Mus musculus

82 known processes

Diablo

diablo homolog (Drosophila)

(Aliases: Smac,0610041G12Rik,AU040403,1700006L01Rik)

Diablo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein processing GO:0016485 163 0.206
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.189
defense response to other organism GO:0098542 197 0.186
protein ubiquitination GO:0016567 171 0.160
regulation of protein maturation GO:1903317 96 0.158
response to organic cyclic compound GO:0014070 198 0.154
cellular response to dna damage stimulus GO:0006974 207 0.153
macromolecule catabolic process GO:0009057 281 0.129
defense response to bacterium GO:0042742 119 0.128
negative regulation of protein processing GO:0010955 79 0.120
protein modification by small protein conjugation or removal GO:0070647 207 0.118
cellular response to hormone stimulus GO:0032870 150 0.101
ripoptosome assembly involved in necroptotic process GO:1901026 6 0.098
negative regulation of necrotic cell death GO:0060547 11 0.093
positive regulation of canonical wnt signaling pathway GO:0090263 29 0.091
protein maturation GO:0051604 176 0.089
protein modification by small protein conjugation GO:0032446 187 0.088
germ cell development GO:0007281 185 0.084
spermatogenesis GO:0007283 284 0.084
placenta development GO:0001890 140 0.084
negative regulation of neuron death GO:1901215 98 0.081
regulation of wnt signaling pathway GO:0030111 123 0.080
regulation of protein processing GO:0070613 96 0.078
negative regulation of protein maturation GO:1903318 79 0.078
inhibition of cysteine type endopeptidase activity GO:0097340 1 0.068
maintenance of protein location in nucleus GO:0051457 2 0.068
negative regulation of hydrolase activity GO:0051346 71 0.065
response to steroid hormone GO:0048545 56 0.064
regulation of neuron death GO:1901214 134 0.064
negative regulation of cellular protein metabolic process GO:0032269 247 0.063
negative regulation of proteolysis GO:0045861 74 0.061
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.060
positive regulation of wnt signaling pathway GO:0030177 45 0.058
cellular response to lipid GO:0071396 145 0.057
negative regulation of neuron apoptotic process GO:0043524 92 0.055
inflammatory response GO:0006954 244 0.055
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.055
nitrogen compound transport GO:0071705 271 0.053
cellular response to organic cyclic compound GO:0071407 87 0.050
regulation of reactive oxygen species metabolic process GO:2000377 40 0.048
negative regulation of phosphorylation GO:0042326 166 0.048
regulation of protein ubiquitination GO:0031396 52 0.048
protein polyubiquitination GO:0000209 33 0.047
cellular response to steroid hormone stimulus GO:0071383 33 0.047
regulation of cellular senescence GO:2000772 6 0.045
negative regulation of molecular function GO:0044092 258 0.044
tolerance induction to self antigen GO:0002513 4 0.044
negative regulation of endopeptidase activity GO:0010951 44 0.043
regulation of endopeptidase activity GO:0052548 89 0.043
lens fiber cell apoptotic process GO:1990086 4 0.043
reactive oxygen species metabolic process GO:0072593 84 0.043
positive regulation of cell activation GO:0050867 158 0.043
protein localization to nucleus GO:0034504 121 0.042
innate immune response GO:0045087 157 0.042
mitotic cell cycle GO:0000278 195 0.040
positive regulation of protein modification process GO:0031401 299 0.039
lymphocyte differentiation GO:0030098 242 0.039
response to radiation GO:0009314 165 0.039
male gonad development GO:0008584 88 0.039
negative regulation of peptidase activity GO:0010466 46 0.039
response to estrogen GO:0043627 24 0.038
detection of stimulus GO:0051606 84 0.038
regulation of proteolysis GO:0030162 164 0.037
aromatic compound catabolic process GO:0019439 286 0.037
neural plate mediolateral regionalization GO:0021998 1 0.037
regulation of kinase activity GO:0043549 249 0.037
positive regulation of lymphocyte activation GO:0051251 140 0.037
retina development in camera type eye GO:0060041 119 0.036
negative regulation of cell development GO:0010721 169 0.036
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.036
wnt signaling pathway GO:0016055 188 0.036
smoothened signaling pathway GO:0007224 105 0.034
