Mus musculus

136 known processes

Ctcf

CCCTC-binding factor

(Aliases: AW108038)

Ctcf biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
gene silencing GO:0016458 38 0.873
chromatin modification GO:0016568 187 0.872
chromatin silencing GO:0006342 15 0.852
cellular response to dna damage stimulus GO:0006974 207 0.791
negative regulation of gene expression epigenetic GO:0045814 15 0.789
dna metabolic process GO:0006259 303 0.739
regulation of dna endoreduplication GO:0032875 3 0.539
dna repair GO:0006281 107 0.501
histone modification GO:0016570 159 0.435
meiotic cell cycle process GO:1903046 77 0.369
chromatin organization GO:0006325 206 0.360
axonogenesis GO:0007409 274 0.325
regulation of chromatin modification GO:1903308 57 0.304
histone methylation GO:0016571 71 0.258
protein dna complex subunit organization GO:0071824 28 0.253
Human
spermatid development GO:0007286 108 0.243
spermatid differentiation GO:0048515 115 0.227
neuron projection guidance GO:0097485 141 0.223
male gamete generation GO:0048232 285 0.211
mrna processing GO:0006397 63 0.209
blastocyst development GO:0001824 80 0.207
mrna metabolic process GO:0016071 84 0.188
regulation of mrna splicing via spliceosome GO:0048024 32 0.179
posttranscriptional gene silencing GO:0016441 10 0.159
negative regulation of chromatin silencing GO:0031936 1 0.151
chromatin silencing at rdna GO:0000183 3 0.143
spermatogenesis GO:0007283 284 0.140
rna splicing via transesterification reactions GO:0000375 43 0.140
negative regulation of rna splicing GO:0033119 12 0.128
nucleobase containing small molecule metabolic process GO:0055086 352 0.127
cellular amino acid metabolic process GO:0006520 103 0.125
apoptotic signaling pathway GO:0097190 306 0.121
macromolecule methylation GO:0043414 120 0.110
alternative mrna splicing via spliceosome GO:0000380 12 0.109
mrna splicing via spliceosome GO:0000398 43 0.108
rna processing GO:0006396 105 0.107
covalent chromatin modification GO:0016569 163 0.105
ncrna 3 end processing GO:0043628 2 0.102
rna interference GO:0016246 2 0.101
regulation of cellular amine metabolic process GO:0033238 20 0.099
double strand break repair GO:0006302 48 0.098
respiratory system development GO:0060541 190 0.096
microtubule cytoskeleton organization GO:0000226 157 0.091
microtubule nucleation GO:0007020 2 0.090
mitotic cell cycle process GO:1903047 159 0.090
telomere maintenance GO:0000723 19 0.088
regulation of rna splicing GO:0043484 37 0.087
regulation of transcription by chromatin organization GO:0034401 0 0.086
rna splicing GO:0008380 54 0.086
peptidyl amino acid modification GO:0018193 336 0.081
regulation of cell cycle GO:0051726 281 0.080
regulation of cellular amino acid metabolic process GO:0006521 5 0.080
negative regulation of cellular component organization GO:0051129 194 0.079
endocytosis GO:0006897 168 0.073
stem cell differentiation GO:0048863 268 0.073
microtubule based process GO:0007017 236 0.072
regulation of histone modification GO:0031056 56 0.071
fat cell differentiation GO:0045444 160 0.071
multicellular organism growth GO:0035264 161 0.070
dna templated transcription termination GO:0006353 4 0.070
protein deacetylation GO:0006476 32 0.067
dendrite development GO:0016358 115 0.065
histone h3 k4 methylation GO:0051568 23 0.064
axon guidance GO:0007411 141 0.062
regulation of dna dependent dna replication GO:0090329 8 0.060
termination of rna polymerase ii transcription GO:0006369 1 0.059
positive regulation of chromatin modification GO:1903310 28 0.058
regulation of mrna metabolic process GO:1903311 43 0.058
rna localization GO:0006403 23 0.057
microtubule polymerization or depolymerization GO:0031109 26 0.057
regulation of mrna processing GO:0050684 41 0.054
cognition GO:0050890 149 0.053
nucleotide metabolic process GO:0009117 332 0.051
heterocycle catabolic process GO:0046700 280 0.051
histone deacetylation GO:0016575 26 0.051
meiotic cell cycle GO:0051321 122 0.050
regulation of chromatin silencing GO:0031935 2 0.050
chemotaxis GO:0006935 247 0.050
regulation of alternative mrna splicing via spliceosome GO:0000381 8 0.049
rhythmic process GO:0048511 174 0.048
protein complex disassembly GO:0043241 40 0.048
cell cycle checkpoint GO:0000075 47 0.048
negative regulation of chromosome organization GO:2001251 30 0.047
cell type specific apoptotic process GO:0097285 268 0.047
germ cell development GO:0007281 185 0.046
nuclear division GO:0000280 158 0.046
dna conformation change GO:0071103 37 0.046
Human
