Mus musculus

240 known processes

Stat3

signal transducer and activator of transcription 3

(Aliases: Aprf,AW109958,1110034C02Rik)

Stat3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of immune system process GO:0002683 209 1.000
Mouse
cytokine production GO:0001816 319 1.000
Mouse
cytokine mediated signaling pathway GO:0019221 115 1.000
Human Mouse
regulation of defense response GO:0031347 233 1.000
Mouse
negative regulation of t cell activation GO:0050868 65 1.000
regulation of cytokine production GO:0001817 266 1.000
Mouse
cellular response to peptide GO:1901653 92 0.999
regulation of cell activation GO:0050865 289 0.999
Mouse
negative regulation of leukocyte differentiation GO:1902106 51 0.999
cd4 positive alpha beta t cell activation GO:0035710 45 0.999
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.999
Mouse
production of molecular mediator of immune response GO:0002440 103 0.999
Mouse
type i interferon signaling pathway GO:0060337 10 0.999
Mouse
cd4 positive alpha beta t cell lineage commitment GO:0043373 6 0.999
Mouse
t cell activation GO:0042110 289 0.998
Mouse
regulation of natural killer cell differentiation GO:0032823 11 0.998
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.998
peptidyl tyrosine phosphorylation GO:0018108 143 0.998
Mouse
positive regulation of defense response GO:0031349 124 0.998
Mouse
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.997
immune effector process GO:0002252 321 0.997
Mouse
t cell differentiation GO:0030217 174 0.997
Mouse
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.997
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.997
Human Mouse
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.997
Mouse
regulation of mast cell differentiation GO:0060375 3 0.996
Mouse
regulation of t cell differentiation GO:0045580 83 0.996
Mouse
regulation of response to wounding GO:1903034 189 0.996
Mouse
leukocyte differentiation GO:0002521 342 0.996
Mouse
activation of janus kinase activity GO:0042976 2 0.995
t helper cell differentiation GO:0042093 28 0.995
Mouse
cellular response to interferon gamma GO:0071346 25 0.995
Mouse
adaptive immune response GO:0002250 155 0.995
Mouse
peptidyl tyrosine modification GO:0018212 145 0.994
Mouse
immune response activating signal transduction GO:0002757 116 0.994
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.994
jak stat cascade GO:0007259 42 0.993
negative regulation of interferon gamma mediated signaling pathway GO:0060336 1 0.993
myeloid cell homeostasis GO:0002262 114 0.993
Mouse
cellular response to interleukin 4 GO:0071353 21 0.993
Mouse
cellular amino acid metabolic process GO:0006520 103 0.993
Mouse
response to organic cyclic compound GO:0014070 198 0.993
Human Mouse Rat
cellular response to growth hormone stimulus GO:0071378 7 0.992
lymphocyte differentiation GO:0030098 242 0.992
Mouse
alpha beta t cell lineage commitment GO:0002363 7 0.992
Mouse
response to lipopolysaccharide GO:0032496 128 0.992
Mouse
regulation of lymphocyte activation GO:0051249 240 0.992
Mouse
response to molecule of bacterial origin GO:0002237 143 0.991
Mouse
response to interleukin 15 GO:0070672 3 0.991
Mouse
interleukin 6 mediated signaling pathway GO:0070102 6 0.991
Human
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.991
Mouse
taurine metabolic process GO:0019530 4 0.991
Mouse
positive regulation of mast cell differentiation GO:0060376 1 0.990
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.990
immune response regulating signaling pathway GO:0002764 125 0.990
cellular response to peptide hormone stimulus GO:0071375 92 0.990
creatinine metabolic process GO:0046449 3 0.990
Mouse
defense response to other organism GO:0098542 197 0.989
negative regulation of alpha beta t cell activation GO:0046636 18 0.989
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.989
Mouse
regulation of mast cell apoptotic process GO:0033025 5 0.989
Mouse
cellular response to biotic stimulus GO:0071216 92 0.989
Mouse
jak stat cascade involved in growth hormone signaling pathway GO:0060397 4 0.988
regulation of alpha beta t cell differentiation GO:0046637 35 0.988
myeloid cell differentiation GO:0030099 233 0.987
Mouse
response to organonitrogen compound GO:0010243 246 0.986
