Mus musculus

5 known processes

Akr1c21

aldo-keto reductase family 1, member C21

(Aliases: MGC102401,AI315367,9430025F20Rik)

Akr1c21 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
progesterone metabolic process GO:0042448 4 0.568
Human
anion transport GO:0006820 177 0.496
lipid biosynthetic process GO:0008610 179 0.475
Human Mouse
amino acid transmembrane transport GO:0003333 37 0.434
monocarboxylic acid metabolic process GO:0032787 191 0.419
Human
organic acid transport GO:0015849 101 0.413
response to phenylpropanoid GO:0080184 22 0.371
regulation of hormone levels GO:0010817 211 0.351
Human
organic anion transport GO:0015711 137 0.312
anion transmembrane transport GO:0098656 71 0.312
negative regulation of iron ion transport GO:0034757 1 0.292
organic hydroxy compound metabolic process GO:1901615 203 0.282
Human
dibenzo p dioxin metabolic process GO:0018894 1 0.275
carboxylic acid transport GO:0046942 100 0.272
cellular ketone metabolic process GO:0042180 84 0.254
Human
carnitine transmembrane transport GO:1902603 3 0.250
response to stilbenoid GO:0035634 22 0.246
carnitine transport GO:0015879 3 0.208
hormone metabolic process GO:0042445 86 0.206
Human
carboxylic acid biosynthetic process GO:0046394 86 0.200
Human
cellular lipid metabolic process GO:0044255 323 0.189
Human
steroid metabolic process GO:0008202 119 0.187
Human Mouse
cellular response to lipid GO:0071396 145 0.177
Human
response to organic cyclic compound GO:0014070 198 0.165
Human
c21 steroid hormone biosynthetic process GO:0006700 3 0.163
amino acid transport GO:0006865 61 0.156
benzene containing compound metabolic process GO:0042537 5 0.146
cellular response to inorganic substance GO:0071241 37 0.144
Human
nitrogen compound transport GO:0071705 271 0.140
amino acid betaine transport GO:0015838 3 0.136
small molecule biosynthetic process GO:0044283 132 0.132
Human
oxidation reduction process GO:0055114 342 0.129
cellular amino acid metabolic process GO:0006520 103 0.122
response to organonitrogen compound GO:0010243 246 0.113
progesterone biosynthetic process GO:0006701 1 0.112
regulation of secretion GO:0051046 274 0.110
glycerolipid metabolic process GO:0046486 122 0.108
monocarboxylic acid transport GO:0015718 44 0.105
regulation of defense response GO:0031347 233 0.104
cellular alcohol metabolic process GO:0044107 3 0.103
cellular response to hormone stimulus GO:0032870 150 0.102
Human
vitamin metabolic process GO:0006766 23 0.095
Human
alcohol metabolic process GO:0006066 116 0.087
Human
amino acid betaine metabolic process GO:0006577 7 0.085
skin development GO:0043588 220 0.084
Human
androgen metabolic process GO:0008209 11 0.084
Human
regulation of cellular ketone metabolic process GO:0010565 66 0.082
Human
androgen biosynthetic process GO:0006702 4 0.080
Human
response to peptide hormone GO:0043434 127 0.078
amine metabolic process GO:0009308 45 0.074
cofactor metabolic process GO:0051186 80 0.074
Human
ion transmembrane transport GO:0034220 361 0.073
fatty acid metabolic process GO:0006631 121 0.070
Human
steroid biosynthetic process GO:0006694 47 0.069
Human Mouse
fat soluble vitamin biosynthetic process GO:0042362 4 0.068
protein maturation GO:0051604 176 0.068
diterpenoid metabolic process GO:0016101 24 0.068
Human
protein kinase b signaling GO:0043491 74 0.066
Human
regulation of lipid biosynthetic process GO:0046890 54 0.065
Human
response to peptide GO:1901652 136 0.065
positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 2 0.064
response to molecule of bacterial origin GO:0002237 143 0.063
testosterone biosynthetic process GO:0061370 2 0.062
Human
neutral lipid metabolic process GO:0006638 57 0.062
transmembrane transport GO:0055085 412 0.061
