Mus musculus

15 known processes

Tpp1

tripeptidyl peptidase I

(Aliases: Cln2,TPP-I)

Tpp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protection from non homologous end joining at telomere GO:0031848 4 0.391
vacuole organization GO:0007033 38 0.196
membrane lipid biosynthetic process GO:0046467 32 0.186
lysosome organization GO:0007040 21 0.169
anatomical structure homeostasis GO:0060249 145 0.141
Human
negative regulation of protein metabolic process GO:0051248 282 0.105
telomere maintenance in response to dna damage GO:0043247 4 0.104
cellular ketone metabolic process GO:0042180 84 0.104
regulation of cellular amino acid metabolic process GO:0006521 5 0.076
sphingolipid catabolic process GO:0030149 7 0.076
sphingolipid metabolic process GO:0006665 45 0.074
cellular lipid metabolic process GO:0044255 323 0.066
organonitrogen compound catabolic process GO:1901565 264 0.062
Human
sphingolipid biosynthetic process GO:0030148 26 0.062
amine metabolic process GO:0009308 45 0.061
triglyceride metabolic process GO:0006641 51 0.061
ceramide biosynthetic process GO:0046513 20 0.061
cellular amino acid metabolic process GO:0006520 103 0.061
lytic vacuole organization GO:0080171 21 0.060
tissue homeostasis GO:0001894 115 0.055
Human
regulation of cellular catabolic process GO:0031329 242 0.050
regulation of body fluid levels GO:0050878 162 0.047
protein processing GO:0016485 163 0.046
phospholipid transfer to membrane GO:0006649 2 0.045
wound healing GO:0042060 157 0.041
lipid catabolic process GO:0016042 69 0.041
ceramide metabolic process GO:0006672 31 0.041
reactive oxygen species metabolic process GO:0072593 84 0.038
apoptotic signaling pathway GO:0097190 306 0.037
sterol metabolic process GO:0016125 58 0.037
macromolecule catabolic process GO:0009057 281 0.035
regulation of apoptotic signaling pathway GO:2001233 197 0.035
oxidation reduction process GO:0055114 342 0.034
sterol transport GO:0015918 38 0.034
alcohol metabolic process GO:0006066 116 0.033
regulation of peptidase activity GO:0052547 96 0.033
carbohydrate derivative catabolic process GO:1901136 231 0.033
negative regulation of cellular protein metabolic process GO:0032269 247 0.032
regulation of removal of superoxide radicals GO:2000121 4 0.032
anion transport GO:0006820 177 0.031
cellular amine metabolic process GO:0044106 44 0.031
transmembrane transport GO:0055085 412 0.031
sensory perception GO:0007600 245 0.030
neuronal action potential GO:0019228 54 0.029
peptidyl amino acid modification GO:0018193 336 0.029
regulation of phosphatidylcholine catabolic process GO:0010899 2 0.028
dna metabolic process GO:0006259 303 0.027
endocytosis GO:0006897 168 0.027
regulation of cellular amine metabolic process GO:0033238 20 0.027
regulation of mapk cascade GO:0043408 248 0.027
multicellular organismal signaling GO:0035637 91 0.026
cellular response to extracellular stimulus GO:0031668 81 0.026
cation transmembrane transport GO:0098655 266 0.026
ion transmembrane transport GO:0034220 361 0.026
telomere capping GO:0016233 4 0.025
regulation of membrane potential GO:0042391 192 0.025
male gamete generation GO:0048232 285 0.025
regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling GO:0003027 1 0.025
blood coagulation GO:0007596 76 0.025
protein catabolic process GO:0030163 221 0.025
glycolipid metabolic process GO:0006664 25 0.025
response to organic cyclic compound GO:0014070 198 0.025
cholesterol metabolic process GO:0008203 56 0.025
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.024
regulation of reactive oxygen species metabolic process GO:2000377 40 0.024
single fertilization GO:0007338 82 0.024
negative regulation of glycoprotein metabolic process GO:1903019 3 0.024
positive regulation of mapk cascade GO:0043410 170 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.023
macroautophagy GO:0016236 21 0.023
purine ribonucleoside metabolic process GO:0046128 241 0.023
dna recombination GO:0006310 92 0.023
organophosphate catabolic process GO:0046434 232 0.022
gland development GO:0048732 330 0.022
organic hydroxy compound metabolic process GO:1901615 203 0.022
circulatory system process GO:0003013 197 0.022
glycosphingolipid catabolic process GO:0046479 5 0.022
mapk cascade GO:0000165 281 0.022
blastocyst hatching GO:0001835 4 0.022