negative regulation of protein metabolic process GO:0051248 282 0.986
negative regulation of defense response GO:0031348 77 0.986
peptidyl amino acid modification GO:0018193 336 0.986
Mouse
cellular ketone metabolic process GO:0042180 84 0.986
Mouse
t cell activation involved in immune response GO:0002286 43 0.986
Mouse
regulation of inflammatory response GO:0050727 147 0.985
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.985
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.985
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.985
interleukin 4 mediated signaling pathway GO:0035771 2 0.985
Mouse
t cell homeostasis GO:0043029 35 0.985
Mouse
regulation of b cell activation GO:0050864 81 0.984
Mouse
alpha beta t cell differentiation GO:0046632 69 0.984
Mouse
regulation of adaptive immune response GO:0002819 90 0.984
Mouse
alpha beta t cell activation involved in immune response GO:0002287 31 0.984
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.983
regulation of natural killer cell proliferation GO:0032817 2 0.983
Mouse
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.983
Mouse
regulation of kinase activity GO:0043549 249 0.982
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.981
Mouse
defense response to virus GO:0051607 68 0.980
t cell differentiation involved in immune response GO:0002292 30 0.979
Mouse
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.978
regulation of chemokine secretion GO:0090196 4 0.978
cellular response to lipid GO:0071396 145 0.977
Mouse
positive regulation of cytokine biosynthetic process GO:0042108 40 0.977
Mouse
regulation of lymphocyte proliferation GO:0050670 117 0.977
Mouse
dna metabolic process GO:0006259 303 0.976
Mouse
lactation GO:0007595 25 0.975
Mouse
regulation of t helper 1 cell differentiation GO:0045625 7 0.975
positive regulation of leukocyte differentiation GO:1902107 86 0.974
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.974
creatine metabolic process GO:0006600 4 0.974
Mouse
positive regulation of cytokine production GO:0001819 174 0.973
Mouse
regulation of cytokine biosynthetic process GO:0042035 59 0.972
Mouse
cellular lactam metabolic process GO:0072338 3 0.971
Mouse
cellular response to amino acid stimulus GO:0071230 29 0.970
regulation of lymphocyte differentiation GO:0045619 107 0.969
Mouse
negative regulation of t cell differentiation GO:0045581 23 0.968
regulation of t cell activation GO:0050863 170 0.968
Mouse
regulation of leukocyte proliferation GO:0070663 121 0.967
Mouse
interferon gamma mediated signaling pathway GO:0060333 5 0.966
Mouse
negative regulation of cytokine production GO:0001818 84 0.965
response to interferon gamma GO:0034341 34 0.965
Mouse
prolactin signaling pathway GO:0038161 5 0.965
Mouse
negative regulation of cell activation GO:0050866 111 0.963
positive regulation of natural killer cell proliferation GO:0032819 2 0.962
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.962
alpha beta t cell activation GO:0046631 91 0.961
Mouse
negative regulation of phosphorylation GO:0042326 166 0.960
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.960
cellular response to molecule of bacterial origin GO:0071219 83 0.959
Mouse
response to amino acid GO:0043200 37 0.959
regulation of jak stat cascade GO:0046425 34 0.959
interleukin 11 mediated signaling pathway GO:0038154 2 0.958
positive regulation of inflammatory response GO:0050729 47 0.957
Mouse
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.956
Mouse
lymphocyte homeostasis GO:0002260 64 0.956
Mouse
lymphocyte activation involved in immune response GO:0002285 93 0.954
Mouse
positive regulation of activated t cell proliferation GO:0042104 8 0.954
Mouse
cellular amine metabolic process GO:0044106 44 0.953
positive regulation of isotype switching to ige isotypes GO:0048295 4 0.953
Mouse
positive regulation of immune effector process GO:0002699 107 0.952
Mouse
citrate metabolic process GO:0006101 3 0.952
Mouse
response to corticosteroid GO:0031960 20 0.951
positive regulation of protein modification process GO:0031401 299 0.951
interleukin 18 mediated signaling pathway GO:0035655 2 0.951
negative regulation of lymphocyte differentiation GO:0045620 32 0.951
