Mus musculus

51 known processes

Scn1a

sodium channel, voltage-gated, type I, alpha

(Aliases: Nav1.1,B230332M13)

Scn1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cardiac muscle cell contraction GO:0086003 7 0.779
Mouse
ion transmembrane transport GO:0034220 361 0.720
transmembrane transport GO:0055085 412 0.634
multicellular organismal response to stress GO:0033555 62 0.622
Mouse
synaptic transmission GO:0007268 329 0.615
cation transmembrane transport GO:0098655 266 0.536
regulation of membrane depolarization GO:0003254 11 0.458
Mouse
actin filament based movement GO:0030048 23 0.447
Mouse
sa node cell action potential GO:0086015 4 0.441
Mouse
ventricular cardiac muscle cell action potential GO:0086005 4 0.417
neuromuscular process GO:0050905 99 0.413
action potential GO:0001508 78 0.391
anion transport GO:0006820 177 0.371
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.354
Mouse
regulation of actin filament based process GO:0032970 99 0.340
Mouse
regulation of synaptic plasticity GO:0048167 87 0.321
inorganic ion transmembrane transport GO:0098660 234 0.300
regulation of ion transport GO:0043269 215 0.292
metal ion homeostasis GO:0055065 189 0.280
Mouse
regulation of ion homeostasis GO:2000021 64 0.265
Mouse
regulation of response to drug GO:2001023 2 0.251
fear response GO:0042596 33 0.221
neuron neuron synaptic transmission GO:0007270 69 0.215
regulation of membrane potential GO:0042391 192 0.213
regulation of neurotransmitter levels GO:0001505 87 0.199
positive regulation of ryanodine sensitive calcium release channel activity GO:0060316 1 0.181
regulation of neuronal synaptic plasticity GO:0048168 30 0.181
cell communication involved in cardiac conduction GO:0086065 9 0.178
Mouse
cell type specific apoptotic process GO:0097285 268 0.174
Mouse
sensory perception of mechanical stimulus GO:0050954 107 0.173
Mouse
cognition GO:0050890 149 0.172
regulation of postsynaptic membrane potential GO:0060078 48 0.166
cation homeostasis GO:0055080 212 0.161
Mouse
actin mediated cell contraction GO:0070252 15 0.158
Mouse
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 12 0.148
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 12 0.148
positive regulation of cell death GO:0010942 224 0.147
cell cell signaling involved in cardiac conduction GO:0086019 6 0.144
Mouse
locomotory behavior GO:0007626 195 0.143
regulation of ion transmembrane transport GO:0034765 119 0.140
membrane organization GO:0061024 245 0.140
sodium ion transmembrane transport GO:0035725 49 0.138
divalent inorganic cation transport GO:0072511 178 0.137
cardiac muscle cell action potential GO:0086001 11 0.136
Mouse
organic anion transport GO:0015711 137 0.136
regulation of cardiac muscle cell contraction GO:0086004 11 0.124
Mouse
regulation of feeding behavior GO:0060259 3 0.123
positive regulation of cardiac muscle contraction GO:0060452 2 0.122
neurotransmitter secretion GO:0007269 62 0.120
learning GO:0007612 98 0.120
protein localization to membrane GO:0072657 108 0.119
regulation of neuron projection development GO:0010975 169 0.119
ribonucleoside triphosphate catabolic process GO:0009203 199 0.118
positive regulation of programmed cell death GO:0043068 218 0.114
av node cell to bundle of his cell communication GO:0086067 2 0.112
regulation of transmembrane transport GO:0034762 128 0.110
exocytosis GO:0006887 121 0.110
response to alkaloid GO:0043279 34 0.110
g protein coupled receptor signaling pathway GO:0007186 243 0.109
inorganic cation transmembrane transport GO:0098662 207 0.100
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 10 0.095
establishment of organelle localization GO:0051656 122 0.093
cardiac conduction GO:0061337 17 0.088
Mouse
establishment of glial blood brain barrier GO:0060857 2 0.087
transmission of nerve impulse GO:0019226 76 0.086
protein localization to juxtaparanode region of axon GO:0071205 4 0.086
sensory perception GO:0007600 245 0.084
Mouse
