Mus musculus

49 known processes

Tmc2

transmembrane channel-like gene family 2

(Aliases: CWEA2)

Tmc2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
defense response to other organism GO:0098542 197 0.421
regulation of defense response GO:0031347 233 0.219
defense response to bacterium GO:0042742 119 0.171
regulation of innate immune response GO:0045088 91 0.119
macromolecule catabolic process GO:0009057 281 0.119
leukocyte differentiation GO:0002521 342 0.095
regulation of inflammatory response GO:0050727 147 0.093
regulation of multi organism process GO:0043900 111 0.093
cellular amine metabolic process GO:0044106 44 0.090
cellular macromolecule catabolic process GO:0044265 206 0.087
regulation of cellular amine metabolic process GO:0033238 20 0.078
organophosphate biosynthetic process GO:0090407 122 0.076
immune effector process GO:0002252 321 0.076
multicellular organismal signaling GO:0035637 91 0.061
response to acid chemical GO:0001101 111 0.061
inflammatory response GO:0006954 244 0.060
organonitrogen compound biosynthetic process GO:1901566 192 0.060
cytokine production GO:0001816 319 0.059
nucleoside phosphate biosynthetic process GO:1901293 79 0.057
cation transport GO:0006812 399 0.057
positive regulation of cellular amine metabolic process GO:0033240 5 0.055
cation transmembrane transport GO:0098655 266 0.054
amine metabolic process GO:0009308 45 0.054
amino acid betaine transport GO:0015838 3 0.052
negative regulation of cellular component organization GO:0051129 194 0.052
negative regulation of cell development GO:0010721 169 0.050
positive regulation of defense response GO:0031349 124 0.050
stem cell development GO:0048864 219 0.050
negative regulation of defense response GO:0031348 77 0.049
regulation of cellular amino acid metabolic process GO:0006521 5 0.049
sensory perception of mechanical stimulus GO:0050954 107 0.048
leukocyte migration GO:0050900 124 0.048
calcium ion transport GO:0006816 159 0.048
transmembrane transport GO:0055085 412 0.047
regulation of system process GO:0044057 200 0.046
regulation of cytokine production GO:0001817 266 0.046
regulation of protein transport GO:0051223 163 0.046
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.045
positive regulation of innate immune response GO:0045089 80 0.044
regulation of establishment of protein localization GO:0070201 181 0.042
positive regulation of protein modification process GO:0031401 299 0.042
detection of chemical stimulus involved in sensory perception of taste GO:0050912 3 0.042
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.042
protein modification by small protein conjugation or removal GO:0070647 207 0.041
cell division GO:0051301 120 0.039
protein catabolic process GO:0030163 221 0.039
striated muscle tissue development GO:0014706 293 0.038
t cell activation GO:0042110 289 0.038
leukocyte mediated immunity GO:0002443 174 0.038
positive regulation of cell death GO:0010942 224 0.038
fertilization GO:0009566 127 0.038
regulation of ion transport GO:0043269 215 0.037
epithelial cell proliferation GO:0050673 174 0.037
regulation of cellular ketone metabolic process GO:0010565 66 0.036
positive regulation of nervous system development GO:0051962 221 0.036
stem cell maintenance GO:0019827 130 0.035
regulation of neuron differentiation GO:0045664 281 0.035
nucleobase containing small molecule metabolic process GO:0055086 352 0.035
protein secretion GO:0009306 111 0.035
positive regulation of cell development GO:0010720 237 0.035
positive regulation of transferase activity GO:0051347 167 0.035
embryonic skeletal system development GO:0048706 120 0.034
homeostasis of number of cells GO:0048872 210 0.034
regionalization GO:0003002 337 0.034
t cell differentiation GO:0030217 174 0.033
cellular response to lipid GO:0071396 145 0.033
