |
|
|
chemotaxis
|
GO:0006935 |
247 |
0.714
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.709
|
Rat |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.709
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.708
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.708
|
|
|
|
positive regulation by symbiont of defense related host nitric oxide production
|
GO:0052347 |
1 |
0.707
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.704
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.702
|
Mouse |
|
|
macrophage activation
|
GO:0042116 |
27 |
0.700
|
Mouse |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.699
|
|
|
|
regulation of chemokine biosynthetic process
|
GO:0045073 |
8 |
0.696
|
Mouse |
|
|
cholesterol metabolic process
|
GO:0008203 |
56 |
0.694
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.691
|
|
|
|
cellular response to peptide
|
GO:1901653 |
92 |
0.682
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.681
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
52 |
0.679
|
|
|
|
myeloid cell apoptotic process
|
GO:0033028 |
22 |
0.678
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.678
|
Mouse |
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.675
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
85 |
0.673
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.672
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.672
|
|
|
|
transcription factor import into nucleus
|
GO:0042991 |
26 |
0.671
|
Mouse |
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.669
|
Mouse |
|
|
organ or tissue specific immune response
|
GO:0002251 |
13 |
0.667
|
|
|
|
angiogenesis
|
GO:0001525 |
201 |
0.661
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
114 |
0.660
|
Mouse |
|
|
inflammatory response
|
GO:0006954 |
244 |
0.660
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.654
|
|
|
|
negative regulation of chemokine biosynthetic process
|
GO:0045079 |
2 |
0.652
|
Mouse |
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.651
|
Mouse |
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
42 |
0.650
|
Mouse |
|
|
defense response to gram positive bacterium
|
GO:0050830 |
50 |
0.649
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
61 |
0.644
|
|
|
|
interferon beta biosynthetic process
|
GO:0045350 |
4 |
0.636
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.633
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.627
|
|
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
53 |
0.624
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
56 |
0.618
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.618
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.616
|
Mouse |
|
|
response to defense related host nitric oxide production
|
GO:0052565 |
2 |
0.615
|
|
|
|
regulation of nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070424 |
3 |
0.612
|
|
|
|
lipid transport
|
GO:0006869 |
98 |
0.608
|
|
|
|
nuclear import
|
GO:0051170 |
95 |
0.605
|
Mouse |
|
|
regulation of type 2 immune response
|
GO:0002828 |
18 |
0.603
|
|
|
|
wound healing involved in inflammatory response
|
GO:0002246 |
4 |
0.603
|
|
|
|
induction by organism of immune response of other organism involved in symbiotic interaction
|
GO:0052558 |
1 |
0.603
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
69 |
0.602
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.601
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.601
|
|
|
|
negative regulation of interleukin 10 secretion
|
GO:2001180 |
2 |
0.600
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.600
|
Mouse |
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.596
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.595
|
Mouse |
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.593
|
Mouse |
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.591
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.588
|
|
|
|
regulation of b cell mediated immunity
|
GO:0002712 |
37 |
0.587
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
27 |
0.579
|
|
|
|
interleukin 5 secretion
|
GO:0072603 |
2 |
0.578
|
|
|
|
protein maturation
|
GO:0051604 |
176 |
0.576
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.573
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.572
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.564
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.564
|
Mouse |
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.561
|
Mouse |
|
|
response to glucocorticoid
|
GO:0051384 |
20 |
0.558
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.556
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.553
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.552
|
|
|
|
positive regulation of glial cell proliferation
|
GO:0060252 |
4 |
0.547
|
|
|
|
tyrosine phosphorylation of stat1 protein
|
GO:0042508 |
3 |
0.546
|
|
|
|
type i interferon signaling pathway
|
GO:0060337 |
10 |
0.544
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.544
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.542
|
|
|
|
regulation of macrophage activation
|
GO:0043030 |
17 |
0.537
|
