Mus musculus

187 known processes

Hcls1

hematopoietic cell specific Lyn substrate 1

(Aliases: HS1,AW213261)

Hcls1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of b cell receptor signaling pathway GO:0050861 4 0.717
regulation of actin filament length GO:0030832 45 0.703
Human
regulation of leukocyte differentiation GO:1902105 159 0.599
actin cytoskeleton organization GO:0030036 220 0.562
Human Mouse
regulation of cell activation GO:0050865 289 0.561
amine metabolic process GO:0009308 45 0.560
cellular amino acid metabolic process GO:0006520 103 0.535
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.482
positive regulation of cellular component biogenesis GO:0044089 94 0.469
cellular ketone metabolic process GO:0042180 84 0.441
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.407
regulation of actin filament based process GO:0032970 99 0.398
Human
actin filament bundle assembly GO:0051017 40 0.396
positive regulation of gtp catabolic process GO:0033126 85 0.371
cation transport GO:0006812 399 0.361
t cell activation GO:0042110 289 0.359
homotypic cell cell adhesion GO:0034109 28 0.357
immune effector process GO:0002252 321 0.355
regulation of cellular ketone metabolic process GO:0010565 66 0.351
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.351
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.351
cell adhesion GO:0007155 329 0.351
positive regulation of mapk cascade GO:0043410 170 0.346
negative regulation of synapse assembly GO:0051964 3 0.335
platelet degranulation GO:0002576 6 0.321
regulation of cellular amino acid metabolic process GO:0006521 5 0.321
regulation of cellular amine metabolic process GO:0033238 20 0.313
regulation of actin polymerization or depolymerization GO:0008064 45 0.311
Human
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.311
positive regulation of cellular amine metabolic process GO:0033240 5 0.311
mast cell proliferation GO:0070662 4 0.309
cellular lipid metabolic process GO:0044255 323 0.309
sequestering of metal ion GO:0051238 19 0.307
regulation of innate immune response GO:0045088 91 0.300
positive regulation of podosome assembly GO:0071803 3 0.297
regulation of cell motility GO:2000145 236 0.296
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.296
organelle assembly GO:0070925 177 0.292
Mouse
regulation of mast cell proliferation GO:0070666 4 0.287
regulation of cellular component biogenesis GO:0044087 181 0.273
Human
sequestering of calcium ion GO:0051208 18 0.269
regulation of protein complex assembly GO:0043254 83 0.265
Human
regulation of phospholipase c activity GO:1900274 3 0.264
single organism cell adhesion GO:0098602 156 0.259
ras protein signal transduction GO:0007265 77 0.252
Mouse
protein catabolic process GO:0030163 221 0.252
nucleotide metabolic process GO:0009117 332 0.250
leukocyte proliferation GO:0070661 172 0.246
regulation of vesicle mediated transport GO:0060627 139 0.245
rho protein signal transduction GO:0007266 32 0.245
olfactory learning GO:0008355 2 0.242
cytosolic calcium ion transport GO:0060401 48 0.232
antigen receptor mediated signaling pathway GO:0050851 64 0.228
regulation of cytoskeleton organization GO:0051493 122 0.226
Human
regulation of cell adhesion GO:0030155 154 0.221
purine nucleotide metabolic process GO:0006163 302 0.220
regulation of homeostatic process GO:0032844 182 0.219
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.218
single organismal cell cell adhesion GO:0016337 131 0.217
positive regulation of t cell activation GO:0050870 101 0.211
immune response regulating signaling pathway GO:0002764 125 0.211
podosome assembly GO:0071800 6 0.207
Mouse
cellular amine metabolic process GO:0044106 44 0.206
cellular metal ion homeostasis GO:0006875 151 0.204
regulation of cell shape GO:0008360 39 0.203
fc receptor mediated stimulatory signaling pathway GO:0002431 4 0.202
leukocyte cell cell adhesion GO:0007159 14 0.201
