Mus musculus

0 known processes

Klhl12

kelch-like 12 (Drosophila)

(Aliases: MGC7076,C3ip1)

Klhl12 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
amine metabolic process GO:0009308 45 0.063
cellular amine metabolic process GO:0044106 44 0.062
regulation of cellular amine metabolic process GO:0033238 20 0.061
protein modification by small protein conjugation or removal GO:0070647 207 0.059
Human
cellular amino acid metabolic process GO:0006520 103 0.057
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.054
histone modification GO:0016570 159 0.051
regulation of cellular amino acid metabolic process GO:0006521 5 0.050
protein modification by small protein conjugation GO:0032446 187 0.048
Human
positive regulation of cellular amine metabolic process GO:0033240 5 0.042
cellular ketone metabolic process GO:0042180 84 0.042
regulation of cellular ketone metabolic process GO:0010565 66 0.039
peptidyl amino acid modification GO:0018193 336 0.037
chromatin organization GO:0006325 206 0.035
nucleobase containing small molecule metabolic process GO:0055086 352 0.034
protein ubiquitination GO:0016567 171 0.033
Human
macromolecule catabolic process GO:0009057 281 0.033
covalent chromatin modification GO:0016569 163 0.029
apoptotic signaling pathway GO:0097190 306 0.028
Mouse
transmembrane transport GO:0055085 412 0.027
cellular macromolecule catabolic process GO:0044265 206 0.027
chromatin modification GO:0016568 187 0.027
cellular nitrogen compound catabolic process GO:0044270 280 0.027
aromatic compound catabolic process GO:0019439 286 0.026
heterocycle catabolic process GO:0046700 280 0.026
negative regulation of protein metabolic process GO:0051248 282 0.025
dna metabolic process GO:0006259 303 0.025
purine containing compound metabolic process GO:0072521 311 0.025
regulation of organelle organization GO:0033043 289 0.025
regulation of cellular catabolic process GO:0031329 242 0.025
organophosphate catabolic process GO:0046434 232 0.025
ribose phosphate metabolic process GO:0019693 291 0.025
positive regulation of protein modification process GO:0031401 299 0.024
male gamete generation GO:0048232 285 0.024
Mouse
cytoplasmic transport GO:0016482 234 0.024
Human
methylation GO:0032259 134 0.024
regulation of hydrolase activity GO:0051336 246 0.024
microtubule based process GO:0007017 236 0.024
negative regulation of cellular protein metabolic process GO:0032269 247 0.024
positive regulation of apoptotic process GO:0043065 217 0.023
glycosyl compound catabolic process GO:1901658 206 0.023
small gtpase mediated signal transduction GO:0007264 97 0.023
intracellular protein transport GO:0006886 204 0.023
purine ribonucleoside metabolic process GO:0046128 241 0.023
purine nucleoside metabolic process GO:0042278 241 0.022
macromolecule methylation GO:0043414 120 0.022
nucleotide metabolic process GO:0009117 332 0.022
nucleoside metabolic process GO:0009116 246 0.022
modification dependent protein catabolic process GO:0019941 133 0.021
negative regulation of cellular component organization GO:0051129 194 0.021
purine containing compound catabolic process GO:0072523 213 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
glycosyl compound metabolic process GO:1901657 246 0.021
ubiquitin dependent protein catabolic process GO:0006511 129 0.021
organic cyclic compound catabolic process GO:1901361 295 0.021
ribonucleotide metabolic process GO:0009259 291 0.021
positive regulation of cell death GO:0010942 224 0.021
positive regulation of programmed cell death GO:0043068 218 0.020
cellular protein catabolic process GO:0044257 155 0.020
purine nucleotide metabolic process GO:0006163 302 0.020
posttranscriptional regulation of gene expression GO:0010608 155 0.020
protein catabolic process GO:0030163 221 0.020
nitrogen compound transport GO:0071705 271 0.020
nucleoside triphosphate metabolic process GO:0009141 230 0.020
negative regulation of molecular function GO:0044092 258 0.019
regulation of cellular component biogenesis GO:0044087 181 0.019
ribonucleoside metabolic process GO:0009119 245 0.019
ribonucleoside catabolic process GO:0042454 206 0.019
purine ribonucleotide metabolic process GO:0009150 290 0.019
organelle fission GO:0048285 170 0.019
regulation of ion transport GO:0043269 215 0.019
protein maturation GO:0051604 176 0.019
purine ribonucleoside catabolic process GO:0046130 205 0.019
organonitrogen compound biosynthetic process GO:1901566 192 0.018
purine nucleoside triphosphate catabolic process GO:0009146 203 0.018
leukocyte differentiation GO:0002521 342 0.018
