Mus musculus

124 known processes

Eif2ak1

eukaryotic translation initiation factor 2 alpha kinase 1

(Aliases: MGC118066,Hri)

Eif2ak1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation GO:0032446 187 0.123
protein modification by small protein conjugation or removal GO:0070647 207 0.104
small gtpase mediated signal transduction GO:0007264 97 0.092
ras protein signal transduction GO:0007265 77 0.085
cellular ketone metabolic process GO:0042180 84 0.067
amine metabolic process GO:0009308 45 0.064
regulation of cellular amino acid metabolic process GO:0006521 5 0.062
protein ubiquitination GO:0016567 171 0.057
peptidyl amino acid modification GO:0018193 336 0.054
regulation of cellular ketone metabolic process GO:0010565 66 0.053
transmembrane transport GO:0055085 412 0.051
membrane organization GO:0061024 245 0.051
cellular response to peptide hormone stimulus GO:0071375 92 0.050
response to peptide GO:1901652 136 0.047
endomembrane system organization GO:0010256 147 0.046
cellular amine metabolic process GO:0044106 44 0.046
carbohydrate metabolic process GO:0005975 230 0.046
regulation of cell cycle GO:0051726 281 0.046
macroautophagy GO:0016236 21 0.044
posttranscriptional regulation of gene expression GO:0010608 155 0.044
regulation of cellular amine metabolic process GO:0033238 20 0.044
translation GO:0006412 93 0.043
cellular lipid metabolic process GO:0044255 323 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.042
dephosphorylation GO:0016311 129 0.041
cellular response to hormone stimulus GO:0032870 150 0.041
t cell activation GO:0042110 289 0.041
nucleotide metabolic process GO:0009117 332 0.040
cell type specific apoptotic process GO:0097285 268 0.039
ion transmembrane transport GO:0034220 361 0.039
myeloid cell differentiation GO:0030099 233 0.039
cellular response to organonitrogen compound GO:0071417 145 0.038
mitotic cell cycle GO:0000278 195 0.038
response to organonitrogen compound GO:0010243 246 0.038
cellular amino acid metabolic process GO:0006520 103 0.038
positive regulation of macroautophagy GO:0016239 3 0.037
organelle assembly GO:0070925 177 0.037
regulation of translation GO:0006417 71 0.036
organonitrogen compound catabolic process GO:1901565 264 0.035
cation transport GO:0006812 399 0.035
spermatogenesis GO:0007283 284 0.035
protein maturation GO:0051604 176 0.034
positive regulation of protein modification process GO:0031401 299 0.034
intracellular protein transport GO:0006886 204 0.034
nitrogen compound transport GO:0071705 271 0.033
cellular response to insulin stimulus GO:0032869 78 0.033
positive regulation of protein phosphorylation GO:0001934 242 0.033
glucose metabolic process GO:0006006 92 0.033
positive regulation of cellular amine metabolic process GO:0033240 5 0.032
proteasomal protein catabolic process GO:0010498 98 0.032
cytoplasmic transport GO:0016482 234 0.032
macromolecule catabolic process GO:0009057 281 0.032
protein catabolic process GO:0030163 221 0.032
regulation of cytokine production GO:0001817 266 0.031
nucleobase containing small molecule metabolic process GO:0055086 352 0.031
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.031
cellular homeostasis GO:0019725 240 0.031
glycerolipid metabolic process GO:0046486 122 0.030
erythrocyte differentiation GO:0030218 88 0.030
male gamete generation GO:0048232 285 0.030
plasma membrane organization GO:0007009 90 0.030
glycerolipid biosynthetic process GO:0045017 50 0.030
purine ribonucleotide metabolic process GO:0009150 290 0.030
myeloid cell homeostasis GO:0002262 114 0.030
regulation of transferase activity GO:0051338 263 0.029
apoptotic signaling pathway GO:0097190 306 0.029
negative regulation of cellular amine metabolic process GO:0033239 1 0.029
regulation of proteolysis GO:0030162 164 0.029
purine nucleoside triphosphate catabolic process GO:0009146 203 0.028
regulation of translational initiation GO:0006446 15 0.027
muscle cell differentiation GO:0042692 261 0.027
cytokine production GO:0001816 319 0.027
homeostasis of number of cells GO:0048872 210 0.027
regulation of hydrolase activity GO:0051336 246 0.027
lipid modification GO:0030258 65 0.027
cation transmembrane transport GO:0098655 266 0.027
hexose metabolic process GO:0019318 98 0.026
multicellular organismal signaling GO:0035637 91 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.026