skin development GO:0043588 220 0.082
cellular response to organonitrogen compound GO:0071417 145 0.080
regulation of homeostatic process GO:0032844 182 0.079
Mouse
calcium mediated signaling using intracellular calcium source GO:0035584 3 0.078
adult locomotory behavior GO:0008344 91 0.076
establishment of vesicle localization GO:0051650 81 0.074
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.073
Mouse
behavioral defense response GO:0002209 28 0.071
axonogenesis GO:0007409 274 0.071
response to organonitrogen compound GO:0010243 246 0.070
vesicle localization GO:0051648 86 0.070
regulation of hydrolase activity GO:0051336 246 0.070
neuronal action potential GO:0019228 54 0.069
positive regulation of striated muscle contraction GO:0045989 3 0.069
purine ribonucleoside metabolic process GO:0046128 241 0.069
anatomical structure maturation GO:0071695 49 0.068
neuron death GO:0070997 154 0.067
Mouse
regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 2 0.066
reflex GO:0060004 22 0.065
membrane depolarization during sa node cell action potential GO:0086046 2 0.065
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.065
skeletal system development GO:0001501 356 0.064
protein localization to organelle GO:0033365 185 0.064
response to organic cyclic compound GO:0014070 198 0.064
Mouse
regulation of actin filament based movement GO:1903115 12 0.064
Mouse
endoplasmic reticulum to cytosol transport GO:1903513 12 0.064
regulation of system process GO:0044057 200 0.064
Mouse
regulation of heart rate GO:0002027 36 0.063
Mouse
learning or memory GO:0007611 148 0.063
multicellular organismal signaling GO:0035637 91 0.062
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.062
cellular ketone metabolic process GO:0042180 84 0.062
regulation of metal ion transport GO:0010959 106 0.061
telencephalon development GO:0021537 186 0.061
regulation of ion transmembrane transporter activity GO:0032412 54 0.061
regulation of organelle organization GO:0033043 289 0.060
endocytosis GO:0006897 168 0.060
membrane depolarization GO:0051899 64 0.060
Mouse
chloride transmembrane transport GO:1902476 24 0.059
positive regulation of heart rate GO:0010460 10 0.059
regulation of mapk cascade GO:0043408 248 0.058
calcium ion homeostasis GO:0055074 127 0.057
regulation of cellular component size GO:0032535 121 0.057
milk ejection GO:0060156 1 0.056
synaptic transmission glycinergic GO:0060012 2 0.056
sensory perception of sound GO:0007605 97 0.056
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.055
cellular ion homeostasis GO:0006873 165 0.054
positive regulation of ion transport GO:0043270 65 0.054
embryonic organ morphogenesis GO:0048562 276 0.053
adult behavior GO:0030534 135 0.053
regulation of muscle contraction GO:0006937 49 0.053
Mouse
nucleobase containing small molecule metabolic process GO:0055086 352 0.053
glycosyl compound metabolic process GO:1901657 246 0.053
purine ribonucleotide catabolic process GO:0009154 208 0.053
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.052
regulation of anatomical structure size GO:0090066 178 0.052
response to extracellular stimulus GO:0009991 127 0.051
cation transport GO:0006812 399 0.051
response to drug GO:0042493 75 0.051
calcium ion transport GO:0006816 159 0.050
conditioned taste aversion GO:0001661 4 0.049
regulation of transporter activity GO:0032409 57 0.049
nucleoside metabolic process GO:0009116 246 0.049
response to histamine GO:0034776 1 0.049
nerve maturation GO:0021682 1 0.048
neuromuscular process controlling posture GO:0050884 14 0.048
organelle localization GO:0051640 179 0.048
purine nucleoside metabolic process GO:0042278 241 0.048
inorganic anion transmembrane transport GO:0098661 29 0.048
cardiac muscle cell action potential involved in contraction GO:0086002 6 0.048
regulation of neurotransmitter secretion GO:0046928 29 0.047
regulation of action potential GO:0098900 4 0.047
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.047
