|
|
regulation of necroptotic process
|
GO:0060544 |
10 |
0.999
|
|
|
|
ripoptosome assembly involved in necroptotic process
|
GO:1901026 |
6 |
0.999
|
|
|
|
regulation of cd8 positive alpha beta cytotoxic t cell extravasation
|
GO:2000452 |
2 |
0.999
|
|
|
|
necroptotic process
|
GO:0070266 |
21 |
0.999
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.988
|
Mouse |
|
|
programmed necrotic cell death
|
GO:0097300 |
28 |
0.973
|
|
|
|
t cell extravasation
|
GO:0072683 |
4 |
0.972
|
|
|
|
cd8 positive alpha beta t cell extravasation
|
GO:0035697 |
3 |
0.970
|
|
|
|
regulation of cd8 positive alpha beta t cell extravasation
|
GO:2000449 |
3 |
0.969
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.961
|
Human Mouse |
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.960
|
|
|
|
cd8 positive alpha beta cytotoxic t cell extravasation
|
GO:0035698 |
2 |
0.935
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.920
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.911
|
Mouse |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.897
|
|
|
|
positive regulation of t cell mediated cytotoxicity
|
GO:0001916 |
15 |
0.885
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.882
|
|
|
|
negative regulation of necrotic cell death
|
GO:0060547 |
11 |
0.871
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.869
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
3 |
0.864
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
10 |
0.863
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.861
|
|
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.839
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.818
|
Mouse |
|
|
regulation of necrotic cell death
|
GO:0010939 |
13 |
0.808
|
|
|
|
t cell homeostasis
|
GO:0043029 |
35 |
0.792
|
Mouse |
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.780
|
Mouse |
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
34 |
0.752
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.747
|
Mouse |
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.744
|
|
|
|
t cell mediated cytotoxicity
|
GO:0001913 |
26 |
0.743
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.734
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.729
|
Mouse |
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.724
|
Mouse |
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.724
|
Mouse |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.721
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
56 |
0.719
|
|
|
|
regulation of t cell mediated cytotoxicity
|
GO:0001914 |
18 |
0.717
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.713
|
Mouse |
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.713
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.704
|
Mouse |
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
34 |
0.702
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.683
|
|
|
|
negative regulation of necroptotic process
|
GO:0060546 |
9 |
0.678
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.660
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.653
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.644
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.637
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.635
|
Mouse |
|
|
t cell mediated immunity
|
GO:0002456 |
50 |
0.629
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.627
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.626
|
Mouse |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.626
|
|
|
|
cell killing
|
GO:0001906 |
67 |
0.619
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.603
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.602
|
Mouse |
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.599
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.597
|
|
|
|
spleen development
|
GO:0048536 |
39 |
0.579
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.566
|
Mouse |
|
|
positive regulation of t cell activation
|
GO:0050870 |
101 |
0.560
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.557
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
61 |
0.553
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.546
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.546
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.540
|
|
|
|
interleukin 2 production
|
GO:0032623 |
33 |
0.539
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.537
|
|
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
1 |
0.525
|
|
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
53 |
0.524
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.508
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.505
|
Mouse |
|
|
cytokine production
|
GO:0001816 |
319 |
0.505
|
Mouse |
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.503
|
|
|
|
regulation of leukocyte mediated cytotoxicity
|
GO:0001910 |
38 |
0.498
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.497
|
Human |
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.489
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.473
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.471
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
61 |
0.470
|
|
|
|
lymph node development
|
GO:0048535 |
18 |
0.470
|
|
|
|
positive regulation of cd8 positive alpha beta t cell extravasation
|
GO:2000451 |
2 |
0.464
|
|
|
|
macrophage differentiation
|
GO:0030225 |
20 |
0.461
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.458
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.455
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.443
|
|
|
|
t cell apoptotic process
|
GO:0070231 |
39 |
0.440
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
65 |
0.431
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.427
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.425
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.419
|
|
|
|
leukocyte mediated cytotoxicity
|
GO:0001909 |
62 |
0.418
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.417
|
Mouse |
|
|
innate immune response
|
GO:0045087 |
157 |
0.414
|
|
|
|
response to interleukin 12
|
GO:0070671 |
2 |
0.413
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.407
|
Mouse |
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.405
|
Mouse |
|
|
regulation of peptidase activity
|
GO:0052547 |
96 |
0.397
