Mus musculus

61 known processes

Casp2

caspase 2

(Aliases: Caspase-2,ICH-1,Nedd2)

Casp2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macromolecule catabolic process GO:0009057 281 0.342
Mouse Worm
histone methylation GO:0016571 71 0.174
cellular nitrogen compound catabolic process GO:0044270 280 0.168
Mouse
regulation of chromatin silencing GO:0031935 2 0.162
negative regulation of cellular protein metabolic process GO:0032269 247 0.149
Mouse
cellular macromolecule catabolic process GO:0044265 206 0.135
Mouse
cellular amine metabolic process GO:0044106 44 0.124
heterocycle catabolic process GO:0046700 280 0.110
Mouse
germ cell development GO:0007281 185 0.099
Fly
amine metabolic process GO:0009308 45 0.097
cellular amino acid metabolic process GO:0006520 103 0.095
regulation of cellular catabolic process GO:0031329 242 0.086
Mouse Fly
regulation of cellular ketone metabolic process GO:0010565 66 0.084
development of primary sexual characteristics GO:0045137 143 0.084
Rat
gene silencing GO:0016458 38 0.084
regulation of cellular amine metabolic process GO:0033238 20 0.081
regulation of cellular amino acid metabolic process GO:0006521 5 0.078
cellular protein catabolic process GO:0044257 155 0.077
regulation of protein stability GO:0031647 52 0.073
gonad morphogenesis GO:0035262 1 0.072
signal transduction involved in dna damage checkpoint GO:0072422 3 0.067
Human
rhythmic process GO:0048511 174 0.067
Rat
intrinsic apoptotic signaling pathway GO:0097193 132 0.067
Mouse
regulation of cell cycle GO:0051726 281 0.065
Human Mouse
negative regulation of protein metabolic process GO:0051248 282 0.062
Mouse
ubiquitin dependent protein catabolic process GO:0006511 129 0.061
response to lipopolysaccharide GO:0032496 128 0.061
Mouse
nucleotide metabolic process GO:0009117 332 0.059
chromatin modification GO:0016568 187 0.059
male gamete generation GO:0048232 285 0.058
Fly
leukocyte differentiation GO:0002521 342 0.058
Mouse
developmental maturation GO:0021700 193 0.058
Fly
negative regulation of molecular function GO:0044092 258 0.057
Mouse
mitotic cell cycle process GO:1903047 159 0.057
Human
response to molecule of bacterial origin GO:0002237 143 0.057
Mouse
macromolecule methylation GO:0043414 120 0.057
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.056
apoptotic signaling pathway GO:0097190 306 0.056
rna 3 end processing GO:0031123 20 0.054
cellular ketone metabolic process GO:0042180 84 0.053
negative regulation of cellular component organization GO:0051129 194 0.053
nucleobase containing small molecule metabolic process GO:0055086 352 0.052
regulation of cell cycle process GO:0010564 160 0.052
Human
skeletal system development GO:0001501 356 0.052
epithelial tube formation GO:0072175 130 0.047
Mouse
methylation GO:0032259 134 0.046
purine containing compound metabolic process GO:0072521 311 0.045
purine ribonucleotide metabolic process GO:0009150 290 0.045
histone lysine methylation GO:0034968 50 0.045
regulation of chromatin modification GO:1903308 57 0.045
dna metabolic process GO:0006259 303 0.044
Mouse
regulation of organelle organization GO:0033043 289 0.042
histone h3 k9 dimethylation GO:0036123 4 0.041
purine nucleotide metabolic process GO:0006163 302 0.041
circulatory system process GO:0003013 197 0.040
tube formation GO:0035148 140 0.039
Mouse
rna processing GO:0006396 105 0.038
multicellular organism growth GO:0035264 161 0.037
peptidyl amino acid modification GO:0018193 336 0.037
protein polyubiquitination GO:0000209 33 0.036
purine nucleoside triphosphate metabolic process GO:0009144 226 0.035
endomembrane system organization GO:0010256 147 0.034
response to organic cyclic compound GO:0014070 198 0.034
Mouse
chromatin organization GO:0006325 206 0.034
negative regulation of translation GO:0017148 22 0.034
regulation of cell cycle g2 m phase transition GO:1902749 10 0.034
protein methylation GO:0006479 81 0.033