anion transmembrane transport GO:0098656 71 0.047
cellular response to ammonium ion GO:0071242 2 0.046
nucleotide metabolic process GO:0009117 332 0.046
ossification GO:0001503 216 0.046
regulation of glutamate receptor signaling pathway GO:1900449 16 0.045
cerebellum development GO:0021549 77 0.045
neuronal action potential propagation GO:0019227 8 0.045
regulation of cellular component biogenesis GO:0044087 181 0.045
glycosyl compound catabolic process GO:1901658 206 0.044
purine nucleotide metabolic process GO:0006163 302 0.044
synaptic vesicle localization GO:0097479 59 0.044
membrane depolarization during action potential GO:0086010 5 0.044
Mouse
organonitrogen compound catabolic process GO:1901565 264 0.043
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.043
regulation of cell projection organization GO:0031344 206 0.042
regulation of nucleoside metabolic process GO:0009118 130 0.042
forebrain development GO:0030900 302 0.042
divalent metal ion transport GO:0070838 172 0.042
chloride transport GO:0006821 32 0.042
ear development GO:0043583 200 0.042
calcium ion transmembrane transport GO:0070588 85 0.042
response to oxygen levels GO:0070482 62 0.041
positive regulation of transmembrane transport GO:0034764 29 0.041
regulation of renin secretion into blood stream GO:1900133 4 0.041
protein polymerization GO:0051258 57 0.041
apoptotic signaling pathway GO:0097190 306 0.041
Mouse
regulation of cation channel activity GO:2001257 22 0.040
positive regulation of mapk cascade GO:0043410 170 0.040
establishment of synaptic vesicle localization GO:0097480 57 0.040
cellular protein complex assembly GO:0043623 116 0.040
sequestering of calcium ion GO:0051208 18 0.040
negative regulation of intracellular signal transduction GO:1902532 167 0.040
regulation of voltage gated calcium channel activity GO:1901385 4 0.039
synapse organization GO:0050808 125 0.039
negative regulation of synaptic transmission glutamatergic GO:0051967 4 0.039
regulation of heart rate by chemical signal GO:0003062 4 0.039
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.039
cell communication by electrical coupling involved in cardiac conduction GO:0086064 2 0.039
neuron migration GO:0001764 122 0.039
membrane depolarization during cardiac muscle cell action potential GO:0086012 5 0.038
Mouse
synaptic vesicle fusion to presynaptic membrane GO:0031629 3 0.038
g protein coupled receptor signaling pathway involved in heart process GO:0086103 4 0.038
regulation of cellular amino acid metabolic process GO:0006521 5 0.038
cellular homeostasis GO:0019725 240 0.038
l alpha amino acid transmembrane transport GO:1902475 23 0.038
positive regulation of nucleoside metabolic process GO:0045979 91 0.037
negative regulation of growth GO:0045926 99 0.037
sensory perception of light stimulus GO:0050953 54 0.037
protein localization to plasma membrane GO:0072659 57 0.037
endomembrane system organization GO:0010256 147 0.037
synaptic vesicle transport GO:0048489 57 0.037
foramen ovale closure GO:0035922 1 0.037
regulation of protein complex assembly GO:0043254 83 0.036
behavioral fear response GO:0001662 28 0.036
nucleoside catabolic process GO:0009164 206 0.036
positive regulation of protein modification process GO:0031401 299 0.036
cellular response to histamine GO:0071420 1 0.036
regulation of cardiac muscle contraction GO:0055117 21 0.035
Mouse
establishment of protein localization to organelle GO:0072594 118 0.035
purine nucleoside triphosphate metabolic process GO:0009144 226 0.035
cellular metal ion homeostasis GO:0006875 151 0.035
cardiac ventricle development GO:0003231 83 0.035
Mouse
wnt signaling pathway GO:0016055 188 0.035
cell junction organization GO:0034330 77 0.035
negative regulation of bone trabecula formation GO:1900155 1 0.035
heart process GO:0003015 94 0.035
Mouse
cellular chemical homeostasis GO:0055082 215 0.035
regulation of cytoskeleton organization GO:0051493 122 0.034
