Mus musculus

5 known processes

Tph2

tryptophan hydroxylase 2

(Aliases: AU043594,Ntph,MGC159133)

Tph2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 342 0.116
circulatory system process GO:0003013 197 0.079
Mouse
regulation of system process GO:0044057 200 0.073
Mouse
response to organonitrogen compound GO:0010243 246 0.070
cellular amino acid metabolic process GO:0006520 103 0.068
Mouse Worm
cellular lipid metabolic process GO:0044255 323 0.066
regulation of secretion GO:0051046 274 0.059
regulation of cellular ketone metabolic process GO:0010565 66 0.057
cellular response to lipid GO:0071396 145 0.054
regulation of neuron differentiation GO:0045664 281 0.054
sensory perception GO:0007600 245 0.051
Mouse
placenta development GO:0001890 140 0.051
nitrogen compound transport GO:0071705 271 0.050
transmembrane transport GO:0055085 412 0.048
negative regulation of protein metabolic process GO:0051248 282 0.047
norepinephrine transport GO:0015874 2 0.046
cation transmembrane transport GO:0098655 266 0.045
muscle contraction GO:0006936 101 0.045
hormone secretion GO:0046879 128 0.044
fatty acid metabolic process GO:0006631 121 0.044
negative regulation of cellular protein metabolic process GO:0032269 247 0.044
regulation of hormone levels GO:0010817 211 0.044
regulation of secretion by cell GO:1903530 249 0.042
male gamete generation GO:0048232 285 0.042
spermatogenesis GO:0007283 284 0.042
ion transmembrane transport GO:0034220 361 0.041
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.041
Fly
organic hydroxy compound transport GO:0015850 93 0.041
lipid biosynthetic process GO:0008610 179 0.039
peptide transport GO:0015833 133 0.039
reactive nitrogen species metabolic process GO:2001057 0 0.039
monocarboxylic acid metabolic process GO:0032787 191 0.038
carbohydrate metabolic process GO:0005975 230 0.038
norepinephrine secretion GO:0048243 2 0.038
macromolecule catabolic process GO:0009057 281 0.038
inorganic cation transmembrane transport GO:0098662 207 0.038
inorganic ion transmembrane transport GO:0098660 234 0.037
cellular ketone metabolic process GO:0042180 84 0.037
drug catabolic process GO:0042737 2 0.036
regulation of response to wounding GO:1903034 189 0.036
purine containing compound metabolic process GO:0072521 311 0.036
nucleobase containing small molecule metabolic process GO:0055086 352 0.035
cellular amine metabolic process GO:0044106 44 0.035
Worm
muscle system process GO:0003012 141 0.034
regulation of cellular amino acid metabolic process GO:0006521 5 0.034
negative regulation of phosphorus metabolic process GO:0010563 184 0.034
regulation of adrenergic receptor signaling pathway GO:0071877 4 0.033
nucleotide metabolic process GO:0009117 332 0.033
regulation of norepinephrine secretion GO:0014061 2 0.033
cell adhesion GO:0007155 329 0.033
response to peptide hormone GO:0043434 127 0.033
exogenous drug catabolic process GO:0042738 1 0.032
nucleoside phosphate metabolic process GO:0006753 338 0.032
sodium ion transmembrane transport GO:0035725 49 0.031
cellular homeostasis GO:0019725 240 0.031
positive regulation of protein modification process GO:0031401 299 0.031
regulation of protein localization GO:0032880 231 0.031
cellular response to epinephrine stimulus GO:0071872 3 0.031
response to lipopolysaccharide GO:0032496 128 0.031
regulation of inflammatory response GO:0050727 147 0.031
carbohydrate derivative biosynthetic process GO:1901137 183 0.031
regulation of cellular amine metabolic process GO:0033238 20 0.030
rhythmic process GO:0048511 174 0.030
Fly
protein catabolic process GO:0030163 221 0.030
regulation of hormone secretion GO:0046883 88 0.030
glucose homeostasis GO:0042593 128 0.030
response to molecule of bacterial origin GO:0002237 143 0.030
organonitrogen compound catabolic process GO:1901565 264 0.029
multi multicellular organism process GO:0044706 109 0.029
Worm
purine nucleotide metabolic process GO:0006163 302 0.028
regulation of feeding behavior GO:0060259 3 0.028
Worm
chromatin organization GO:0006325 206 0.027
response to organic cyclic compound GO:0014070 198 0.027