histone modification GO:0016570 159 0.033
regulation of apoptotic signaling pathway GO:2001233 197 0.032
ossification GO:0001503 216 0.032
cellular response to dna damage stimulus GO:0006974 207 0.032
Human Mouse
epithelial tube morphogenesis GO:0060562 303 0.032
Mouse
negative regulation of protein modification process GO:0031400 163 0.031
Mouse
regulation of myeloid cell differentiation GO:0045637 96 0.031
blood circulation GO:0008015 195 0.031
aromatic compound catabolic process GO:0019439 286 0.030
Mouse
dna alkylation GO:0006305 43 0.030
cardiac muscle contraction GO:0060048 32 0.030
organelle fission GO:0048285 170 0.029
glycosyl compound metabolic process GO:1901657 246 0.029
negative regulation of cellular amine metabolic process GO:0033239 1 0.029
ribonucleoside metabolic process GO:0009119 245 0.029
regulation of chromatin organization GO:1902275 57 0.029
heart contraction GO:0060047 93 0.029
regulation of circadian rhythm GO:0042752 58 0.029
negative regulation of organelle organization GO:0010639 90 0.029
modification dependent macromolecule catabolic process GO:0043632 133 0.029
oocyte axis specification GO:0007309 2 0.028
organophosphate biosynthetic process GO:0090407 122 0.028
spermatogenesis GO:0007283 284 0.028
Fly
modification dependent protein catabolic process GO:0019941 133 0.028
peptidyl lysine modification GO:0018205 77 0.027
organelle assembly GO:0070925 177 0.027
meiotic cell cycle GO:0051321 122 0.027
posttranscriptional regulation of gene expression GO:0010608 155 0.027
embryonic epithelial tube formation GO:0001838 130 0.027
Mouse
nucleoside metabolic process GO:0009116 246 0.025
hematopoietic progenitor cell differentiation GO:0002244 143 0.025
meiotic nuclear division GO:0007126 115 0.025
translation GO:0006412 93 0.025
heart process GO:0003015 94 0.024
protein localization to organelle GO:0033365 185 0.024
positive regulation of neuron differentiation GO:0045666 141 0.024
cell maturation GO:0048469 127 0.023
Fly
regulation of histone modification GO:0031056 56 0.023
regulation of organ morphogenesis GO:2000027 144 0.023
Fly
positive regulation of nervous system development GO:0051962 221 0.023
oxidation reduction process GO:0055114 342 0.023
spermatid development GO:0007286 108 0.023
Fly
localization within membrane GO:0051668 4 0.023
nucleoside catabolic process GO:0009164 206 0.023
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.023
protein modification by small protein conjugation GO:0032446 187 0.022
negative regulation of histone h3 k9 methylation GO:0051573 4 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.022
carbohydrate homeostasis GO:0033500 128 0.022
camera type eye development GO:0043010 266 0.022
Rat
cellular homeostasis GO:0019725 240 0.022
histone acetylation GO:0016573 41 0.022
dna integrity checkpoint GO:0031570 28 0.022
Human
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.022
response to alcohol GO:0097305 48 0.022
Mouse
organic cyclic compound catabolic process GO:1901361 295 0.022
Mouse
ribose phosphate metabolic process GO:0019693 291 0.022
protein modification by small protein conjugation or removal GO:0070647 207 0.021
female gamete generation GO:0007292 74 0.021
Fly
response to radiation GO:0009314 165 0.021
Mouse
regulation of neuron differentiation GO:0045664 281 0.021
myeloid cell homeostasis GO:0002262 114 0.020
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.020
Mouse
muscle tissue development GO:0060537 308 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.020
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.020
circadian rhythm GO:0007623 114 0.020
nucleoside phosphate metabolic process GO:0006753 338 0.020
muscle contraction GO:0006936 101 0.020
dna repair GO:0006281 107 0.020
circadian regulation of gene expression GO:0032922 48 0.020
microtubule cytoskeleton organization GO:0000226 157 0.020