response to hypoxia GO:0001666 58 0.034
cellular divalent inorganic cation homeostasis GO:0072503 127 0.034
ribonucleoside triphosphate metabolic process GO:0009199 220 0.034
bone development GO:0060348 120 0.034
regulation of ryanodine sensitive calcium release channel activity GO:0060314 10 0.033
sensory perception of pain GO:0019233 47 0.033
Mouse
nitrogen compound transport GO:0071705 271 0.033
regulation of synaptic vesicle transport GO:1902803 13 0.033
cellular calcium ion homeostasis GO:0006874 119 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.033
response to amino acid GO:0043200 37 0.033
regulation of cellular ketone metabolic process GO:0010565 66 0.033
regulation of purine nucleotide catabolic process GO:0033121 122 0.033
cellular nitrogen compound catabolic process GO:0044270 280 0.032
regulation of neuron death GO:1901214 134 0.032
cellular amino acid metabolic process GO:0006520 103 0.032
epithelial tube morphogenesis GO:0060562 303 0.032
positive regulation of protein kinase activity GO:0045860 144 0.032
cellular response to organic cyclic compound GO:0071407 87 0.032
g protein coupled glutamate receptor signaling pathway GO:0007216 3 0.032
nucleoside triphosphate catabolic process GO:0009143 205 0.032
ribonucleotide catabolic process GO:0009261 208 0.031
purine nucleoside catabolic process GO:0006152 205 0.031
associative learning GO:0008306 61 0.031
cell adhesion GO:0007155 329 0.031
ribose phosphate metabolic process GO:0019693 291 0.031
purine ribonucleotide metabolic process GO:0009150 290 0.030
positive regulation of cellular catabolic process GO:0031331 148 0.030
purine containing compound metabolic process GO:0072521 311 0.030
intracellular protein transport GO:0006886 204 0.030
positive regulation of cellular amine metabolic process GO:0033240 5 0.030
negative regulation of cellular component organization GO:0051129 194 0.030
l amino acid transport GO:0015807 32 0.030
divalent inorganic cation homeostasis GO:0072507 138 0.030
myotube cell development GO:0014904 60 0.030
cytoplasmic transport GO:0016482 234 0.030
regionalization GO:0003002 337 0.029
ribonucleoside catabolic process GO:0042454 206 0.029
positive regulation of nucleotide metabolic process GO:0045981 114 0.029
positive regulation of hydrolase activity GO:0051345 148 0.029
stem cell development GO:0048864 219 0.029
sequestering of metal ion GO:0051238 19 0.029
regulation of actin cytoskeleton organization GO:0032956 84 0.029
inorganic anion transport GO:0015698 43 0.028
sa node cell to atrial cardiac muscle cell communication GO:0086070 5 0.028
Mouse
visual perception GO:0007601 52 0.028
regulation of neuron apoptotic process GO:0043523 122 0.028
cell maturation GO:0048469 127 0.028
cellular amine metabolic process GO:0044106 44 0.028
atrial ventricular junction remodeling GO:0003294 2 0.028
microtubule cytoskeleton organization GO:0000226 157 0.028
regulation of apoptotic signaling pathway GO:2001233 197 0.028
purine nucleoside triphosphate catabolic process GO:0009146 203 0.028
regulation of purine nucleotide metabolic process GO:1900542 169 0.028
heterocycle catabolic process GO:0046700 280 0.028
muscle system process GO:0003012 141 0.028
Mouse
purine nucleotide catabolic process GO:0006195 211 0.028
regulation of nucleotide metabolic process GO:0006140 169 0.027
negative regulation of neuron apoptotic process GO:0043524 92 0.027
positive regulation of high voltage gated calcium channel activity GO:1901843 1 0.027
exploration behavior GO:0035640 21 0.027
amide transport GO:0042886 138 0.027
synaptic transmission glutamatergic GO:0035249 36 0.027
positive regulation of homeostatic process GO:0032846 64 0.027
multi organism reproductive behavior GO:0044705 29 0.027
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.027
synapse assembly GO:0007416 56 0.027
stem cell differentiation GO:0048863 268 0.027
multi organism behavior GO:0051705 62 0.026
