Mus musculus

0 known processes

Klhl8

kelch-like 8 (Drosophila)

(Aliases: D5Ertd431e,MGC102224,2310001P09Rik)

Klhl8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation or removal GO:0070647 207 0.050
Human Worm
cellular ketone metabolic process GO:0042180 84 0.048
cellular amino acid metabolic process GO:0006520 103 0.047
regulation of cellular ketone metabolic process GO:0010565 66 0.044
purine nucleotide metabolic process GO:0006163 302 0.043
protein modification by small protein conjugation GO:0032446 187 0.041
Human Worm
regulation of cellular amino acid metabolic process GO:0006521 5 0.039
protein ubiquitination GO:0016567 171 0.039
Human Worm
cellular amine metabolic process GO:0044106 44 0.039
amine metabolic process GO:0009308 45 0.038
purine ribonucleotide metabolic process GO:0009150 290 0.036
purine containing compound metabolic process GO:0072521 311 0.035
ras protein signal transduction GO:0007265 77 0.035
microtubule based process GO:0007017 236 0.034
cellular nitrogen compound catabolic process GO:0044270 280 0.033
male gamete generation GO:0048232 285 0.033
Mouse
ribonucleotide metabolic process GO:0009259 291 0.033
nucleotide metabolic process GO:0009117 332 0.033
macromolecule catabolic process GO:0009057 281 0.032
Human Worm
dna metabolic process GO:0006259 303 0.032
spermatogenesis GO:0007283 284 0.032
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.032
carbohydrate derivative catabolic process GO:1901136 231 0.032
ribonucleoside metabolic process GO:0009119 245 0.032
nucleoside metabolic process GO:0009116 246 0.031
positive regulation of cellular amine metabolic process GO:0033240 5 0.031
nucleoside phosphate metabolic process GO:0006753 338 0.031
nucleobase containing small molecule metabolic process GO:0055086 352 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
glycosyl compound metabolic process GO:1901657 246 0.030
purine ribonucleoside metabolic process GO:0046128 241 0.030
response to organonitrogen compound GO:0010243 246 0.029
organophosphate catabolic process GO:0046434 232 0.028
purine nucleoside triphosphate metabolic process GO:0009144 226 0.028
ribonucleoside catabolic process GO:0042454 206 0.028
ubiquitin dependent protein catabolic process GO:0006511 129 0.028
Human Worm
glycosyl compound catabolic process GO:1901658 206 0.027
ribose phosphate metabolic process GO:0019693 291 0.027
peptidyl amino acid modification GO:0018193 336 0.027
regulation of cellular component biogenesis GO:0044087 181 0.027
purine ribonucleotide catabolic process GO:0009154 208 0.027
apoptotic signaling pathway GO:0097190 306 0.027
Mouse
rho protein signal transduction GO:0007266 32 0.027
protein catabolic process GO:0030163 221 0.027
Human Worm
organic cyclic compound catabolic process GO:1901361 295 0.026
purine containing compound catabolic process GO:0072523 213 0.026
purine nucleoside catabolic process GO:0006152 205 0.026
nucleoside catabolic process GO:0009164 206 0.026
purine nucleoside triphosphate catabolic process GO:0009146 203 0.026
microtubule cytoskeleton organization GO:0000226 157 0.026
regulation of organelle organization GO:0033043 289 0.026
aromatic compound catabolic process GO:0019439 286 0.026
regulation of cellular catabolic process GO:0031329 242 0.026
heterocycle catabolic process GO:0046700 280 0.026
ribonucleotide catabolic process GO:0009261 208 0.026
purine nucleoside metabolic process GO:0042278 241 0.026
nucleoside triphosphate metabolic process GO:0009141 230 0.025
organonitrogen compound catabolic process GO:1901565 264 0.025
cellular macromolecule catabolic process GO:0044265 206 0.025
Human Worm
small gtpase mediated signal transduction GO:0007264 97 0.024
regulation of neuron differentiation GO:0045664 281 0.024
ribonucleoside triphosphate catabolic process GO:0009203 199 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.024
nucleotide catabolic process GO:0009166 217 0.023
modification dependent protein catabolic process GO:0019941 133 0.023
Human Worm
membrane organization GO:0061024 245 0.023
negative regulation of cellular protein metabolic process GO:0032269 247 0.023
posttranscriptional regulation of gene expression GO:0010608 155 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.023
Human Worm
positive regulation of programmed cell death GO:0043068 218 0.023
regulation of cell motility GO:2000145 236 0.023
transmembrane transport GO:0055085 412 0.022
purine nucleotide catabolic process GO:0006195 211 0.022
mitotic cell cycle GO:0000278 195 0.022