positive regulation of cellular amine metabolic process GO:0033240 5 0.060
lymphocyte differentiation GO:0030098 242 0.060
cellular response to steroid hormone stimulus GO:0071383 33 0.059
Human
positive regulation of protein kinase b signaling GO:0051897 32 0.059
Human
monocarboxylic acid biosynthetic process GO:0072330 61 0.058
Human
regulation of membrane potential GO:0042391 192 0.057
catecholamine uptake GO:0090493 4 0.057
inorganic anion transport GO:0015698 43 0.057
negative regulation of protein metabolic process GO:0051248 282 0.057
cellular response to antibiotic GO:0071236 4 0.056
acylglycerol metabolic process GO:0006639 55 0.055
cellular response to monosaccharide stimulus GO:0071326 47 0.054
regulation of cell activation GO:0050865 289 0.053
cation transport GO:0006812 399 0.053
response to acid chemical GO:0001101 111 0.053
Human
cellular amine metabolic process GO:0044106 44 0.051
regulation of transferase activity GO:0051338 263 0.050
cellular response to peptide hormone stimulus GO:0071375 92 0.049
negative regulation of cellular protein metabolic process GO:0032269 247 0.049
response to insulin GO:0032868 100 0.049
regulation of neurotransmitter levels GO:0001505 87 0.049
regulation of ion transport GO:0043269 215 0.045
regulation of secretion by cell GO:1903530 249 0.045
intracellular protein transport GO:0006886 204 0.045
Human
cellular response to carbohydrate stimulus GO:0071322 50 0.044
sensory perception GO:0007600 245 0.044
inflammatory response GO:0006954 244 0.044
mitochondrion organization GO:0007005 134 0.043
organic acid biosynthetic process GO:0016053 86 0.043
Human
cellular response to peptide GO:1901653 92 0.043
regulation of metal ion transport GO:0010959 106 0.042
response to oxidative stress GO:0006979 123 0.042
Human
lipid localization GO:0010876 126 0.042
maintenance of location GO:0051235 89 0.041
regulation of cellular amine metabolic process GO:0033238 20 0.041
isoprenoid metabolic process GO:0006720 29 0.041
Human
triglyceride metabolic process GO:0006641 51 0.040
cellular response to hexose stimulus GO:0071331 47 0.040
response to corticosterone GO:0051412 1 0.040
carbohydrate homeostasis GO:0033500 128 0.040
positive regulation of defense response GO:0031349 124 0.040
negative regulation of molecular function GO:0044092 258 0.040
membrane organization GO:0061024 245 0.039
naphthalene metabolic process GO:0018931 1 0.039
protein processing GO:0016485 163 0.038
calcitriol biosynthetic process from calciol GO:0036378 3 0.038
cellular response to cadmium ion GO:0071276 3 0.038
Human
regulation of lymphocyte mediated immunity GO:0002706 84 0.037
leukocyte mediated immunity GO:0002443 174 0.036
cellular response to insulin stimulus GO:0032869 78 0.036
dopamine uptake GO:0090494 4 0.036
response to mineralocorticoid GO:0051385 1 0.036
carbohydrate metabolic process GO:0005975 230 0.035
urate transport GO:0015747 1 0.035
regulation of protein processing GO:0070613 96 0.034
g protein coupled receptor signaling pathway GO:0007186 243 0.034
Human
cellular response to growth factor stimulus GO:0071363 197 0.033
cellular response to organic cyclic compound GO:0071407 87 0.033
Human
response to follicle stimulating hormone GO:0032354 1 0.033
negative regulation of cell proliferation GO:0008285 296 0.033
sulfur compound metabolic process GO:0006790 100 0.033
alpha amino acid metabolic process GO:1901605 59 0.032
regulation of blood pressure GO:0008217 93 0.032
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.032
cellular homeostasis GO:0019725 240 0.032
response to monosaccharide GO:0034284 67 0.032
immune effector process GO:0002252 321 0.031
cellular glucose homeostasis GO:0001678 52 0.031