regulation of cell activation GO:0050865 289 0.033
sensory perception of sound GO:0007605 97 0.033
regulation of kinase activity GO:0043549 249 0.033
axonogenesis GO:0007409 274 0.033
cellular amino acid metabolic process GO:0006520 103 0.033
regulation of cell division GO:0051302 76 0.033
defense response to gram negative bacterium GO:0050829 28 0.032
innate immune response GO:0045087 157 0.032
limb development GO:0060173 166 0.032
b cell activation GO:0042113 161 0.032
regulation of cellular component biogenesis GO:0044087 181 0.031
regulation of transferase activity GO:0051338 263 0.031
chemotaxis GO:0006935 247 0.031
negative regulation of cytokine production GO:0001818 84 0.031
nucleoside phosphate metabolic process GO:0006753 338 0.030
response to growth factor GO:0070848 198 0.030
cellular protein catabolic process GO:0044257 155 0.030
skeletal system development GO:0001501 356 0.030
regulation of cell migration GO:0030334 219 0.030
regulation of lymphocyte proliferation GO:0050670 117 0.030
developmental maturation GO:0021700 193 0.029
divalent metal ion transport GO:0070838 172 0.029
regulation of lymphocyte activation GO:0051249 240 0.029
lymphocyte proliferation GO:0046651 164 0.029
negative regulation of neuron differentiation GO:0045665 101 0.029
sequestering of metal ion GO:0051238 19 0.029
lymphocyte differentiation GO:0030098 242 0.029
cell fate commitment GO:0045165 210 0.029
cellular response to hormone stimulus GO:0032870 150 0.028
protein modification by small protein conjugation GO:0032446 187 0.028
ion transmembrane transport GO:0034220 361 0.028
ameboidal type cell migration GO:0001667 128 0.028
regulation of organelle organization GO:0033043 289 0.027
positive regulation of protein phosphorylation GO:0001934 242 0.027
negative regulation of cell activation GO:0050866 111 0.027
protein ubiquitination GO:0016567 171 0.027
defense response to virus GO:0051607 68 0.027
positive regulation of organelle organization GO:0010638 128 0.027
regulation of protein localization GO:0032880 231 0.027
regulation of angiogenesis GO:0045765 81 0.027
regulation of membrane potential GO:0042391 192 0.026
action potential GO:0001508 78 0.026
regulation of leukocyte differentiation GO:1902105 159 0.026
ear development GO:0043583 200 0.026
neuronal action potential GO:0019228 54 0.026
epidermis development GO:0008544 187 0.026
cell maturation GO:0048469 127 0.026
negative regulation of immune system process GO:0002683 209 0.026
positive regulation of mapk cascade GO:0043410 170 0.025
regulation of interleukin 6 production GO:0032675 55 0.025
fat cell differentiation GO:0045444 160 0.025
positive regulation of cell cycle process GO:0090068 61 0.025
muscle contraction GO:0006936 101 0.024
hematopoietic progenitor cell differentiation GO:0002244 143 0.024
cellular ketone metabolic process GO:0042180 84 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.024
b cell differentiation GO:0030183 78 0.024
muscle tissue development GO:0060537 308 0.024
appendage development GO:0048736 166 0.024
purine containing compound metabolic process GO:0072521 311 0.024
positive regulation of programmed cell death GO:0043068 218 0.023
sensory perception GO:0007600 245 0.023
regulation of t cell activation GO:0050863 170 0.023
blood circulation GO:0008015 195 0.023
g protein coupled receptor signaling pathway GO:0007186 243 0.023
modification dependent protein catabolic process GO:0019941 133 0.022
interspecies interaction between organisms GO:0044419 83 0.022
cellular response to cytokine stimulus GO:0071345 189 0.022
defense response to gram positive bacterium GO:0050830 50 0.022
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.022
stem cell differentiation GO:0048863 268 0.022
regulation of organ morphogenesis GO:2000027 144 0.021