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.950
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 1 0.950
regulation of alpha beta t cell activation GO:0046634 53 0.949
amine metabolic process GO:0009308 45 0.949
negative regulation of glycolytic process GO:0045820 4 0.948
isotype switching to ige isotypes GO:0048289 7 0.946
Mouse
hepaticobiliary system development GO:0061008 67 0.946
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.944
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.942
mast cell proliferation GO:0070662 4 0.941
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.940
t cell proliferation GO:0042098 120 0.939
Mouse
negative regulation of intracellular signal transduction GO:1902532 167 0.936
type 2 immune response GO:0042092 23 0.934
Mouse
response to alcohol GO:0097305 48 0.934
Human Rat
negative regulation of lymphocyte activation GO:0051250 91 0.931
response to peptide hormone GO:0043434 127 0.929
response to interleukin 1 GO:0070555 11 0.929
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.928
natural killer cell proliferation GO:0001787 3 0.927
Mouse
valine metabolic process GO:0006573 4 0.923
Mouse
skin development GO:0043588 220 0.922
Zebrafish
b cell activation GO:0042113 161 0.922
Mouse
positive regulation of cell activation GO:0050867 158 0.922
Mouse
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.922
Mouse
response to glucocorticoid GO:0051384 20 0.919
embryonic placenta development GO:0001892 98 0.918
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.917
regulation of mapk cascade GO:0043408 248 0.916
cellular response to hormone stimulus GO:0032870 150 0.914
tyrosine phosphorylation of stat protein GO:0007260 23 0.914
regulation of myeloid leukocyte differentiation GO:0002761 58 0.914
Mouse
inflammatory response GO:0006954 244 0.912
Mouse Rat
response to interleukin 6 GO:0070741 10 0.911
Human
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.909
Mouse
lymphocyte mediated immunity GO:0002449 139 0.908
Mouse
erythrocyte differentiation GO:0030218 88 0.905
Mouse
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.904
negative regulation of inflammatory response GO:0050728 61 0.904
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.904
cell adhesion GO:0007155 329 0.903
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.902
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.901
regulation of transferase activity GO:0051338 263 0.900
carbohydrate metabolic process GO:0005975 230 0.898
multicellular organism growth GO:0035264 161 0.898
response to radiation GO:0009314 165 0.898
t cell selection GO:0045058 34 0.896
Mouse
nuclear transport GO:0051169 139 0.892
Human
regulation of t cell proliferation GO:0042129 92 0.889
Mouse
cellular response to x ray GO:0071481 2 0.889
response to steroid hormone GO:0048545 56 0.889
Human Rat
negative regulation of t helper 1 type immune response GO:0002826 5 0.884
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.884
macrophage fusion GO:0034238 3 0.883
Mouse
development of primary sexual characteristics GO:0045137 143 0.881
Mouse
negative regulation of syncytium formation by plasma membrane fusion GO:0034242 5 0.877
Mouse
negative regulation of alpha beta t cell differentiation GO:0046639 12 0.875
hormone mediated signaling pathway GO:0009755 23 0.875
Mouse
regulation of isotype switching to ige isotypes GO:0048293 7 0.875
Mouse
leukocyte homeostasis GO:0001776 79 0.874
Mouse
negative regulation of cell proliferation GO:0008285 296 0.873
allantoin metabolic process GO:0000255 3 0.873
Mouse
innate immune response GO:0045087 157 0.872
Mouse
rhythmic process GO:0048511 174 0.870
Mouse
immunoglobulin production GO:0002377 73 0.870
Mouse
somatic diversification of immunoglobulins GO:0016445 43 0.864
Mouse
positive regulation of t cell differentiation GO:0045582 52 0.859
Mouse
t helper 1 cell lineage commitment GO:0002296 2 0.857
Mouse
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.852
positive regulation of t cell activation GO:0050870 101 0.849
Mouse
positive regulation of response to wounding GO:1903036 66 0.849
Mouse
cell activation involved in immune response GO:0002263 126 0.848
Mouse