regulation of catecholamine uptake involved in synaptic transmission GO:0051940 2 0.031
response to growth factor GO:0070848 198 0.031
response to fibroblast growth factor GO:0071774 47 0.031
modified amino acid transport GO:0072337 5 0.031
regulation of cellular amino acid metabolic process GO:0006521 5 0.031
multi multicellular organism process GO:0044706 109 0.031
regulation of carbohydrate biosynthetic process GO:0043255 40 0.030
protein localization to organelle GO:0033365 185 0.030
Human
peptide transport GO:0015833 133 0.030
regulation of protein maturation GO:1903317 96 0.030
chloride transmembrane transport GO:1902476 24 0.030
vitamin d3 metabolic process GO:0070640 3 0.030
macromolecule catabolic process GO:0009057 281 0.029
skeletal muscle organ development GO:0060538 163 0.029
glutathione metabolic process GO:0006749 16 0.028
acute inflammatory response GO:0002526 41 0.028
response to lipopolysaccharide GO:0032496 128 0.028
endocytosis GO:0006897 168 0.028
icosanoid metabolic process GO:0006690 33 0.027
Human
muscle contraction GO:0006936 101 0.027
positive regulation of catecholamine uptake involved in synaptic transmission GO:0051944 2 0.027
response to xenobiotic stimulus GO:0009410 13 0.027
regulation of inflammatory response GO:0050727 147 0.027
regulation of reactive oxygen species metabolic process GO:2000377 40 0.027
Human
inorganic ion transmembrane transport GO:0098660 234 0.027
mapk cascade GO:0000165 281 0.026
carbohydrate biosynthetic process GO:0016051 74 0.026
maternal process involved in female pregnancy GO:0060135 32 0.026
neurotransmitter transport GO:0006836 76 0.026
alcohol biosynthetic process GO:0046165 43 0.026
Human
regulation of complement activation classical pathway GO:0030450 1 0.026
cation transmembrane transport GO:0098655 266 0.025
organic hydroxy compound transport GO:0015850 93 0.025
cellular response to ketone GO:1901655 12 0.025
response to nutrient levels GO:0031667 109 0.025
Human
organic cyclic compound catabolic process GO:1901361 295 0.024
wound healing GO:0042060 157 0.024
negative regulation of protein maturation GO:1903318 79 0.024
cellular modified amino acid metabolic process GO:0006575 63 0.024
regulation of protein kinase activity GO:0045859 232 0.024
cellular response to organonitrogen compound GO:0071417 145 0.024
positive regulation of lipid transport GO:0032370 22 0.023
vitamin d biosynthetic process GO:0042368 3 0.023
inorganic anion transmembrane transport GO:0098661 29 0.023
cation homeostasis GO:0055080 212 0.023
muscle tissue development GO:0060537 308 0.023
sterol metabolic process GO:0016125 58 0.023
fertilization GO:0009566 127 0.022
cellular macromolecule catabolic process GO:0044265 206 0.022
l amino acid transport GO:0015807 32 0.022
regulation of multi organism process GO:0043900 111 0.022
proline transport GO:0015824 3 0.022
positive regulation of protein modification process GO:0031401 299 0.022
gluconeogenesis GO:0006094 39 0.022
hormone secretion GO:0046879 128 0.021
multicellular organism growth GO:0035264 161 0.021
response to testosterone GO:0033574 3 0.021
porphyrin containing compound metabolic process GO:0006778 22 0.021
peptidyl amino acid modification GO:0018193 336 0.021
lipid transport GO:0006869 98 0.021
insulin receptor signaling pathway GO:0008286 49 0.021
regulation of dopamine uptake involved in synaptic transmission GO:0051584 2 0.020
apoptotic signaling pathway GO:0097190 306 0.020
regulation of establishment of protein localization GO:0070201 181 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
cytoplasmic transport GO:0016482 234 0.020
Human
tetrapyrrole metabolic process GO:0033013 22 0.020
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.020