fc receptor mediated inhibitory signaling pathway GO:0002774 1 0.200
immune response inhibiting cell surface receptor signaling pathway GO:0002767 3 0.200
organonitrogen compound catabolic process GO:1901565 264 0.195
negative regulation of protein modification process GO:0031400 163 0.194
negative regulation of protein metabolic process GO:0051248 282 0.194
regulation of actin cytoskeleton organization GO:0032956 84 0.193
Human
regulation of hydrolase activity GO:0051336 246 0.191
regulation of map kinase activity GO:0043405 120 0.191
regulation of transferase activity GO:0051338 263 0.184
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.184
membrane organization GO:0061024 245 0.180
release of sequestered calcium ion into cytosol GO:0051209 42 0.180
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.180
integrin mediated signaling pathway GO:0007229 27 0.179
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 11 0.179
cell substrate adhesion GO:0031589 130 0.178
calcium ion transport GO:0006816 159 0.177
positive regulation of organelle organization GO:0010638 128 0.175
endocytosis GO:0006897 168 0.172
positive regulation of gamma delta t cell activation GO:0046645 6 0.171
negative regulation of cell proliferation GO:0008285 296 0.170
actin filament polymerization GO:0030041 44 0.166
Human
adaptive immune response GO:0002250 155 0.166
regulation of podosome assembly GO:0071801 3 0.164
substrate adhesion dependent cell spreading GO:0034446 30 0.162
axonogenesis GO:0007409 274 0.158
exocytosis GO:0006887 121 0.158
regulation of cell migration GO:0030334 219 0.157
regulation of endocytosis GO:0030100 69 0.156
divalent inorganic cation transport GO:0072511 178 0.155
germ cell development GO:0007281 185 0.154
leukocyte homeostasis GO:0001776 79 0.153
regulation of cellular component size GO:0032535 121 0.151
Human
divalent metal ion transport GO:0070838 172 0.148
positive regulation of cell migration GO:0030335 109 0.146
developmental maturation GO:0021700 193 0.145
actin filament organization GO:0007015 113 0.144
Human Mouse
gamma delta t cell activation GO:0046629 13 0.143
immune response inhibiting signal transduction GO:0002765 4 0.143
positive regulation of lipid kinase activity GO:0090218 11 0.142
gamma delta t cell differentiation GO:0042492 11 0.140
cellular response to growth factor stimulus GO:0071363 197 0.140
peptidyl amino acid modification GO:0018193 336 0.139
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.137
positive regulation of leukocyte differentiation GO:1902107 86 0.137
leukocyte activation involved in immune response GO:0002366 126 0.136
response to growth factor GO:0070848 198 0.134
gland development GO:0048732 330 0.133
positive regulation of phospholipase c activity GO:0010863 2 0.130
regulation of gamma delta t cell activation GO:0046643 9 0.126
positive regulation of hydrolase activity GO:0051345 148 0.125
lymphocyte proliferation GO:0046651 164 0.125
dendritic cell apoptotic process GO:0097048 3 0.124
positive regulation of transferase activity GO:0051347 167 0.122
positive regulation of protein phosphorylation GO:0001934 242 0.122
nucleoside triphosphate catabolic process GO:0009143 205 0.121
regulation of erk1 and erk2 cascade GO:0070372 71 0.120
positive regulation of rho gtpase activity GO:0032321 41 0.119
regulation of ras gtpase activity GO:0032318 88 0.118
cellular response to peptide GO:1901653 92 0.118
cell fate commitment GO:0045165 210 0.118
microtubule cytoskeleton organization GO:0000226 157 0.116
activation of immune response GO:0002253 138 0.115
regulation of protein serine threonine kinase activity GO:0071900 157 0.114
regulation of calcium ion transport into cytosol GO:0010522 31 0.111
regulation of secretion by cell GO:1903530 249 0.110
cytoplasmic transport GO:0016482 234 0.106
Human
regulation of lymphocyte differentiation GO:0045619 107 0.106
actin polymerization or depolymerization GO:0008154 54 0.106
Human