Mouse |
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
60 |
0.533
|
Mouse |
|
|
growth involved in symbiotic interaction
|
GO:0044110 |
23 |
0.531
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.529
|
Mouse |
|
|
acute phase response
|
GO:0006953 |
10 |
0.529
|
Mouse |
|
|
cellular response to interferon gamma
|
GO:0071346 |
25 |
0.528
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.528
|
Mouse |
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.525
|
Mouse |
|
|
organic acid transport
|
GO:0015849 |
101 |
0.524
|
|
|
|
defense response to virus
|
GO:0051607 |
68 |
0.523
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.516
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.513
|
|
|
|
response to interleukin 15
|
GO:0070672 |
3 |
0.512
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.510
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.508
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
10 |
0.507
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.504
|
|
|
|
regulation of nitric oxide synthase biosynthetic process
|
GO:0051769 |
7 |
0.501
|
|
|
|
positive regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042511 |
1 |
0.500
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
54 |
0.498
|
|
|
|
immunoglobulin production involved in immunoglobulin mediated immune response
|
GO:0002381 |
43 |
0.497
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.497
|
Mouse |
|
|
neutrophil migration
|
GO:1990266 |
37 |
0.496
|
|
|
|
modulation by symbiont of defense related host nitric oxide production
|
GO:0052163 |
1 |
0.492
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
30 |
0.490
|
Mouse |
|
|
regulation of macrophage cytokine production
|
GO:0010935 |
8 |
0.488
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.483
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.481
|
|
|
|
regulation of growth of symbiont in host
|
GO:0044126 |
19 |
0.478
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.472
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
49 |
0.466
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.466
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
6 |
0.463
|
|
|
|
cellular response to interleukin 4
|
GO:0071353 |
21 |
0.462
|
|
|
|
glial cell differentiation
|
GO:0010001 |
131 |
0.461
|
|
|
|
interleukin 6 mediated signaling pathway
|
GO:0070102 |
6 |
0.461
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.451
|
|
|
|
positive regulation of transcription factor import into nucleus
|
GO:0042993 |
8 |
0.450
|
Mouse |
|
|
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway
|
GO:0070428 |
3 |
0.441
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
8 |
0.440
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.440
|
Mouse |
|
|
positive t cell selection
|
GO:0043368 |
23 |
0.438
|
|
|
|
fever generation
|
GO:0001660 |
7 |
0.436
|
|
|
|
response to interleukin 4
|
GO:0070670 |
23 |
0.434
|
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.433
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.429
|
|
|
|
positive regulation of apoptotic cell clearance
|
GO:2000427 |
3 |
0.428
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.427
|
Mouse |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.425
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.423
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.420
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
13 |
0.419
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
54 |
0.419
|
|
|
|
acylglycerol metabolic process
|
GO:0006639 |
55 |
0.413
|
|
|
|
negative regulation of interleukin 6 production
|
GO:0032715 |
17 |
0.413
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.412
|
|
|
|
b cell mediated immunity
|
GO:0019724 |
71 |
0.412
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
61 |
0.409
|
Mouse |
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.408
|
|
|
|
negative regulation of secretion
|
GO:0051048 |
61 |
0.408
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.408
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.407
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.407
|
Mouse |
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.399
|
|
|
|
leukocyte migration
|
GO:0050900 |
124 |
0.397
|
|
|
|
regulation of inflammatory response to antigenic stimulus
|
GO:0002861 |
21 |
0.396
|
|
|
|
regulation of antibacterial peptide biosynthetic process
|
GO:0002808 |
1 |
0.395
|
|
|
|
positive regulation of acute inflammatory response
|
GO:0002675 |
16 |
0.395
|
|
|
|
positive regulation of antimicrobial peptide production
|
GO:0002225 |
1 |
0.394
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
61 |
0.392
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.390
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
14 |
0.390
|
|
|
|
response to granulocyte macrophage colony stimulating factor
|
GO:0097012 |
3 |
0.387
|
|
|
|
response to type i interferon
|
GO:0034340 |
12 |
0.385
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
21 |
0.385
|
|
|
|
negative regulation of macrophage apoptotic process
|