negative regulation of protein processing GO:0010955 79 0.020
cellular response to gonadotropin stimulus GO:0071371 4 0.020
terpenoid metabolic process GO:0006721 25 0.020
Human
regulation of cellular component biogenesis GO:0044087 181 0.020
response to inorganic substance GO:0010035 96 0.020
Human
regulation of proteolysis GO:0030162 164 0.020
inflammatory response to antigenic stimulus GO:0002437 30 0.020
regulation of protein localization GO:0032880 231 0.019
cellular response to follicle stimulating hormone stimulus GO:0071372 1 0.019
negative regulation of immune system process GO:0002683 209 0.019
folic acid containing compound metabolic process GO:0006760 3 0.019
lipid homeostasis GO:0055088 63 0.019
regulation of endopeptidase activity GO:0052548 89 0.019
neurotransmitter uptake GO:0001504 14 0.019
cellular response to alcohol GO:0097306 23 0.019
regulation of protein catabolic process GO:0042176 108 0.019
nucleotide metabolic process GO:0009117 332 0.018
cellular response to food GO:0071240 1 0.018
metal ion homeostasis GO:0055065 189 0.018
renal tubular secretion GO:0097254 2 0.018
modification dependent protein catabolic process GO:0019941 133 0.018
cellular response to acid chemical GO:0071229 68 0.018
Human
cellular chemical homeostasis GO:0055082 215 0.018
regulation of cytoplasmic transport GO:1903649 112 0.018
response to alcohol GO:0097305 48 0.018
regulation of intracellular protein transport GO:0033157 82 0.018
cellular alcohol biosynthetic process GO:0044108 3 0.018
phenol containing compound metabolic process GO:0018958 60 0.017
cellular response to molecule of bacterial origin GO:0071219 83 0.017
positive regulation of apoptotic process GO:0043065 217 0.017
Human
secondary alcohol metabolic process GO:1902652 3 0.017
monosaccharide biosynthetic process GO:0046364 44 0.017
purine containing compound metabolic process GO:0072521 311 0.017
regulation of mapk cascade GO:0043408 248 0.017
retinoic acid metabolic process GO:0042573 12 0.017
Human
monoamine transport GO:0015844 33 0.017
reactive oxygen species metabolic process GO:0072593 84 0.017
Human
positive regulation of inflammatory response GO:0050729 47 0.017
regulation of leukocyte mediated immunity GO:0002703 104 0.017
cellular response to lipopolysaccharide GO:0071222 77 0.016
histamine uptake GO:0051615 1 0.016
regulation of response to wounding GO:1903034 189 0.016
regulation of acute inflammatory response GO:0002673 27 0.016
regulation of muscle tissue development GO:1901861 97 0.016
regulation of anatomical structure size GO:0090066 178 0.016
cellular response to oxidative stress GO:0034599 76 0.016
Human
cellular aldehyde metabolic process GO:0006081 12 0.016
Human
positive regulation of protein kinase activity GO:0045860 144 0.016
glucose homeostasis GO:0042593 128 0.016
renal system process GO:0003014 48 0.016
energy derivation by oxidation of organic compounds GO:0015980 77 0.016
cell activation involved in immune response GO:0002263 126 0.016
nucleocytoplasmic transport GO:0006913 139 0.016
Human
ribose phosphate metabolic process GO:0019693 291 0.015
cell substrate adhesion GO:0031589 130 0.015
calcium ion homeostasis GO:0055074 127 0.015
response to estrogen GO:0043627 24 0.015
regulation of kinase activity GO:0043549 249 0.015
regulation of peptide transport GO:0090087 91 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
protein modification by small protein conjugation or removal GO:0070647 207 0.015
pigment metabolic process GO:0042440 32 0.015
regulation of body fluid levels GO:0050878 162 0.015
organic hydroxy compound biosynthetic process GO:1901617 77 0.015
Human
negative regulation of protein modification process GO:0031400 163 0.015
