Mus musculus

35 known processes

Erap1

endoplasmic reticulum aminopeptidase 1

(Aliases: ERAAP,PILSA,Arts1,PILSAP)

Erap1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cytokine production GO:0001817 266 0.408
ribose phosphate metabolic process GO:0019693 291 0.218
aromatic compound catabolic process GO:0019439 286 0.174
interspecies interaction between organisms GO:0044419 83 0.168
organic cyclic compound catabolic process GO:1901361 295 0.166
nucleoside phosphate metabolic process GO:0006753 338 0.153
regulation of response to biotic stimulus GO:0002831 38 0.152
regulation of intracellular transport GO:0032386 159 0.148
type i interferon production GO:0032606 29 0.148
cytokine production GO:0001816 319 0.145
regulation of defense response GO:0031347 233 0.140
regulation of innate immune response GO:0045088 91 0.138
response to lipopolysaccharide GO:0032496 128 0.132
innate immune response GO:0045087 157 0.127
positive regulation of interferon alpha production GO:0032727 4 0.118
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.118
nucleoside catabolic process GO:0009164 206 0.106
glycosyl compound metabolic process GO:1901657 246 0.100
regulation of type i interferon production GO:0032479 22 0.099
immune effector process GO:0002252 321 0.092
positive regulation of hydrolase activity GO:0051345 148 0.092
nucleobase containing small molecule metabolic process GO:0055086 352 0.089
purine ribonucleotide catabolic process GO:0009154 208 0.087
heterocycle catabolic process GO:0046700 280 0.087
cellular response to molecule of bacterial origin GO:0071219 83 0.086
carbohydrate derivative catabolic process GO:1901136 231 0.084
purine nucleoside triphosphate catabolic process GO:0009146 203 0.082
regulation of multi organism process GO:0043900 111 0.079
negative regulation of cellular protein metabolic process GO:0032269 247 0.078
nucleoside triphosphate metabolic process GO:0009141 230 0.074
purine ribonucleotide metabolic process GO:0009150 290 0.069
intracellular protein transport GO:0006886 204 0.068
cellular nitrogen compound catabolic process GO:0044270 280 0.067
cellular response to lipopolysaccharide GO:0071222 77 0.064
cellular response to lipid GO:0071396 145 0.064
nucleoside phosphate catabolic process GO:1901292 222 0.063
defense response to other organism GO:0098542 197 0.063
positive regulation of defense response GO:0031349 124 0.062
cellular response to interferon beta GO:0035458 21 0.062
purine nucleoside catabolic process GO:0006152 205 0.060
ribonucleoside triphosphate metabolic process GO:0009199 220 0.059
regulation of intracellular protein transport GO:0033157 82 0.059
nucleotide metabolic process GO:0009117 332 0.058
cytoplasmic transport GO:0016482 234 0.058
activation of immune response GO:0002253 138 0.057
purine containing compound metabolic process GO:0072521 311 0.056
nucleoside triphosphate catabolic process GO:0009143 205 0.056
cellular response to cytokine stimulus GO:0071345 189 0.055
purine ribonucleoside catabolic process GO:0046130 205 0.055
purine nucleoside triphosphate metabolic process GO:0009144 226 0.055
rig i signaling pathway GO:0039529 4 0.053
dna metabolic process GO:0006259 303 0.053
purine nucleotide catabolic process GO:0006195 211 0.053
defense response to bacterium GO:0042742 119 0.052
purine nucleoside metabolic process GO:0042278 241 0.051
ribonucleotide metabolic process GO:0009259 291 0.050
cellular response to biotic stimulus GO:0071216 92 0.050
response to organic cyclic compound GO:0014070 198 0.049
protein import into nucleus GO:0006606 95 0.049
purine nucleotide metabolic process GO:0006163 302 0.048
negative regulation of molecular function GO:0044092 258 0.047
defense response to virus GO:0051607 68 0.047
cellular ketone metabolic process GO:0042180 84 0.047
regulation of protein localization GO:0032880 231 0.046
purine ribonucleoside metabolic process GO:0046128 241 0.046
ribonucleoside triphosphate catabolic process GO:0009203 199 0.046
response to molecule of bacterial origin GO:0002237 143 0.045
regulation of peptidase activity GO:0052547 96 0.044
ribonucleoside metabolic process GO:0009119 245 0.043
protein import GO:0017038 101 0.043
purine containing compound catabolic process GO:0072523 213 0.043
interleukin 8 production GO:0032637 4 0.042
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.042
cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 4 0.042
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.042
protein modification by small protein conjugation or removal GO:0070647 207 0.042
regulation of hydrolase activity GO:0051336 246 0.042