GO:2000110 |
3 |
0.383
|
|
|
|
modulation of growth of symbiont involved in interaction with host
|
GO:0044144 |
19 |
0.381
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
165 |
0.380
|
|
|
|
alpha beta t cell proliferation
|
GO:0046633 |
21 |
0.379
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
68 |
0.378
|
|
|
|
response to defense related nitric oxide production by other organism involved in symbiotic interaction
|
GO:0052551 |
2 |
0.376
|
|
|
|
negative regulation of interleukin 5 secretion
|
GO:2000663 |
1 |
0.375
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.373
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.373
|
Mouse |
|
|
response to corticosteroid
|
GO:0031960 |
20 |
0.371
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.369
|
Mouse |
|
|
nitric oxide synthase biosynthetic process
|
GO:0051767 |
7 |
0.369
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
116 |
0.366
|
|
|
|
positive regulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction
|
GO:0052345 |
1 |
0.365
|
|
|
|
isotype switching
|
GO:0045190 |
36 |
0.363
|
|
|
|
t cell lineage commitment
|
GO:0002360 |
13 |
0.362
|
|
|
|
regulation of cytokine secretion
|
GO:0050707 |
61 |
0.361
|
Mouse |
|
|
negative regulation of nik nf kappab signaling
|
GO:1901223 |
2 |
0.359
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.358
|
|
|
|
regulation of fatty acid metabolic process
|
GO:0019217 |
28 |
0.357
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
71 |
0.356
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.356
|
|
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.355
|
Mouse |
|
|
allantoin metabolic process
|
GO:0000255 |
3 |
0.354
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
65 |
0.354
|
|
|
|
inflammatory cell apoptotic process
|
GO:0006925 |
11 |
0.353
|
|
|
|
interleukin 18 production
|
GO:0032621 |
4 |
0.351
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
122 |
0.349
|
|
|
|
regulation of mast cell proliferation
|
GO:0070666 |
4 |
0.346
|
|
|
|
cd4 positive alpha beta t cell lineage commitment
|
GO:0043373 |
6 |
0.343
|
|
|
|
t helper 1 cell differentiation
|
GO:0045063 |
13 |
0.342
|
Mouse |
|
|
vascular endothelial growth factor production
|
GO:0010573 |
13 |
0.342
|
|
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.340
|
|
|
|
negative regulation of response to cytokine stimulus
|
GO:0060761 |
9 |
0.338
|
Mouse |
|
|
immunoglobulin production
|
GO:0002377 |
73 |
0.335
|
|
|
|
response to interferon gamma
|
GO:0034341 |
34 |
0.333
|
|
|
|
t cell homeostasis
|
GO:0043029 |
35 |
0.332
|
|
|
|
alpha amino acid metabolic process
|
GO:1901605 |
59 |
0.330
|
|
|
|
regulation of vascular endothelial growth factor production
|
GO:0010574 |
13 |
0.329
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.327
|
Mouse |
|
|
positive regulation of cell migration
|
GO:0030335 |
109 |
0.326
|
|
|
|
positive regulation of macrophage activation
|
GO:0043032 |
10 |
0.326
|
Mouse |
|
|
t cell extravasation
|
GO:0072683 |
4 |
0.323
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
3 |
0.321
|
|
|
|
creatinine metabolic process
|
GO:0046449 |
3 |
0.321
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.319
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.319
|
|
|
|
regulation of humoral immune response
|
GO:0002920 |
22 |
0.317
|
|
|
|
modulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction
|
GO:0052302 |
1 |
0.317
|
|
|
|
zymogen activation
|
GO:0031638 |
41 |
0.316
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.315
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.312
|
Mouse |
|
|
regulation of interleukin 6 biosynthetic process
|
GO:0045408 |
11 |
0.310
|
|
|
|
fatty acid transport
|
GO:0015908 |
28 |
0.307
|
|
|
|
response to interleukin 18
|
GO:0070673 |
4 |
0.307
|
Mouse |
|
|
progesterone metabolic process
|
GO:0042448 |
4 |
0.303
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.303
|
|
|
|
negative regulation of leukocyte apoptotic process
|
GO:2000107 |
31 |
0.302
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
119 |
0.302
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.300
|
|
|
|
regulation of immunoglobulin production
|
GO:0002637 |
42 |
0.298
|
|
|
|
carboxylic acid transport
|
GO:0046942 |
100 |
0.298
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.298
|
Mouse |
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
43 |
0.297
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.296
|
|
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
23 |
0.295
|
Mouse |
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
39 |
0.294
|
|
|
|
interleukin 11 mediated signaling pathway
|
GO:0038154 |
2 |
0.293
|
|
|
|
regulation of interleukin 5 secretion
|
GO:2000662 |
2 |
0.293
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
43 |
0.292
|
Mouse |
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.289
|
|
|
|
regulation of cytokine secretion involved in immune response
|
GO:0002739 |
4 |
0.288
|
|
|
|
prolactin signaling pathway
|
GO:0038161 |
5 |
0.286
|
|
|
|
somatic recombination of immunoglobulin gene segments