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.396
|
Mouse |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.396
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.396
|
Mouse |
|
|
regulation of t cell extravasation
|
GO:2000407 |
3 |
0.393
|
|
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
23 |
0.392
|
|
|
|
protein maturation
|
GO:0051604 |
176 |
0.390
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.386
|
Mouse |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.384
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
55 |
0.373
|
Mouse |
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.372
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
52 |
0.369
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.355
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.355
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.352
|
Mouse |
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
19 |
0.347
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.346
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.341
|
Mouse |
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.337
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
49 |
0.326
|
|
|
|
regulation of cell killing
|
GO:0031341 |
40 |
0.323
|
|
|
|
hepatocyte apoptotic process
|
GO:0097284 |
11 |
0.323
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
27 |
0.320
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.314
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.311
|
|
|
|
regulation of activated t cell proliferation
|
GO:0046006 |
16 |
0.310
|
Mouse |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.308
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.307
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.300
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
54 |
0.292
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902043 |
13 |
0.290
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
2 |
0.289
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.285
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.280
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.273
|
Mouse |
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.272
|
Mouse |
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.271
|
|
|
|
defense response to virus
|
GO:0051607 |
68 |
0.267
|
|
|
|
anion transport
|
GO:0006820 |
177 |
0.267
|
|
|
|
regulation of t cell apoptotic process
|
GO:0070232 |
28 |
0.264
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
71 |
0.264
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.262
|
Mouse |
|
|
t cell migration
|
GO:0072678 |
19 |
0.257
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.256
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
45 |
0.256
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.254
|
Mouse |
|
|
positive regulation of interferon gamma production
|
GO:0032729 |
39 |
0.252
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
84 |
0.251
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.250
|
Mouse |
|
|
positive regulation of t cell extravasation
|
GO:2000409 |
2 |
0.250
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.247
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.247
|
|
|
|
cellular response to peptidoglycan
|
GO:0071224 |
4 |
0.244
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
26 |
0.243
|
Human |
|
|
gland development
|
GO:0048732 |
330 |
0.236
|
|
|
|
regulation of alpha beta t cell proliferation
|
GO:0046640 |
18 |
0.233
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.233
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
182 |
0.232
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.231
|
|
|
|
positive regulation of response to cytokine stimulus
|
GO:0060760 |
11 |
0.231
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
61 |
0.230
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.230
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.230
|
|
|
|
lymphocyte migration
|
GO:0072676 |
26 |
0.230
|
|
|
|
protein oligomerization
|
GO:0051259 |
67 |
0.225
|
|
|
|
leukocyte migration
|
GO:0050900 |
124 |
0.222
|
|
|
|
thymus development
|
GO:0048538 |
41 |
0.220
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.220
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.217
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
39 |
0.216
|
|
|
|
protein processing
|
GO:0016485 |
163 |
0.215
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
3 |
0.214
|
|
|
|
positive regulation of macrophage differentiation
|
GO:0045651 |
5 |
0.212
|
Human |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.210
|
|
|
|
interleukin 8 production
|
GO:0032637 |
4 |
0.203
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.202
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
142 |
0.201
|
Mouse |
|
|
nik nf kappab signaling
|
GO:0038061 |
14 |
0.201
|
|
|
|
zymogen activation
|
GO:0031638 |
41 |
0.200
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.200
|
Mouse |
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.198
|
Mouse |
|
|
signal transduction in absence of ligand
|
GO:0038034 |
55 |
0.195
|
Mouse |
|
|
tumor necrosis factor production
|
GO:0032640 |
50 |
0.194
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.193
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.193
|
|
|
|
regulation of alpha beta t cell differentiation
|
GO:0046637 |
35 |
0.192
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.189
|
|
|
|
negative regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902443 |
3 |
0.187
|
|
|
|
regulation of interferon gamma production
|
GO:0032649 |
57 |
0.187
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
55 |
0.186
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.186
|
Mouse |
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
6 |
0.184
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.182
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.180
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.179
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.179
|
Mouse |
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
50 |
0.177
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.174
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.173
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.173