trachea cartilage morphogenesis GO:0060535 4 0.015
temperature homeostasis GO:0001659 26 0.015
regulation of hydrolase activity GO:0051336 246 0.015
cellular protein complex assembly GO:0043623 116 0.015
fibrinolysis GO:0042730 3 0.015
leukocyte differentiation GO:0002521 342 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
inter male aggressive behavior GO:0002121 3 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.015
erk1 and erk2 cascade GO:0070371 77 0.014
purine containing compound catabolic process GO:0072523 213 0.014
cellular response to glucose stimulus GO:0071333 45 0.014
peptide secretion GO:0002790 114 0.014
monosaccharide metabolic process GO:0005996 106 0.014
response to drug GO:0042493 75 0.014
regulation of protein kinase b signaling GO:0051896 56 0.014
Human
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.014
organonitrogen compound biosynthetic process GO:1901566 192 0.014
regulation of organelle organization GO:0033043 289 0.014
negative regulation of protein phosphorylation GO:0001933 126 0.014
cellular response to toxic substance GO:0097237 7 0.014
response to steroid hormone GO:0048545 56 0.014
Human
catecholamine uptake involved in synaptic transmission GO:0051934 4 0.014
fatty acid derivative metabolic process GO:1901568 33 0.014
Human
regulation of cytokine production GO:0001817 266 0.013
regulation of endocytosis GO:0030100 69 0.013
multicellular organismal signaling GO:0035637 91 0.013
hexose biosynthetic process GO:0019319 39 0.013
neuron neuron synaptic transmission GO:0007270 69 0.013
carnitine metabolic process GO:0009437 7 0.013
interspecies interaction between organisms GO:0044419 83 0.013
cellular protein catabolic process GO:0044257 155 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
heme metabolic process GO:0042168 16 0.013
regulation of anion transport GO:0044070 27 0.013
homeostasis of number of cells GO:0048872 210 0.013
neuron death GO:0070997 154 0.013
positive regulation of lipid metabolic process GO:0045834 40 0.013
fatty acid biosynthetic process GO:0006633 41 0.013
cytokine mediated signaling pathway GO:0019221 115 0.013
synaptic transmission GO:0007268 329 0.013
positive regulation of cellular ph reduction GO:0032849 2 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
innate immune response GO:0045087 157 0.013
response to dexamethasone GO:0071548 8 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
mineralocorticoid biosynthetic process GO:0006705 1 0.013
regulation of apoptotic signaling pathway GO:2001233 197 0.013
c21 steroid hormone metabolic process GO:0008207 7 0.013
Human
organophosphate catabolic process GO:0046434 232 0.013
protein catabolic process GO:0030163 221 0.013
purine nucleotide catabolic process GO:0006195 211 0.013
protein targeting GO:0006605 143 0.012
Human
positive regulation of organelle organization GO:0010638 128 0.012
response to extracellular stimulus GO:0009991 127 0.012
Human
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
myeloid cell differentiation GO:0030099 233 0.012
purine nucleotide metabolic process GO:0006163 302 0.012
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
response to hydrogen peroxide GO:0042542 32 0.012
lipid storage GO:0019915 36 0.012
positive regulation of response to wounding GO:1903036 66 0.012
development of primary female sexual characteristics GO:0046545 73 0.012
regulation of cellular catabolic process GO:0031329 242 0.012
naphthalene containing compound metabolic process GO:0090420 1 0.012
locomotory behavior GO:0007626 195 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.012
dopamine uptake involved in synaptic transmission GO:0051583 4 0.012
chemokine metabolic process GO:0050755 10 0.012