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.027
response to corticosterone GO:0051412 1 0.027
histone modification GO:0016570 159 0.026
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.026
cellular response to monoamine stimulus GO:0071868 3 0.026
developmental maturation GO:0021700 193 0.026
mapk cascade GO:0000165 281 0.026
regulation of anatomical structure size GO:0090066 178 0.026
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.026
cellular chemical homeostasis GO:0055082 215 0.026
response to catecholamine GO:0071869 4 0.026
cellular response to organic cyclic compound GO:0071407 87 0.026
regulation of protein serine threonine kinase activity GO:0071900 157 0.025
ribonucleotide metabolic process GO:0009259 291 0.025
regulation of muscle system process GO:0090257 80 0.025
regulation of hydrolase activity GO:0051336 246 0.025
organic acid biosynthetic process GO:0016053 86 0.025
negative regulation of cell proliferation GO:0008285 296 0.025
negative regulation of phosphorylation GO:0042326 166 0.025
anion transport GO:0006820 177 0.024
positive regulation of cell development GO:0010720 237 0.024
negative regulation of molecular function GO:0044092 258 0.024
organic anion transport GO:0015711 137 0.024
protein maturation GO:0051604 176 0.024
carbohydrate homeostasis GO:0033500 128 0.024
regulation of organelle organization GO:0033043 289 0.024
ribose phosphate metabolic process GO:0019693 291 0.023
reactive oxygen species biosynthetic process GO:1903409 8 0.023
glucose metabolic process GO:0006006 92 0.023
intracellular protein transport GO:0006886 204 0.023
intracellular receptor signaling pathway GO:0030522 74 0.023
fat cell differentiation GO:0045444 160 0.023
Mouse
forebrain development GO:0030900 302 0.023
monosaccharide metabolic process GO:0005996 106 0.022
alpha amino acid catabolic process GO:1901606 18 0.022
positive regulation of defense response GO:0031349 124 0.022
g protein coupled receptor signaling pathway GO:0007186 243 0.022
positive regulation of nervous system development GO:0051962 221 0.022
organonitrogen compound biosynthetic process GO:1901566 192 0.022
Mouse Worm Fly
cation transport GO:0006812 399 0.022
locomotory behavior GO:0007626 195 0.021
Mouse
cation homeostasis GO:0055080 212 0.021
carboxylic acid biosynthetic process GO:0046394 86 0.021
negative regulation of phosphate metabolic process GO:0045936 184 0.021
positive regulation of vasoconstriction GO:0045907 4 0.021
cellular amino acid catabolic process GO:0009063 25 0.021
reactive oxygen species metabolic process GO:0072593 84 0.021
purine ribonucleotide metabolic process GO:0009150 290 0.021
maintenance of location GO:0051235 89 0.020
Worm
regulation of blood pressure GO:0008217 93 0.020
divalent inorganic cation homeostasis GO:0072507 138 0.020
regulation of transferase activity GO:0051338 263 0.020
amide transport GO:0042886 138 0.020
response to peptide GO:1901652 136 0.020
learning GO:0007612 98 0.020
Mouse
response to inorganic substance GO:0010035 96 0.020
epithelial cell development GO:0002064 159 0.020
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.020
membrane organization GO:0061024 245 0.020
camera type eye development GO:0043010 266 0.019
Mouse
metal ion homeostasis GO:0055065 189 0.019
positive regulation of response to wounding GO:1903036 66 0.019
cellular response to catecholamine stimulus GO:0071870 3 0.019
response to mineralocorticoid GO:0051385 1 0.019
hexose metabolic process GO:0019318 98 0.019
regulation of tube size GO:0035150 57 0.019
regulation of heart contraction GO:0008016 77 0.019
Mouse
cellular response to hormone stimulus GO:0032870 150 0.019
regulation of circadian sleep wake cycle GO:0042749 3 0.019
Fly
protein targeting GO:0006605 143 0.019
negative regulation of protein modification process GO:0031400 163 0.019
response to acid chemical GO:0001101 111 0.018
divalent inorganic cation transport GO:0072511 178 0.018
learning or memory GO:0007611 148 0.018
Mouse
blood circulation GO:0008015 195 0.018
Mouse
regulation of ion transmembrane transport GO:0034765 119 0.018