regulation of protein targeting GO:1903533 61 0.846
i kappab kinase nf kappab signaling GO:0007249 85 0.845
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.845
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.842
liver development GO:0001889 66 0.842
layer formation in cerebral cortex GO:0021819 13 0.836
cellular response to interleukin 6 GO:0071354 9 0.835
Human
regulation of leukocyte mediated immunity GO:0002703 104 0.833
Mouse
positive regulation of adaptive immune response GO:0002821 61 0.832
Mouse
mammary gland lobule development GO:0061377 22 0.830
negative regulation of neuron death GO:1901215 98 0.830
Rat
succinate metabolic process GO:0006105 4 0.828
Mouse
positive regulation of macrophage activation GO:0043032 10 0.828
protein autophosphorylation GO:0046777 61 0.828
regulation of protein transport GO:0051223 163 0.828
cellular response to organic cyclic compound GO:0071407 87 0.826
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 10 0.824
negative regulation of cellular protein metabolic process GO:0032269 247 0.821
regulation of type 2 immune response GO:0002828 18 0.819
Mouse
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.818
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 10 0.815
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.813
stem cell maintenance GO:0019827 130 0.811
regulation of interleukin 6 production GO:0032675 55 0.810
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.807
Mouse
positive regulation of leukocyte proliferation GO:0070665 73 0.806
Mouse
spleen development GO:0048536 39 0.803
regulation of protein kinase activity GO:0045859 232 0.802
positive regulation of dna recombination GO:0045911 17 0.801
Mouse
somatic diversification of immune receptors GO:0002200 53 0.800
Mouse
negative regulation of macrophage fusion GO:0034240 1 0.794
Mouse
positive regulation of t cell proliferation GO:0042102 52 0.790
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.788
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.785
negative regulation of type 2 immune response GO:0002829 8 0.783
Mouse
negative regulation of t helper cell differentiation GO:0045623 9 0.783
regulation of protein localization GO:0032880 231 0.781
negative regulation of molecular function GO:0044092 258 0.780
gland development GO:0048732 330 0.777
Mouse
proteasomal protein catabolic process GO:0010498 98 0.772
mast cell apoptotic process GO:0033024 5 0.770
Mouse
macromolecule methylation GO:0043414 120 0.769
positive regulation of mast cell proliferation GO:0070668 3 0.767
Mouse
cellular protein catabolic process GO:0044257 155 0.767
negative regulation of interleukin 6 production GO:0032715 17 0.766
progesterone metabolic process GO:0042448 4 0.765
Mouse
positive regulation of t cell anergy GO:0002669 4 0.765
response to oxygen levels GO:0070482 62 0.762
positive regulation of antimicrobial peptide production GO:0002225 1 0.760
urea cycle GO:0000050 2 0.749
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.746
regulation of b cell differentiation GO:0045577 23 0.745
Mouse
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.743
Mouse
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.742
positive regulation of innate immune response GO:0045089 80 0.742
Mouse
negative regulation of multi organism process GO:0043901 68 0.741
body morphogenesis GO:0010171 45 0.736
activation of immune response GO:0002253 138 0.734
epithelial cell proliferation GO:0050673 174 0.733
Mouse
t cell lineage commitment GO:0002360 13 0.732
Mouse
positive regulation of mapk cascade GO:0043410 170 0.729
cerebral cortex radially oriented cell migration GO:0021799 31 0.729
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.728
Mouse
response to type i interferon GO:0034340 12 0.727
Mouse
isotype switching GO:0045190 36 0.726
Mouse
regulation of neuron death GO:1901214 134 0.725
Rat
negative regulation of leukocyte proliferation GO:0070664 46 0.721
t helper 2 cell differentiation GO:0045064 12 0.721
female gamete generation GO:0007292 74 0.721
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.719
isoleucine metabolic process GO:0006549 4 0.719
Mouse
t cell receptor signaling pathway GO:0050852 46 0.718
neuron apoptotic process GO:0051402 142 0.718
