Mus musculus

86 known processes

Eif2ak4

eukaryotic translation initiation factor 2 alpha kinase 4

(Aliases: 2610011M03,GCN2,MGCN2)

Eif2ak4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ras protein signal transduction GO:0007265 77 0.113
cellular nitrogen compound catabolic process GO:0044270 280 0.093
regulation of cellular amino acid metabolic process GO:0006521 5 0.093
amine metabolic process GO:0009308 45 0.083
aromatic compound catabolic process GO:0019439 286 0.078
organic cyclic compound catabolic process GO:1901361 295 0.071
regulation of cellular amine metabolic process GO:0033238 20 0.067
cellular amine metabolic process GO:0044106 44 0.064
positive regulation of cellular amine metabolic process GO:0033240 5 0.061
small gtpase mediated signal transduction GO:0007264 97 0.061
organonitrogen compound catabolic process GO:1901565 264 0.059
cellular ketone metabolic process GO:0042180 84 0.057
nucleoside phosphate metabolic process GO:0006753 338 0.055
regulation of cellular ketone metabolic process GO:0010565 66 0.055
peptidyl amino acid modification GO:0018193 336 0.049
cellular amino acid metabolic process GO:0006520 103 0.047
Yeast
nucleoside triphosphate metabolic process GO:0009141 230 0.047
positive regulation of gtp catabolic process GO:0033126 85 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
positive regulation of ras gtpase activity GO:0032320 65 0.044
purine nucleotide metabolic process GO:0006163 302 0.043
cellular response to dna damage stimulus GO:0006974 207 0.043
Yeast
ribonucleotide metabolic process GO:0009259 291 0.043
purine nucleoside catabolic process GO:0006152 205 0.040
regulation of hydrolase activity GO:0051336 246 0.040
ribonucleoside triphosphate metabolic process GO:0009199 220 0.039
purine nucleoside triphosphate metabolic process GO:0009144 226 0.039
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.038
neuronal action potential GO:0019228 54 0.038
nucleoside phosphate catabolic process GO:1901292 222 0.038
microtubule based process GO:0007017 236 0.038
ribonucleotide catabolic process GO:0009261 208 0.038
purine ribonucleotide metabolic process GO:0009150 290 0.038
positive regulation of protein modification process GO:0031401 299 0.038
ribonucleoside metabolic process GO:0009119 245 0.038
organophosphate catabolic process GO:0046434 232 0.038
action potential GO:0001508 78 0.037
heterocycle catabolic process GO:0046700 280 0.036
transmembrane transport GO:0055085 412 0.036
regulation of membrane potential GO:0042391 192 0.035
peptidyl serine phosphorylation GO:0018105 74 0.035
positive regulation of gtpase activity GO:0043547 85 0.035
positive regulation of protein phosphorylation GO:0001934 242 0.034
rho protein signal transduction GO:0007266 32 0.033
purine containing compound metabolic process GO:0072521 311 0.033
regulation of nucleotide metabolic process GO:0006140 169 0.033
regulation of organelle organization GO:0033043 289 0.032
positive regulation of nucleotide metabolic process GO:0045981 114 0.032
purine nucleotide catabolic process GO:0006195 211 0.032
purine ribonucleoside metabolic process GO:0046128 241 0.032
regulation of purine nucleotide metabolic process GO:1900542 169 0.032
nucleoside metabolic process GO:0009116 246 0.031
regulation of ras gtpase activity GO:0032318 88 0.031
cation transport GO:0006812 399 0.031
apoptotic signaling pathway GO:0097190 306 0.031
cell type specific apoptotic process GO:0097285 268 0.031
glycosyl compound metabolic process GO:1901657 246 0.030
positive regulation of nucleotide catabolic process GO:0030813 88 0.030
nucleoside catabolic process GO:0009164 206 0.029
multicellular organismal signaling GO:0035637 91 0.028
purine containing compound catabolic process GO:0072523 213 0.028
nucleotide metabolic process GO:0009117 332 0.027
positive regulation of nucleoside metabolic process GO:0045979 91 0.027
positive regulation of hydrolase activity GO:0051345 148 0.027
regulation of cellular component biogenesis GO:0044087 181 0.027
macromolecule catabolic process GO:0009057 281 0.027
negative regulation of phosphorus metabolic process GO:0010563 184 0.027
cell adhesion GO:0007155 329 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
guanosine containing compound catabolic process GO:1901069 144 0.026
glycosyl compound catabolic process GO:1901658 206 0.026
posttranscriptional regulation of gene expression GO:0010608 155 0.026
