Mus musculus

70 known processes

Phgdh

3-phosphoglycerate dehydrogenase

(Aliases: PGD,A10,3-PGDH,MGC117966,PGDH,MGC113796,SERA,PGAD,3PGDH,4930479N23)

Phgdh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.151
cellular ketone metabolic process GO:0042180 84 0.106
purine nucleobase biosynthetic process GO:0009113 3 0.105
cellular amine metabolic process GO:0044106 44 0.067
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.059
negative regulation of protein metabolic process GO:0051248 282 0.051
mapk cascade GO:0000165 281 0.051
regulation of cellular ketone metabolic process GO:0010565 66 0.050
negative regulation of cellular protein metabolic process GO:0032269 247 0.049
cellular response to dna damage stimulus GO:0006974 207 0.046
organic cyclic compound catabolic process GO:1901361 295 0.043
male gamete generation GO:0048232 285 0.041
amine metabolic process GO:0009308 45 0.040
positive regulation of cellular amine metabolic process GO:0033240 5 0.040
peptidyl tyrosine modification GO:0018212 145 0.040
regulation of protein kinase activity GO:0045859 232 0.038
chromatin organization GO:0006325 206 0.037
regulation of kinase activity GO:0043549 249 0.037
regulation of cellular amine metabolic process GO:0033238 20 0.036
peptidyl amino acid modification GO:0018193 336 0.036
positive regulation of protein phosphorylation GO:0001934 242 0.035
nitrogen compound transport GO:0071705 271 0.034
heterocycle catabolic process GO:0046700 280 0.033
purine nucleobase metabolic process GO:0006144 4 0.032
organonitrogen compound biosynthetic process GO:1901566 192 0.032
lymphocyte mediated immunity GO:0002449 139 0.031
positive regulation of apoptotic process GO:0043065 217 0.028
small gtpase mediated signal transduction GO:0007264 97 0.027
negative regulation of protein modification process GO:0031400 163 0.026
regulation of organelle organization GO:0033043 289 0.026
anion transport GO:0006820 177 0.026
aromatic compound catabolic process GO:0019439 286 0.026
regulation of mapk cascade GO:0043408 248 0.026
organic acid transport GO:0015849 101 0.025
positive regulation of protein modification process GO:0031401 299 0.025
regulation of cellular amino acid metabolic process GO:0006521 5 0.025
leukocyte mediated immunity GO:0002443 174 0.025
purine ribonucleoside metabolic process GO:0046128 241 0.025
folic acid containing compound metabolic process GO:0006760 3 0.024
leukocyte proliferation GO:0070661 172 0.024
negative regulation of phosphorylation GO:0042326 166 0.024
carboxylic acid biosynthetic process GO:0046394 86 0.023
purine nucleotide metabolic process GO:0006163 302 0.023
ras protein signal transduction GO:0007265 77 0.023
dna recombination GO:0006310 92 0.023
nucleobase containing small molecule metabolic process GO:0055086 352 0.023
cellular homeostasis GO:0019725 240 0.023
inflammatory response GO:0006954 244 0.022
cellular amino acid biosynthetic process GO:0008652 22 0.022
cellular nitrogen compound catabolic process GO:0044270 280 0.022
cell maturation GO:0048469 127 0.022
nucleoside triphosphate catabolic process GO:0009143 205 0.022
alpha amino acid biosynthetic process GO:1901607 15 0.021
alpha amino acid metabolic process GO:1901605 59 0.021
oxidation reduction process GO:0055114 342 0.021
defense response to other organism GO:0098542 197 0.021
regulation of defense response GO:0031347 233 0.021
organophosphate catabolic process GO:0046434 232 0.020
translation GO:0006412 93 0.020
organic acid biosynthetic process GO:0016053 86 0.020
microtubule based process GO:0007017 236 0.020
transmembrane transport GO:0055085 412 0.019
negative regulation of molecular function GO:0044092 258 0.019
carbohydrate metabolic process GO:0005975 230 0.019
cytoplasmic transport GO:0016482 234 0.019
nucleoside triphosphate metabolic process GO:0009141 230 0.019
nucleoside metabolic process GO:0009116 246 0.018
regulation of cell projection organization GO:0031344 206 0.018
regulation of transferase activity GO:0051338 263 0.018
epithelial cell development GO:0002064 159 0.018
endocytosis GO:0006897 168 0.018
compound eye development GO:0048749 1 0.018
positive regulation of transferase activity GO:0051347 167 0.017
organelle fission GO:0048285 170 0.017
purine containing compound metabolic process GO:0072521 311 0.017
regulation of response to wounding GO:1903034 189 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
immune effector process GO:0002252 321 0.017
peptidyl tyrosine phosphorylation GO:0018108 143 0.016
spermatogenesis GO:0007283 284 0.016
regulation of neuron differentiation GO:0045664 281 0.016
small molecule biosynthetic process GO:0044283 132 0.016
protein processing GO:0016485 163 0.016
regulation of protein serine threonine kinase activity GO:0071900 157 0.016
regulation of secretion GO:0051046 274 0.016
regulation of neuron death GO:1901214 134 0.016
glycosyl compound metabolic process GO:1901657 246 0.016
regulation of secretion by cell GO:1903530 249 0.016
positive regulation of immune effector process GO:0002699 107 0.016
carbohydrate homeostasis GO:0033500 128 0.016
regulation of cytokine production GO:0001817 266 0.016
lateral inhibition GO:0046331 1 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
response to organonitrogen compound GO:0010243 246 0.016
chemotaxis GO:0006935 247 0.016
negative regulation of protein processing GO:0010955 79 0.016
cellular response to lipid GO:0071396 145 0.016
organonitrogen compound catabolic process GO:1901565 264 0.015
t cell activation GO:0042110 289 0.015