positive regulation of growth hormone receptor signaling pathway GO:0060399 3 0.716
homeostasis of number of cells GO:0048872 210 0.713
Mouse
gonad development GO:0008406 141 0.712
Mouse
regionalization GO:0003002 337 0.710
epidermis development GO:0008544 187 0.710
Zebrafish
mammary gland epithelium development GO:0061180 65 0.709
Mouse
t helper 1 type immune response GO:0042088 25 0.705
Mouse
mapk cascade GO:0000165 281 0.702
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.701
regulation of lymphocyte mediated immunity GO:0002706 84 0.700
Mouse
defense response to bacterium GO:0042742 119 0.698
regulation of production of molecular mediator of immune response GO:0002700 65 0.696
Mouse
regulation of hormone levels GO:0010817 211 0.695
Mouse
regulation of protein import into nucleus GO:0042306 52 0.694
positive regulation of lymphocyte activation GO:0051251 140 0.693
Mouse
acute inflammatory response GO:0002526 41 0.692
Rat
regulation of antimicrobial humoral response GO:0002759 3 0.691
negative regulation of cd4 positive alpha beta t cell differentiation GO:0043371 9 0.691
regulation of activation of jak2 kinase activity GO:0010534 1 0.684
germ cell development GO:0007281 185 0.683
regulation of establishment of protein localization GO:0070201 181 0.683
cholesterol metabolic process GO:0008203 56 0.683
regulation of carbohydrate metabolic process GO:0006109 75 0.682
regulation of t helper cell differentiation GO:0045622 14 0.679
negative regulation of erythrocyte differentiation GO:0045647 5 0.679
Mouse
b cell activation involved in immune response GO:0002312 50 0.677
Mouse
regulation of mast cell proliferation GO:0070666 4 0.677
Mouse
nik nf kappab signaling GO:0038061 14 0.676
macrophage activation GO:0042116 27 0.675
negative regulation of t cell proliferation GO:0042130 38 0.673
oxaloacetate metabolic process GO:0006107 5 0.673
Mouse
cellular response to lipopolysaccharide GO:0071222 77 0.673
Mouse
epithelial cell development GO:0002064 159 0.673
luteinization GO:0001553 8 0.672
Mouse
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.672
leukocyte proliferation GO:0070661 172 0.672
Mouse
regulation of defense response to virus by host GO:0050691 8 0.672
alpha amino acid metabolic process GO:1901605 59 0.670
Mouse
ovulation GO:0030728 15 0.670
protein catabolic process GO:0030163 221 0.662
positive regulation of lymphocyte proliferation GO:0050671 70 0.661
Mouse
response to peptide GO:1901652 136 0.661
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.658
radial glia guided migration of purkinje cell GO:0021942 6 0.657
negative regulation of tyrosine phosphorylation of stat protein GO:0042532 3 0.654
response to endoplasmic reticulum stress GO:0034976 53 0.650
response to dsrna GO:0043331 30 0.649
Mouse
response to drug GO:0042493 75 0.645
Rat
cytokine biosynthetic process GO:0042089 68 0.643
Mouse
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.640
negative regulation of mast cell apoptotic process GO:0033026 4 0.639
Mouse
ovulation cycle GO:0042698 59 0.637
Mouse
antibacterial peptide production GO:0002778 2 0.636
fibroblast migration GO:0010761 21 0.635
regulation of neuron apoptotic process GO:0043523 122 0.635
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.634
Mouse
regulation of cytokine production involved in immune response GO:0002718 26 0.631
negative regulation of phosphorus metabolic process GO:0010563 184 0.631
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.630
t helper 1 cell differentiation GO:0045063 13 0.629
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.627
cellular response to oxidative stress GO:0034599 76 0.627
antigen receptor mediated signaling pathway GO:0050851 64 0.626
cellular response to growth factor stimulus GO:0071363 197 0.622
Mouse
myeloid leukocyte activation GO:0002274 83 0.622
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.617
leukocyte mediated immunity GO:0002443 174 0.616
Mouse
regulation of b cell mediated immunity GO:0002712 37 0.614
Mouse
lymphocyte anergy GO:0002249 4 0.613
positive regulation of intracellular transport GO:0032388 70 0.612
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.611
Mouse