developmental growth involved in morphogenesis GO:0060560 138 0.034
regulation of cysteine type endopeptidase activity GO:2000116 65 0.033
positive regulation of mapk cascade GO:0043410 170 0.033
regulation of system process GO:0044057 200 0.033
negative regulation of cellular component organization GO:0051129 194 0.032
positive regulation of cell death GO:0010942 224 0.032
positive regulation of neuron differentiation GO:0045666 141 0.032
regulation of cell activation GO:0050865 289 0.032
programmed necrotic cell death GO:0097300 28 0.031
skeletal system morphogenesis GO:0048705 203 0.031
organic cyclic compound catabolic process GO:1901361 295 0.031
male sex differentiation GO:0046661 109 0.031
development of primary male sexual characteristics GO:0046546 88 0.031
regulation of necroptotic process GO:0060544 10 0.031
urogenital system development GO:0001655 261 0.031
spermatid development GO:0007286 108 0.030
positive regulation of cell projection organization GO:0031346 95 0.030
regulation of embryonic development GO:0045995 71 0.030
epithelium migration GO:0090132 63 0.029
male gamete generation GO:0048232 285 0.029
cell adhesion GO:0007155 329 0.029
positive regulation of cell development GO:0010720 237 0.028
t cell activation GO:0042110 289 0.028
negative regulation of cysteine type endopeptidase activity GO:2000117 22 0.028
cellular response to estrogen stimulus GO:0071391 12 0.028
positive regulation of apoptotic process GO:0043065 217 0.027
stem cell proliferation GO:0072089 117 0.027
circulatory system process GO:0003013 197 0.027
rhythmic process GO:0048511 174 0.027
regulation of blood pressure GO:0008217 93 0.027
regulation of cellular catabolic process GO:0031329 242 0.026
regulation of lymphocyte activation GO:0051249 240 0.026
regulation of stem cell proliferation GO:0072091 78 0.026
stem cell maintenance GO:0019827 130 0.026
necrotic cell death GO:0070265 30 0.026
positive regulation of protein phosphorylation GO:0001934 242 0.026
stem cell differentiation GO:0048863 268 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
negative regulation of necroptotic process GO:0060546 9 0.026
renal system development GO:0072001 225 0.026
protein localization to organelle GO:0033365 185 0.026
mrna metabolic process GO:0016071 84 0.025
nucleobase containing small molecule metabolic process GO:0055086 352 0.025
ovarian follicle development GO:0001541 40 0.025
cellular nitrogen compound catabolic process GO:0044270 280 0.025
mesendoderm development GO:0048382 3 0.025
protein catabolic process GO:0030163 221 0.025
male meiosis i GO:0007141 16 0.025
cell aging GO:0007569 35 0.024
nucleotide metabolic process GO:0009117 332 0.024
cellular macromolecule catabolic process GO:0044265 206 0.024
nucleoside phosphate metabolic process GO:0006753 338 0.024
positive regulation of protein ubiquitination GO:0031398 27 0.024
muscle cell differentiation GO:0042692 261 0.024
meiotic nuclear division GO:0007126 115 0.024
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.024
blood circulation GO:0008015 195 0.024
protein targeting GO:0006605 143 0.024
positive regulation of cellular amine metabolic process GO:0033240 5 0.024
maintenance of protein localization in organelle GO:0072595 2 0.023
regulation of binding GO:0051098 111 0.023
positive regulation of programmed cell death GO:0043068 218 0.023
regulation of apoptotic signaling pathway GO:2001233 197 0.023
cell type specific apoptotic process GO:0097285 268 0.023
fused antrum stage GO:0048165 1 0.023
meiotic cell cycle GO:0051321 122 0.023
spermatid differentiation GO:0048515 115 0.023
protein import into nucleus GO:0006606 95 0.023
rna processing GO:0006396 105 0.023
neuron apoptotic process GO:0051402 142 0.023
regulation of hormone levels GO:0010817 211 0.022
mesenchyme development GO:0060485 152 0.022
bronchus morphogenesis GO:0060434 2 0.022
negative regulation of apoptotic signaling pathway GO:2001234 104 0.022
zymogen inhibition GO:0097341 1 0.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.022
positive regulation of protein kinase activity GO:0045860 144 0.022
negative regulation of reactive oxygen species metabolic process GO:2000378 10 0.022
