Mus musculus

66 known processes

Htra2

HtrA serine peptidase 2

(Aliases: AI481710,Omi,mnd2,Prss25)

Htra2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
amine metabolic process GO:0009308 45 0.055
cellular amino acid metabolic process GO:0006520 103 0.054
negative regulation of molecular function GO:0044092 258 0.046
nucleobase containing small molecule metabolic process GO:0055086 352 0.044
cellular response to dna damage stimulus GO:0006974 207 0.041
Human
regulation of cellular amine metabolic process GO:0033238 20 0.040
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.038
cellular amine metabolic process GO:0044106 44 0.037
positive regulation of cell death GO:0010942 224 0.037
positive regulation of protein modification process GO:0031401 299 0.037
nitrogen compound transport GO:0071705 271 0.036
protein ubiquitination GO:0016567 171 0.034
regulation of cellular amino acid metabolic process GO:0006521 5 0.033
negative regulation of cellular protein metabolic process GO:0032269 247 0.032
positive regulation of cellular amine metabolic process GO:0033240 5 0.031
protein modification by small protein conjugation GO:0032446 187 0.031
cell type specific apoptotic process GO:0097285 268 0.030
cellular ketone metabolic process GO:0042180 84 0.029
negative regulation of phosphorylation GO:0042326 166 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
macromolecule catabolic process GO:0009057 281 0.028
Human
gland development GO:0048732 330 0.028
reactive oxygen species metabolic process GO:0072593 84 0.028
nuclear division GO:0000280 158 0.028
ion transmembrane transport GO:0034220 361 0.027
translation GO:0006412 93 0.027
carbohydrate derivative biosynthetic process GO:1901137 183 0.027
protein processing GO:0016485 163 0.027
transmembrane transport GO:0055085 412 0.027
inflammatory response GO:0006954 244 0.025
nucleotide metabolic process GO:0009117 332 0.025
regulation of protein complex assembly GO:0043254 83 0.025
negative regulation of protein metabolic process GO:0051248 282 0.025
mitotic cell cycle process GO:1903047 159 0.025
cellular response to cytokine stimulus GO:0071345 189 0.025
Human
cation transport GO:0006812 399 0.025
response to organic cyclic compound GO:0014070 198 0.025
positive regulation of apoptotic process GO:0043065 217 0.025
placenta development GO:0001890 140 0.025
cellular homeostasis GO:0019725 240 0.024
organelle fission GO:0048285 170 0.024
mitotic cell cycle GO:0000278 195 0.024
nucleoside phosphate metabolic process GO:0006753 338 0.024
activation of immune response GO:0002253 138 0.024
neuron death GO:0070997 154 0.023
regulation of proteolysis GO:0030162 164 0.022
Human Fly
protein maturation GO:0051604 176 0.022
membrane organization GO:0061024 245 0.022
cytoplasmic transport GO:0016482 234 0.022
negative regulation of phosphorus metabolic process GO:0010563 184 0.022
organonitrogen compound biosynthetic process GO:1901566 192 0.022
cell adhesion GO:0007155 329 0.021
dna metabolic process GO:0006259 303 0.021
spermatogenesis GO:0007283 284 0.021
Fly
defense response to bacterium GO:0042742 119 0.021
regulation of protein kinase activity GO:0045859 232 0.020
regulation of reactive oxygen species metabolic process GO:2000377 40 0.020
response to acid chemical GO:0001101 111 0.020
Human
cellular response to hormone stimulus GO:0032870 150 0.020
negative regulation of phosphate metabolic process GO:0045936 184 0.019
t cell activation GO:0042110 289 0.019
immune effector process GO:0002252 321 0.019
leukocyte proliferation GO:0070661 172 0.019
cytokine production GO:0001816 319 0.019
meiotic nuclear division GO:0007126 115 0.018
mitochondrion organization GO:0007005 134 0.018
regulation of cellular ketone metabolic process GO:0010565 66 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.018
Mouse
necroptotic process GO:0070266 21 0.018
negative regulation of necroptotic process GO:0060546 9 0.017
regulation of cell cycle GO:0051726 281 0.017
positive regulation of programmed cell death GO:0043068 218 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
regulation of transferase activity GO:0051338 263 0.017
positive regulation of protein phosphorylation GO:0001934 242 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
protein localization to organelle GO:0033365 185 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
regulation of necroptotic process GO:0060544 10 0.016
regulation of cellular response to stress GO:0080135 159 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
leukocyte differentiation GO:0002521 342 0.016
defense response to other organism GO:0098542 197 0.016
innate immune response GO:0045087 157 0.016
purine ribonucleoside metabolic process GO:0046128 241 0.016
neuron apoptotic process GO:0051402 142 0.015
skeletal system development GO:0001501 356 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
Human
regulation of cell activation GO:0050865 289 0.015
regulation of kinase activity GO:0043549 249 0.015
wnt signaling pathway GO:0016055 188 0.015
response to oxidative stress GO:0006979 123 0.015
lymphocyte proliferation GO:0046651 164 0.015
sensory perception GO:0007600 245 0.015
positive regulation of lymphocyte activation GO:0051251 140 0.015
cation transmembrane transport GO:0098655 266 0.015
b cell activation GO:0042113 161 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
male gamete generation GO:0048232 285 0.014
Fly