cytosolic calcium ion homeostasis GO:0051480 70 0.026
regulation of hormone levels GO:0010817 211 0.026
central nervous system neuron differentiation GO:0021953 162 0.026
digestive tract morphogenesis GO:0048546 147 0.026
positive regulation of nucleotide catabolic process GO:0030813 88 0.026
actin filament polymerization GO:0030041 44 0.026
long term synaptic potentiation GO:0060291 25 0.026
appendage morphogenesis GO:0035107 149 0.026
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 10 0.025
axon guidance GO:0007411 141 0.025
mapk cascade GO:0000165 281 0.025
calcium ion dependent exocytosis GO:0017156 35 0.025
inner ear receptor cell differentiation GO:0060113 61 0.025
membrane hyperpolarization GO:0060081 21 0.025
regulation of calcium ion transport GO:0051924 69 0.025
purine containing compound catabolic process GO:0072523 213 0.025
activation of mapkkk activity GO:0000185 1 0.024
canonical wnt signaling pathway GO:0060070 130 0.024
organic hydroxy compound metabolic process GO:1901615 203 0.024
cellular response to dna damage stimulus GO:0006974 207 0.024
memory GO:0007613 58 0.024
cardiac muscle contraction GO:0060048 32 0.024
Mouse
nucleoside phosphate catabolic process GO:1901292 222 0.024
regulation of neuron differentiation GO:0045664 281 0.024
response to ammonium ion GO:0060359 21 0.024
small gtpase mediated signal transduction GO:0007264 97 0.024
regulation of short term neuronal synaptic plasticity GO:0048172 8 0.024
digestive tract development GO:0048565 190 0.024
regulation of neurotransmitter transport GO:0051588 35 0.024
regulation of secretion GO:0051046 274 0.024
protein oligomerization GO:0051259 67 0.023
axon ensheathment GO:0008366 76 0.023
regulation of membrane depolarization during action potential GO:0098902 1 0.023
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering GO:0097113 3 0.023
activation of mapkk activity GO:0000186 15 0.023
regulation of vesicle mediated transport GO:0060627 139 0.023
regulation of proteolysis GO:0030162 164 0.023
nerve development GO:0021675 67 0.023
regulation of exocytosis GO:0017157 61 0.023
lung proximal distal axis specification GO:0061115 1 0.022
nucleotide catabolic process GO:0009166 217 0.022
epidermis development GO:0008544 187 0.022
positive regulation of cell projection organization GO:0031346 95 0.022
blood vessel morphogenesis GO:0048514 285 0.022
regulation of striated muscle contraction GO:0006942 25 0.022
Mouse
male genitalia morphogenesis GO:0048808 4 0.022
cardiac muscle hypertrophy GO:0003300 23 0.022
developmental maturation GO:0021700 193 0.021
skeletal muscle organ development GO:0060538 163 0.021
potassium ion transport GO:0006813 52 0.021
carboxylic acid transport GO:0046942 100 0.021
negative regulation of phosphorus metabolic process GO:0010563 184 0.021
terminal button organization GO:0072553 3 0.021
ras protein signal transduction GO:0007265 77 0.021
metencephalon development GO:0022037 89 0.021
microtubule polymerization or depolymerization GO:0031109 26 0.021
positive regulation of neuron projection development GO:0010976 79 0.021
cell cell junction organization GO:0045216 72 0.021
embryonic skeletal system development GO:0048706 120 0.021
intrinsic apoptotic signaling pathway GO:0097193 132 0.021
Mouse
regulation of protein kinase activity GO:0045859 232 0.021
organophosphate catabolic process GO:0046434 232 0.021
gland development GO:0048732 330 0.021
synaptic vesicle recycling GO:0036465 19 0.021
ribonucleotide metabolic process GO:0009259 291 0.021
negative regulation of cytoskeleton organization GO:0051494 36 0.021
positive regulation of cell development GO:0010720 237 0.021
carbohydrate metabolic process GO:0005975 230 0.021
dephosphorylation GO:0016311 129 0.021
negative regulation of apoptotic signaling pathway GO:2001234 104 0.021
response to calcium ion GO:0051592 20 0.020
regulation of cellular catabolic process GO:0031329 242 0.020
regulation of cytoplasmic transport GO:1903649 112 0.020