regulation of chromosome organization GO:0033044 83 0.015
ribose phosphate metabolic process GO:0019693 291 0.015
b cell activation GO:0042113 161 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.015
ion transmembrane transport GO:0034220 361 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
positive regulation of protein kinase activity GO:0045860 144 0.014
regulation of cellular component size GO:0032535 121 0.014
morphogenesis of a branching structure GO:0001763 203 0.014
regulation of protein maturation GO:1903317 96 0.014
sensory perception GO:0007600 245 0.014
nucleoside catabolic process GO:0009164 206 0.014
mrna metabolic process GO:0016071 84 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.014
nucleotide metabolic process GO:0009117 332 0.014
ribonucleotide catabolic process GO:0009261 208 0.014
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.014
monocarboxylic acid metabolic process GO:0032787 191 0.014
cell division GO:0051301 120 0.014
carbohydrate derivative catabolic process GO:1901136 231 0.014
regulation of anatomical structure size GO:0090066 178 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
regulation of cell activation GO:0050865 289 0.014
hatching GO:0035188 4 0.013
mitotic cell cycle process GO:1903047 159 0.013
gonad development GO:0008406 141 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
regulation of hormone levels GO:0010817 211 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.013
production of molecular mediator of immune response GO:0002440 103 0.013
maintenance of location GO:0051235 89 0.013
alcohol metabolic process GO:0006066 116 0.013
developmental maturation GO:0021700 193 0.013
lymphocyte proliferation GO:0046651 164 0.013
meiotic nuclear division GO:0007126 115 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.013
regulation of ion transport GO:0043269 215 0.013
germ cell development GO:0007281 185 0.013
nucleoside phosphate catabolic process GO:1901292 222 0.013
regulation of cell cycle GO:0051726 281 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
positive regulation of neuron differentiation GO:0045666 141 0.012
response to light stimulus GO:0009416 135 0.012
stem cell proliferation GO:0072089 117 0.012
cell type specific apoptotic process GO:0097285 268 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
purine ribonucleotide metabolic process GO:0009150 290 0.012
regulation of cell cycle process GO:0010564 160 0.012
membrane organization GO:0061024 245 0.012
negative regulation of proteolysis GO:0045861 74 0.012
carboxylic acid transport GO:0046942 100 0.012
organelle assembly GO:0070925 177 0.012
regulation of cell size GO:0008361 72 0.012
negative regulation of immune system process GO:0002683 209 0.012
regulation of cellular response to stress GO:0080135 159 0.012
nucleotide catabolic process GO:0009166 217 0.012
oocyte construction GO:0007308 2 0.011
gliogenesis GO:0042063 141 0.011
axonogenesis GO:0007409 274 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
dephosphorylation GO:0016311 129 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
regulation of protein localization GO:0032880 231 0.011
apoptotic signaling pathway GO:0097190 306 0.011
nucleobase biosynthetic process GO:0046112 3 0.011
anatomical structure homeostasis GO:0060249 145 0.011
negative regulation of nervous system development GO:0051961 156 0.011
regulation of hydrolase activity GO:0051336 246 0.011
positive regulation of kinase activity GO:0033674 155 0.011
cellular chemical homeostasis GO:0055082 215 0.011
glial cell differentiation GO:0010001 131 0.011
regulation of interleukin 6 production GO:0032675 55 0.011
striated muscle tissue development GO:0014706 293 0.011
ribonucleoside triphosphate metabolic process GO:0009199 220 0.011
regulation of erk1 and erk2 cascade GO:0070372 71 0.011
regulation of engulfment of apoptotic cell GO:1901074 2 0.011
negative regulation of protein maturation GO:1903318 79 0.011
leukocyte differentiation GO:0002521 342 0.011
camera type eye development GO:0043010 266 0.011
nuclear division GO:0000280 158 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.011
neuron apoptotic process GO:0051402 142 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
rna processing GO:0006396 105 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.010
nuclear dna replication GO:0033260 3 0.010
positive regulation of cytokine production GO:0001819 174 0.010
cellularization GO:0007349 1 0.010
response to lipopolysaccharide GO:0032496 128 0.010
nucleoside phosphate metabolic process GO:0006753 338 0.010
coenzyme metabolic process GO:0006732 52 0.010
regulation of neuron projection development GO:0010975 169 0.010
gland development GO:0048732 330 0.010
actin cytoskeleton organization GO:0030036 220 0.010
digestive tract development GO:0048565 190 0.010
dna repair GO:0006281 107 0.010
chromatin modification GO:0016568 187 0.010
cation transport GO:0006812 399 0.010
microtubule cytoskeleton organization GO:0000226 157 0.010
response to organic cyclic compound GO:0014070 198 0.010
response to peptide GO:1901652 136 0.010
regionalization GO:0003002 337 0.010
positive regulation of programmed cell death GO:0043068 218 0.010

Phgdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.032
disease of cellular proliferation DOID:14566 0 0.032
disease of metabolism DOID:0014667 0 0.020
Human
inherited metabolic disorder DOID:655 0 0.020
Human
organ system cancer DOID:0050686 0 0.016
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013