modification dependent protein catabolic process GO:0019941 133 0.025
nucleotide catabolic process GO:0009166 217 0.025
neuronal action potential GO:0019228 54 0.025
actin filament polymerization GO:0030041 44 0.025
response to insulin GO:0032868 100 0.025
monosaccharide metabolic process GO:0005996 106 0.025
engulfment of apoptotic cell GO:0043652 3 0.025
anion transport GO:0006820 177 0.024
vesicle organization GO:0016050 60 0.024
regulation of kinase activity GO:0043549 249 0.024
regulation of establishment of protein localization GO:0070201 181 0.024
lipid biosynthetic process GO:0008610 179 0.024
cellular response to peptide GO:1901653 92 0.024
protein localization to membrane GO:0072657 108 0.024
ubiquitin dependent protein catabolic process GO:0006511 129 0.023
dna metabolic process GO:0006259 303 0.023
positive regulation of endopeptidase activity GO:0010950 43 0.023
organic cyclic compound catabolic process GO:1901361 295 0.023
regulation of cellular catabolic process GO:0031329 242 0.023
cellular protein catabolic process GO:0044257 155 0.023
metal ion homeostasis GO:0055065 189 0.023
regulation of lymphocyte activation GO:0051249 240 0.023
response to endoplasmic reticulum stress GO:0034976 53 0.023
synaptic transmission GO:0007268 329 0.022
regulation of protein localization GO:0032880 231 0.022
purine ribonucleoside catabolic process GO:0046130 205 0.022
protein autophosphorylation GO:0046777 61 0.022
negative regulation of cellular protein metabolic process GO:0032269 247 0.022
regulation of cell cycle process GO:0010564 160 0.022
cellular chemical homeostasis GO:0055082 215 0.022
response to nutrient levels GO:0031667 109 0.022
protein localization to organelle GO:0033365 185 0.022
vacuole organization GO:0007033 38 0.022
cation homeostasis GO:0055080 212 0.022
multicellular organism growth GO:0035264 161 0.022
phosphatidylinositol phosphorylation GO:0046854 23 0.021
organophosphate catabolic process GO:0046434 232 0.021
stem cell differentiation GO:0048863 268 0.021
autophagic vacuole assembly GO:0000045 13 0.021
cellular response to starvation GO:0009267 57 0.021
compound eye development GO:0048749 1 0.021
embryonic organ morphogenesis GO:0048562 276 0.021
positive regulation of proteolysis GO:0045862 85 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
regulation of transmembrane transport GO:0034762 128 0.021
glycerophospholipid metabolic process GO:0006650 71 0.021
negative regulation of cell cycle GO:0045786 123 0.021
regulation of membrane potential GO:0042391 192 0.021
immune effector process GO:0002252 321 0.021
cellular ion homeostasis GO:0006873 165 0.021
organic acid transport GO:0015849 101 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.021
chromatin modification GO:0016568 187 0.021
carbohydrate derivative catabolic process GO:1901136 231 0.020
spermatid differentiation GO:0048515 115 0.020
phospholipid metabolic process GO:0006644 87 0.020
aromatic compound catabolic process GO:0019439 286 0.020
cellular macromolecule catabolic process GO:0044265 206 0.020
inorganic ion transmembrane transport GO:0098660 234 0.020
negative regulation of cellular component organization GO:0051129 194 0.020
purine nucleoside triphosphate metabolic process GO:0009144 226 0.019
rho protein signal transduction GO:0007266 32 0.019
microtubule based process GO:0007017 236 0.019
actin cytoskeleton organization GO:0030036 220 0.019
positive regulation of programmed cell death GO:0043068 218 0.019
purine nucleotide metabolic process GO:0006163 302 0.019
inorganic cation transmembrane transport GO:0098662 207 0.019
glycosyl compound metabolic process GO:1901657 246 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
ribonucleotide metabolic process GO:0009259 291 0.019
regulation of mapk cascade GO:0043408 248 0.019
regulation of cell activation GO:0050865 289 0.019
oxidation reduction process GO:0055114 342 0.019
regulation of protein stability GO:0031647 52 0.019
regulation of protein kinase activity GO:0045859 232 0.019
mapk cascade GO:0000165 281 0.019
protein processing GO:0016485 163 0.019
protein polymerization GO:0051258 57 0.019
peptidyl threonine phosphorylation GO:0018107 31 0.019
cellular calcium ion homeostasis GO:0006874 119 0.019
regulation of organelle organization GO:0033043 289 0.019
cellular metal ion homeostasis GO:0006875 151 0.019