regulation of blood vessel size GO:0050880 56 0.018
regulation of fat cell differentiation GO:0045598 81 0.018
Mouse
regulation of kinase activity GO:0043549 249 0.018
regulation of cell projection organization GO:0031344 206 0.018
cellular response to dna damage stimulus GO:0006974 207 0.018
epinephrine transport GO:0048241 1 0.018
regulation of protein kinase activity GO:0045859 232 0.018
organic cyclic compound catabolic process GO:1901361 295 0.018
regulation of cell cycle GO:0051726 281 0.018
negative regulation of intracellular signal transduction GO:1902532 167 0.018
monocarboxylic acid biosynthetic process GO:0072330 61 0.018
peptidyl amino acid modification GO:0018193 336 0.018
negative regulation of cellular amine metabolic process GO:0033239 1 0.018
regulation of mapk cascade GO:0043408 248 0.017
aromatic compound catabolic process GO:0019439 286 0.017
urogenital system development GO:0001655 261 0.017
response to light stimulus GO:0009416 135 0.017
cytoplasmic transport GO:0016482 234 0.017
epidermis development GO:0008544 187 0.017
developmental growth involved in morphogenesis GO:0060560 138 0.017
regulation of protein transport GO:0051223 163 0.017
regulation of peptide transport GO:0090087 91 0.017
regulation of establishment of protein localization GO:0070201 181 0.017
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.017
skeletal muscle organ development GO:0060538 163 0.017
detection of stimulus GO:0051606 84 0.017
cellular nitrogen compound catabolic process GO:0044270 280 0.017
cellular response to lipopolysaccharide GO:0071222 77 0.017
inflammatory response GO:0006954 244 0.017
regulation of androgen receptor signaling pathway GO:0060765 3 0.017
monoamine transport GO:0015844 33 0.017
striated muscle contraction GO:0006941 45 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.017
purine nucleoside metabolic process GO:0042278 241 0.017
regulation of purine nucleotide metabolic process GO:1900542 169 0.017
peptide secretion GO:0002790 114 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
response to steroid hormone GO:0048545 56 0.016
nucleoside metabolic process GO:0009116 246 0.016
regulation of blood circulation GO:1903522 93 0.016
Mouse
posttranscriptional regulation of gene expression GO:0010608 155 0.016
insulin secretion GO:0030073 89 0.016
divalent metal ion transport GO:0070838 172 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
axonogenesis GO:0007409 274 0.016
heart contraction GO:0060047 93 0.016
Mouse
regulation of defense response GO:0031347 233 0.016
small molecule biosynthetic process GO:0044283 132 0.016
embryonic placenta development GO:0001892 98 0.016
striated muscle tissue development GO:0014706 293 0.016
cellular protein complex assembly GO:0043623 116 0.016
muscle tissue development GO:0060537 308 0.015
apoptotic signaling pathway GO:0097190 306 0.015
hematopoietic progenitor cell differentiation GO:0002244 143 0.015
multicellular organismal signaling GO:0035637 91 0.015
heart process GO:0003015 94 0.015
Mouse
cell growth GO:0016049 130 0.015
nucleotide catabolic process GO:0009166 217 0.015
peptide hormone secretion GO:0030072 109 0.015
cellular response to molecule of bacterial origin GO:0071219 83 0.015
organelle localization GO:0051640 179 0.015
regulation of protein catabolic process GO:0042176 108 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
negative regulation of hormone secretion GO:0046888 20 0.015
synaptic transmission GO:0007268 329 0.015
Mouse
heterocycle catabolic process GO:0046700 280 0.015
defense response to other organism GO:0098542 197 0.015
nuclear division GO:0000280 158 0.015
covalent chromatin modification GO:0016569 163 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
positive regulation of sodium ion transmembrane transport GO:1902307 4 0.014
nucleotide biosynthetic process GO:0009165 78 0.014
organelle fission GO:0048285 170 0.014
regulation of neurotransmitter levels GO:0001505 87 0.014
positive regulation of neuron differentiation GO:0045666 141 0.014
positive regulation of cell death GO:0010942 224 0.014
fertilization GO:0009566 127 0.014