regulation of protein maturation GO:1903317 96 0.022
dephosphorylation GO:0016311 129 0.022
regulation of vesicle mediated transport GO:0060627 139 0.021
natural killer cell degranulation GO:0043320 3 0.021
regulation of transferase activity GO:0051338 263 0.021
protein kinase b signaling GO:0043491 74 0.021
skin development GO:0043588 220 0.021
nucleobase containing small molecule metabolic process GO:0055086 352 0.021
ear development GO:0043583 200 0.020
cellular response to external stimulus GO:0071496 88 0.020
peptidyl tyrosine modification GO:0018212 145 0.020
regulation of proteolysis GO:0030162 164 0.020
tissue remodeling GO:0048771 102 0.020
Human
regulation of dna recombination GO:0000018 34 0.020
cholesterol homeostasis GO:0042632 44 0.020
cellular macromolecule catabolic process GO:0044265 206 0.020
multicellular organismal homeostasis GO:0048871 164 0.019
Human
maintenance of location GO:0051235 89 0.019
amyloid precursor protein biosynthetic process GO:0042983 3 0.019
regulation of secretion by cell GO:1903530 249 0.019
generation of precursor metabolites and energy GO:0006091 103 0.019
positive regulation of cellular catabolic process GO:0031331 148 0.019
regulation of amyloid precursor protein biosynthetic process GO:0042984 3 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
hindbrain development GO:0030902 128 0.019
blood circulation GO:0008015 195 0.019
regulation of map kinase activity GO:0043405 120 0.019
response to reactive oxygen species GO:0000302 56 0.019
exocytosis GO:0006887 121 0.018
cellular response to nutrient levels GO:0031669 64 0.018
regulation of cellular ketone metabolic process GO:0010565 66 0.018
skeletal system development GO:0001501 356 0.018
regulation of protein processing GO:0070613 96 0.018
negative regulation of proteolysis GO:0045861 74 0.018
regulation of defense response GO:0031347 233 0.018
regulation of ossification GO:0030278 112 0.018
negative regulation of protein maturation GO:1903318 79 0.018
negative regulation of dna recombination GO:0045910 13 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.018
epidermis development GO:0008544 187 0.018
adult behavior GO:0030534 135 0.018
organelle localization GO:0051640 179 0.017
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.017
cytokine production GO:0001816 319 0.017
cellular response to thyroid hormone stimulus GO:0097067 1 0.017
reactive oxygen species biosynthetic process GO:1903409 8 0.017
purine nucleotide metabolic process GO:0006163 302 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.017
positive regulation of phagocytosis GO:0050766 26 0.016
cation homeostasis GO:0055080 212 0.016
cellular response to lipid GO:0071396 145 0.016
lipid biosynthetic process GO:0008610 179 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
vesicle organization GO:0016050 60 0.016
membrane lipid catabolic process GO:0046466 8 0.016
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.016
ensheathment of neurons GO:0007272 76 0.016
negative regulation of molecular function GO:0044092 258 0.016
regulation of angiotensin levels in blood GO:0002002 4 0.016
beta amyloid clearance GO:0097242 2 0.016
nucleoside metabolic process GO:0009116 246 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
ribonucleoside metabolic process GO:0009119 245 0.016
smoothened signaling pathway GO:0007224 105 0.016
sterol homeostasis GO:0055092 45 0.016
regulation of blood pressure GO:0008217 93 0.016
sphingosine metabolic process GO:0006670 4 0.016
regulation of beta amyloid clearance GO:1900221 1 0.016
spermatogenesis GO:0007283 284 0.016
positive regulation of macroautophagy GO:0016239 3 0.015
striated muscle tissue development GO:0014706 293 0.015
ossification GO:0001503 216 0.015
leukocyte differentiation GO:0002521 342 0.015
peptidyl tyrosine phosphorylation GO:0018108 143 0.015
hair cycle GO:0042633 90 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.015
regulation of plasma lipoprotein particle levels GO:0097006 23 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
fertilization GO:0009566 127 0.015
metal ion homeostasis GO:0055065 189 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.015
positive regulation of protein modification process GO:0031401 299 0.015
positive regulation of endocytosis GO:0045807 42 0.015