positive regulation of osteoblast differentiation GO:0045669 34 0.610
interleukin 27 mediated signaling pathway GO:0070106 1 0.606
digestive tract development GO:0048565 190 0.600
Zebrafish
regulation of nucleocytoplasmic transport GO:0046822 73 0.600
regulation of secretion by cell GO:1903530 249 0.599
positive regulation of b cell mediated immunity GO:0002714 26 0.598
Mouse
negative regulation of cellular component organization GO:0051129 194 0.598
Mouse
response to lithium ion GO:0010226 10 0.595
t cell differentiation in thymus GO:0033077 77 0.595
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.592
Mouse
glycolytic process GO:0006096 20 0.590
cellular response to inorganic substance GO:0071241 37 0.590
placenta development GO:0001890 140 0.581
negative regulation of phosphate metabolic process GO:0045936 184 0.579
regulation of defense response to virus GO:0050688 18 0.578
regulation of cellular response to stress GO:0080135 159 0.578
cellular response to dna damage stimulus GO:0006974 207 0.578
cell type specific apoptotic process GO:0097285 268 0.576
Mouse
activation of mapkk activity GO:0000186 15 0.573
response to granulocyte macrophage colony stimulating factor GO:0097012 3 0.571
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.569
blastoderm segmentation GO:0007350 13 0.562
lung development GO:0030324 164 0.562
intrinsic apoptotic signaling pathway GO:0097193 132 0.561
regulation of cell migration GO:0030334 219 0.558
positive regulation of protein complex assembly GO:0031334 45 0.553
positive regulation of protein transport GO:0051222 93 0.551
t cell anergy GO:0002870 4 0.551
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.550
negative regulation of lymphocyte proliferation GO:0050672 45 0.544
dna recombination GO:0006310 92 0.543
Mouse
segmentation GO:0035282 93 0.542
dna alkylation GO:0006305 43 0.542
dna methylation GO:0006306 43 0.537
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.536
Mouse
negative regulation of response to cytokine stimulus GO:0060761 9 0.535
regulation of mitotic cell cycle GO:0007346 126 0.534
Mouse
positive regulation of apoptotic process GO:0043065 217 0.534
Mouse
regulation of response to biotic stimulus GO:0002831 38 0.531
regulation of peptidyl serine phosphorylation GO:0033135 39 0.530
covalent chromatin modification GO:0016569 163 0.529
glial cell differentiation GO:0010001 131 0.527
histone modification GO:0016570 159 0.525
regulation of natural killer cell mediated immunity GO:0002715 19 0.524
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.522
myeloid leukocyte differentiation GO:0002573 119 0.520
Mouse
positive regulation of immature t cell proliferation GO:0033091 4 0.519
negative regulation of cellular amine metabolic process GO:0033239 1 0.519
regulation of innate immune response GO:0045088 91 0.514
Mouse
cell fate commitment GO:0045165 210 0.514
Mouse
epidermal growth factor receptor signaling pathway GO:0007173 28 0.509
transformed cell apoptotic process GO:0006927 3 0.509
cellular response to metal ion GO:0071248 31 0.508
axon ensheathment GO:0008366 76 0.504
reactive oxygen species metabolic process GO:0072593 84 0.503
Rat
lymphocyte proliferation GO:0046651 164 0.501
Mouse
regulation of macrophage fusion GO:0034239 3 0.501
Mouse
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.500
positive regulation of cellular component biogenesis GO:0044089 94 0.500
cellular response to interleukin 18 GO:0071351 3 0.498
phagocytosis GO:0006909 66 0.498
response to tumor necrosis factor GO:0034612 26 0.498
response to estrogen GO:0043627 24 0.498
Human Rat
organonitrogen compound biosynthetic process GO:1901566 192 0.496
Rat
t helper 17 cell lineage commitment GO:0072540 4 0.496
apoptotic signaling pathway GO:0097190 306 0.494
modulation by virus of host morphology or physiology GO:0019048 3 0.494
female sex differentiation GO:0046660 84 0.491
Mouse
response to alkaloid GO:0043279 34 0.491
negative regulation of protein modification process GO:0031400 163 0.489
steroid metabolic process GO:0008202 119 0.489
Mouse
stem cell development GO:0048864 219 0.489
cellular macromolecule catabolic process GO:0044265 206 0.487
positive regulation of myeloid cell differentiation GO:0045639 43 0.487
Mouse