blood circulation GO:0008015 195 0.020
Mouse
oxidation reduction process GO:0055114 342 0.020
cell cell signaling involved in lung development GO:0060495 1 0.020
multicellular organism growth GO:0035264 161 0.020
skeletal muscle fiber development GO:0048741 58 0.020
female genitalia morphogenesis GO:0048807 3 0.020
glutamate receptor signaling pathway GO:0007215 35 0.020
establishment of neuroblast polarity GO:0045200 1 0.020
digestive system development GO:0055123 200 0.020
positive regulation of atpase activity GO:0032781 3 0.020
regulation of synaptic vesicle exocytosis GO:2000300 11 0.020
maintenance of location GO:0051235 89 0.020
male anatomical structure morphogenesis GO:0090598 4 0.020
vesicle organization GO:0016050 60 0.020
hormone secretion GO:0046879 128 0.020
regulation of calcium ion transport into cytosol GO:0010522 31 0.020
sodium ion transport GO:0006814 73 0.020
regulation of synaptic transmission glutamatergic GO:0051966 19 0.020
circulatory system process GO:0003013 197 0.020
Mouse
organic hydroxy compound transport GO:0015850 93 0.020
organic cyclic compound catabolic process GO:1901361 295 0.020
plasma membrane organization GO:0007009 90 0.020
negative regulation of neuron death GO:1901215 98 0.020
mechanoreceptor differentiation GO:0042490 67 0.020
regulation of synaptic vesicle fusion to presynaptic membrane GO:0031630 2 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
telencephalon cell migration GO:0022029 55 0.019
positive regulation of nervous system development GO:0051962 221 0.019
positive regulation of adenosine receptor signaling pathway GO:0060168 1 0.019
outflow tract morphogenesis GO:0003151 53 0.019
peptide secretion GO:0002790 114 0.019
embryonic limb morphogenesis GO:0030326 126 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
negative regulation of phosphorylation GO:0042326 166 0.019
organonitrogen compound biosynthetic process GO:1901566 192 0.019
response to light stimulus GO:0009416 135 0.019
regulation of peptidase activity GO:0052547 96 0.019
positive regulation of apoptotic process GO:0043065 217 0.019
cellular response to osmotic stress GO:0071470 7 0.019
Mouse
neuromuscular process controlling balance GO:0050885 59 0.019
directional locomotion GO:0033058 3 0.018
nucleoside triphosphate metabolic process GO:0009141 230 0.018
response to osmotic stress GO:0006970 21 0.018
Mouse
substantia nigra development GO:0021762 2 0.018
inner ear receptor cell development GO:0060119 39 0.018
positive regulation of transporter activity GO:0032411 17 0.018
ensheathment of neurons GO:0007272 76 0.018
response to nutrient levels GO:0031667 109 0.018
negative regulation of protein complex disassembly GO:0043242 22 0.018
cytosolic calcium ion transport GO:0060401 48 0.018
neurotransmitter transport GO:0006836 76 0.018
regulation of cell growth GO:0001558 91 0.018
regulation of nucleotide catabolic process GO:0030811 122 0.018
embryonic digit morphogenesis GO:0042733 56 0.018
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9 0.018
sensory organ morphogenesis GO:0090596 242 0.018
olfactory learning GO:0008355 2 0.018
second messenger mediated signaling GO:0019932 73 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.017
regulation of calcium ion transmembrane transport GO:1903169 20 0.017
regulation of peptide transport GO:0090087 91 0.017
positive regulation of secretion GO:0051047 130 0.017
response to inorganic substance GO:0010035 96 0.017
myotube differentiation GO:0014902 105 0.017
negative regulation of cytosolic calcium ion concentration GO:0051481 2 0.017
retina development in camera type eye GO:0060041 119 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.017
regulation of erk1 and erk2 cascade GO:0070372 71 0.017
aromatic compound catabolic process GO:0019439 286 0.017
positive regulation of neuron differentiation GO:0045666 141 0.017
positive regulation of long term neuronal synaptic plasticity GO:0048170 3 0.017