nucleoside phosphate catabolic process GO:1901292 222 0.019
inflammatory response GO:0006954 244 0.019
cellular protein complex assembly GO:0043623 116 0.018
regulation of cellular component size GO:0032535 121 0.018
cellular component assembly involved in morphogenesis GO:0010927 139 0.018
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.018
leukocyte differentiation GO:0002521 342 0.018
ribonucleoside triphosphate catabolic process GO:0009203 199 0.018
negative regulation of phosphorylation GO:0042326 166 0.018
cell adhesion GO:0007155 329 0.018
extrinsic apoptotic signaling pathway GO:0097191 126 0.018
regulation of ion transmembrane transport GO:0034765 119 0.018
cellular response to dna damage stimulus GO:0006974 207 0.018
cellular carbohydrate metabolic process GO:0044262 119 0.018
negative regulation of intracellular signal transduction GO:1902532 167 0.018
purine nucleotide catabolic process GO:0006195 211 0.018
regulation of apoptotic signaling pathway GO:2001233 197 0.018
ribose phosphate metabolic process GO:0019693 291 0.018
response to acid chemical GO:0001101 111 0.018
response to oxidative stress GO:0006979 123 0.018
divalent inorganic cation transport GO:0072511 178 0.018
cognition GO:0050890 149 0.018
positive regulation of cell death GO:0010942 224 0.017
purine containing compound metabolic process GO:0072521 311 0.017
sequestering of metal ion GO:0051238 19 0.017
chromatin organization GO:0006325 206 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
purine ribonucleoside metabolic process GO:0046128 241 0.017
regulation of secretion GO:0051046 274 0.017
endocytosis GO:0006897 168 0.017
response to growth factor GO:0070848 198 0.017
regulation of homeostatic process GO:0032844 182 0.017
purine ribonucleotide catabolic process GO:0009154 208 0.017
gland development GO:0048732 330 0.017
lipid phosphorylation GO:0046834 25 0.017
establishment of vesicle localization GO:0051650 81 0.017
response to light stimulus GO:0009416 135 0.017
positive regulation of cellular catabolic process GO:0031331 148 0.017
meiotic cell cycle process GO:1903046 77 0.017
organic anion transport GO:0015711 137 0.017
maintenance of location GO:0051235 89 0.017
regulation of protein catabolic process GO:0042176 108 0.017
regulation of vesicle mediated transport GO:0060627 139 0.017
negative regulation of protein metabolic process GO:0051248 282 0.016
divalent inorganic cation homeostasis GO:0072507 138 0.016
negative regulation of protein modification process GO:0031400 163 0.016
regulation of proteasomal protein catabolic process GO:0061136 46 0.016
divalent metal ion transport GO:0070838 172 0.016
mitotic cell cycle process GO:1903047 159 0.016
positive regulation of necrotic cell death GO:0010940 1 0.016
regulation of ras protein signal transduction GO:0046578 114 0.016
transmission of nerve impulse GO:0019226 76 0.016
glucose homeostasis GO:0042593 128 0.016
glycosyl compound catabolic process GO:1901658 206 0.016
reactive nitrogen species metabolic process GO:2001057 0 0.016
sequestering of calcium ion GO:0051208 18 0.016
negative regulation of cell development GO:0010721 169 0.016
autophagy GO:0006914 45 0.016
mrna metabolic process GO:0016071 84 0.016
response to extracellular stimulus GO:0009991 127 0.016
heterocycle catabolic process GO:0046700 280 0.016
learning or memory GO:0007611 148 0.016
ribonucleoside metabolic process GO:0009119 245 0.016
carboxylic acid transport GO:0046942 100 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.015
hexose biosynthetic process GO:0019319 39 0.015
regulation of cell projection organization GO:0031344 206 0.015
carbohydrate biosynthetic process GO:0016051 74 0.015
nucleoside triphosphate catabolic process GO:0009143 205 0.015
regulation of mitotic cell cycle GO:0007346 126 0.015
action potential GO:0001508 78 0.015
carbohydrate derivative biosynthetic process GO:1901137 183 0.015
single organism cell adhesion GO:0098602 156 0.015
mitochondrion organization GO:0007005 134 0.015
establishment of organelle localization GO:0051656 122 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
innate immune response GO:0045087 157 0.015
methylation GO:0032259 134 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.015
germ cell development GO:0007281 185 0.015
wnt signaling pathway GO:0016055 188 0.015