cellular ketone metabolic process GO:0042180 84 0.046
negative regulation of cell cycle process GO:0010948 69 0.046
histone lysine methylation GO:0034968 50 0.045
intracellular mrna localization GO:0008298 4 0.044
stem cell maintenance GO:0019827 130 0.044
regulation of cellular response to stress GO:0080135 159 0.044
mitotic cell cycle GO:0000278 195 0.043
positive regulation of histone modification GO:0031058 28 0.043
meiotic nuclear division GO:0007126 115 0.043
mrna transport GO:0051028 13 0.043
nitrogen compound transport GO:0071705 271 0.042
spliceosomal complex assembly GO:0000245 6 0.042
regulation of chromosome organization GO:0033044 83 0.042
translation GO:0006412 93 0.041
viral process GO:0016032 41 0.041
snorna metabolic process GO:0016074 1 0.041
regulation of mapk cascade GO:0043408 248 0.041
positive regulation of chromosome organization GO:2001252 33 0.041
histone acetylation GO:0016573 41 0.041
forebrain development GO:0030900 302 0.040
cell fate commitment GO:0045165 210 0.040
posttranscriptional gene silencing by rna GO:0035194 10 0.040
negative regulation of fibroblast apoptotic process GO:2000270 6 0.040
humoral immune response GO:0006959 57 0.039
chromatin mediated maintenance of transcription GO:0048096 2 0.039
sensory perception GO:0007600 245 0.039
ribonucleoprotein complex subunit organization GO:0071826 28 0.038
cellular amine metabolic process GO:0044106 44 0.037
homeostasis of number of cells GO:0048872 210 0.037
stem cell development GO:0048864 219 0.036
meiotic chromosome segregation GO:0045132 19 0.036
negative regulation of cell cycle GO:0045786 123 0.036
mrna stabilization GO:0048255 9 0.035
heart morphogenesis GO:0003007 178 0.035
negative regulation of organelle organization GO:0010639 90 0.035
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.034
methylation GO:0032259 134 0.034
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.034
organelle fission GO:0048285 170 0.033
purine containing compound catabolic process GO:0072523 213 0.033
purine nucleotide catabolic process GO:0006195 211 0.033
gonad development GO:0008406 141 0.032
mapk cascade GO:0000165 281 0.032
organic cyclic compound catabolic process GO:1901361 295 0.032
female sex differentiation GO:0046660 84 0.032
blood circulation GO:0008015 195 0.031
negative regulation of dna dependent dna replication GO:2000104 1 0.031
amine metabolic process GO:0009308 45 0.031
dna integrity checkpoint GO:0031570 28 0.031
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.031
genetic imprinting GO:0071514 27 0.030
muscle contraction GO:0006936 101 0.030
sister chromatid segregation GO:0000819 20 0.030
negative regulation of mrna splicing via spliceosome GO:0048025 12 0.030
regulation of cell cycle process GO:0010564 160 0.030
aromatic compound catabolic process GO:0019439 286 0.029
adult behavior GO:0030534 135 0.029
nucleus organization GO:0006997 45 0.028
regulation of organelle organization GO:0033043 289 0.028
ribonucleoside monophosphate metabolic process GO:0009161 80 0.028
peptidyl lysine modification GO:0018205 77 0.027
sensory perception of sound GO:0007605 97 0.027
neuron maturation GO:0042551 29 0.027
mitotic sister chromatid cohesion GO:0007064 1 0.027
positive regulation of protein modification process GO:0031401 299 0.027
protein localization to nucleus GO:0034504 121 0.026
rna stabilization GO:0043489 9 0.026
regionalization GO:0003002 337 0.026
Fly
nucleoside phosphate metabolic process GO:0006753 338 0.026
development of primary sexual characteristics GO:0045137 143 0.026
rna transport GO:0050658 18 0.026
gene silencing by rna GO:0031047 19 0.026
purine ribonucleoside catabolic process GO:0046130 205 0.026
compound eye development GO:0048749 1 0.026
nuclear transport GO:0051169 139 0.025
protein deacylation GO:0035601 36 0.024
purine nucleoside triphosphate catabolic process GO:0009146 203 0.024
mitotic sister chromatid segregation GO:0000070 14 0.024
blastocyst growth GO:0001832 23 0.024
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.024
purine ribonucleotide catabolic process GO:0009154 208 0.024
innate immune response GO:0045087 157 0.023
segmentation GO:0035282 93 0.023
Fly
male sex differentiation GO:0046661 109 0.023
posttranscriptional regulation of gene expression GO:0010608 155 0.023
ribose phosphate metabolic process GO:0019693 291 0.023
learning or memory GO:0007611 148 0.023
nucleoside monophosphate metabolic process GO:0009123 85 0.022
negative regulation of intracellular signal transduction GO:1902532 167 0.022