protein localization to organelle GO:0033365 185 0.041
organonitrogen compound catabolic process GO:1901565 264 0.041
nucleotide catabolic process GO:0009166 217 0.041
regulation of cellular catabolic process GO:0031329 242 0.040
b cell activation GO:0042113 161 0.039
leukocyte mediated cytotoxicity GO:0001909 62 0.039
positive regulation of innate immune response GO:0045089 80 0.038
leukocyte mediated immunity GO:0002443 174 0.038
nucleoside metabolic process GO:0009116 246 0.038
protein modification by small protein conjugation GO:0032446 187 0.038
inflammatory response GO:0006954 244 0.038
glycosyl compound catabolic process GO:1901658 206 0.037
positive regulation of type i interferon production GO:0032481 14 0.037
activation of innate immune response GO:0002218 56 0.037
response to organonitrogen compound GO:0010243 246 0.036
response to dsrna GO:0043331 30 0.035
nucleoside monophosphate metabolic process GO:0009123 85 0.035
macromolecule catabolic process GO:0009057 281 0.035
Mouse
protein maturation GO:0051604 176 0.035
regulation of establishment of protein localization GO:0070201 181 0.034
negative regulation of protein metabolic process GO:0051248 282 0.034
cell type specific apoptotic process GO:0097285 268 0.034
response to interferon gamma GO:0034341 34 0.034
immune response regulating signaling pathway GO:0002764 125 0.034
atp metabolic process GO:0046034 75 0.033
apoptotic signaling pathway GO:0097190 306 0.033
defense response to gram positive bacterium GO:0050830 50 0.033
myeloid leukocyte differentiation GO:0002573 119 0.033
cellular amino acid metabolic process GO:0006520 103 0.033
membrane organization GO:0061024 245 0.032
establishment of protein localization to organelle GO:0072594 118 0.032
positive regulation of immune effector process GO:0002699 107 0.032
regulation of membrane potential GO:0042391 192 0.032
regulation of defense response to bacterium GO:1900424 3 0.032
ribonucleoside monophosphate metabolic process GO:0009161 80 0.032
ribonucleotide catabolic process GO:0009261 208 0.032
positive regulation of cytokine production GO:0001819 174 0.031
nucleocytoplasmic transport GO:0006913 139 0.031
negative regulation of cytokine production GO:0001818 84 0.031
regulation of proteolysis GO:0030162 164 0.031
positive regulation of proteolysis GO:0045862 85 0.031
leukocyte differentiation GO:0002521 342 0.030
negative regulation of phosphorus metabolic process GO:0010563 184 0.030
immune response activating signal transduction GO:0002757 116 0.030
metal ion homeostasis GO:0055065 189 0.030
nitrogen compound transport GO:0071705 271 0.030
regulation of nucleocytoplasmic transport GO:0046822 73 0.029
negative regulation of immune system process GO:0002683 209 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.029
organophosphate catabolic process GO:0046434 232 0.029
regulation of protein targeting GO:1903533 61 0.028
cellular amine metabolic process GO:0044106 44 0.028
lymphocyte mediated immunity GO:0002449 139 0.028
stem cell development GO:0048864 219 0.028
respiratory system development GO:0060541 190 0.028
transmembrane transport GO:0055085 412 0.028
posttranscriptional regulation of gene expression GO:0010608 155 0.028
hatching GO:0035188 4 0.028
regulation of schwann cell proliferation GO:0010624 2 0.027
cellular response to dna damage stimulus GO:0006974 207 0.026
reactive oxygen species metabolic process GO:0072593 84 0.026
regulation of reactive oxygen species metabolic process GO:2000377 40 0.026
negative regulation of phosphorylation GO:0042326 166 0.026
negative regulation of multi organism process GO:0043901 68 0.026
protein processing GO:0016485 163 0.025
single organism nuclear import GO:1902593 95 0.025
negative regulation of cell proliferation GO:0008285 296 0.025
negative regulation of phosphate metabolic process GO:0045936 184 0.025
negative regulation of protein phosphorylation GO:0001933 126 0.025
negative regulation of protein modification process GO:0031400 163 0.025
regulation of leukocyte apoptotic process GO:2000106 56 0.025
compound eye development GO:0048749 1 0.024
gtp catabolic process GO:0006184 143 0.024
nuclear transport GO:0051169 139 0.024
regulation of interferon alpha production GO:0032647 5 0.024
purine nucleoside monophosphate metabolic process GO:0009126 81 0.024
negative regulation of intracellular transport GO:0032387 38 0.024
positive regulation of programmed cell death GO:0043068 218 0.024
positive regulation of antimicrobial humoral response GO:0002760 2 0.024
epithelial tube morphogenesis GO:0060562 303 0.023