cellular response to lipid GO:0071396 145 0.014
Human
regulation of homeostatic process GO:0032844 182 0.014
meiotic cell cycle GO:0051321 122 0.014
response to organonitrogen compound GO:0010243 246 0.014
fertilization GO:0009566 127 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
peptidyl amino acid modification GO:0018193 336 0.014
skeletal muscle organ development GO:0060538 163 0.014
carbohydrate metabolic process GO:0005975 230 0.013
apoptotic signaling pathway GO:0097190 306 0.013
methylation GO:0032259 134 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
regulation of mapk cascade GO:0043408 248 0.013
response to steroid hormone GO:0048545 56 0.013
multi organism behavior GO:0051705 62 0.013
ribonucleotide metabolic process GO:0009259 291 0.013
regulation of response to wounding GO:1903034 189 0.013
aromatic compound catabolic process GO:0019439 286 0.013
regulation of cell migration GO:0030334 219 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
cellular response to acid chemical GO:0071229 68 0.013
Human
regulation of hydrolase activity GO:0051336 246 0.013
Human Fly
negative regulation of immune system process GO:0002683 209 0.013
regulation of wnt signaling pathway GO:0030111 123 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
intraspecies interaction between organisms GO:0051703 21 0.013
regulation of body fluid levels GO:0050878 162 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
positive regulation of transferase activity GO:0051347 167 0.013
striated muscle tissue development GO:0014706 293 0.013
myotube differentiation GO:0014902 105 0.013
social behavior GO:0035176 21 0.012
t cell proliferation GO:0042098 120 0.012
necrotic cell death GO:0070265 30 0.012
regulation of membrane potential GO:0042391 192 0.012
leukocyte migration GO:0050900 124 0.012
protein catabolic process GO:0030163 221 0.012
Human
response to radiation GO:0009314 165 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
regulation of hormone levels GO:0010817 211 0.012
posttranscriptional regulation of gene expression GO:0010608 155 0.012
nuclear transport GO:0051169 139 0.012
oxidation reduction process GO:0055114 342 0.012
regulation of protein processing GO:0070613 96 0.012
regulation of neuron death GO:1901214 134 0.012
regulation of t cell activation GO:0050863 170 0.012
regulation of neuron differentiation GO:0045664 281 0.012
cellular chemical homeostasis GO:0055082 215 0.012
dna repair GO:0006281 107 0.012
cellular nitrogen compound catabolic process GO:0044270 280 0.012
immune response activating signal transduction GO:0002757 116 0.011
negative regulation of protein modification process GO:0031400 163 0.011
response to lipopolysaccharide GO:0032496 128 0.011
regulation of cell cycle phase transition GO:1901987 77 0.011
organelle localization GO:0051640 179 0.011
canonical wnt signaling pathway GO:0060070 130 0.011
regulation of mitotic cell cycle phase transition GO:1901990 73 0.011
sensory organ morphogenesis GO:0090596 242 0.011
regulation of ion transport GO:0043269 215 0.011
divalent inorganic cation transport GO:0072511 178 0.011
epithelial cell proliferation GO:0050673 174 0.011
regulation of defense response GO:0031347 233 0.011
lymphocyte differentiation GO:0030098 242 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
small gtpase mediated signal transduction GO:0007264 97 0.011
cellular protein catabolic process GO:0044257 155 0.011
Human
regulation of inflammatory response GO:0050727 147 0.011
telencephalon development GO:0021537 186 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
protein polyubiquitination GO:0000209 33 0.011
cytokine mediated signaling pathway GO:0019221 115 0.011
peptide transport GO:0015833 133 0.011
muscle cell differentiation GO:0042692 261 0.011
regulation of cell projection organization GO:0031344 206 0.011
regulation of cell cycle process GO:0010564 160 0.011
carbohydrate derivative catabolic process GO:1901136 231 0.011
response to light stimulus GO:0009416 135 0.011
negative regulation of transferase activity GO:0051348 85 0.011
positive regulation of cell activation GO:0050867 158 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
stem cell differentiation GO:0048863 268 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
detection of stimulus GO:0051606 84 0.011
glycoprotein metabolic process GO:0009100 116 0.011
negative regulation of neuron apoptotic process GO:0043524 92 0.011
regulation of cell motility GO:2000145 236 0.010
regulation of organelle organization GO:0033043 289 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.010
sequestering of calcium ion GO:0051208 18 0.010
nucleotide catabolic process GO:0009166 217 0.010
divalent metal ion transport GO:0070838 172 0.010
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
cell division GO:0051301 120 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
Human Mouse
purine containing compound metabolic process GO:0072521 311 0.010
connective tissue development GO:0061448 179 0.010
regulation of protein localization GO:0032880 231 0.010
protein modification by small protein conjugation or removal GO:0070647 207 0.010
germ cell development GO:0007281 185 0.010

Htra2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
Human
nervous system disease DOID:863 0 0.035
Human
central nervous system disease DOID:331 0 0.014
Human
neurodegenerative disease DOID:1289 0 0.010
Human