regulation of cell migration GO:0030334 219 0.022
tissue migration GO:0090130 68 0.022
mesenchymal cell development GO:0014031 93 0.021
gonad development GO:0008406 141 0.021
regulation of cellular amino acid metabolic process GO:0006521 5 0.021
positive regulation of b cell tolerance induction GO:0002663 2 0.021
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.021
maternal determination of anterior posterior axis embryo GO:0008358 2 0.021
regulation of cell cycle GO:0051726 281 0.021
response to monosaccharide GO:0034284 67 0.021
skeletal system development GO:0001501 356 0.020
mesoderm development GO:0007498 100 0.020
regulation of ripoptosome assembly involved in necroptotic process GO:1902442 3 0.020
response to peptide hormone GO:0043434 127 0.020
embryonic organ morphogenesis GO:0048562 276 0.020
regulation of cellular amine metabolic process GO:0033238 20 0.020
regulation of lung blood pressure GO:0014916 2 0.020
inhibition of cysteine type endopeptidase activity involved in apoptotic process GO:1990001 1 0.020
oocyte axis specification GO:0007309 2 0.020
negative regulation of nervous system development GO:0051961 156 0.020
activin receptor signaling pathway GO:0032924 18 0.020
trachea formation GO:0060440 3 0.020
neuron death GO:0070997 154 0.020
macromolecule methylation GO:0043414 120 0.020
response to sterol GO:0036314 4 0.020
regulation of cellular component biogenesis GO:0044087 181 0.019
organ regeneration GO:0031100 2 0.019
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.019
neural precursor cell proliferation GO:0061351 121 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
regionalization GO:0003002 337 0.019
mesoderm structural organization GO:0048338 1 0.019
t cell differentiation GO:0030217 174 0.019
regulation of neuron apoptotic process GO:0043523 122 0.019
regulation of hydrolase activity GO:0051336 246 0.018
response to acid chemical GO:0001101 111 0.018
cellular amine metabolic process GO:0044106 44 0.018
organelle fission GO:0048285 170 0.018
negative regulation of phosphorus metabolic process GO:0010563 184 0.018
kidney development GO:0001822 213 0.018
regulation of t cell activation GO:0050863 170 0.018
dna repair GO:0006281 107 0.018
forebrain development GO:0030900 302 0.018
translation GO:0006412 93 0.018
chondrocyte hypertrophy GO:0003415 4 0.018
ameboidal type cell migration GO:0001667 128 0.018
regulation of anatomical structure size GO:0090066 178 0.018
response to extracellular stimulus GO:0009991 127 0.018
response to organonitrogen compound GO:0010243 246 0.018
regulation of epithelial cell proliferation GO:0050678 141 0.018
extrinsic apoptotic signaling pathway GO:0097191 126 0.018
necroptotic process GO:0070266 21 0.017
purine ribonucleoside metabolic process GO:0046128 241 0.017
lipid localization GO:0010876 126 0.017
regulation of map kinase activity GO:0043405 120 0.017
positive regulation of cell migration GO:0030335 109 0.017
female gamete generation GO:0007292 74 0.017
multi multicellular organism process GO:0044706 109 0.017
nucleocytoplasmic transport GO:0006913 139 0.017
nuclear transport GO:0051169 139 0.017
heterocycle catabolic process GO:0046700 280 0.017
cartilage development GO:0051216 140 0.017
locomotory behavior GO:0007626 195 0.016
maternal process involved in female pregnancy GO:0060135 32 0.016
development of primary sexual characteristics GO:0045137 143 0.016
sensory organ morphogenesis GO:0090596 242 0.016
embryonic appendage morphogenesis GO:0035113 126 0.016
negative regulation of protein complex assembly GO:0031333 25 0.016
methylation GO:0032259 134 0.016
appendage development GO:0048736 166 0.016
single organism nuclear import GO:1902593 95 0.016
cellular amino acid metabolic process GO:0006520 103 0.016
molting cycle GO:0042303 90 0.016
epithelial cell migration GO:0010631 63 0.016
fat cell differentiation GO:0045444 160 0.016
negative regulation of cellular catabolic process GO:0031330 47 0.016
purine containing compound catabolic process GO:0072523 213 0.015
oxidation reduction process GO:0055114 342 0.015
lung morphogenesis GO:0060425 50 0.015
regulation of ion transport GO:0043269 215 0.015
developmental cell growth GO:0048588 84 0.015
regulation of peptide secretion GO:0002791 77 0.015