positive regulation of cell motility GO:2000147 116 0.103
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.102
regulation of dendritic cell apoptotic process GO:2000668 3 0.102
regulation of erythrocyte differentiation GO:0045646 23 0.102
cellular calcium ion homeostasis GO:0006874 119 0.102
digestive system development GO:0055123 200 0.101
positive regulation of phospholipase activity GO:0010518 3 0.101
regulation of homotypic cell cell adhesion GO:0034110 13 0.100
regulation of cytokine secretion GO:0050707 61 0.100
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.098
small gtpase mediated signal transduction GO:0007264 97 0.098
Mouse
cell cell junction organization GO:0045216 72 0.097
mitotic cell cycle process GO:1903047 159 0.097
platelet activation GO:0030168 40 0.096
nucleoside catabolic process GO:0009164 206 0.096
digestive tract development GO:0048565 190 0.096
regulation of kinase activity GO:0043549 249 0.096
regulation of lipid metabolic process GO:0019216 118 0.096
positive regulation of kinase activity GO:0033674 155 0.095
interleukin 4 production GO:0032633 24 0.095
mammary gland morphogenesis GO:0060443 54 0.095
regulation of regulated secretory pathway GO:1903305 20 0.095
phospholipid metabolic process GO:0006644 87 0.094
myeloid leukocyte activation GO:0002274 83 0.093
regulation of body fluid levels GO:0050878 162 0.093
response to transforming growth factor beta GO:0071559 88 0.093
negative regulation of immune system process GO:0002683 209 0.093
cell adhesion mediated by integrin GO:0033627 18 0.093
positive regulation of cell projection organization GO:0031346 95 0.093
b cell receptor signaling pathway GO:0050853 20 0.093
regulation of nucleotide catabolic process GO:0030811 122 0.092
ribonucleoside triphosphate catabolic process GO:0009203 199 0.092
negative regulation of phosphorus metabolic process GO:0010563 184 0.091
purine nucleoside triphosphate metabolic process GO:0009144 226 0.091
axon guidance GO:0007411 141 0.091
dendritic spine maintenance GO:0097062 4 0.090
Mouse
regulation of protein localization GO:0032880 231 0.090
Human
t cell proliferation GO:0042098 120 0.089
toll like receptor 4 signaling pathway GO:0034142 9 0.089
long term memory GO:0007616 15 0.089
regulation of lymphocyte proliferation GO:0050670 117 0.088
positive regulation of t cell proliferation GO:0042102 52 0.088
cellular homeostasis GO:0019725 240 0.088
negative regulation of intracellular signal transduction GO:1902532 167 0.087
carbohydrate transport GO:0008643 62 0.087
microtubule based process GO:0007017 236 0.087
protein autophosphorylation GO:0046777 61 0.087
positive regulation of gtpase activity GO:0043547 85 0.087
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.086
purine containing compound metabolic process GO:0072521 311 0.085
lysosome localization GO:0032418 20 0.085
regulation of actin filament polymerization GO:0030833 38 0.085
Human
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.084
neuron projection guidance GO:0097485 141 0.084
establishment or maintenance of cell polarity GO:0007163 86 0.083
regionalization GO:0003002 337 0.082
positive regulation of protein kinase activity GO:0045860 144 0.082
regulation of cell projection organization GO:0031344 206 0.082
purine ribonucleotide metabolic process GO:0009150 290 0.081
negative regulation of phosphorylation GO:0042326 166 0.081
ribonucleoside triphosphate metabolic process GO:0009199 220 0.080
cell maturation GO:0048469 127 0.079
oogenesis GO:0048477 56 0.079
cellular chemical homeostasis GO:0055082 215 0.079
t cell differentiation GO:0030217 174 0.079
regulation of organelle organization GO:0033043 289 0.079
Human
nucleoside phosphate catabolic process GO:1901292 222 0.079
coagulation GO:0050817 78 0.079
negative regulation of homeostatic process GO:0032845 71 0.078
synapse organization GO:0050808 125 0.078
Mouse
response to peptide GO:1901652 136 0.078
negative regulation of kinase activity GO:0033673 81 0.078