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.170
|
Mouse |
|
|
positive regulation of tumor necrosis factor production
|
GO:0032760 |
30 |
0.169
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
41 |
0.169
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.169
|
|
|
|
chemokine production
|
GO:0032602 |
34 |
0.167
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.163
|
|
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.163
|
Mouse |
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.160
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.158
|
|
|
|
positive regulation of alpha beta t cell differentiation
|
GO:0046638 |
28 |
0.156
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.152
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.152
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.148
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
51 |
0.148
|
|
|
|
cellular extravasation
|
GO:0045123 |
17 |
0.147
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.145
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
58 |
0.143
|
Human |
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
89 |
0.142
|
|
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
31 |
0.141
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.138
|
Mouse |
|
|
ripoptosome assembly
|
GO:0097343 |
6 |
0.136
|
|
|
|
epidermis development
|
GO:0008544 |
187 |
0.135
|
Mouse |
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.134
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.131
|
Mouse |
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.130
|
Mouse |
|
|
organic acid transport
|
GO:0015849 |
101 |
0.130
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
130 |
0.130
|
Mouse |
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.129
|
|
|
|
regulation of cd4 positive alpha beta t cell activation
|
GO:2000514 |
24 |
0.128
|
|
|
|
antibacterial peptide production
|
GO:0002778 |
2 |
0.124
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.121
|
Mouse |
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.120
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
85 |
0.119
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.118
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.116
|
Mouse |
|
|
membrane organization
|
GO:0061024 |
245 |
0.116
|
|
|
|
regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902041 |
22 |
0.115
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
30 |
0.115
|
|
|
|
fibril organization
|
GO:0097435 |
2 |
0.114
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.114
|
Mouse |
|
|
negative regulation of b cell activation
|
GO:0050869 |
27 |
0.114
|
Mouse |
|
|
alpha beta t cell differentiation
|
GO:0046632 |
69 |
0.113
|
|
|
|
macromolecule deacylation
|
GO:0098732 |
37 |
0.112
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
183 |
0.108
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
36 |
0.107
|
|
|
|
positive regulation of type i interferon mediated signaling pathway
|
GO:0060340 |
4 |
0.107
|
|
|
|
peptide transport
|
GO:0015833 |
133 |
0.107
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.106
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.105
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
49 |
0.105
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.104
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.102
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
74 |
0.101
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
116 |
0.101
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.100
|
Human Mouse |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.100
|
Mouse |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.100
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
43 |
0.099
|
|
|
|
lipid localization
|
GO:0010876 |
126 |
0.097
|
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.097
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
71 |
0.096
|
|
|
|
protein homooligomerization
|
GO:0051260 |
43 |
0.094
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.094
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.092
|
Mouse |
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.092
|
Mouse |
|
|
positive regulation of protein transport
|
GO:0051222 |
93 |
0.091
|
Mouse |
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.091
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.090
|
|
|
|
positive regulation of t helper 1 cell differentiation
|
GO:0045627 |
4 |
0.090
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.090
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.089
|
Mouse |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.088
|
Human Mouse |
|
|
cellular response to type i interferon
|
GO:0071357 |
10 |
0.087
|
|
|
|
positive regulation of leukocyte mediated cytotoxicity
|
GO:0001912 |
31 |
0.086
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
25 |
0.086
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
88 |
0.085
|
Human |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.084
|
|
|
|
regulation of protein deacetylation
|
GO:0090311 |
17 |
0.083
|
|
|
|
negative regulation of t cell apoptotic process
|
GO:0070233 |
18 |
0.083
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.083
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.082
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.082
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.082
|
Mouse |
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
52 |
0.081
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.081
|
Mouse |
|
|
cellular ion homeostasis
|
GO:0006873 |
165 |
0.079
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
26 |
0.078
|
|
|
|
spermatogenesis
|
GO:0007283 |
284 |
0.077
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.077
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.077
|
|
|
|
autophagy
|
GO:0006914 |
45 |
0.077
|
Mouse |
|
|
positive regulation of alpha beta t cell activation
|
GO:0046635 |
39 |
0.076
|
|
|
|
neural tube development
|
GO:0021915 |
160 |
0.076
|
|
|
|
regulation of antibacterial peptide production
|
GO:0002786 |
1 |
0.076
|
|
|
|
sensory perception
|
GO:0007600 |
245 |
0.075
|
Mouse |
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.075
|
Mouse |
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.075
|
|
|
|