neuronal action potential GO:0019228 54 0.486
leukocyte activation involved in immune response GO:0002366 126 0.482
Mouse
positive regulation of defense response to virus by host GO:0002230 6 0.480
chromatin modification GO:0016568 187 0.478
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.478
positive regulation of kinase activity GO:0033674 155 0.476
response to heat GO:0009408 27 0.475
cytokine metabolic process GO:0042107 71 0.472
Mouse
hindbrain radial glia guided cell migration GO:0021932 12 0.471
positive regulation of chemokine production GO:0032722 22 0.471
pattern recognition receptor signaling pathway GO:0002221 47 0.469
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.469
regulation of cell adhesion GO:0030155 154 0.467
Mouse
activation of innate immune response GO:0002218 56 0.461
regulation of multi organism process GO:0043900 111 0.460
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.458
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.457
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.455
cellular response to granulocyte macrophage colony stimulating factor stimulus GO:0097011 3 0.452
Mouse
gliogenesis GO:0042063 141 0.450
regulation of defense response to bacterium GO:1900424 3 0.449
positive regulation of jak stat cascade GO:0046427 22 0.448
positive regulation of cell adhesion GO:0045785 80 0.448
fibroblast proliferation GO:0048144 35 0.446
regulation of macrophage differentiation GO:0045649 9 0.446
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.446
lipid localization GO:0010876 126 0.445
Mouse
growth hormone receptor signaling pathway GO:0060396 7 0.444
macrophage differentiation GO:0030225 20 0.441
negative regulation of response to wounding GO:1903035 77 0.441
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.440
cellular response to interleukin 15 GO:0071350 2 0.436
mucosal associated lymphoid tissue development GO:0048537 12 0.435
Mouse
positive regulation of transcription by galactose GO:0000411 1 0.433
mammary gland epithelial cell proliferation GO:0033598 24 0.433
Mouse
urea metabolic process GO:0019627 3 0.432
regulation of transforming growth factor beta2 production GO:0032909 2 0.431
dendritic cell cytokine production GO:0002371 3 0.431
regulation of cytoplasmic transport GO:1903649 112 0.431
organ growth GO:0035265 117 0.430
body fluid secretion GO:0007589 53 0.429
Mouse
response to insulin GO:0032868 100 0.428
digestive system development GO:0055123 200 0.427
Zebrafish
protein localization to organelle GO:0033365 185 0.426
Human
cellular carbohydrate catabolic process GO:0044275 15 0.426
regulation of t cell anergy GO:0002667 4 0.426
stem cell differentiation GO:0048863 268 0.425
positive regulation of interferon gamma production GO:0032729 39 0.423
interleukin 2 mediated signaling pathway GO:0038110 2 0.423
regulation of angiogenesis GO:0045765 81 0.421
urogenital system development GO:0001655 261 0.420
Mouse
natural killer cell mediated immunity GO:0002228 29 0.419
Mouse
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.414
positive regulation of cytoplasmic transport GO:1903651 40 0.412
cellular response to type i interferon GO:0071357 10 0.412
Mouse
regulation of protein import into nucleus translocation GO:0033158 2 0.411
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.410
negative regulation of chemokine biosynthetic process GO:0045079 2 0.408
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.407
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.406
Rat
activation induced cell death of t cells GO:0006924 10 0.401
ossification GO:0001503 216 0.397
positive regulation of fibroblast proliferation GO:0048146 20 0.395
positive regulation of mirna metabolic process GO:2000630 1 0.394
hormone metabolic process GO:0042445 86 0.394
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.393
response to oxidative stress GO:0006979 123 0.392

Stat3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.928
disease of cellular proliferation DOID:14566 0 0.928
organ system cancer DOID:0050686 0 0.928
immune system cancer DOID:0060083 0 0.776
disease of metabolism DOID:0014667 0 0.472
inherited metabolic disorder DOID:655 0 0.472
hematologic cancer DOID:2531 0 0.457