bone development GO:0060348 120 0.015
regulation of cellular ketone metabolic process GO:0010565 66 0.015
myeloid leukocyte activation GO:0002274 83 0.015
positive regulation of stem cell proliferation GO:2000648 59 0.015
germ line stem cell division GO:0042078 2 0.015
myeloid leukocyte differentiation GO:0002573 119 0.015
female sex differentiation GO:0046660 84 0.015
dna metabolic process GO:0006259 303 0.015
oogenesis stage GO:0022605 3 0.015
embryonic limb morphogenesis GO:0030326 126 0.015
adult locomotory behavior GO:0008344 91 0.015
ribonucleotide metabolic process GO:0009259 291 0.015
positive regulation of t cell differentiation GO:0045582 52 0.015
limb development GO:0060173 166 0.015
inorganic cation transmembrane transport GO:0098662 207 0.015
mrna processing GO:0006397 63 0.015
striated muscle tissue development GO:0014706 293 0.015
oocyte construction GO:0007308 2 0.014
canonical wnt signaling pathway GO:0060070 130 0.014
neuron projection extension GO:1990138 64 0.014
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.014
trachea development GO:0060438 18 0.014
stem cell development GO:0048864 219 0.014
amine metabolic process GO:0009308 45 0.014
positive regulation of transferase activity GO:0051347 167 0.014
negative regulation of vasoconstriction GO:0045906 2 0.014
negative regulation of protein metabolic process GO:0051248 282 0.014
negative regulation of intracellular signal transduction GO:1902532 167 0.014
regulation of secretion by cell GO:1903530 249 0.014
glucose metabolic process GO:0006006 92 0.014
tissue homeostasis GO:0001894 115 0.014
regulation of neuron differentiation GO:0045664 281 0.014
response to uv GO:0009411 44 0.014
regulation of ion transmembrane transport GO:0034765 119 0.014
intracellular mrna localization GO:0008298 4 0.014
purine containing compound metabolic process GO:0072521 311 0.014
positive regulation of nervous system development GO:0051962 221 0.014
limb morphogenesis GO:0035108 149 0.014
positive regulation of lymphocyte differentiation GO:0045621 61 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
male meiosis GO:0007140 37 0.014
maternal placenta development GO:0001893 20 0.014
response to alcohol GO:0097305 48 0.014
ovulation cycle GO:0042698 59 0.014
gland development GO:0048732 330 0.013
chromatin modification GO:0016568 187 0.013
apoptotic signaling pathway GO:0097190 306 0.013
regulation of protein complex assembly GO:0043254 83 0.013
regulation of b cell tolerance induction GO:0002661 2 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
muscle tissue development GO:0060537 308 0.013
positive regulation of endothelial cell proliferation GO:0001938 17 0.013
response to insulin GO:0032868 100 0.013
regulation of intracellular protein transport GO:0033157 82 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
regulation of organ morphogenesis GO:2000027 144 0.013
regulation of smad protein import into nucleus GO:0060390 3 0.013
response to oxygen levels GO:0070482 62 0.013
epidermis development GO:0008544 187 0.013
regulation of mesenchymal cell proliferation GO:0010464 37 0.013
embryonic skeletal system development GO:0048706 120 0.013
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.013
ureteric bud development GO:0001657 94 0.013
regulation of mitotic cell cycle GO:0007346 126 0.013
hindbrain development GO:0030902 128 0.013
intracellular protein transport GO:0006886 204 0.013
nucleotide catabolic process GO:0009166 217 0.012
blastocyst development GO:0001824 80 0.012
negative regulation of defense response GO:0031348 77 0.012
oogenesis GO:0048477 56 0.012
regulation of protein targeting GO:1903533 61 0.012
pole plasm assembly GO:0007315 2 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
regulation of tolerance induction to self antigen GO:0002649 1 0.012
embryonic skeletal system morphogenesis GO:0048704 91 0.012
hair follicle development GO:0001942 85 0.012
response to light stimulus GO:0009416 135 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
myeloid dendritic cell activation GO:0001773 25 0.012
regulation of mapk cascade GO:0043408 248 0.012
acetylcholine transport GO:0015870 2 0.012
camera type eye development GO:0043010 266 0.012