response to acid chemical GO:0001101 111 0.015
placenta development GO:0001890 140 0.014
organic hydroxy compound transport GO:0015850 93 0.014
muscle tissue development GO:0060537 308 0.014
transmission of nerve impulse GO:0019226 76 0.014
biomineral tissue development GO:0031214 64 0.014
endomembrane system organization GO:0010256 147 0.014
renal system development GO:0072001 225 0.014
cell recognition GO:0008037 83 0.014
visual behavior GO:0007632 45 0.014
sensory perception of sound GO:0007605 97 0.014
glycerolipid metabolic process GO:0046486 122 0.014
myelination GO:0042552 74 0.014
kidney development GO:0001822 213 0.014
epithelial cell proliferation GO:0050673 174 0.014
embryonic placenta development GO:0001892 98 0.014
response to light stimulus GO:0009416 135 0.014
positive regulation of phagocytosis engulfment GO:0060100 3 0.014
positive regulation of cytokine production GO:0001819 174 0.014
ribonucleotide metabolic process GO:0009259 291 0.014
norepinephrine transport GO:0015874 2 0.014
positive regulation of secretion GO:0051047 130 0.014
heart process GO:0003015 94 0.014
liver development GO:0001889 66 0.013
protein localization to vacuole GO:0072665 4 0.013
organophosphate ester transport GO:0015748 28 0.013
glycolipid catabolic process GO:0019377 5 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.013
response to starvation GO:0042594 65 0.013
regulation of lymphocyte mediated immunity GO:0002706 84 0.013
positive regulation of coagulation GO:0050820 13 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.013
homeostasis of number of cells GO:0048872 210 0.013
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.013
lipoprotein metabolic process GO:0042157 43 0.013
aminoglycan metabolic process GO:0006022 34 0.013
nucleotide metabolic process GO:0009117 332 0.013
negative regulation of protein processing GO:0010955 79 0.013
cellular homeostasis GO:0019725 240 0.013
leukocyte mediated immunity GO:0002443 174 0.013
heart morphogenesis GO:0003007 178 0.013
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.013
sulfur compound metabolic process GO:0006790 100 0.013
cell type specific apoptotic process GO:0097285 268 0.013
skeletal system morphogenesis GO:0048705 203 0.013
cellular response to molecule of bacterial origin GO:0071219 83 0.013
hepatocyte growth factor receptor signaling pathway GO:0048012 3 0.013
ras protein signal transduction GO:0007265 77 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.013
lipid localization GO:0010876 126 0.013
regulation of cellular response to stress GO:0080135 159 0.013
regulation of cytokine production GO:0001817 266 0.013
establishment of vesicle localization GO:0051650 81 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
interspecies interaction between organisms GO:0044419 83 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
fatty acid metabolic process GO:0006631 121 0.012
negative regulation of neuron apoptotic process GO:0043524 92 0.012
plasma membrane organization GO:0007009 90 0.012
sensory organ morphogenesis GO:0090596 242 0.012
atp catabolic process GO:0006200 55 0.012
positive regulation of dna templated transcription elongation GO:0032786 2 0.012
regulation of cell cycle process GO:0010564 160 0.012
regulation of system process GO:0044057 200 0.012
lipid transport GO:0006869 98 0.012
negative regulation of transferase activity GO:0051348 85 0.012
negative regulation of glycoprotein biosynthetic process GO:0010561 3 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
plasma lipoprotein particle clearance GO:0034381 13 0.012
glycerophospholipid metabolic process GO:0006650 71 0.012
cellular response to starvation GO:0009267 57 0.012
interleukin 6 production GO:0032635 58 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
negative regulation of hydrolase activity GO:0051346 71 0.012
bone mineralization GO:0030282 54 0.012
molting cycle GO:0042303 90 0.012
cellular response to oxygen radical GO:0071450 14 0.012
regulation of protein kinase activity GO:0045859 232 0.012
regulation of cellular response to growth factor stimulus GO:0090287 82 0.012
cytokinetic process GO:0032506 2 0.012
cerebellum development GO:0021549 77 0.012
lung development GO:0030324 164 0.012