nucleoside phosphate catabolic process GO:1901292 222 0.020
divalent metal ion transport GO:0070838 172 0.020
negative regulation of cell development GO:0010721 169 0.020
striated muscle contraction GO:0006941 45 0.019
histone h4 k16 acetylation GO:0043984 3 0.019
cellular lipid metabolic process GO:0044255 323 0.019
protein catabolic process GO:0030163 221 0.019
Worm
spermatid differentiation GO:0048515 115 0.019
Fly
positive regulation of cell cycle process GO:0090068 61 0.019
Human
canonical wnt signaling pathway GO:0060070 130 0.019
ribonucleotide metabolic process GO:0009259 291 0.019
regulation of hormone levels GO:0010817 211 0.019
cell type specific apoptotic process GO:0097285 268 0.019
Mouse Rat Fly
regulation of cell division GO:0051302 76 0.019
regulation of histone h3 k9 methylation GO:0051570 8 0.019
mrna 3 end processing GO:0031124 16 0.019
carbohydrate derivative biosynthetic process GO:1901137 183 0.018
lymphocyte differentiation GO:0030098 242 0.018
response to extracellular stimulus GO:0009991 127 0.018
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 4 0.018
negative regulation of chromatin silencing GO:0031936 1 0.018
protein secretion GO:0009306 111 0.018
Mouse
protein maturation GO:0051604 176 0.018
Human Mouse Worm Fly
oocyte anterior posterior axis specification GO:0007314 2 0.018
b cell activation GO:0042113 161 0.018
Mouse
purine nucleoside catabolic process GO:0006152 205 0.018
mitotic cell cycle GO:0000278 195 0.018
Human
negative regulation of cell proliferation GO:0008285 296 0.018
Mouse Fly
purine nucleoside monophosphate metabolic process GO:0009126 81 0.018
asymmetric neuroblast division GO:0055059 1 0.017
microtubule based process GO:0007017 236 0.017
covalent chromatin modification GO:0016569 163 0.017
ion transmembrane transport GO:0034220 361 0.017
innate immune response GO:0045087 157 0.017
Fly
purine nucleoside metabolic process GO:0042278 241 0.017
sulfur compound metabolic process GO:0006790 100 0.017
regulation of mrna stability GO:0043488 23 0.017
negative regulation of nervous system development GO:0051961 156 0.017
response to transforming growth factor beta GO:0071559 88 0.017
skeletal muscle cell differentiation GO:0035914 66 0.017
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.017
amp metabolic process GO:0046033 4 0.017
nucleus organization GO:0006997 45 0.016
protein alkylation GO:0008213 81 0.016
negative regulation of histone methylation GO:0031061 10 0.016
purine containing compound catabolic process GO:0072523 213 0.016
cytokine production GO:0001816 319 0.016
Mouse
regulation of multi organism process GO:0043900 111 0.016
Fly
sensory organ morphogenesis GO:0090596 242 0.016
Fly
regulation of system process GO:0044057 200 0.016
regulation of cellular component biogenesis GO:0044087 181 0.016
nuclear transcribed mrna poly a tail shortening GO:0000289 7 0.016
regulation of cell activation GO:0050865 289 0.016
Mouse
axonogenesis GO:0007409 274 0.016
cation transmembrane transport GO:0098655 266 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
rna catabolic process GO:0006401 29 0.016
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.016
immune effector process GO:0002252 321 0.016
Fly
purine nucleotide catabolic process GO:0006195 211 0.016
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.016
nucleoside phosphate biosynthetic process GO:1901293 79 0.016
transmembrane transport GO:0055085 412 0.016
membrane organization GO:0061024 245 0.016
Worm
purine nucleoside triphosphate catabolic process GO:0009146 203 0.016
regulation of blood circulation GO:1903522 93 0.016
negative regulation of cell cycle process GO:0010948 69 0.015
Human
mitotic chromosome condensation GO:0007076 1 0.015
gonad development GO:0008406 141 0.015
Rat
glial cell apoptotic process GO:0034349 3 0.015
Mouse
protein deacetylation GO:0006476 32 0.015
negative regulation of gene silencing GO:0060969 2 0.015