negative regulation of prostatic bud formation GO:0060686 4 0.012
cation transport GO:0006812 399 0.012
response to growth factor GO:0070848 198 0.012
female gonad development GO:0008585 71 0.012
regulation of angiogenesis GO:0045765 81 0.012
hormone metabolic process GO:0042445 86 0.012
immune effector process GO:0002252 321 0.012
organelle localization GO:0051640 179 0.012
organ growth GO:0035265 117 0.012
cation transmembrane transport GO:0098655 266 0.012
connective tissue development GO:0061448 179 0.012
posttranscriptional regulation of gene expression GO:0010608 155 0.012
regulation of membrane potential GO:0042391 192 0.011
protein import GO:0017038 101 0.011
alpha beta t cell activation GO:0046631 91 0.011
telencephalon development GO:0021537 186 0.011
regulation of cell projection organization GO:0031344 206 0.011
regulation of lymphocyte differentiation GO:0045619 107 0.011
respiratory system development GO:0060541 190 0.011
regulation of vasculature development GO:1901342 88 0.011
nucleoside catabolic process GO:0009164 206 0.011
nuclear import GO:0051170 95 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
bmp signaling pathway GO:0030509 93 0.011
detection of biotic stimulus GO:0009595 10 0.011
cardiac chamber morphogenesis GO:0003206 93 0.011
regulation of intracellular transport GO:0032386 159 0.011
ion transmembrane transport GO:0034220 361 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
ribonucleotide catabolic process GO:0009261 208 0.011
endothelial cell migration GO:0043542 44 0.011
detection of bacterium GO:0016045 7 0.011
peptidyl amino acid modification GO:0018193 336 0.011
cerebellum development GO:0021549 77 0.011
lateral inhibition GO:0046331 1 0.011
positive regulation of binding GO:0051099 49 0.011
segmentation GO:0035282 93 0.011
vascular process in circulatory system GO:0003018 62 0.011
chromatin organization GO:0006325 206 0.011
microtubule based process GO:0007017 236 0.011
interleukin 8 production GO:0032637 4 0.011
meiotic cell cycle process GO:1903046 77 0.011
peptidyl threonine modification GO:0018210 31 0.011
hair cycle GO:0042633 90 0.011
heart formation GO:0060914 16 0.011
regulation of cell growth GO:0001558 91 0.011
inorganic ion transmembrane transport GO:0098660 234 0.011
regulation of neural precursor cell proliferation GO:2000177 70 0.011
regulation of anti mullerian hormone signaling pathway GO:1902612 1 0.010
ear morphogenesis GO:0042471 118 0.010
positive regulation of protein catabolic process GO:0045732 60 0.010
response to peptide GO:1901652 136 0.010
regulation of transferase activity GO:0051338 263 0.010
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.010
regulation of alpha beta t cell activation GO:0046634 53 0.010
ribonucleoside triphosphate metabolic process GO:0009199 220 0.010
pituitary gland development GO:0021983 38 0.010
positive regulation of kinase activity GO:0033674 155 0.010
endocrine system development GO:0035270 98 0.010
glycosyl compound catabolic process GO:1901658 206 0.010
trachea morphogenesis GO:0060439 8 0.010
sperm motility GO:0030317 47 0.010
metencephalon development GO:0022037 89 0.010
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.010
regulation of protein binding GO:0043393 60 0.010
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
neuron projection extension involved in neuron projection guidance GO:1902284 14 0.010
positive regulation of intracellular protein transport GO:0090316 42 0.010
negative regulation of cell proliferation GO:0008285 296 0.010
regulation of epithelial cell migration GO:0010632 35 0.010
odontogenesis GO:0042476 78 0.010
negative regulation of immune system process GO:0002683 209 0.010
amide transport GO:0042886 138 0.010
skin development GO:0043588 220 0.010
heart morphogenesis GO:0003007 178 0.010

Diablo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
musculoskeletal system disease DOID:17 0 0.019
connective tissue disease DOID:65 0 0.019
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
nervous system disease DOID:863 0 0.013
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.011
central nervous system disease DOID:331 0 0.011
neurodegenerative disease DOID:1289 0 0.011