|
GO:0016447 |
42 |
0.284
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
2 |
0.282
|
|
|
|
jak stat cascade involved in growth hormone signaling pathway
|
GO:0060397 |
4 |
0.282
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.281
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.280
|
|
|
|
positive regulation of lipid transport
|
GO:0032370 |
22 |
0.280
|
|
|
|
positive regulation of immune complex clearance by monocytes and macrophages
|
GO:0090265 |
2 |
0.280
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
118 |
0.279
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
121 |
0.279
|
|
|
|
organic anion transport
|
GO:0015711 |
137 |
0.278
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
203 |
0.277
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
65 |
0.276
|
|
|
|
cellular response to interleukin 6
|
GO:0071354 |
9 |
0.275
|
|
|
|
regulation of neutrophil chemotaxis
|
GO:0090022 |
14 |
0.274
|
|
|
|
somatic diversification of immune receptors
|
GO:0002200 |
53 |
0.274
|
|
|
|
cellular response to granulocyte macrophage colony stimulating factor stimulus
|
GO:0097011 |
3 |
0.273
|
|
|
|
phagocytosis
|
GO:0006909 |
66 |
0.272
|
|
|
|
interleukin 10 secretion
|
GO:0072608 |
4 |
0.272
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.271
|
Mouse |
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.270
|
|
|
|
negative regulation of angiogenesis
|
GO:0016525 |
25 |
0.268
|
|
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
3 |
0.267
|
|
|
|
macrophage cytokine production
|
GO:0010934 |
9 |
0.267
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.266
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.266
|
Mouse |
|
|
negative regulation of t helper 1 type immune response
|
GO:0002826 |
5 |
0.266
|
Mouse |
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
68 |
0.264
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
61 |
0.260
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.260
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
19 |
0.258
|
|
|
|
immune complex clearance by monocytes and macrophages
|
GO:0002436 |
2 |
0.255
|
|
|
|
positive regulation of nucleotide binding oligomerization domain containing 1 signaling pathway
|
GO:0070430 |
1 |
0.253
|
|
|
|
connective tissue replacement involved in inflammatory response wound healing
|
GO:0002248 |
3 |
0.253
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
30 |
0.252
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.251
|
|
|
|
response to oxygen levels
|
GO:0070482 |
62 |
0.251
|
|
|
|
citrate metabolic process
|
GO:0006101 |
3 |
0.249
|
|
|
|
response to steroid hormone
|
GO:0048545 |
56 |
0.247
|
|
|
|
regulation of membrane protein ectodomain proteolysis
|
GO:0051043 |
3 |
0.245
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
34 |
0.243
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.243
|
|
|
|
myeloid leukocyte cytokine production
|
GO:0061082 |
12 |
0.242
|
|
|
|
cell cell recognition
|
GO:0009988 |
44 |
0.241
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
61 |
0.240
|
|
|
|
positive regulation of fever generation
|
GO:0031622 |
6 |
0.240
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.238
|
|
|
|
lymphocyte migration
|
GO:0072676 |
26 |
0.236
|
|
|
|
lipid homeostasis
|
GO:0055088 |
63 |
0.234
|
|
|
|
neutral lipid metabolic process
|
GO:0006638 |
57 |
0.233
|
|
|
|
response to bacterial lipoprotein
|
GO:0032493 |
4 |
0.231
|
|
|
|
regulation of mast cell differentiation
|
GO:0060375 |
3 |
0.230
|
|
|
|
dna recombination
|
GO:0006310 |
92 |
0.229
|
|
|
|
acid secretion
|
GO:0046717 |
33 |
0.228
|
|
|
|
temperature homeostasis
|
GO:0001659 |
26 |
0.227
|
|
|
|
necroptotic process
|
GO:0070266 |
21 |
0.227
|
|
|
|
positive regulation of brown fat cell differentiation
|
GO:0090336 |
4 |
0.226
|
|
|
|
negative regulation of b cell proliferation
|
GO:0030889 |
13 |
0.226
|
|
|
|
somatic diversification of immunoglobulins involved in immune response
|
GO:0002208 |
36 |
0.224
|
|
|
|
positive regulation of b cell mediated immunity
|
GO:0002714 |
26 |
0.223
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.222
|
|
|
|
positive regulation of organic acid transport
|
GO:0032892 |
11 |
0.222
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
55 |
0.220
|
|
|
|
positive regulation of cytokine secretion involved in immune response
|
GO:0002741 |
2 |
0.220
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.219
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.219
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.217
|
|
|
|
negative regulation of blood vessel morphogenesis
|
GO:2000181 |
25 |
0.215
|
|
|
|
activation of mapk activity
|
GO:0000187 |
59 |
0.215
|
|
|
|
type 2 immune response
|
GO:0042092 |
23 |
0.215
|
|
|
|
amide transport
|
GO:0042886 |
138 |
0.214
|
Mouse |
|
|
positive regulation of gliogenesis
|
GO:0014015 |
27 |
0.214
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.213
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
25 |
0.213
|
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.213
|
|
|
|