ribonucleoside triphosphate catabolic process GO:0009203 199 0.022
regulation of chromatin organization GO:1902275 57 0.022
circulatory system process GO:0003013 197 0.022
phagocytosis GO:0006909 66 0.022
hematopoietic progenitor cell differentiation GO:0002244 143 0.021
purine containing compound metabolic process GO:0072521 311 0.021
response to lipopolysaccharide GO:0032496 128 0.021
ribonucleoside monophosphate catabolic process GO:0009158 57 0.021
macromolecule catabolic process GO:0009057 281 0.021
cytoplasmic transport GO:0016482 234 0.021
regulation of mitotic cell cycle GO:0007346 126 0.020
developmental maturation GO:0021700 193 0.020
nucleoside catabolic process GO:0009164 206 0.020
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.020
synapse assembly involved in innervation GO:0060386 1 0.020
protein localization to organelle GO:0033365 185 0.020
regulation of protein complex disassembly GO:0043244 28 0.019
atp metabolic process GO:0046034 75 0.019
organonitrogen compound catabolic process GO:1901565 264 0.019
purine nucleotide metabolic process GO:0006163 302 0.019
immune effector process GO:0002252 321 0.019
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.019
sensory organ morphogenesis GO:0090596 242 0.018
regulation of mitotic cell cycle phase transition GO:1901990 73 0.018
regulation of cellular ketone metabolic process GO:0010565 66 0.018
mitotic cell cycle checkpoint GO:0007093 31 0.018
digestive tract development GO:0048565 190 0.018
response to molecule of bacterial origin GO:0002237 143 0.018
positive regulation of cellular amine metabolic process GO:0033240 5 0.018
rna 3 end processing GO:0031123 20 0.017
nucleoside metabolic process GO:0009116 246 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
regulation of apoptotic signaling pathway GO:2001233 197 0.017
histone h3 k4 trimethylation GO:0080182 5 0.017
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
nucleocytoplasmic transport GO:0006913 139 0.016
3 utr mediated mrna stabilization GO:0070935 2 0.016
regulation of cell cycle phase transition GO:1901987 77 0.016
mitotic spindle organization GO:0007052 10 0.016
nuclear envelope organization GO:0006998 11 0.016
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.016
negative regulation of mrna metabolic process GO:1903312 13 0.016
regulation of circadian rhythm GO:0042752 58 0.016
mitotic nuclear division GO:0007067 48 0.016
negative regulation of mrna processing GO:0050686 12 0.016
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.016
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
canonical wnt signaling pathway GO:0060070 130 0.016
positive regulation of mapk cascade GO:0043410 170 0.016
positive regulation of growth GO:0045927 104 0.016
nucleobase containing compound transport GO:0015931 27 0.016
ribonucleoside metabolic process GO:0009119 245 0.016
negative regulation of nervous system development GO:0051961 156 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.016
nerve development GO:0021675 67 0.015
histone h4 acetylation GO:0043967 10 0.015
negative regulation of protein modification process GO:0031400 163 0.015
glycosyl compound metabolic process GO:1901657 246 0.015
regulation of system process GO:0044057 200 0.015
skin development GO:0043588 220 0.015
peptidyl lysine trimethylation GO:0018023 12 0.015
central nervous system neuron axonogenesis GO:0021955 28 0.015
antimicrobial humoral response GO:0019730 11 0.015
negative regulation of protein metabolic process GO:0051248 282 0.015
digestive tract morphogenesis GO:0048546 147 0.015
molting cycle GO:0042303 90 0.015
protein acylation GO:0043543 64 0.015
response to radiation GO:0009314 165 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.015
spindle organization GO:0007051 28 0.015
oxidation reduction process GO:0055114 342 0.015
positive regulation of binding GO:0051099 49 0.015
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.015
myeloid cell differentiation GO:0030099 233 0.014
leukocyte differentiation GO:0002521 342 0.014
female gonad development GO:0008585 71 0.014
epithelial cell development GO:0002064 159 0.014
peptidyl lysine methylation GO:0018022 29 0.014
limb development GO:0060173 166 0.014
regulation of neuron projection development GO:0010975 169 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
anatomical structure homeostasis GO:0060249 145 0.014
negative regulation of cell cycle phase transition GO:1901988 48 0.014
positive regulation of histone h3 k4 methylation GO:0051571 5 0.014