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.078
positive regulation of dendritic cell apoptotic process GO:2000670 3 0.078
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.078
calcium ion transport into cytosol GO:0060402 48 0.077
leukocyte mediated immunity GO:0002443 174 0.077
mitotic cell cycle GO:0000278 195 0.077
digestive tract morphogenesis GO:0048546 147 0.076
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.076
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.075
protein polymerization GO:0051258 57 0.075
Human
regulation of ras protein signal transduction GO:0046578 114 0.075
negative regulation of transferase activity GO:0051348 85 0.074
regulation of t cell differentiation GO:0045580 83 0.074
regulation of ion homeostasis GO:2000021 64 0.073
alpha beta t cell differentiation GO:0046632 69 0.073
purine ribonucleoside metabolic process GO:0046128 241 0.073
arp2 3 complex mediated actin nucleation GO:0034314 3 0.073
negative regulation of phosphate metabolic process GO:0045936 184 0.072
activation of phospholipase c activity GO:0007202 2 0.072
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.072
regulation of cellular catabolic process GO:0031329 242 0.071
muscle cell differentiation GO:0042692 261 0.071
ribonucleoside catabolic process GO:0042454 206 0.071
cellularization GO:0007349 1 0.071
regulation of blood coagulation GO:0030193 28 0.070
adherens junction organization GO:0034332 28 0.070
female gamete generation GO:0007292 74 0.069
negative regulation of leukocyte differentiation GO:1902106 51 0.069
substrate dependent cell migration GO:0006929 18 0.069
Mouse
lymphocyte homeostasis GO:0002260 64 0.069
regulation of anatomical structure size GO:0090066 178 0.069
Human
negative regulation of mast cell proliferation GO:0070667 1 0.069
response to organonitrogen compound GO:0010243 246 0.069
regulation of lymphocyte activation GO:0051249 240 0.068
blood coagulation GO:0007596 76 0.068
sensory perception of mechanical stimulus GO:0050954 107 0.068
positive regulation of protein complex assembly GO:0031334 45 0.067
lymphocyte differentiation GO:0030098 242 0.067
neuron migration GO:0001764 122 0.067
regulation of protein kinase activity GO:0045859 232 0.066
cell junction assembly GO:0034329 52 0.066
regulation of t cell proliferation GO:0042129 92 0.065
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.065
wound healing GO:0042060 157 0.065
pattern recognition receptor signaling pathway GO:0002221 47 0.064
platelet aggregation GO:0070527 20 0.064
cell junction organization GO:0034330 77 0.064
positive regulation of programmed cell death GO:0043068 218 0.063
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.063
filtration diaphragm assembly GO:0036058 1 0.063
purine nucleotide catabolic process GO:0006195 211 0.063
cellular protein complex assembly GO:0043623 116 0.062
Human
cytosolic calcium ion homeostasis GO:0051480 70 0.062
tolerance induction to self antigen GO:0002513 4 0.062
cellular ion homeostasis GO:0006873 165 0.062
regulation of organelle assembly GO:1902115 19 0.062
purine ribonucleotide catabolic process GO:0009154 208 0.062
cellular response to hormone stimulus GO:0032870 150 0.060
peptidyl tyrosine phosphorylation GO:0018108 143 0.060
regulation of gamma delta t cell differentiation GO:0045586 9 0.060
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.060
regulation of myeloid cell differentiation GO:0045637 96 0.059
regulation of cell projection assembly GO:0060491 38 0.059
organelle localization GO:0051640 179 0.059
regulation of calcium ion transport GO:0051924 69 0.059
regulation of secretion GO:0051046 274 0.059
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.059
positive regulation of cytoskeleton organization GO:0051495 49 0.059
purine nucleoside metabolic process GO:0042278 241 0.059
purine ribonucleoside catabolic process GO:0046130 205 0.059