immune effector process GO:0002252 321 0.025
ribonucleoside catabolic process GO:0042454 206 0.025
cytoplasmic transport GO:0016482 234 0.025
negative regulation of intracellular signal transduction GO:1902532 167 0.025
gtp catabolic process GO:0006184 143 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.025
protein modification by small protein conjugation or removal GO:0070647 207 0.025
activation of immune response GO:0002253 138 0.025
transmission of nerve impulse GO:0019226 76 0.024
epithelial tube morphogenesis GO:0060562 303 0.024
cation transmembrane transport GO:0098655 266 0.023
protein modification by small protein conjugation GO:0032446 187 0.023
myelination GO:0042552 74 0.023
regulation of purine nucleotide catabolic process GO:0033121 122 0.023
lung development GO:0030324 164 0.023
cytokine production GO:0001816 319 0.023
nucleobase containing small molecule metabolic process GO:0055086 352 0.023
purine ribonucleotide catabolic process GO:0009154 208 0.023
muscle tissue development GO:0060537 308 0.022
regulation of neuron projection development GO:0010975 169 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.022
peptidyl serine modification GO:0018209 83 0.022
negative regulation of phosphate metabolic process GO:0045936 184 0.022
chromatin organization GO:0006325 206 0.022
canonical wnt signaling pathway GO:0060070 130 0.022
purine nucleoside triphosphate catabolic process GO:0009146 203 0.022
ribonucleoside triphosphate catabolic process GO:0009203 199 0.022
regulation of neuron differentiation GO:0045664 281 0.022
camera type eye development GO:0043010 266 0.022
actin filament organization GO:0007015 113 0.022
purine nucleoside metabolic process GO:0042278 241 0.021
negative regulation of cellular amine metabolic process GO:0033239 1 0.021
embryonic epithelial tube formation GO:0001838 130 0.021
purine ribonucleoside catabolic process GO:0046130 205 0.021
negative regulation of cell proliferation GO:0008285 296 0.021
respiratory system development GO:0060541 190 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
forebrain development GO:0030900 302 0.021
actin cytoskeleton organization GO:0030036 220 0.021
hematopoietic progenitor cell differentiation GO:0002244 143 0.020
compound eye development GO:0048749 1 0.020
regulation of gtp catabolic process GO:0033124 113 0.020
regulation of cellular catabolic process GO:0031329 242 0.020
ion transmembrane transport GO:0034220 361 0.020
positive regulation of rho gtpase activity GO:0032321 41 0.020
tube formation GO:0035148 140 0.020
wnt signaling pathway GO:0016055 188 0.020
regulation of transferase activity GO:0051338 263 0.020
regulation of nucleoside metabolic process GO:0009118 130 0.019
nucleoside triphosphate catabolic process GO:0009143 205 0.019
regulation of mapk cascade GO:0043408 248 0.019
respiratory tube development GO:0030323 167 0.019
regulation of wnt signaling pathway GO:0030111 123 0.019
organelle assembly GO:0070925 177 0.019
ensheathment of neurons GO:0007272 76 0.019
regulation of secretion GO:0051046 274 0.019
membrane organization GO:0061024 245 0.019
leukocyte differentiation GO:0002521 342 0.019
guanosine containing compound metabolic process GO:1901068 144 0.019
ossification GO:0001503 216 0.018
neural tube closure GO:0001843 90 0.018
maintenance of location GO:0051235 89 0.018
histone modification GO:0016570 159 0.018
regulation of cytokine production GO:0001817 266 0.018
negative regulation of molecular function GO:0044092 258 0.018
nucleotide catabolic process GO:0009166 217 0.018
sensory perception GO:0007600 245 0.018
regulation of cell migration GO:0030334 219 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.018
axon ensheathment GO:0008366 76 0.018
negative regulation of neuron death GO:1901215 98 0.018
dna metabolic process GO:0006259 303 0.018
inorganic cation transmembrane transport GO:0098662 207 0.018
innate immune response GO:0045087 157 0.018
organonitrogen compound biosynthetic process GO:1901566 192 0.018
Yeast
cellular homeostasis GO:0019725 240 0.018
organelle localization GO:0051640 179 0.017
positive regulation of cell development GO:0010720 237 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
regulation of ras protein signal transduction GO:0046578 114 0.017
response to organonitrogen compound GO:0010243 246 0.017