amine metabolic process GO:0009308 45 0.014
Worm
negative regulation of blood pressure GO:0045776 22 0.014
ossification GO:0001503 216 0.014
chromatin modification GO:0016568 187 0.014
tissue remodeling GO:0048771 102 0.014
Mouse
renal system development GO:0072001 225 0.014
circadian regulation of gene expression GO:0032922 48 0.014
chemotaxis GO:0006935 247 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.014
lipid transport GO:0006869 98 0.014
response to glucagon GO:0033762 3 0.014
nucleocytoplasmic transport GO:0006913 139 0.013
response to radiation GO:0009314 165 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
regulation of ion transport GO:0043269 215 0.013
response to oxygen levels GO:0070482 62 0.013
blood vessel morphogenesis GO:0048514 285 0.013
nuclear transport GO:0051169 139 0.013
cytokine production GO:0001816 319 0.013
microtubule based process GO:0007017 236 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
catecholamine transport GO:0051937 21 0.013
organelle assembly GO:0070925 177 0.013
histone acetylation GO:0016573 41 0.013
regulation of circadian rhythm GO:0042752 58 0.013
Fly
alpha amino acid metabolic process GO:1901605 59 0.012
Mouse Worm
negative regulation of secretion by cell GO:1903531 54 0.012
photoreceptor cell differentiation GO:0046530 52 0.012
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
anatomical structure homeostasis GO:0060249 145 0.012
potassium ion transport GO:0006813 52 0.012
circadian rhythm GO:0007623 114 0.012
Fly
response to monoamine GO:0071867 4 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
serotonin uptake GO:0051610 3 0.012
circadian sleep wake cycle GO:0042745 5 0.012
Fly
l glutamate uptake involved in synaptic transmission GO:0051935 3 0.012
regulation of transmembrane transport GO:0034762 128 0.012
nucleoside phosphate catabolic process GO:1901292 222 0.012
regulation of vasculature development GO:1901342 88 0.012
positive regulation of phospholipase c activity GO:0010863 2 0.012
regulation of protein maturation GO:1903317 96 0.012
response to vitamin a GO:0033189 1 0.012
vasodilation GO:0042311 28 0.012
response to nutrient levels GO:0031667 109 0.012
small gtpase mediated signal transduction GO:0007264 97 0.012
modification dependent protein catabolic process GO:0019941 133 0.012
regulation of cell migration GO:0030334 219 0.012
positive regulation of mapk cascade GO:0043410 170 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
regulation of cellular catabolic process GO:0031329 242 0.012
neurotransmitter uptake GO:0001504 14 0.012
calcium ion homeostasis GO:0055074 127 0.012
regulation of presynaptic membrane organization GO:1901629 3 0.012
protein modification by small protein conjugation or removal GO:0070647 207 0.012
regulation of sodium ion transmembrane transport GO:1902305 9 0.012
protein localization to organelle GO:0033365 185 0.012
cellular macromolecule catabolic process GO:0044265 206 0.012
response to oxidative stress GO:0006979 123 0.012
female sex differentiation GO:0046660 84 0.012
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
peptidyl cysteine modification GO:0018198 8 0.012
intrinsic apoptotic signaling pathway GO:0097193 132 0.012
positive regulation of nitric oxide synthase activity GO:0051000 2 0.011
regulation of neuron projection development GO:0010975 169 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
regulation of muscle contraction GO:0006937 49 0.011
cyclic nucleotide metabolic process GO:0009187 59 0.011
regulation of dna damage checkpoint GO:2000001 3 0.011
negative regulation of secretion GO:0051048 61 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
respiratory tube development GO:0030323 167 0.011
organic acid transport GO:0015849 101 0.011
purine nucleoside catabolic process GO:0006152 205 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
cellular response to peptide GO:1901653 92 0.011
positive regulation of transferase activity GO:0051347 167 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.011
blastocyst growth GO:0001832 23 0.011
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.011