response to peptide hormone GO:0043434 127 0.059
regulation of natural killer cell activation GO:0032814 22 0.058
glycosyl compound metabolic process GO:1901657 246 0.058
leukocyte apoptotic process GO:0071887 71 0.058
Human
regulation of t cell activation GO:0050863 170 0.058
negative regulation of map kinase activity GO:0043407 34 0.058
defense response to other organism GO:0098542 197 0.057
regulation of hormone levels GO:0010817 211 0.057
metal ion homeostasis GO:0055065 189 0.057
positive regulation of t cell differentiation GO:0045582 52 0.056
multicellular organismal homeostasis GO:0048871 164 0.056
leukocyte chemotaxis GO:0030595 69 0.056
nucleobase containing small molecule metabolic process GO:0055086 352 0.056
bone remodeling GO:0046849 53 0.056
ribonucleoside metabolic process GO:0009119 245 0.056
detection of stimulus GO:0051606 84 0.056
t cell activation involved in immune response GO:0002286 43 0.055
negative regulation of myeloid cell differentiation GO:0045638 38 0.055
cellular response to peptide hormone stimulus GO:0071375 92 0.054
forebrain development GO:0030900 302 0.054
mapk cascade GO:0000165 281 0.054
erk1 and erk2 cascade GO:0070371 77 0.054
mammary gland epithelium development GO:0061180 65 0.054
purine nucleoside triphosphate catabolic process GO:0009146 203 0.054
positive regulation of cell activation GO:0050867 158 0.054
endoderm development GO:0007492 45 0.053
cell activation involved in immune response GO:0002263 126 0.053
leukocyte differentiation GO:0002521 342 0.053
myeloid cell homeostasis GO:0002262 114 0.053
regulation of metal ion transport GO:0010959 106 0.053
neutrophil chemotaxis GO:0030593 36 0.053
regulation of leukocyte mediated immunity GO:0002703 104 0.052
positive regulation of cellular catabolic process GO:0031331 148 0.052
response to alcohol GO:0097305 48 0.052
gonad development GO:0008406 141 0.052
erythrocyte differentiation GO:0030218 88 0.051
innate immune response GO:0045087 157 0.051
positive regulation of actin filament polymerization GO:0030838 26 0.051
regulation of protein catabolic process GO:0042176 108 0.050
learning GO:0007612 98 0.050
memory GO:0007613 58 0.050
toll like receptor 2 signaling pathway GO:0034134 6 0.050
g protein coupled receptor signaling pathway GO:0007186 243 0.050
regulation of mapk cascade GO:0043408 248 0.050
positive regulation of nucleoside metabolic process GO:0045979 91 0.050
cognition GO:0050890 149 0.049
regulation of gtp catabolic process GO:0033124 113 0.049
response to insulin GO:0032868 100 0.049
regulation of mast cell activation involved in immune response GO:0033006 17 0.049
positive regulation of protein modification process GO:0031401 299 0.049
learning or memory GO:0007611 148 0.049
cell chemotaxis GO:0060326 81 0.049
negative regulation of cell activation GO:0050866 111 0.049
response to extracellular stimulus GO:0009991 127 0.048
carbohydrate metabolic process GO:0005975 230 0.048
myeloid leukocyte differentiation GO:0002573 119 0.048
development of primary sexual characteristics GO:0045137 143 0.048
regulation of cell adhesion mediated by integrin GO:0033628 13 0.048
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.048
regulation of intracellular transport GO:0032386 159 0.047
Human
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.047
cation homeostasis GO:0055080 212 0.047
negative regulation of cellular amine metabolic process GO:0033239 1 0.047
nucleotide catabolic process GO:0009166 217 0.047
hemostasis GO:0007599 78 0.047
gastrulation GO:0007369 116 0.046
activation of mapk activity GO:0000187 59 0.046
b cell activation GO:0042113 161 0.046
positive regulation of secretion by cell GO:1903532 114 0.046
pole plasm assembly GO:0007315 2 0.046
glycosyl compound catabolic process GO:1901658 206 0.045
dendrite development GO:0016358 115 0.045
regulation of toll like receptor signaling pathway GO:0034121 20 0.045
t cell receptor signaling pathway GO:0050852 46 0.045