regulation of protein localization GO:0032880 231 0.022
negative regulation of cellular component organization GO:0051129 194 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.022
protein localization to organelle GO:0033365 185 0.022
nucleoside triphosphate catabolic process GO:0009143 205 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.022
spermatid development GO:0007286 108 0.021
Mouse
cellular lipid metabolic process GO:0044255 323 0.021
positive regulation of cell development GO:0010720 237 0.021
cell adhesion GO:0007155 329 0.021
regulation of cell projection organization GO:0031344 206 0.021
spermatid differentiation GO:0048515 115 0.021
Mouse
cation transport GO:0006812 399 0.020
negative regulation of protein metabolic process GO:0051248 282 0.020
positive regulation of cell death GO:0010942 224 0.020
immune effector process GO:0002252 321 0.020
cell type specific apoptotic process GO:0097285 268 0.020
cytoplasmic transport GO:0016482 234 0.020
organelle assembly GO:0070925 177 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.020
organelle localization GO:0051640 179 0.020
intracellular protein transport GO:0006886 204 0.020
mitotic cell cycle process GO:1903047 159 0.020
cellular protein complex assembly GO:0043623 116 0.019
germ cell development GO:0007281 185 0.019
Mouse
positive regulation of apoptotic process GO:0043065 217 0.019
purine ribonucleoside catabolic process GO:0046130 205 0.019
regulation of neuron projection development GO:0010975 169 0.019
positive regulation of protein modification process GO:0031401 299 0.019
inorganic ion transmembrane transport GO:0098660 234 0.018
regulation of kinase activity GO:0043549 249 0.018
establishment of organelle localization GO:0051656 122 0.018
negative regulation of molecular function GO:0044092 258 0.018
modification dependent macromolecule catabolic process GO:0043632 133 0.018
Human Worm
stem cell differentiation GO:0048863 268 0.018
endomembrane system organization GO:0010256 147 0.018
regulation of anatomical structure size GO:0090066 178 0.018
gtp metabolic process GO:0046039 144 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.018
muscle cell differentiation GO:0042692 261 0.017
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
cellular component assembly involved in morphogenesis GO:0010927 139 0.017
regulation of cell cycle GO:0051726 281 0.017
regulation of transferase activity GO:0051338 263 0.017
regulation of membrane potential GO:0042391 192 0.017
regulation of hormone levels GO:0010817 211 0.017
mapk cascade GO:0000165 281 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
cellular response to hormone stimulus GO:0032870 150 0.017
organelle fission GO:0048285 170 0.017
Worm
cation transmembrane transport GO:0098655 266 0.017
axonogenesis GO:0007409 274 0.017
regulation of protein kinase activity GO:0045859 232 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.017
positive regulation of protein phosphorylation GO:0001934 242 0.017
protein localization to membrane GO:0072657 108 0.017
morphogenesis of embryonic epithelium GO:0016331 159 0.016
regulation of cell migration GO:0030334 219 0.016
synaptic transmission GO:0007268 329 0.016
positive regulation of cellular catabolic process GO:0031331 148 0.016
nucleocytoplasmic transport GO:0006913 139 0.016
ion transmembrane transport GO:0034220 361 0.016
oxidation reduction process GO:0055114 342 0.016
cellular response to dna damage stimulus GO:0006974 207 0.016
positive regulation of nervous system development GO:0051962 221 0.016
nuclear division GO:0000280 158 0.016
Worm
regulation of cytoskeleton organization GO:0051493 122 0.016
wnt signaling pathway GO:0016055 188 0.016
proteasomal protein catabolic process GO:0010498 98 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
Mouse
cellular protein catabolic process GO:0044257 155 0.016
Human Worm
striated muscle tissue development GO:0014706 293 0.016
regulation of hydrolase activity GO:0051336 246 0.016
carbohydrate metabolic process GO:0005975 230 0.016
response to growth factor GO:0070848 198 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
t cell activation GO:0042110 289 0.015
fat cell differentiation GO:0045444 160 0.015
methylation GO:0032259 134 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.015
cell fate commitment GO:0045165 210 0.015
neuron death GO:0070997 154 0.015
nitrogen compound transport GO:0071705 271 0.015
regulation of mapk cascade GO:0043408 248 0.015
lymphocyte differentiation GO:0030098 242 0.015