nucleoside phosphate catabolic process GO:1901292 222 0.018
cation transport GO:0006812 399 0.018
mitotic cell cycle process GO:1903047 159 0.018
ribonucleoside triphosphate catabolic process GO:0009203 199 0.018
purine nucleotide catabolic process GO:0006195 211 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
immune effector process GO:0002252 321 0.017
purine nucleoside catabolic process GO:0006152 205 0.017
regulation of kinase activity GO:0043549 249 0.017
cellular lipid metabolic process GO:0044255 323 0.017
regulation of membrane potential GO:0042391 192 0.017
lipid biosynthetic process GO:0008610 179 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
stem cell differentiation GO:0048863 268 0.017
response to oxidative stress GO:0006979 123 0.017
transmission of nerve impulse GO:0019226 76 0.017
carbohydrate derivative catabolic process GO:1901136 231 0.017
protein targeting GO:0006605 143 0.017
cell type specific apoptotic process GO:0097285 268 0.016
ras protein signal transduction GO:0007265 77 0.016
cellular response to dna damage stimulus GO:0006974 207 0.016
protein localization to organelle GO:0033365 185 0.016
purine ribonucleotide catabolic process GO:0009154 208 0.016
spermatogenesis GO:0007283 284 0.016
Mouse
positive regulation of organelle organization GO:0010638 128 0.016
mitotic cell cycle GO:0000278 195 0.016
cation transmembrane transport GO:0098655 266 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
positive regulation of nervous system development GO:0051962 221 0.016
modification dependent macromolecule catabolic process GO:0043632 133 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
Mouse
inflammatory response GO:0006954 244 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
action potential GO:0001508 78 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.015
inorganic ion transmembrane transport GO:0098660 234 0.015
regulation of protein kinase activity GO:0045859 232 0.015
neuronal action potential GO:0019228 54 0.015
synaptic transmission GO:0007268 329 0.015
ribonucleoside triphosphate metabolic process GO:0009199 220 0.015
membrane organization GO:0061024 245 0.015
Human
nucleotide catabolic process GO:0009166 217 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.015
lymphocyte differentiation GO:0030098 242 0.015
response to organonitrogen compound GO:0010243 246 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.014
protein acylation GO:0043543 64 0.014
organelle localization GO:0051640 179 0.014
Human
negative regulation of immune system process GO:0002683 209 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
b cell activation GO:0042113 161 0.014
regulation of transferase activity GO:0051338 263 0.014
establishment of protein localization to organelle GO:0072594 118 0.014
carbohydrate metabolic process GO:0005975 230 0.014
nucleoside triphosphate catabolic process GO:0009143 205 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.014
regulation of cell activation GO:0050865 289 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
regulation of protein localization GO:0032880 231 0.014
response to radiation GO:0009314 165 0.014
multicellular organismal signaling GO:0035637 91 0.014
nucleoside catabolic process GO:0009164 206 0.014
t cell activation GO:0042110 289 0.014
cellular homeostasis GO:0019725 240 0.014
regulation of cell motility GO:2000145 236 0.014
gland development GO:0048732 330 0.014
inorganic cation transmembrane transport GO:0098662 207 0.014
ion transmembrane transport GO:0034220 361 0.014
regulation of multi organism process GO:0043900 111 0.014
mapk cascade GO:0000165 281 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
skeletal system development GO:0001501 356 0.013
wnt signaling pathway GO:0016055 188 0.013
Human Zebrafish
peptidyl lysine modification GO:0018205 77 0.013
positive regulation of cell development GO:0010720 237 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
spermatid development GO:0007286 108 0.013
Mouse
stem cell development GO:0048864 219 0.013
carboxylic acid biosynthetic process GO:0046394 86 0.013
nuclear division GO:0000280 158 0.013
neuron death GO:0070997 154 0.013
compound eye development GO:0048749 1 0.013
regulation of chromatin modification GO:1903308 57 0.013
protein import GO:0017038 101 0.013
regulation of histone modification GO:0031056 56 0.013
regulation of proteolysis GO:0030162 164 0.013
intrinsic apoptotic signaling pathway GO:0097193 132 0.013
Mouse