regionalization GO:0003002 337 0.015
protein targeting GO:0006605 143 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.015
negative regulation of nervous system development GO:0051961 156 0.015
cellular response to amino acid stimulus GO:0071230 29 0.015
phagocytosis GO:0006909 66 0.015
regulation of protein serine threonine kinase activity GO:0071900 157 0.015
positive regulation of apoptotic process GO:0043065 217 0.015
regulation of glucose metabolic process GO:0010906 60 0.014
citrate metabolic process GO:0006101 3 0.014
purine nucleoside catabolic process GO:0006152 205 0.014
ribonucleoside triphosphate metabolic process GO:0009199 220 0.014
cellular response to external stimulus GO:0071496 88 0.014
carbohydrate homeostasis GO:0033500 128 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
peptidyl serine phosphorylation GO:0018105 74 0.014
negative regulation of cell proliferation GO:0008285 296 0.014
membrane fusion GO:0061025 38 0.014
vesicle localization GO:0051648 86 0.014
response to osmotic stress GO:0006970 21 0.014
lymphocyte differentiation GO:0030098 242 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
macromolecule methylation GO:0043414 120 0.014
regulation of cellular protein catabolic process GO:1903362 61 0.014
regulation of clathrin mediated endocytosis GO:2000369 4 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
organelle fission GO:0048285 170 0.014
b cell differentiation GO:0030183 78 0.014
mitochondrion distribution GO:0048311 4 0.014
adaptive immune response GO:0002250 155 0.014
sensory organ morphogenesis GO:0090596 242 0.014
regulation of reactive oxygen species metabolic process GO:2000377 40 0.014
positive regulation of mapk cascade GO:0043410 170 0.014
cellular response to cytokine stimulus GO:0071345 189 0.014
guanosine containing compound metabolic process GO:1901068 144 0.014
protein localization to nucleus GO:0034504 121 0.014
axonogenesis GO:0007409 274 0.014
protein methylation GO:0006479 81 0.013
lateral inhibition GO:0046331 1 0.013
nucleoside metabolic process GO:0009116 246 0.013
nuclear division GO:0000280 158 0.013
glycerophospholipid biosynthetic process GO:0046474 32 0.013
positive regulation of protein transport GO:0051222 93 0.013
insulin receptor signaling pathway GO:0008286 49 0.013
meiotic cell cycle GO:0051321 122 0.013
response to inorganic substance GO:0010035 96 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
cellular nitrogen compound catabolic process GO:0044270 280 0.013
peptidyl serine modification GO:0018209 83 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.013
peptide transport GO:0015833 133 0.013
lymphocyte proliferation GO:0046651 164 0.013
b cell activation GO:0042113 161 0.013
retrograde transport endosome to golgi GO:0042147 2 0.013
cell division GO:0051301 120 0.013
organophosphate biosynthetic process GO:0090407 122 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
striated muscle tissue development GO:0014706 293 0.013
phosphatidylinositol metabolic process GO:0046488 45 0.013
muscle tissue development GO:0060537 308 0.013
regulation of ion transport GO:0043269 215 0.012
guanosine containing compound catabolic process GO:1901069 144 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
positive regulation of intracellular transport GO:0032388 70 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
adult behavior GO:0030534 135 0.012
cilium morphogenesis GO:0060271 102 0.012
digestive tract development GO:0048565 190 0.012
histone modification GO:0016570 159 0.012
protein localization to plasma membrane GO:0072659 57 0.012
response to radiation GO:0009314 165 0.012
multi multicellular organism process GO:0044706 109 0.012
stem cell development GO:0048864 219 0.012
positive regulation of transferase activity GO:0051347 167 0.012
myeloid leukocyte differentiation GO:0002573 119 0.012
regulation of cell migration GO:0030334 219 0.012
rna interference GO:0016246 2 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
rna processing GO:0006396 105 0.012
neuron death GO:0070997 154 0.012
cellular divalent inorganic cation homeostasis GO:0072503 127 0.012
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.012
glycoprotein biosynthetic process GO:0009101 89 0.012
covalent chromatin modification GO:0016569 163 0.012
macromolecular complex disassembly GO:0032984 43 0.012