regulation of ion transport GO:0043269 215 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.017
retina development in camera type eye GO:0060041 119 0.017
microtubule cytoskeleton organization GO:0000226 157 0.017
regulation of cell activation GO:0050865 289 0.017
regulation of rho protein signal transduction GO:0035023 71 0.017
regulation of nucleotide catabolic process GO:0030811 122 0.017
adult locomotory behavior GO:0008344 91 0.017
epithelial tube formation GO:0072175 130 0.017
regulation of cell motility GO:2000145 236 0.017
dna repair GO:0006281 107 0.017
morphogenesis of embryonic epithelium GO:0016331 159 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.016
neuron death GO:0070997 154 0.016
asymmetric neuroblast division GO:0055059 1 0.016
cellular response to lipid GO:0071396 145 0.016
protein ubiquitination GO:0016567 171 0.016
positive regulation of organelle organization GO:0010638 128 0.016
central nervous system neuron differentiation GO:0021953 162 0.016
gtp metabolic process GO:0046039 144 0.016
developmental maturation GO:0021700 193 0.016
muscle cell differentiation GO:0042692 261 0.016
lipid localization GO:0010876 126 0.016
negative regulation of cellular protein metabolic process GO:0032269 247 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.016
divalent inorganic cation transport GO:0072511 178 0.016
digestive system development GO:0055123 200 0.016
response to radiation GO:0009314 165 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
regulation of protein kinase activity GO:0045859 232 0.016
regulation of secretion by cell GO:1903530 249 0.016
carbohydrate derivative biosynthetic process GO:1901137 183 0.016
regulation of neuron death GO:1901214 134 0.016
positive regulation of apoptotic signaling pathway GO:2001235 95 0.016
positive regulation of kinase activity GO:0033674 155 0.016
regulation of neuron apoptotic process GO:0043523 122 0.015
metal ion homeostasis GO:0055065 189 0.015
b cell activation GO:0042113 161 0.015
engulfment of apoptotic cell GO:0043652 3 0.015
blood circulation GO:0008015 195 0.015
protein polymerization GO:0051258 57 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
nitrogen compound transport GO:0071705 271 0.015
response to lipopolysaccharide GO:0032496 128 0.015
positive regulation of cell death GO:0010942 224 0.015
positive regulation of nervous system development GO:0051962 221 0.015
homeostasis of number of cells GO:0048872 210 0.015
multicellular organism growth GO:0035264 161 0.014
leukocyte mediated immunity GO:0002443 174 0.014
gland development GO:0048732 330 0.014
circulatory system process GO:0003013 197 0.014
regulation of protein serine threonine kinase activity GO:0071900 157 0.014
carbohydrate derivative catabolic process GO:1901136 231 0.014
negative regulation of neuron apoptotic process GO:0043524 92 0.014
production of molecular mediator of immune response GO:0002440 103 0.014
regulation of homeostatic process GO:0032844 182 0.014
chemotaxis GO:0006935 247 0.014
divalent metal ion transport GO:0070838 172 0.014
negative regulation of protein modification process GO:0031400 163 0.014
mrna metabolic process GO:0016071 84 0.014
regulation of ossification GO:0030278 112 0.014
regulation of ion transmembrane transport GO:0034765 119 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
immune response regulating signaling pathway GO:0002764 125 0.014
protein targeting GO:0006605 143 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
divalent inorganic cation homeostasis GO:0072507 138 0.013
regulation of binding GO:0051098 111 0.013
retrograde transport endosome to golgi GO:0042147 2 0.013
cellular chemical homeostasis GO:0055082 215 0.013
organelle fission GO:0048285 170 0.013
dephosphorylation GO:0016311 129 0.013
regulation of protein localization GO:0032880 231 0.013
translation GO:0006412 93 0.013
anatomical structure homeostasis GO:0060249 145 0.013
calcium ion homeostasis GO:0055074 127 0.013
endocytosis GO:0006897 168 0.013
spermatogenesis GO:0007283 284 0.013
response to oxidative stress GO:0006979 123 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
mapk cascade GO:0000165 281 0.013
tube closure GO:0060606 91 0.013
positive regulation of cytokine production GO:0001819 174 0.013
regulation of cellular response to stress GO:0080135 159 0.013
fat cell differentiation GO:0045444 160 0.013
axonogenesis GO:0007409 274 0.013
stem cell proliferation GO:0072089 117 0.013