respiratory system development GO:0060541 190 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.013
proteasomal protein catabolic process GO:0010498 98 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
cytokine production GO:0001816 319 0.013
regulation of hormone levels GO:0010817 211 0.012
protein localization to nucleus GO:0034504 121 0.012
glycerolipid metabolic process GO:0046486 122 0.012
regulation of chromosome organization GO:0033044 83 0.012
endomembrane system organization GO:0010256 147 0.012
protein alkylation GO:0008213 81 0.012
response to organic cyclic compound GO:0014070 198 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
regulation of neuron differentiation GO:0045664 281 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
response to extracellular stimulus GO:0009991 127 0.012
protein methylation GO:0006479 81 0.012
cellular protein complex assembly GO:0043623 116 0.012
regulation of cell migration GO:0030334 219 0.012
cofactor metabolic process GO:0051186 80 0.012
regulation of intracellular transport GO:0032386 159 0.012
nuclear transport GO:0051169 139 0.012
negative regulation of cell development GO:0010721 169 0.012
small molecule biosynthetic process GO:0044283 132 0.012
anion transport GO:0006820 177 0.012
sulfur compound metabolic process GO:0006790 100 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
regulation of cytokine production GO:0001817 266 0.012
negative regulation of protein modification process GO:0031400 163 0.012
regulation of mapk cascade GO:0043408 248 0.012
protein import into nucleus GO:0006606 95 0.012
regulation of cell cycle GO:0051726 281 0.012
protein processing GO:0016485 163 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
cofactor biosynthetic process GO:0051188 41 0.012
dephosphorylation GO:0016311 129 0.011
regulation of t cell activation GO:0050863 170 0.011
cell adhesion GO:0007155 329 0.011
myeloid cell differentiation GO:0030099 233 0.011
anatomical structure homeostasis GO:0060249 145 0.011
Mouse
organic acid biosynthetic process GO:0016053 86 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
locomotory behavior GO:0007626 195 0.011
Mouse
regulation of transmembrane transport GO:0034762 128 0.011
histone methylation GO:0016571 71 0.011
cellular response to lipid GO:0071396 145 0.011
muscle cell differentiation GO:0042692 261 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
stem cell maintenance GO:0019827 130 0.011
asymmetric stem cell division GO:0098722 3 0.011
regulation of secretion GO:0051046 274 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
rho protein signal transduction GO:0007266 32 0.011
spermatid differentiation GO:0048515 115 0.011
Mouse
regulation of cellular response to stress GO:0080135 159 0.011
regulation of defense response GO:0031347 233 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
regulation of secretion by cell GO:1903530 249 0.011
coenzyme metabolic process GO:0006732 52 0.011
single organism nuclear import GO:1902593 95 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
rna processing GO:0006396 105 0.010
negative regulation of intracellular signal transduction GO:1902532 167 0.010
Mouse
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
regulation of response to wounding GO:1903034 189 0.010
regulation of metal ion transport GO:0010959 106 0.010
response to light stimulus GO:0009416 135 0.010
lymphocyte mediated immunity GO:0002449 139 0.010
regulation of purine nucleotide catabolic process GO:0033121 122 0.010
nuclear import GO:0051170 95 0.010
regulation of protein catabolic process GO:0042176 108 0.010
multicellular organism growth GO:0035264 161 0.010
placenta development GO:0001890 140 0.010
carbohydrate homeostasis GO:0033500 128 0.010
negative regulation of cellular amine metabolic process GO:0033239 1 0.010
tube formation GO:0035148 140 0.010
gtp catabolic process GO:0006184 143 0.010
homeostasis of number of cells GO:0048872 210 0.010
Mouse
maintenance of location GO:0051235 89 0.010
glucose homeostasis GO:0042593 128 0.010
response to inorganic substance GO:0010035 96 0.010
respiratory tube development GO:0030323 167 0.010

Klhl12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
musculoskeletal system disease DOID:17 0 0.021
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
cancer DOID:162 0 0.016
central nervous system disease DOID:331 0 0.014
immune system disease DOID:2914 0 0.013
muscle tissue disease DOID:66 0 0.011
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
neurodegenerative disease DOID:1289 0 0.010