negative regulation of molecular function GO:0044092 258 0.012
negative regulation of immune system process GO:0002683 209 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.012
development of primary sexual characteristics GO:0045137 143 0.011
exocytosis GO:0006887 121 0.011
calcium ion homeostasis GO:0055074 127 0.011
skeletal system development GO:0001501 356 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
regulation of nucleoside metabolic process GO:0009118 130 0.011
chemotaxis GO:0006935 247 0.011
blastocyst development GO:0001824 80 0.011
establishment of protein localization to membrane GO:0090150 54 0.011
calcium ion transport GO:0006816 159 0.011
cellular response to extracellular stimulus GO:0031668 81 0.011
regulation of t cell activation GO:0050863 170 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
notch signaling pathway GO:0007219 71 0.011
regulation of actin filament based process GO:0032970 99 0.011
retina development in camera type eye GO:0060041 119 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
skeletal system morphogenesis GO:0048705 203 0.011
regulation of hormone levels GO:0010817 211 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
regulation of peptidase activity GO:0052547 96 0.011
glycoprotein metabolic process GO:0009100 116 0.011
intra golgi vesicle mediated transport GO:0006891 1 0.011
cell growth GO:0016049 130 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
negative regulation of glial cell proliferation GO:0060253 4 0.011
regulation of endocytosis GO:0030100 69 0.011
regulation of endopeptidase activity GO:0052548 89 0.011
response to peptide hormone GO:0043434 127 0.011
positive regulation of gtpase activity GO:0043547 85 0.011
phosphorylated carbohydrate dephosphorylation GO:0046838 4 0.011
defense response to other organism GO:0098542 197 0.011
cell fate commitment GO:0045165 210 0.011
transition metal ion transport GO:0000041 38 0.011
regulation of cell size GO:0008361 72 0.011
negative regulation of cell cycle process GO:0010948 69 0.011
positive regulation of secretion by cell GO:1903532 114 0.011
phospholipid biosynthetic process GO:0008654 36 0.011
wound healing GO:0042060 157 0.011
amide transport GO:0042886 138 0.010
regulation of protein processing GO:0070613 96 0.010
gtp catabolic process GO:0006184 143 0.010
anion transmembrane transport GO:0098656 71 0.010
positive regulation of cell activation GO:0050867 158 0.010
regulation of cytoskeleton organization GO:0051493 122 0.010
regulation of striated muscle cell differentiation GO:0051153 81 0.010
regulation of body fluid levels GO:0050878 162 0.010
regulation of anatomical structure size GO:0090066 178 0.010
ear development GO:0043583 200 0.010
organic acid biosynthetic process GO:0016053 86 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.010
peptidyl threonine modification GO:0018210 31 0.010
organelle localization GO:0051640 179 0.010
neuron apoptotic process GO:0051402 142 0.010
meiotic nuclear division GO:0007126 115 0.010
ossification GO:0001503 216 0.010
actin filament organization GO:0007015 113 0.010
receptor mediated endocytosis GO:0006898 51 0.010
fatty acid transmembrane transport GO:1902001 1 0.010
positive regulation of peptidase activity GO:0010952 49 0.010
oocyte axis specification GO:0007309 2 0.010
positive regulation of homeostatic process GO:0032846 64 0.010
axon ensheathment GO:0008366 76 0.010
purine containing compound catabolic process GO:0072523 213 0.010
cell substrate adhesion GO:0031589 130 0.010
actin polymerization or depolymerization GO:0008154 54 0.010
l amino acid transport GO:0015807 32 0.010
carbohydrate transport GO:0008643 62 0.010
asymmetric stem cell division GO:0098722 3 0.010
small molecule catabolic process GO:0044282 71 0.010
reactive oxygen species metabolic process GO:0072593 84 0.010
multicellular organismal homeostasis GO:0048871 164 0.010
monosaccharide transport GO:0015749 58 0.010

Eif2ak1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.027
disease of anatomical entity DOID:7 0 0.027
hematopoietic system disease DOID:74 0 0.025
nervous system disease DOID:863 0 0.021
central nervous system disease DOID:331 0 0.018
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.014
disease of metabolism DOID:0014667 0 0.011
neurodegenerative disease DOID:1289 0 0.011