muscle cell differentiation GO:0042692 261 0.012
cellular calcium ion homeostasis GO:0006874 119 0.012
regulation of striated muscle cell differentiation GO:0051153 81 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
nucleoside catabolic process GO:0009164 206 0.012
positive regulation of cell development GO:0010720 237 0.012
sensory perception of mechanical stimulus GO:0050954 107 0.012
regulation of complement activation GO:0030449 7 0.012
striated muscle tissue development GO:0014706 293 0.012
protein polymerization GO:0051258 57 0.012
positive regulation of secretion GO:0051047 130 0.012
regulation of gluconeogenesis GO:0006111 30 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
Human
regulation of feeding behavior GO:0060259 3 0.011
keratinocyte migration GO:0051546 3 0.011
nucleoside metabolic process GO:0009116 246 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
bile acid metabolic process GO:0008206 17 0.011
Human
regulation of transmembrane transport GO:0034762 128 0.011
response to metal ion GO:0010038 47 0.011
Human
dopamine transport GO:0015872 15 0.011
secondary metabolic process GO:0019748 18 0.011
Human
leydig cell differentiation GO:0033327 10 0.011
negative regulation of proteolysis GO:0045861 74 0.011
generation of precursor metabolites and energy GO:0006091 103 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
positive regulation of secretion by cell GO:1903532 114 0.011
fatty acid transport GO:0015908 28 0.011
negative regulation of sterol transport GO:0032372 4 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.011
midgut development GO:0007494 4 0.011
leukocyte proliferation GO:0070661 172 0.011
calcium ion transport GO:0006816 159 0.011
peptide hormone secretion GO:0030072 109 0.011
negative regulation of cholesterol efflux GO:0090370 4 0.011
fat soluble vitamin metabolic process GO:0006775 11 0.011
endocrine process GO:0050886 39 0.011
protein localization to nucleus GO:0034504 121 0.011
Human
development of primary male sexual characteristics GO:0046546 88 0.011
Human
endomembrane system organization GO:0010256 147 0.011
regulation of map kinase activity GO:0043405 120 0.011
adaptive immune response GO:0002250 155 0.010
negative regulation of phosphate metabolic process GO:0045936 184 0.010
hematopoietic progenitor cell differentiation GO:0002244 143 0.010
hexose metabolic process GO:0019318 98 0.010
fat soluble vitamin catabolic process GO:0042363 1 0.010
cellular carbohydrate metabolic process GO:0044262 119 0.010
transmission of nerve impulse GO:0019226 76 0.010
female gamete generation GO:0007292 74 0.010
regulation of system process GO:0044057 200 0.010
positive regulation of vasoconstriction GO:0045907 4 0.010
positive regulation of proteolysis GO:0045862 85 0.010
positive regulation of ion transport GO:0043270 65 0.010
ribonucleoside metabolic process GO:0009119 245 0.010
cellular nitrogen compound catabolic process GO:0044270 280 0.010
regulation of intracellular transport GO:0032386 159 0.010
cognition GO:0050890 149 0.010
drug metabolic process GO:0017144 4 0.010
prevention of polyspermy GO:0060468 4 0.010
response to bile acid GO:1903412 1 0.010

Akr1c21 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.305
lipid metabolism disorder DOID:3146 0 0.305
inherited metabolic disorder DOID:655 0 0.305
steroid inherited metabolic disorder DOID:1701 0 0.305
immune system disease DOID:2914 0 0.031
disease of anatomical entity DOID:7 0 0.031
congenital adrenal hyperplasia DOID:0050811 0 0.031
cancer DOID:162 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
organ system cancer DOID:0050686 0 0.021
hematopoietic system disease DOID:74 0 0.019
urinary system disease DOID:18 0 0.013