positive regulation of activated t cell proliferation
|
GO:0042104 |
8 |
0.212
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.211
|
|
|
|
growth of symbiont in host
|
GO:0044117 |
23 |
0.209
|
|
|
|
cell chemotaxis
|
GO:0060326 |
81 |
0.209
|
|
|
|
regulation of natural killer cell proliferation
|
GO:0032817 |
2 |
0.208
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.207
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.206
|
|
|
|
somatic diversification of immune receptors via germline recombination within a single locus
|
GO:0002562 |
51 |
0.206
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.205
|
|
|
|
interleukin 13 secretion
|
GO:0072611 |
2 |
0.205
|
|
|
|
regulation of t helper 1 type immune response
|
GO:0002825 |
17 |
0.203
|
Mouse |
|
|
regulation of toll like receptor signaling pathway
|
GO:0034121 |
20 |
0.202
|
|
|
|
jak stat cascade
|
GO:0007259 |
42 |
0.201
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.201
|
|
|
|
response to dsrna
|
GO:0043331 |
30 |
0.199
|
|
|
|
regulation of interleukin 18 production
|
GO:0032661 |
3 |
0.198
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
40 |
0.198
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
53 |
0.197
|
|
|
|
eosinophil activation
|
GO:0043307 |
1 |
0.195
|
|
|
|
glucose homeostasis
|
GO:0042593 |
128 |
0.194
|
Rat |
|
|
interleukin 4 mediated signaling pathway
|
GO:0035771 |
2 |
0.194
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.194
|
|
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.193
|
|
|
|
regulation of myeloid cell apoptotic process
|
GO:0033032 |
19 |
0.192
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
3 |
0.191
|
|
|
|
positive regulation of neuron apoptotic process
|
GO:0043525 |
25 |
0.190
|
|
|
|
regulation of prostaglandin endoperoxide synthase activity
|
GO:0060584 |
2 |
0.188
|
|
|
|
positive regulation of lipopolysaccharide mediated signaling pathway
|
GO:0031666 |
5 |
0.187
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.187
|
Mouse |
|
|
regulation of mast cell apoptotic process
|
GO:0033025 |
5 |
0.187
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.185
|
|
|
|
positive regulation of interleukin 12 production
|
GO:0032735 |
21 |
0.185
|
|
|
|
regulation of ossification
|
GO:0030278 |
112 |
0.184
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
87 |
0.182
|
|
|
|
defense response to gram negative bacterium
|
GO:0050829 |
28 |
0.180
|
|
|
|
positive regulation of lipid biosynthetic process
|
GO:0046889 |
18 |
0.180
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
182 |
0.180
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.179
|
|
|
|
positive regulation of defense response to bacterium
|
GO:1900426 |
1 |
0.178
|
|
|
|
regulation of interleukin 1 secretion
|
GO:0050704 |
15 |
0.177
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.177
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.177
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
116 |
0.176
|
|
|
|
anion transport
|
GO:0006820 |
177 |
0.176
|
|
|
|
response to peptidoglycan
|
GO:0032494 |
9 |
0.176
|
|
|
|
granulocyte migration
|
GO:0097530 |
43 |
0.176
|
|
|
|
positive regulation of nitric oxide synthase biosynthetic process
|
GO:0051770 |
6 |
0.175
|
|
|
|
response to inorganic substance
|
GO:0010035 |
96 |
0.174
|
Rat |
|
|
lipid localization
|
GO:0010876 |
126 |
0.173
|
|
|
|
regulation of alpha beta t cell proliferation
|
GO:0046640 |
18 |
0.172
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
40 |
0.172
|
Mouse |
|
|
positive regulation of b cell activation
|
GO:0050871 |
49 |
0.172
|
|
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
26 |
0.171
|
Mouse |
|
|
positive regulation of behavior
|
GO:0048520 |
40 |
0.169
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.168
|
Mouse |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.168
|
|
|
|
isotype switching to ige isotypes
|
GO:0048289 |
7 |
0.168
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.166
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.165
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.165
|
|
|
|
cellular response to amino acid stimulus
|
GO:0071230 |
29 |
0.163
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
82 |
0.163
|
Mouse |
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
0 |
0.163
|
|
|
|
negative regulation of odontogenesis of dentin containing tooth
|
GO:0042489 |
1 |
0.162
|
|
|
|
peptide secretion
|
GO:0002790 |
114 |
0.161
|
|
|
|
isoleucine metabolic process
|
GO:0006549 |
4 |
0.161
|
|
|
|
mammary gland lobule development
|
GO:0061377 |
22 |
0.161
|
|
|
|
positive regulation of interleukin 18 production
|
GO:0032741 |
2 |
0.159
|
|
|
|
response to molecule of fungal origin
|
GO:0002238 |
4 |
0.159
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.159
|
|
|
|
negative regulation of interferon gamma mediated signaling pathway
|
GO:0060336 |
1 |
0.159
|
|
|
|
regulation of carbohydrate metabolic process
|
GO:0006109 |
75 |
0.159
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.158
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
2 |
0.158
|
|