guanosine containing compound metabolic process GO:1901068 144 0.015
meiotic nuclear division GO:0007126 115 0.015
Worm
cellular response to lipid GO:0071396 145 0.015
cellular response to organonitrogen compound GO:0071417 145 0.015
lipid biosynthetic process GO:0008610 179 0.015
chromatin organization GO:0006325 206 0.015
inorganic cation transmembrane transport GO:0098662 207 0.015
neural tube development GO:0021915 160 0.015
muscle tissue development GO:0060537 308 0.015
leukocyte differentiation GO:0002521 342 0.015
cilium morphogenesis GO:0060271 102 0.015
guanosine containing compound catabolic process GO:1901069 144 0.015
protein polymerization GO:0051258 57 0.015
regulation of actin filament based process GO:0032970 99 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
cell substrate adhesion GO:0031589 130 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
negative regulation of intracellular signal transduction GO:1902532 167 0.014
Mouse
cellular homeostasis GO:0019725 240 0.014
regulation of intracellular transport GO:0032386 159 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
macromolecule methylation GO:0043414 120 0.014
actin cytoskeleton organization GO:0030036 220 0.014
homeostasis of number of cells GO:0048872 210 0.014
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.014
response to lipopolysaccharide GO:0032496 128 0.013
response to molecule of bacterial origin GO:0002237 143 0.013
regulation of cellular component size GO:0032535 121 0.013
innate immune response GO:0045087 157 0.013
gtp catabolic process GO:0006184 143 0.013
compound eye development GO:0048749 1 0.013
regulation of purine nucleotide metabolic process GO:1900542 169 0.013
adult behavior GO:0030534 135 0.013
Mouse
neural precursor cell proliferation GO:0061351 121 0.013
regulation of protein catabolic process GO:0042176 108 0.013
reactive oxygen species metabolic process GO:0072593 84 0.013
cell division GO:0051301 120 0.013
cognition GO:0050890 149 0.013
action potential GO:0001508 78 0.013
neuronal action potential GO:0019228 54 0.013
positive regulation of neuron differentiation GO:0045666 141 0.013
regionalization GO:0003002 337 0.013
intrinsic apoptotic signaling pathway GO:0097193 132 0.013
Mouse
camera type eye development GO:0043010 266 0.013
translation GO:0006412 93 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
regulation of protein transport GO:0051223 163 0.013
response to peptide GO:1901652 136 0.013
dephosphorylation GO:0016311 129 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
positive regulation of transferase activity GO:0051347 167 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
multicellular organismal signaling GO:0035637 91 0.013
regulation of secretion GO:0051046 274 0.013
multicellular organism growth GO:0035264 161 0.013
negative regulation of immune system process GO:0002683 209 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.013
regulation of cell cycle process GO:0010564 160 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
regulation of multi organism process GO:0043900 111 0.013
cytokine production GO:0001816 319 0.012
regulation of gtp catabolic process GO:0033124 113 0.012
response to peptide hormone GO:0043434 127 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
protein import into nucleus GO:0006606 95 0.012
b cell activation GO:0042113 161 0.012
neural tube formation GO:0001841 108 0.012
male anatomical structure morphogenesis GO:0090598 4 0.012
Mouse
regulation of proteolysis GO:0030162 164 0.012
negative regulation of synapse assembly GO:0051964 3 0.012
positive regulation of cellular component biogenesis GO:0044089 94 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
response to radiation GO:0009314 165 0.012
regulation of nucleoside metabolic process GO:0009118 130 0.012
regulation of cell activation GO:0050865 289 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
regulation of purine nucleotide catabolic process GO:0033121 122 0.012
oocyte axis specification GO:0007309 2 0.012
transmission of nerve impulse GO:0019226 76 0.012
positive regulation of organelle organization GO:0010638 128 0.012
maintenance of location GO:0051235 89 0.012
regulation of ion transport GO:0043269 215 0.012
regulation of defense response GO:0031347 233 0.012
telencephalon development GO:0021537 186 0.012
nuclear transport GO:0051169 139 0.012
gland development GO:0048732 330 0.012
positive regulation of protein catabolic process GO:0045732 60 0.012
response to insulin GO:0032868 100 0.012