cell growth GO:0016049 130 0.015
cellular response to organonitrogen compound GO:0071417 145 0.015
protein acylation GO:0043543 64 0.015
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 12 0.015
protein ubiquitination GO:0016567 171 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
Mouse
regulation of purine nucleotide metabolic process GO:1900542 169 0.015
negative regulation of neuron differentiation GO:0045665 101 0.015
divalent inorganic cation transport GO:0072511 178 0.015
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.015
regulation of asymmetric cell division GO:0009786 4 0.015
positive regulation of protein modification process GO:0031401 299 0.015
somatic diversification of immune receptors via somatic mutation GO:0002566 8 0.015
organophosphate catabolic process GO:0046434 232 0.015
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.015
response to organonitrogen compound GO:0010243 246 0.015
Mouse
regulation of mitotic cell cycle GO:0007346 126 0.015
Human
ribonucleoside triphosphate metabolic process GO:0009199 220 0.015
nuclear division GO:0000280 158 0.015
response to nutrient levels GO:0031667 109 0.014
neural tube development GO:0021915 160 0.014
Mouse
rna interference GO:0016246 2 0.014
cell junction organization GO:0034330 77 0.014
nitrogen compound transport GO:0071705 271 0.014
lung development GO:0030324 164 0.014
glucose homeostasis GO:0042593 128 0.014
positive regulation of proteolysis GO:0045862 85 0.014
Mouse Fly
negative regulation of transcription from rna polymerase i promoter GO:0016479 2 0.014
peptidyl lysine methylation GO:0018022 29 0.014
myeloid cell differentiation GO:0030099 233 0.014
Mouse
pharynx development GO:0060465 1 0.014
positive regulation of cell development GO:0010720 237 0.014
Fly
lateral inhibition GO:0046331 1 0.014
positive regulation of cell death GO:0010942 224 0.014
muscle cell differentiation GO:0042692 261 0.014
nucleoside monophosphate metabolic process GO:0009123 85 0.014
nucleoside bisphosphate biosynthetic process GO:0033866 6 0.014
positive regulation of cellular amine metabolic process GO:0033240 5 0.014
histone h3 k9 methylation GO:0051567 17 0.013
immunoglobulin production GO:0002377 73 0.013
regulation of cytoplasmic mrna processing body assembly GO:0010603 2 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.013
learning or memory GO:0007611 148 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
negative regulation of ossification GO:0030279 49 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
morphogenesis of a branching epithelium GO:0061138 193 0.013
mitotic nuclear division GO:0007067 48 0.013
production of molecular mediator of immune response GO:0002440 103 0.013
Fly
wound healing GO:0042060 157 0.013
glycerolipid metabolic process GO:0046486 122 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
Mouse Fly
skeletal system morphogenesis GO:0048705 203 0.013
positive regulation of defense response GO:0031349 124 0.013
Fly
dna modification GO:0006304 50 0.013
asymmetric stem cell division GO:0098722 3 0.013
gland development GO:0048732 330 0.013
Fly
respiratory tube development GO:0030323 167 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
positive regulation of cell cycle GO:0045787 92 0.013
Human
response to heat GO:0009408 27 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
oocyte construction GO:0007308 2 0.012
definitive hemopoiesis GO:0060216 20 0.012
maternal determination of anterior posterior axis embryo GO:0008358 2 0.012
protein localization to nucleus GO:0034504 121 0.012
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.012
Human
anatomical structure homeostasis GO:0060249 145 0.012
regulation of protein transport GO:0051223 163 0.012
Mouse
regulation of rna stability GO:0043487 26 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
proteasomal protein catabolic process GO:0010498 98 0.012