neuron apoptotic process GO:0051402 142 0.013
lateral inhibition GO:0046331 1 0.012
placenta development GO:0001890 140 0.012
limb development GO:0060173 166 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
t cell activation GO:0042110 289 0.012
organic anion transport GO:0015711 137 0.012
mitotic cell cycle GO:0000278 195 0.012
regulation of cell projection organization GO:0031344 206 0.012
response to light stimulus GO:0009416 135 0.012
lymphocyte activation involved in immune response GO:0002285 93 0.012
skeletal system development GO:0001501 356 0.012
positive regulation of glial cell proliferation GO:0060252 4 0.012
regulation of kinase activity GO:0043549 249 0.012
positive regulation of cellular catabolic process GO:0031331 148 0.012
regulation of cytoskeleton organization GO:0051493 122 0.012
neural tube development GO:0021915 160 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.012
myosin filament assembly GO:0031034 2 0.012
neural tube formation GO:0001841 108 0.012
cell recognition GO:0008037 83 0.012
anion transport GO:0006820 177 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
rhythmic process GO:0048511 174 0.012
synaptic transmission GO:0007268 329 0.012
intracellular protein transport GO:0006886 204 0.012
multi multicellular organism process GO:0044706 109 0.011
cellular macromolecule catabolic process GO:0044265 206 0.011
inorganic ion transmembrane transport GO:0098660 234 0.011
atp metabolic process GO:0046034 75 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.011
urogenital system development GO:0001655 261 0.011
mrna processing GO:0006397 63 0.011
primary neural tube formation GO:0014020 95 0.011
cell activation involved in immune response GO:0002263 126 0.011
myosin filament organization GO:0031033 3 0.011
positive regulation of neuron differentiation GO:0045666 141 0.011
renal system development GO:0072001 225 0.011
embryonic limb morphogenesis GO:0030326 126 0.011
regulation of protein complex assembly GO:0043254 83 0.011
carbohydrate metabolic process GO:0005975 230 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
methylation GO:0032259 134 0.011
regulation of cell cycle GO:0051726 281 0.011
asymmetric stem cell division GO:0098722 3 0.011
negative regulation of immune system process GO:0002683 209 0.011
leukocyte migration GO:0050900 124 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
cellular lipid metabolic process GO:0044255 323 0.011
dna recombination GO:0006310 92 0.011
terminal button organization GO:0072553 3 0.011
positive regulation of transferase activity GO:0051347 167 0.011
protein secretion GO:0009306 111 0.011
wound healing GO:0042060 157 0.011
sequestering of metal ion GO:0051238 19 0.011
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.010
cation homeostasis GO:0055080 212 0.010
pharynx development GO:0060465 1 0.010
sequestering of calcium ion GO:0051208 18 0.010
positive regulation of immune effector process GO:0002699 107 0.010
cellular protein complex assembly GO:0043623 116 0.010
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.010
regulation of anatomical structure size GO:0090066 178 0.010
Fly
negative regulation of cellular component organization GO:0051129 194 0.010
response to growth factor GO:0070848 198 0.010
lymphocyte differentiation GO:0030098 242 0.010
skin development GO:0043588 220 0.010
cellular response to organonitrogen compound GO:0071417 145 0.010
striated muscle tissue development GO:0014706 293 0.010
positive regulation of defense response GO:0031349 124 0.010
positive regulation of rac gtpase activity GO:0032855 14 0.010
mitotic cell cycle process GO:1903047 159 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.010
sensory organ morphogenesis GO:0090596 242 0.010
kidney development GO:0001822 213 0.010
t cell proliferation GO:0042098 120 0.010
g protein coupled receptor signaling pathway GO:0007186 243 0.010
cellular divalent inorganic cation homeostasis GO:0072503 127 0.010

Eif2ak4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.046
nervous system disease DOID:863 0 0.046
sensory system disease DOID:0050155 0 0.019
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018
disease of metabolism DOID:0014667 0 0.017
inherited metabolic disorder DOID:655 0 0.017
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
retinal disease DOID:5679 0 0.011
retinal degeneration DOID:8466 0 0.010