learning or memory GO:0007611 148 0.012
regulation of cytoplasmic transport GO:1903649 112 0.012
regulation of cellular response to stress GO:0080135 159 0.012
primary neural tube formation GO:0014020 95 0.012
response to acid chemical GO:0001101 111 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
protein targeting GO:0006605 143 0.012
regulation of nucleotide metabolic process GO:0006140 169 0.012
adaptive immune response GO:0002250 155 0.012
negative regulation of organelle organization GO:0010639 90 0.012
lateral inhibition GO:0046331 1 0.011
cell growth GO:0016049 130 0.011
negative regulation of nervous system development GO:0051961 156 0.011
myeloid cell differentiation GO:0030099 233 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
chemotaxis GO:0006935 247 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
protein localization to nucleus GO:0034504 121 0.011
fertilization GO:0009566 127 0.011
Mouse
organonitrogen compound biosynthetic process GO:1901566 192 0.011
microtubule based movement GO:0007018 84 0.011
establishment or maintenance of cell polarity GO:0007163 86 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
cell activation involved in immune response GO:0002263 126 0.011
dna repair GO:0006281 107 0.011
glial cell differentiation GO:0010001 131 0.011
skeletal system development GO:0001501 356 0.011
cellularization GO:0007349 1 0.011
regulation of cell adhesion GO:0030155 154 0.011
regulation of cytokine production GO:0001817 266 0.011
glycerolipid metabolic process GO:0046486 122 0.011
epithelial tube formation GO:0072175 130 0.011
blood vessel morphogenesis GO:0048514 285 0.011
mitochondrion organization GO:0007005 134 0.011
intracellular mrna localization GO:0008298 4 0.011
striated muscle myosin thick filament assembly GO:0071688 1 0.011
forebrain development GO:0030900 302 0.011
regulation of secretion by cell GO:1903530 249 0.011
tube formation GO:0035148 140 0.011
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
oocyte construction GO:0007308 2 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
stem cell development GO:0048864 219 0.011
sequestering of metal ion GO:0051238 19 0.011
lipid localization GO:0010876 126 0.011
male genitalia morphogenesis GO:0048808 4 0.011
Mouse
actin filament polymerization GO:0030041 44 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
mrna metabolic process GO:0016071 84 0.011
small molecule biosynthetic process GO:0044283 132 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
myosin filament assembly GO:0031034 2 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.011
smoothened signaling pathway GO:0007224 105 0.011
mitotic cytokinesis GO:0000281 4 0.011
asymmetric stem cell division GO:0098722 3 0.010
sensory perception GO:0007600 245 0.010
striated muscle cell development GO:0055002 125 0.010
cytokinetic process GO:0032506 2 0.010
sequestering of calcium ion GO:0051208 18 0.010
regulation of transmembrane transport GO:0034762 128 0.010
regulation of intracellular protein transport GO:0033157 82 0.010
skeletal muscle organ development GO:0060538 163 0.010
plasma membrane organization GO:0007009 90 0.010
neuron apoptotic process GO:0051402 142 0.010
asymmetric neuroblast division GO:0055059 1 0.010
endocytosis GO:0006897 168 0.010
regulation of neuron death GO:1901214 134 0.010
phospholipid metabolic process GO:0006644 87 0.010
rna processing GO:0006396 105 0.010
cellular response to lipopolysaccharide GO:0071222 77 0.010
response to extracellular stimulus GO:0009991 127 0.010
positive regulation of cell motility GO:2000147 116 0.010
positive regulation of nucleotide metabolic process GO:0045981 114 0.010
cellular response to biotic stimulus GO:0071216 92 0.010
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.010
skin development GO:0043588 220 0.010
Mouse
monocarboxylic acid metabolic process GO:0032787 191 0.010
actin filament based movement GO:0030048 23 0.010
negative regulation of protein modification process GO:0031400 163 0.010
response to organic cyclic compound GO:0014070 198 0.010
inflammatory response GO:0006954 244 0.010
cytoskeleton dependent intracellular transport GO:0030705 50 0.010

Klhl8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
nervous system disease DOID:863 0 0.047
central nervous system disease DOID:331 0 0.026
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
musculoskeletal system disease DOID:17 0 0.016
neurodegenerative disease DOID:1289 0 0.013
cardiovascular system disease DOID:1287 0 0.012
brain disease DOID:936 0 0.012