regulation of inflammatory response GO:0050727 147 0.012
Mouse
regulation of heart contraction GO:0008016 77 0.012
protein processing GO:0016485 163 0.012
Human Mouse Worm Fly
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
germ line stem cell division GO:0042078 2 0.012
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.012
Human
negative regulation of phagocytosis GO:0050765 4 0.012
ribonucleotide biosynthetic process GO:0009260 59 0.012
negative regulation of cell activation GO:0050866 111 0.012
Mouse
inflammatory response GO:0006954 244 0.012
Mouse
embryonic organ morphogenesis GO:0048562 276 0.012
dendrite development GO:0016358 115 0.012
Fly
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
regulation of neuron projection development GO:0010975 169 0.012
response to temperature stimulus GO:0009266 55 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
Mouse
organic hydroxy compound metabolic process GO:1901615 203 0.011
Fly
establishment or maintenance of neuroblast polarity GO:0045196 1 0.011
receptor mediated endocytosis GO:0006898 51 0.011
development of primary male sexual characteristics GO:0046546 88 0.011
cardiac muscle cell contraction GO:0086003 7 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
Mouse
developmental cell growth GO:0048588 84 0.011
internal peptidyl lysine acetylation GO:0018393 42 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
positive regulation of nucleoside metabolic process GO:0045979 91 0.011
negative regulation of phosphate metabolic process GO:0045936 184 0.011
Mouse
nuclear envelope organization GO:0006998 11 0.011
ribonucleoside biosynthetic process GO:0042455 21 0.011
regulation of osteoblast differentiation GO:0045667 67 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.011
macromolecular complex disassembly GO:0032984 43 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.011
peptidyl serine phosphorylation GO:0018105 74 0.011
response to monosaccharide GO:0034284 67 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
cytoplasmic transport GO:0016482 234 0.011
nuclear transport GO:0051169 139 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
negative regulation of gene expression epigenetic GO:0045814 15 0.011
somatic cell dna recombination GO:0016444 51 0.011
positive regulation of myeloid cell differentiation GO:0045639 43 0.011
neural precursor cell proliferation GO:0061351 121 0.011
skeletal muscle organ development GO:0060538 163 0.011
regulation of nucleotide catabolic process GO:0030811 122 0.011
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.010
Human
inorganic cation transmembrane transport GO:0098662 207 0.010
positive regulation of histone h3 k4 methylation GO:0051571 5 0.010
protein targeting GO:0006605 143 0.010
response to endoplasmic reticulum stress GO:0034976 53 0.010
Mouse
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.010
cation transport GO:0006812 399 0.010
endocytosis GO:0006897 168 0.010
Worm
cellular protein complex assembly GO:0043623 116 0.010
sulfur compound biosynthetic process GO:0044272 37 0.010
neuron death GO:0070997 154 0.010
Mouse Rat
regulation of homeostatic process GO:0032844 182 0.010
ribonucleoside bisphosphate metabolic process GO:0033875 9 0.010
establishment or maintenance of cell polarity GO:0007163 86 0.010
mrna metabolic process GO:0016071 84 0.010
kidney development GO:0001822 213 0.010
megakaryocyte differentiation GO:0030219 26 0.010
maintenance of location GO:0051235 89 0.010
tube closure GO:0060606 91 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
Mouse
regulation of myeloid leukocyte differentiation GO:0002761 58 0.010
cellular response to cytokine stimulus GO:0071345 189 0.010

Casp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 0 0.019
central nervous system disease DOID:331 0 0.017
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
physical disorder DOID:0080015 0 0.010