interferon gamma production
|
GO:0032609 |
67 |
0.074
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
41 |
0.074
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.074
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.073
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.073
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.071
|
|
|
|
regulation of interleukin 1 alpha production
|
GO:0032650 |
4 |
0.070
|
Mouse |
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.069
|
|
|
|
regulation of immunological synapse formation
|
GO:2000520 |
2 |
0.069
|
|
|
|
organic anion transport
|
GO:0015711 |
137 |
0.069
|
|
|
|
regulation of macrophage differentiation
|
GO:0045649 |
9 |
0.069
|
Human |
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.068
|
Mouse |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.068
|
Mouse |
|
|
type i interferon production
|
GO:0032606 |
29 |
0.068
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.066
|
|
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
37 |
0.066
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.066
|
Mouse |
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.066
|
Mouse |
|
|
alpha beta t cell differentiation involved in immune response
|
GO:0002293 |
30 |
0.066
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.066
|
Human |
|
|
forebrain development
|
GO:0030900 |
302 |
0.065
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.065
|
|
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.064
|
|
|
|
regulation of defense response to bacterium
|
GO:1900424 |
3 |
0.064
|
|
|
|
maintenance of location
|
GO:0051235 |
89 |
0.064
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
61 |
0.064
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
70 |
0.063
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.063
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
70 |
0.062
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
18 |
0.062
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.062
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.061
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.061
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.061
|
|
|
|
response to water
|
GO:0009415 |
1 |
0.061
|
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.061
|
|
|
|
regulation of antigen receptor mediated signaling pathway
|
GO:0050854 |
29 |
0.061
|
|
|
|
regulation of antibacterial peptide biosynthetic process
|
GO:0002808 |
1 |
0.060
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.059
|
Mouse |
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.059
|
|
|
|
glial cell apoptotic process
|
GO:0034349 |
3 |
0.059
|
Mouse |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.058
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.058
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
179 |
0.058
|
|
|
|
cd4 positive alpha beta t cell activation
|
GO:0035710 |
45 |
0.058
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
23 |
0.057
|
Mouse |
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
24 |
0.057
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
96 |
0.057
|
Human |
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.057
|
|
|
|
positive regulation of antibacterial peptide biosynthetic process
|
GO:0006963 |
1 |
0.057
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.056
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.056
|
|
|
|
regulation of autophagy
|
GO:0010506 |
30 |
0.056
|
Mouse |
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.056
|
Mouse |
|
|
inflammatory response
|
GO:0006954 |
244 |
0.055
|
Mouse |
|
|
monocarboxylic acid transport
|
GO:0015718 |
44 |
0.055
|
|
|
|
positive regulation of antimicrobial peptide production
|
GO:0002225 |
1 |
0.055
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
130 |
0.055
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.054
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.054
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.054
|
|
|
|
positive regulation of antimicrobial peptide biosynthetic process
|
GO:0002807 |
1 |
0.054
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
62 |
0.053
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.053
|
|
|
|
regulation of type i interferon mediated signaling pathway
|
GO:0060338 |
7 |
0.053
|
|
|
|
positive regulation of phosphatase activity
|
GO:0010922 |
4 |
0.052
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.052
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.052
|
Human |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.052
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.052
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.051
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
82 |
0.051
|
Mouse |
|
|
angiogenesis
|
GO:0001525 |
201 |
0.051
|
|
|
|
keratinocyte differentiation
|
GO:0030216 |
48 |
0.050
|
Mouse |
|
|
regulation of t helper cell differentiation
|
GO:0045622 |
14 |
0.050
|
|
|
|
translation
|
GO:0006412 |
93 |
0.050
|
|
|
|
interleukin 6 production
|
GO:0032635 |
58 |
0.050
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.049
|
|
|
|
negative regulation of lymphocyte apoptotic process
|
GO:0070229 |
24 |
0.049
|
|
|
|
protein deacetylation
|
GO:0006476 |
32 |
0.048
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.048
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.048
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.048
|
|
|
|
regulation of t helper 1 cell differentiation
|
GO:0045625 |
7 |
0.048
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001240 |
16 |
0.048
|
|
|
|
ear development
|
GO:0043583 |
200 |
0.047
|
|
|
|
negative regulation of t cell proliferation
|
GO:0042130 |
38 |
0.047
|
Mouse |
|
|
male gamete generation
|
GO:0048232 |
285 |
0.047
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.047
|
|
|
|
regulation of t cell migration
|
GO:2000404 |
12 |
0.047
|
|
|
|
organelle localization
|
GO:0051640 |
179 |
0.046
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
96 |
0.046
|
|
|
|
regulation of lymphocyte migration
|
GO:2000401 |
14 |
0.046
|
|
|
|
dna catabolic process endonucleolytic
|
GO:0000737 |
15 |
0.046
|
Mouse |
|
|
anion transmembrane transport
|
GO:0098656 |
71 |
0.045
|
|
|
|
type i interferon signaling pathway
|
GO:0060337 |