oxidation reduction process GO:0055114 342 0.023
mitochondrion organization GO:0007005 134 0.023
viral life cycle GO:0019058 36 0.023
regulation of autophagy GO:0010506 30 0.023
membrane depolarization GO:0051899 64 0.023
regulation of cytoplasmic transport GO:1903649 112 0.023
regulation of antimicrobial humoral response GO:0002759 3 0.023
carbohydrate metabolic process GO:0005975 230 0.023
ribonucleoside catabolic process GO:0042454 206 0.022
protein ubiquitination GO:0016567 171 0.022
cation transport GO:0006812 399 0.022
regulation of nlrp3 inflammasome complex assembly GO:1900225 4 0.022
epidermis development GO:0008544 187 0.022
maintenance of location GO:0051235 89 0.022
defense response to gram negative bacterium GO:0050829 28 0.022
positive regulation of rig i signaling pathway GO:1900246 1 0.022
protein localization to nucleus GO:0034504 121 0.022
antimicrobial peptide biosynthetic process GO:0002777 2 0.022
lung development GO:0030324 164 0.022
regulation of interleukin 1 alpha production GO:0032650 4 0.021
pattern recognition receptor signaling pathway GO:0002221 47 0.021
regulation of rig i signaling pathway GO:0039535 2 0.021
negative regulation of intracellular protein transport GO:0090317 27 0.021
regulation of cellular ketone metabolic process GO:0010565 66 0.021
positive regulation of apoptotic process GO:0043065 217 0.021
protein targeting GO:0006605 143 0.021
cellular lipid metabolic process GO:0044255 323 0.021
regulation of protein transport GO:0051223 163 0.021
extrinsic apoptotic signaling pathway GO:0097191 126 0.020
regulation of endopeptidase activity GO:0052548 89 0.020
negative regulation of interferon alpha production GO:0032687 1 0.020
regulation of lymphocyte activation GO:0051249 240 0.020
regulation of secretion GO:0051046 274 0.020
ion transmembrane transport GO:0034220 361 0.020
macromolecule glycosylation GO:0043413 55 0.020
regulation of protein localization to nucleus GO:1900180 60 0.019
respiratory tube development GO:0030323 167 0.019
progesterone metabolic process GO:0042448 4 0.019
cellular response to hormone stimulus GO:0032870 150 0.019
negative regulation of nervous system development GO:0051961 156 0.019
extracellular matrix organization GO:0030198 147 0.019
glycoprotein metabolic process GO:0009100 116 0.019
natural killer cell proliferation GO:0001787 3 0.019
negative regulation of nlrp3 inflammasome complex assembly GO:1900226 2 0.019
negative regulation of protein transport GO:0051224 46 0.018
ribonucleoside monophosphate catabolic process GO:0009158 57 0.018
protein catabolic process GO:0030163 221 0.018
Mouse
cell killing GO:0001906 67 0.018
regulation of cell cycle GO:0051726 281 0.018
response to endoplasmic reticulum stress GO:0034976 53 0.018
organophosphate biosynthetic process GO:0090407 122 0.018
positive regulation of cellular catabolic process GO:0031331 148 0.018
pyroptosis GO:0070269 8 0.018
positive regulation of cell death GO:0010942 224 0.018
innate immune response activating signal transduction GO:0002758 50 0.018
endomembrane system organization GO:0010256 147 0.018
regulation of response to wounding GO:1903034 189 0.018
regulation of interleukin 8 production GO:0032677 3 0.018
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.018
antibacterial peptide production GO:0002778 2 0.017
rna processing GO:0006396 105 0.017
nuclear import GO:0051170 95 0.017
cellular macromolecule catabolic process GO:0044265 206 0.017
adaptive immune response GO:0002250 155 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.017
regulation of protein import into nucleus GO:0042306 52 0.017
monocarboxylic acid metabolic process GO:0032787 191 0.017
regulation of transferase activity GO:0051338 263 0.017
peptide metabolic process GO:0006518 46 0.017
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.017
regulation of leukocyte differentiation GO:1902105 159 0.017
cellular component assembly involved in morphogenesis GO:0010927 139 0.017
multicellular organismal signaling GO:0035637 91 0.016
muscle cell differentiation GO:0042692 261 0.016
regulation of protein ubiquitination GO:0031396 52 0.016
stem cell differentiation GO:0048863 268 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.016
viral process GO:0016032 41 0.016
spleen development GO:0048536 39 0.016
cellular amide metabolic process GO:0043603 58 0.016
positive regulation of endopeptidase activity GO:0010950 43 0.016
positive regulation of viral entry into host cell GO:0046598 3 0.016
blood vessel morphogenesis GO:0048514 285 0.016
regulation of cell activation GO:0050865 289 0.016