response to retinoic acid GO:0032526 56 0.045
mesodermal cell migration GO:0008078 4 0.044
protein localization to organelle GO:0033365 185 0.044
Human
dephosphorylation GO:0016311 129 0.044
peptidyl tyrosine modification GO:0018212 145 0.044
parallel actin filament bundle assembly GO:0030046 2 0.044
regulation of synapse assembly GO:0051963 29 0.044
cellular response to cytokine stimulus GO:0071345 189 0.043
Human
regulation of lipid kinase activity GO:0043550 14 0.043
cellular nitrogen compound catabolic process GO:0044270 280 0.043
insulin receptor signaling pathway GO:0008286 49 0.043
regulation of ion transport GO:0043269 215 0.043
regulation of b cell differentiation GO:0045577 23 0.043
regulation of leukocyte proliferation GO:0070663 121 0.043
positive regulation of cell death GO:0010942 224 0.042
positive regulation of lymphocyte differentiation GO:0045621 61 0.042
response to ethanol GO:0045471 18 0.042
ribose phosphate metabolic process GO:0019693 291 0.042
detection of external stimulus GO:0009581 61 0.042
sensory perception GO:0007600 245 0.041
homeostasis of number of cells GO:0048872 210 0.041
positive regulation of nucleotide catabolic process GO:0030813 88 0.041
tissue homeostasis GO:0001894 115 0.041
regulation of protein binding GO:0043393 60 0.041
mast cell mediated immunity GO:0002448 20 0.041
myeloid cell differentiation GO:0030099 233 0.041
regulation of response to wounding GO:1903034 189 0.040
negative regulation of cellular protein metabolic process GO:0032269 247 0.040
establishment of organelle localization GO:0051656 122 0.039
activation of innate immune response GO:0002218 56 0.039
cellular carbohydrate metabolic process GO:0044262 119 0.039
toll like receptor signaling pathway GO:0002224 38 0.039
tyrosine phosphorylation of stat protein GO:0007260 23 0.039
positive regulation of catecholamine secretion GO:0033605 2 0.038
negative regulation of protein phosphorylation GO:0001933 126 0.038
positive regulation of lipid metabolic process GO:0045834 40 0.038
negative regulation of mapk cascade GO:0043409 65 0.038
regulation of rho protein signal transduction GO:0035023 71 0.038
canonical wnt signaling pathway GO:0060070 130 0.038
positive regulation of cell adhesion GO:0045785 80 0.038
membrane invagination GO:0010324 17 0.037
b cell apoptotic process GO:0001783 19 0.037
regulation of purine nucleotide catabolic process GO:0033121 122 0.037
leukocyte degranulation GO:0043299 27 0.037
regulation of neuron projection development GO:0010975 169 0.037
regulation of exocytosis GO:0017157 61 0.037
inflammatory response GO:0006954 244 0.037
regulation of lymphocyte apoptotic process GO:0070228 41 0.036
positive regulation of apoptotic process GO:0043065 217 0.036
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.036
morphogenesis of embryonic epithelium GO:0016331 159 0.036
sensory organ morphogenesis GO:0090596 242 0.036
nucleoside triphosphate metabolic process GO:0009141 230 0.036
regulation of purine nucleotide metabolic process GO:1900542 169 0.035
nucleoside metabolic process GO:0009116 246 0.034
negative regulation of nervous system development GO:0051961 156 0.034
cardiac muscle tissue development GO:0048738 130 0.034
mammary gland duct morphogenesis GO:0060603 38 0.034
regulation of protein transport GO:0051223 163 0.034
Human
regulation of mast cell degranulation GO:0043304 16 0.034
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.034
regulation of cd8 positive alpha beta t cell activation GO:2001185 3 0.034
regulation of actin nucleation GO:0051125 4 0.033
cell type specific apoptotic process GO:0097285 268 0.033
Human
glucose transport GO:0015758 56 0.033
positive regulation of cell development GO:0010720 237 0.033
nk t cell differentiation GO:0001865 8 0.033
negative regulation of cell migration GO:0030336 59 0.033
cytokine mediated signaling pathway GO:0019221 115 0.033
bone resorption GO:0045453 38 0.033