receptor mediated endocytosis GO:0006898 51 0.014
regulation of mrna stability GO:0043488 23 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
cajal body organization GO:0030576 1 0.013
nucleosome positioning GO:0016584 4 0.013
Human
atp dependent chromatin remodeling GO:0043044 9 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
b cell differentiation GO:0030183 78 0.013
telencephalon development GO:0021537 186 0.013
histone h4 k16 acetylation GO:0043984 3 0.013
transcription from rna polymerase iii promoter GO:0006383 3 0.013
hair cycle GO:0042633 90 0.013
atp catabolic process GO:0006200 55 0.013
ras protein signal transduction GO:0007265 77 0.013
spindle assembly involved in meiosis GO:0090306 4 0.013
negative regulation of synapse assembly GO:0051964 3 0.013
wnt signaling pathway GO:0016055 188 0.013
male meiosis GO:0007140 37 0.013
positive regulation of cell cycle process GO:0090068 61 0.013
respiratory tube development GO:0030323 167 0.013
formation of organ boundary GO:0010160 1 0.013
circadian rhythm GO:0007623 114 0.013
regulation of multi organism process GO:0043900 111 0.012
protein methylation GO:0006479 81 0.012
lung development GO:0030324 164 0.012
regulation of microtubule depolymerization GO:0031114 13 0.012
maintenance of protein location in nucleus GO:0051457 2 0.012
oogenesis GO:0048477 56 0.012
regulation of neuron differentiation GO:0045664 281 0.012
purine ribonucleotide metabolic process GO:0009150 290 0.012
histone mrna metabolic process GO:0008334 3 0.012
regulation of translation GO:0006417 71 0.012
negative regulation of cellular amine metabolic process GO:0033239 1 0.012
regulation of neuron apoptotic process GO:0043523 122 0.012
ribonucleotide metabolic process GO:0009259 291 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
regulation of response to dna damage stimulus GO:2001020 34 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
chromatin remodeling GO:0006338 32 0.012
establishment of rna localization GO:0051236 18 0.012
regulation of kinase activity GO:0043549 249 0.012
regulation of nuclear division GO:0051783 56 0.012
regulation of histone deacetylation GO:0031063 12 0.012
protein depolymerization GO:0051261 34 0.012
lymphocyte differentiation GO:0030098 242 0.012
negative regulation of protein complex disassembly GO:0043242 22 0.011
olfactory learning GO:0008355 2 0.011
response to organic cyclic compound GO:0014070 198 0.011
female gamete generation GO:0007292 74 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
adult locomotory behavior GO:0008344 91 0.011
organophosphate catabolic process GO:0046434 232 0.011
palate development GO:0060021 76 0.011
regulation of intracellular transport GO:0032386 159 0.011
regulation of myeloid cell differentiation GO:0045637 96 0.011
rna catabolic process GO:0006401 29 0.011
negative regulation of gene silencing GO:0060969 2 0.011
regulation of fat cell differentiation GO:0045598 81 0.011
mitotic chromosome condensation GO:0007076 1 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.011
digestive system development GO:0055123 200 0.011
cell division GO:0051301 120 0.011
negative regulation of cytoskeleton organization GO:0051494 36 0.011
negative regulation of wnt signaling pathway GO:0030178 73 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.011
primary mirna processing GO:0031053 1 0.011
viral life cycle GO:0019058 36 0.010
interspecies interaction between organisms GO:0044419 83 0.010
centrosome organization GO:0051297 26 0.010
regulation of rna stability GO:0043487 26 0.010
negative regulation of mitotic cell cycle GO:0045930 58 0.010
sensory perception of mechanical stimulus GO:0050954 107 0.010
dna topological change GO:0006265 2 0.010
positive regulation of histone methylation GO:0031062 16 0.010
multicellular organismal aging GO:0010259 24 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.010
positive regulation of programmed cell death GO:0043068 218 0.010
purine ribonucleoside metabolic process GO:0046128 241 0.010
mrna splice site selection GO:0006376 5 0.010
positive regulation of protein phosphorylation GO:0001934 242 0.010
engulfment of apoptotic cell GO:0043652 3 0.010
camera type eye development GO:0043010 266 0.010
meiosis i GO:0007127 60 0.010

Ctcf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cornelia de lange syndrome DOID:11725 0 0.040
disease of mental health DOID:150 0 0.032
disease of anatomical entity DOID:7 0 0.010
nervous system disease DOID:863 0 0.010