dna repair GO:0006281 107 0.016
amine metabolic process GO:0009308 45 0.016
muscle cell development GO:0055001 133 0.016
guanosine containing compound metabolic process GO:1901068 144 0.016
connective tissue development GO:0061448 179 0.016
carbohydrate derivative biosynthetic process GO:1901137 183 0.016
cell adhesion GO:0007155 329 0.016
regulation of hormone levels GO:0010817 211 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
guanosine containing compound catabolic process GO:1901069 144 0.016
digestive system development GO:0055123 200 0.016
interferon beta production GO:0032608 16 0.016
cell activation involved in immune response GO:0002263 126 0.016
multicellular organism growth GO:0035264 161 0.016
multicellular organismal homeostasis GO:0048871 164 0.016
leukocyte apoptotic process GO:0071887 71 0.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
i kappab kinase nf kappab signaling GO:0007249 85 0.015
regulation of purine nucleotide metabolic process GO:1900542 169 0.015
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.015
myeloid cell differentiation GO:0030099 233 0.015
action potential GO:0001508 78 0.015
regulation of mapk cascade GO:0043408 248 0.015
er nucleus signaling pathway GO:0006984 27 0.015
anion transport GO:0006820 177 0.015
lipid biosynthetic process GO:0008610 179 0.015
regulation of defense response to virus by host GO:0050691 8 0.015
cellular carbohydrate metabolic process GO:0044262 119 0.015
positive regulation of viral genome replication GO:0045070 2 0.015
lymphocyte apoptotic process GO:0070227 54 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.015
cellular metal ion homeostasis GO:0006875 151 0.014
muscle tissue development GO:0060537 308 0.014
sensory perception GO:0007600 245 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
glycosylation GO:0070085 62 0.014
cellular ion homeostasis GO:0006873 165 0.014
fatty acid metabolic process GO:0006631 121 0.014
rna interference GO:0016246 2 0.014
viral gene expression GO:0019080 3 0.014
angiogenesis GO:0001525 201 0.014
adhesion of symbiont to host GO:0044406 8 0.014
cation homeostasis GO:0055080 212 0.014
regulation of cellular amino acid metabolic process GO:0006521 5 0.014
negative regulation of cell development GO:0010721 169 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
cellular response to oxidative stress GO:0034599 76 0.014
epithelial cell proliferation GO:0050673 174 0.014
regulation of secretion by cell GO:1903530 249 0.014
positive regulation of mda 5 signaling pathway GO:1900245 1 0.014
ossification GO:0001503 216 0.014
neuronal action potential GO:0019228 54 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.013
lymphocyte differentiation GO:0030098 242 0.013
regulation of neuron differentiation GO:0045664 281 0.013
peptidyl amino acid modification GO:0018193 336 0.013
regulation of b cell activation GO:0050864 81 0.013
cation transmembrane transport GO:0098655 266 0.013
chromatin organization GO:0006325 206 0.013
covalent chromatin modification GO:0016569 163 0.013
positive regulation of peptidase activity GO:0010952 49 0.013
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.013
autophagy GO:0006914 45 0.013
amide transport GO:0042886 138 0.013
leukocyte homeostasis GO:0001776 79 0.013
skeletal system development GO:0001501 356 0.013
cellular response to external stimulus GO:0071496 88 0.013
regulation of apoptotic signaling pathway GO:2001233 197 0.013
negative regulation of cytoplasmic transport GO:1903650 29 0.013
alcohol metabolic process GO:0006066 116 0.013
hormone metabolic process GO:0042445 86 0.013
epithelial cell development GO:0002064 159 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
striated muscle tissue development GO:0014706 293 0.012
urogenital system development GO:0001655 261 0.012
Mouse
anatomical structure homeostasis GO:0060249 145 0.012
interleukin 6 production GO:0032635 58 0.012
antimicrobial peptide production GO:0002775 2 0.012
regulation of interferon gamma production GO:0032649 57 0.012
regulation of cellular amine metabolic process GO:0033238 20 0.012
positive regulation of nervous system development GO:0051962 221 0.012
regulation of neuron death GO:1901214 134 0.012
positive regulation of cellular amine metabolic process GO:0033240 5 0.012
limb morphogenesis GO:0035108 149 0.012
ear development GO:0043583 200 0.012
engulfment of apoptotic cell GO:0043652 3 0.012
synaptic transmission GO:0007268 329 0.012
positive regulation of protein transport GO:0051222 93 0.012
meiotic cell cycle process GO:1903046 77 0.012