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.017
protein homooligomerization GO:0051260 43 0.017
amine metabolic process GO:0009308 45 0.017
regulation of protein depolymerization GO:1901879 26 0.016
bmp signaling pathway GO:0030509 93 0.016
defecation GO:0030421 1 0.016
membrane fusion GO:0061025 38 0.016
oocyte anterior posterior axis specification GO:0007314 2 0.016
pole plasm assembly GO:0007315 2 0.016
limb morphogenesis GO:0035108 149 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.016
microtubule based process GO:0007017 236 0.016
regulation of protein catabolic process GO:0042176 108 0.016
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.016
glutamine family amino acid biosynthetic process GO:0009084 2 0.016
camera type eye development GO:0043010 266 0.016
ear morphogenesis GO:0042471 118 0.016
clustering of voltage gated potassium channels GO:0045163 2 0.016
oocyte axis specification GO:0007309 2 0.016
nucleoside monophosphate metabolic process GO:0009123 85 0.016
regulation of intracellular transport GO:0032386 159 0.016
regulation of respiratory system process GO:0044065 13 0.016
response to acid chemical GO:0001101 111 0.016
calcium ion transport into cytosol GO:0060402 48 0.016
mesenchyme development GO:0060485 152 0.016
germ cell development GO:0007281 185 0.016
synaptic vesicle priming GO:0016082 8 0.015
cell communication by electrical coupling GO:0010644 4 0.015
engulfment of apoptotic cell GO:0043652 3 0.015
establishment or maintenance of neuroblast polarity GO:0045196 1 0.015
regulation of calcium ion transmembrane transporter activity GO:1901019 20 0.015
negative regulation of molecular function GO:0044092 258 0.015
positive regulation of ion transmembrane transport GO:0034767 24 0.015
striated muscle hypertrophy GO:0014897 24 0.015
righting reflex GO:0060013 9 0.015
gastrulation GO:0007369 116 0.015
establishment of protein localization to endoplasmic reticulum GO:0072599 2 0.015
maternal determination of anterior posterior axis embryo GO:0008358 2 0.015
lipid modification GO:0030258 65 0.015
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.015
regulation of muscle system process GO:0090257 80 0.015
Mouse
regulation of secretion by cell GO:1903530 249 0.015
transition metal ion transport GO:0000041 38 0.015
cellular response to abiotic stimulus GO:0071214 56 0.015
Mouse
hindbrain development GO:0030902 128 0.015
amino acid transport GO:0006865 61 0.015
mitochondrion organization GO:0007005 134 0.014
multi multicellular organism process GO:0044706 109 0.014
synaptic vesicle exocytosis GO:0016079 26 0.014
mitotic cell cycle process GO:1903047 159 0.014
regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 1 0.014
cell proliferation in external granule layer GO:0021924 10 0.014
response to purine containing compound GO:0014074 28 0.014
negative regulation of cell development GO:0010721 169 0.014
positive regulation of transferase activity GO:0051347 167 0.014
positive regulation of calcium ion transmembrane transporter activity GO:1901021 8 0.014
regulation of high voltage gated calcium channel activity GO:1901841 2 0.014
embryonic appendage morphogenesis GO:0035113 126 0.014
wound healing GO:0042060 157 0.014
sensory perception of touch GO:0050975 2 0.014

Scn1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.106
muscular disease DOID:0080000 0 0.106
heart disease DOID:114 0 0.106
cardiomyopathy DOID:0050700 0 0.106
disease of anatomical entity DOID:7 0 0.106
intrinsic cardiomyopathy DOID:0060036 0 0.106
cardiovascular system disease DOID:1287 0 0.106
arrhythmogenic right ventricular cardiomyopathy DOID:0050431 0 0.106
musculoskeletal system disease DOID:17 0 0.106
muscle tissue disease DOID:66 0 0.106
nervous system disease DOID:863 0 0.029
neuromuscular disease DOID:440 0 0.015
charcot marie tooth disease DOID:10595 0 0.015
neuropathy DOID:870 0 0.015
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014