regulation of mitotic cell cycle GO:0007346 126 0.032
ribonucleotide metabolic process GO:0009259 291 0.032
regulation of leukocyte degranulation GO:0043300 20 0.032
peptide transport GO:0015833 133 0.032
negative regulation of lymphocyte proliferation GO:0050672 45 0.032
guanosine containing compound catabolic process GO:1901069 144 0.032
protein localization to membrane GO:0072657 108 0.032
cellular response to organonitrogen compound GO:0071417 145 0.031
negative regulation of ras protein signal transduction GO:0046580 18 0.031
engulfment of apoptotic cell GO:0043652 3 0.031
striated muscle tissue development GO:0014706 293 0.031
blood circulation GO:0008015 195 0.031
maintenance of location GO:0051235 89 0.031
Mouse
purine nucleoside catabolic process GO:0006152 205 0.031
b cell activation involved in immune response GO:0002312 50 0.031
cellular component assembly involved in morphogenesis GO:0010927 139 0.030
response to oxidative stress GO:0006979 123 0.030
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.030
multicellular organism growth GO:0035264 161 0.030
erbb signaling pathway GO:0038127 32 0.030
divalent inorganic cation homeostasis GO:0072507 138 0.030
positive regulation of map kinase activity GO:0043406 84 0.029
wnt signaling pathway GO:0016055 188 0.029
nuclear division GO:0000280 158 0.029
mast cell activation GO:0045576 27 0.029
neuron apoptotic process GO:0051402 142 0.029
monosaccharide transport GO:0015749 58 0.029
positive regulation of canonical wnt signaling pathway GO:0090263 29 0.029
substrate dependent cell migration cell extension GO:0006930 4 0.029
Mouse
regulation of neuron death GO:1901214 134 0.028
negative regulation of cell motility GO:2000146 61 0.028
heterocycle catabolic process GO:0046700 280 0.028
vesicle organization GO:0016050 60 0.028
regulation of system process GO:0044057 200 0.028
jak stat cascade GO:0007259 42 0.028
apoptotic signaling pathway GO:0097190 306 0.027
Mouse
regulation of establishment of protein localization GO:0070201 181 0.027
Human
endodermal cell fate specification GO:0001714 4 0.027
associative learning GO:0008306 61 0.027
positive regulation of secretion GO:0051047 130 0.027
regulation of jak stat cascade GO:0046425 34 0.027
defense response to virus GO:0051607 68 0.027
positive regulation of thymocyte migration GO:2000412 2 0.027
peptide hormone secretion GO:0030072 109 0.027
regulation of b cell activation GO:0050864 81 0.026
negative regulation of b cell activation GO:0050869 27 0.026
phagocytosis GO:0006909 66 0.026
purine containing compound catabolic process GO:0072523 213 0.026
macromolecule catabolic process GO:0009057 281 0.026
hormone secretion GO:0046879 128 0.026
regulation of nucleoside metabolic process GO:0009118 130 0.026
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.026
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.026
innate immune response activating signal transduction GO:0002758 50 0.026
myosin filament assembly GO:0031034 2 0.026
cd4 positive alpha beta t cell activation GO:0035710 45 0.026
synapse assembly GO:0007416 56 0.026
Mouse
syncytium formation GO:0006949 43 0.025
oocyte anterior posterior axis specification GO:0007314 2 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.025
activation of rac gtpase activity GO:0032863 2 0.025
protein secretion GO:0009306 111 0.025
mast cell degranulation GO:0043303 19 0.025
integrin activation GO:0033622 8 0.025
carbohydrate derivative biosynthetic process GO:1901137 183 0.025
cellular divalent inorganic cation homeostasis GO:0072503 127 0.025
positive regulation of cytokine production GO:0001819 174 0.025
positive regulation of neutrophil migration GO:1902624 12 0.025
regulation of leukocyte apoptotic process GO:2000106 56 0.025
Human
lamellipodium organization GO:0097581 29 0.025

Hcls1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.045
disease of anatomical entity DOID:7 0 0.045
primary immunodeficiency disease DOID:612 0 0.032