skeletal muscle organ development GO:0060538 163 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.011
positive regulation of cell killing GO:0031343 33 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
pharynx development GO:0060465 1 0.011
regulation of hydrolase activity GO:0051336 246 0.011
metencephalon development GO:0022037 89 0.011
muscle contraction GO:0006936 101 0.011
neuromuscular process controlling balance GO:0050885 59 0.011
atp metabolic process GO:0046034 75 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
immune effector process GO:0002252 321 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
embryonic organ morphogenesis GO:0048562 276 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
organism emergence from protective structure GO:0071684 4 0.011
regulation of organelle organization GO:0033043 289 0.011
cellular divalent inorganic cation homeostasis GO:0072503 127 0.011
regulation of multi organism process GO:0043900 111 0.011
locomotory behavior GO:0007626 195 0.011
Zebrafish
response to molecule of bacterial origin GO:0002237 143 0.011
wnt signaling pathway GO:0016055 188 0.011
cellular lipid catabolic process GO:0044242 52 0.011
developmental cell growth GO:0048588 84 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
regulation of cellular protein catabolic process GO:1903362 61 0.011
neutral lipid metabolic process GO:0006638 57 0.011
action potential GO:0001508 78 0.011
positive regulation of homeostatic process GO:0032846 64 0.011
regulation of bone resorption GO:0045124 24 0.011
positive regulation of response to wounding GO:1903036 66 0.011
negative regulation of type b pancreatic cell apoptotic process GO:2000675 3 0.011
positive regulation of transferase activity GO:0051347 167 0.011
cofactor transport GO:0051181 4 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.011
regulation of cell cycle GO:0051726 281 0.011
rho protein signal transduction GO:0007266 32 0.011
regulation of cell activation GO:0050865 289 0.010
leukocyte migration GO:0050900 124 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
purine nucleoside metabolic process GO:0042278 241 0.010
erk1 and erk2 cascade GO:0070371 77 0.010
nitrogen compound transport GO:0071705 271 0.010
receptor mediated endocytosis GO:0006898 51 0.010
purine nucleoside triphosphate metabolic process GO:0009144 226 0.010
isoprenoid metabolic process GO:0006720 29 0.010
gliogenesis GO:0042063 141 0.010
dopamine catabolic process GO:0042420 4 0.010
hemostasis GO:0007599 78 0.010
phospholipid metabolic process GO:0006644 87 0.010
intrinsic apoptotic signaling pathway GO:0097193 132 0.010
hatching GO:0035188 4 0.010
adult locomotory behavior GO:0008344 91 0.010
small gtpase mediated signal transduction GO:0007264 97 0.010
positive regulation of cholesterol storage GO:0010886 3 0.010
purine ribonucleotide catabolic process GO:0009154 208 0.010
positive regulation of reverse cholesterol transport GO:1903064 1 0.010
positive regulation of apoptotic signaling pathway GO:2001235 95 0.010
inflammatory response GO:0006954 244 0.010
vitamin metabolic process GO:0006766 23 0.010
regulation of secretion GO:0051046 274 0.010
pigmentation GO:0043473 71 0.010
regulation of leukocyte mediated immunity GO:0002703 104 0.010
cellular response to biotic stimulus GO:0071216 92 0.010

Tpp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.966
Human
inherited metabolic disorder DOID:655 0 0.966
Human
lipid storage disease DOID:9455 0 0.700
Human
lysosomal storage disease DOID:3211 0 0.700
Human
sphingolipidosis DOID:1927 0 0.700
sensory system disease DOID:0050155 0 0.059
disease of anatomical entity DOID:7 0 0.059
nervous system disease DOID:863 0 0.059
retinal disease DOID:5679 0 0.045
eye and adnexa disease DOID:1492 0 0.045
eye disease DOID:5614 0 0.045
immune system disease DOID:2914 0 0.038
central nervous system disease DOID:331 0 0.036
brain disease DOID:936 0 0.027
lymphatic system disease DOID:75 0 0.026
retinal degeneration DOID:8466 0 0.014
acquired metabolic disease DOID:0060158 0 0.013
dementia DOID:1307 0 0.013
disease of mental health DOID:150 0 0.013
cognitive disorder DOID:1561 0 0.013
bone disease DOID:0080001 0 0.011
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011
epilepsy syndrome DOID:1826 0 0.011
electroclinical syndrome DOID:0050701 0 0.011