10 |
0.045
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.045
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.045
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
58 |
0.045
|
|
|
|
protein deacylation
|
GO:0035601 |
36 |
0.045
|
|
|
|
negative thymic t cell selection
|
GO:0045060 |
12 |
0.045
|
|
|
|
positive regulation of protein oligomerization
|
GO:0032461 |
4 |
0.044
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.044
|
|
|
|
positive regulation of antimicrobial humoral response
|
GO:0002760 |
2 |
0.044
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.044
|
|
|
|
membrane depolarization
|
GO:0051899 |
64 |
0.044
|
Mouse |
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
3 |
0.043
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.043
|
|
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.043
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.043
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.043
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.043
|
|
|
|
response to interleukin 1
|
GO:0070555 |
11 |
0.042
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
162 |
0.042
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.042
|
|
|
|
positive regulation of defense response to bacterium
|
GO:1900426 |
1 |
0.042
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
59 |
0.042
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
160 |
0.042
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
48 |
0.041
|
|
|
|
stem cell differentiation
|
GO:0048863 |
268 |
0.041
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.041
|
|
|
|
amide transport
|
GO:0042886 |
138 |
0.041
|
|
|
|
positive regulation of alpha beta t cell proliferation
|
GO:0046641 |
12 |
0.041
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.041
|
Mouse |
|
|
antibacterial peptide biosynthetic process
|
GO:0002780 |
2 |
0.040
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.040
|
|
|
|
regulation of antimicrobial peptide biosynthetic process
|
GO:0002805 |
1 |
0.040
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.040
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.040
|
Mouse |
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.040
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.040
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.039
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
114 |
0.039
|
|
|
|
respiratory system development
|
GO:0060541 |
190 |
0.039
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.039
|
|
|
|
cellular response to steroid hormone stimulus
|
GO:0071383 |
33 |
0.039
|
Mouse |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.039
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.039
|
|
|
|
branching morphogenesis of an epithelial tube
|
GO:0048754 |
159 |
0.039
|
|
|
|
endomembrane system organization
|
GO:0010256 |
147 |
0.039
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.038
|
|
|
|
antimicrobial peptide production
|
GO:0002775 |
2 |
0.038
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.038
|
|
|
|
response to starvation
|
GO:0042594 |
65 |
0.038
|
|
|
|
positive regulation of protein deacetylation
|
GO:0090312 |
9 |
0.038
|
|
|
|
lung development
|
GO:0030324 |
164 |
0.038
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.038
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.037
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.037
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.037
|
|
|
|
lipid transport
|
GO:0006869 |
98 |
0.037
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.037
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.037
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
54 |
0.037
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.037
|
|
|
|
inflammatory response to antigenic stimulus
|
GO:0002437 |
30 |
0.036
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.036
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.036
|
|
|
|
defense response to gram negative bacterium
|
GO:0050829 |
28 |
0.036
|
|
|
|
extracellular structure organization
|
GO:0043062 |
148 |
0.036
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
104 |
0.036
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.036
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.036
|
|
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
67 |
0.036
|
|
|
|
dephosphorylation
|
GO:0016311 |
129 |
0.035
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.035
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
43 |
0.035
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.034
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
53 |
0.034
|
Mouse |
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
28 |
0.034
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
145 |
0.034
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.034
|
|
|
|
positive regulation of cd4 positive alpha beta t cell differentiation
|
GO:0043372 |
14 |
0.033
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.033
|
|
|
|
vesicle organization
|
GO:0016050 |
60 |
0.033
|
|
|
|
positive regulation of necroptotic process
|
GO:0060545 |
1 |
0.033
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.033
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.032
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.032
|
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.032
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.032
|
Mouse |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.032
|
|
|
|
carboxylic acid transport
|
GO:0046942 |
100 |
0.032
|
|
|
|
nuclear import
|
GO:0051170 |
95 |
0.032
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
50 |
0.032
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
132 |
0.032
|
|
|
|
cytokine secretion
|
GO:0050663 |
72 |
0.031
|
Mouse |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.031
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.031
|
Mouse |
|
|
actin filament polymerization
|
GO:0030041 |
44 |
0.031
|
|
|
|
regulation of interleukin 1 beta secretion
|
GO:0050706 |
15 |
0.030
|
Mouse |
|
|
regulation of antimicrobial peptide production
|
GO:0002784 |
1 |
0.030
|
|
|
|
cardiac muscle cell contraction
|
GO:0086003 |
7 |
0.030
|
|
|
|
positive regulation of interferon alpha production
|
GO:0032727 |
4 |
0.030
|
|