regulation of viral genome replication GO:0045069 13 0.012
positive regulation of cell development GO:0010720 237 0.012
double strand break repair GO:0006302 48 0.012
homeostasis of number of cells GO:0048872 210 0.012
negative regulation of protein localization to nucleus GO:1900181 23 0.012
regulation of actin nucleation GO:0051125 4 0.012
rhythmic process GO:0048511 174 0.011
regulation of protein catabolic process GO:0042176 108 0.011
t cell activation GO:0042110 289 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
extracellular structure organization GO:0043062 148 0.011
t cell mediated cytotoxicity GO:0001913 26 0.011
atp catabolic process GO:0006200 55 0.011
regulation of body fluid levels GO:0050878 162 0.011
defense response to protozoan GO:0042832 25 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.011
regulation of t cell activation GO:0050863 170 0.011
purine nucleoside monophosphate catabolic process GO:0009128 58 0.011
regulation of natural killer cell mediated cytotoxicity GO:0042269 19 0.011
mapk cascade GO:0000165 281 0.011
neuron apoptotic process GO:0051402 142 0.011
morphogenesis of a branching structure GO:0001763 203 0.011
b cell activation involved in immune response GO:0002312 50 0.011
stem cell maintenance GO:0019827 130 0.011
regulation of antimicrobial peptide production GO:0002784 1 0.011
mrna metabolic process GO:0016071 84 0.011
regulation of lymphocyte differentiation GO:0045619 107 0.011
inorganic ion transmembrane transport GO:0098660 234 0.011
sequestering of metal ion GO:0051238 19 0.011
activation of cysteine type endopeptidase activity GO:0097202 27 0.011
organism emergence from protective structure GO:0071684 4 0.011
organic anion transport GO:0015711 137 0.011
lymphocyte activation involved in immune response GO:0002285 93 0.011
positive regulation of interleukin 1 alpha secretion GO:0050717 3 0.011
response to nutrient levels GO:0031667 109 0.011
gtp metabolic process GO:0046039 144 0.011
positive regulation of nucleotide metabolic process GO:0045981 114 0.011
small gtpase mediated signal transduction GO:0007264 97 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
regulation of lymphocyte apoptotic process GO:0070228 41 0.011
lipid localization GO:0010876 126 0.011
natural killer cell activation GO:0030101 44 0.011
sequestering of calcium ion GO:0051208 18 0.011
regulation of kinase activity GO:0043549 249 0.011
regulation of production of molecular mediator of immune response GO:0002700 65 0.011
glycoprotein biosynthetic process GO:0009101 89 0.011
immunoglobulin production GO:0002377 73 0.011
microtubule based process GO:0007017 236 0.011
response to oxidative stress GO:0006979 123 0.011
positive regulation of apoptotic signaling pathway GO:2001235 95 0.011
limb development GO:0060173 166 0.010
response to peptide hormone GO:0043434 127 0.010
schwann cell proliferation GO:0014010 2 0.010
regulation of purine nucleotide catabolic process GO:0033121 122 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010
inorganic cation transmembrane transport GO:0098662 207 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.010
cartilage development GO:0051216 140 0.010
negative regulation of cellular amine metabolic process GO:0033239 1 0.010
striated muscle cell development GO:0055002 125 0.010
response to light stimulus GO:0009416 135 0.010
negative regulation of protein modification by small protein conjugation or removal GO:1903321 20 0.010
cellular chemical homeostasis GO:0055082 215 0.010
cellular response to organonitrogen compound GO:0071417 145 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.010
carbohydrate homeostasis GO:0033500 128 0.010
skin development GO:0043588 220 0.010
positive regulation of nucleotide catabolic process GO:0030813 88 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.010
t cell apoptotic process GO:0070231 39 0.010
negative regulation of immune effector process GO:0002698 55 0.010
response to radiation GO:0009314 165 0.010
protein glycosylation GO:0006486 55 0.010
response to growth factor GO:0070848 198 0.010
glial cell differentiation GO:0010001 131 0.010
production of molecular mediator of immune response GO:0002440 103 0.010
cytokine mediated signaling pathway GO:0019221 115 0.010
cell fate commitment GO:0045165 210 0.010
nucleoside monophosphate catabolic process GO:0009125 59 0.010

Erap1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.037
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
musculoskeletal system disease DOID:17 0 0.013
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013