mitochondrion distribution GO:0048311 4 0.011
protein ubiquitination GO:0016567 171 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.011
endocrine system development GO:0035270 98 0.011
organophosphate catabolic process GO:0046434 232 0.011
response to temperature stimulus GO:0009266 55 0.011
ubiquitin dependent protein catabolic process GO:0006511 129 0.011
glycosyl compound metabolic process GO:1901657 246 0.011
regulation of anion transport GO:0044070 27 0.011
l amino acid transport GO:0015807 32 0.011
anatomical structure maturation GO:0071695 49 0.011
nucleoside catabolic process GO:0009164 206 0.011
generation of precursor metabolites and energy GO:0006091 103 0.011
cellular ion homeostasis GO:0006873 165 0.011
cellular protein catabolic process GO:0044257 155 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.011
negative regulation of androgen receptor signaling pathway GO:0060766 3 0.011
peptidyl serine phosphorylation GO:0018105 74 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
cellular response to acid chemical GO:0071229 68 0.011
developmental cell growth GO:0048588 84 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
positive regulation of cellular amine metabolic process GO:0033240 5 0.011
response to drug GO:0042493 75 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.011
purine nucleoside triphosphate metabolic process GO:0009144 226 0.011
carbohydrate derivative catabolic process GO:1901136 231 0.011
response to extracellular stimulus GO:0009991 127 0.011
liver development GO:0001889 66 0.011
regulation of cell cycle process GO:0010564 160 0.011
regulation of cell activation GO:0050865 289 0.011
regulation of peptide secretion GO:0002791 77 0.011
cellular component assembly involved in morphogenesis GO:0010927 139 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.011
fatty acid biosynthetic process GO:0006633 41 0.011
respiratory system development GO:0060541 190 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
innate immune response GO:0045087 157 0.011
small molecule catabolic process GO:0044282 71 0.011
calcium ion transmembrane transport GO:0070588 85 0.010
positive regulation of fatty acid oxidation GO:0046321 4 0.010
hormone metabolic process GO:0042445 86 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.010
regulation of cell adhesion GO:0030155 154 0.010
pancreas development GO:0031016 57 0.010
leukocyte mediated immunity GO:0002443 174 0.010
feeding behavior GO:0007631 62 0.010
Mouse Worm
cytosolic calcium ion homeostasis GO:0051480 70 0.010
regulation of membrane potential GO:0042391 192 0.010
regulation of cytokine production GO:0001817 266 0.010
ribonucleoside catabolic process GO:0042454 206 0.010
cellular calcium ion homeostasis GO:0006874 119 0.010
transmission of nerve impulse GO:0019226 76 0.010
cellular metal ion homeostasis GO:0006875 151 0.010
carbohydrate biosynthetic process GO:0016051 74 0.010
positive regulation of monooxygenase activity GO:0032770 2 0.010
vascular process in circulatory system GO:0003018 62 0.010
regulation of chromatin silencing GO:0031935 2 0.010
regulation of action potential GO:0098900 4 0.010
purine nucleotide catabolic process GO:0006195 211 0.010
icosanoid metabolic process GO:0006690 33 0.010
myosin filament assembly GO:0031034 2 0.010
leukocyte differentiation GO:0002521 342 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.010
carboxylic acid transport GO:0046942 100 0.010
epinephrine secretion GO:0048242 1 0.010
carboxylic acid catabolic process GO:0046395 51 0.010
response to insulin GO:0032868 100 0.010
response to hyperoxia GO:0055093 2 0.010
negative regulation of fat cell differentiation GO:0045599 36 0.010
purine containing compound biosynthetic process GO:0072522 70 0.010

Tph2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.065
nervous system disease DOID:863 0 0.065
central nervous system disease DOID:331 0 0.023
musculoskeletal system disease DOID:17 0 0.015
neurodegenerative disease DOID:1289 0 0.013
connective tissue disease DOID:65 0 0.012
sensory system disease DOID:0050155 0 0.011