purine nucleotide biosynthetic process GO:0006164 65 0.021
carbohydrate derivative biosynthetic process GO:1901137 183 0.021
cellular nitrogen compound catabolic process GO:0044270 280 0.021
gland development GO:0048732 330 0.020
protein localization to organelle GO:0033365 185 0.020
inner ear receptor cell differentiation GO:0060113 61 0.020
cell fate specification GO:0001708 72 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.020
divalent inorganic cation transport GO:0072511 178 0.020
negative regulation of nlrp3 inflammasome complex assembly GO:1900226 2 0.020
regulation of purine nucleotide metabolic process GO:1900542 169 0.020
response to lipopolysaccharide GO:0032496 128 0.020
regulation of cell projection organization GO:0031344 206 0.020
regulation of response to wounding GO:1903034 189 0.019
transmission of nerve impulse GO:0019226 76 0.019
regulation of mapk cascade GO:0043408 248 0.019
tissue homeostasis GO:0001894 115 0.019
axon guidance GO:0007411 141 0.019
regulation of tumor necrosis factor production GO:0032680 49 0.019
regulation of cell motility GO:2000145 236 0.019
skeletal muscle organ development GO:0060538 163 0.019
peptidyl tyrosine modification GO:0018212 145 0.019
lymphocyte homeostasis GO:0002260 64 0.019
positive regulation of protein kinase activity GO:0045860 144 0.019
cellular protein complex assembly GO:0043623 116 0.019
positive regulation of epithelial cell proliferation GO:0050679 68 0.019
purine nucleotide metabolic process GO:0006163 302 0.019
regulation of ion transmembrane transport GO:0034765 119 0.019
mapk cascade GO:0000165 281 0.019
regulation of secretion GO:0051046 274 0.018
positive regulation of cytokine production GO:0001819 174 0.018
bundle of his development GO:0003166 4 0.018
morphogenesis of a branching structure GO:0001763 203 0.018
circulatory system process GO:0003013 197 0.018
nuclear transport GO:0051169 139 0.018
regulation of transmembrane transport GO:0034762 128 0.018
limb morphogenesis GO:0035108 149 0.018
midgut development GO:0007494 4 0.018
neuron migration GO:0001764 122 0.018
heart contraction GO:0060047 93 0.018
mechanoreceptor differentiation GO:0042490 67 0.018
protein maturation GO:0051604 176 0.018
inorganic ion transmembrane transport GO:0098660 234 0.017
embryonic organ morphogenesis GO:0048562 276 0.017
purine containing compound biosynthetic process GO:0072522 70 0.017
organic hydroxy compound metabolic process GO:1901615 203 0.017
neuron projection guidance GO:0097485 141 0.017
positive regulation of chemotaxis GO:0050921 38 0.017
dna modification GO:0006304 50 0.017
cytoplasmic transport GO:0016482 234 0.017
muscle system process GO:0003012 141 0.017
wound healing GO:0042060 157 0.017
viral gene expression GO:0019080 3 0.017
metanephric loop of henle development GO:0072236 4 0.017
organelle fission GO:0048285 170 0.017
regulation of cell cycle GO:0051726 281 0.016
regulation of cellular response to stress GO:0080135 159 0.016
immune response regulating signaling pathway GO:0002764 125 0.016
myeloid cell differentiation GO:0030099 233 0.016
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.016
ribose phosphate metabolic process GO:0019693 291 0.016
ventral spinal cord interneuron fate commitment GO:0060579 14 0.016
camera type eye development GO:0043010 266 0.016
negative regulation of molecular function GO:0044092 258 0.016
odontogenesis of dentin containing tooth GO:0042475 66 0.016
ubiquitin dependent protein catabolic process GO:0006511 129 0.016
intracellular protein transport GO:0006886 204 0.016
positive regulation of protein transport GO:0051222 93 0.016
regulation of epithelial cell proliferation GO:0050678 141 0.016
diencephalon development GO:0021536 63 0.016
ribonucleotide biosynthetic process GO:0009260 59 0.016
endocytosis GO:0006897 168 0.016
memory GO:0007613 58 0.016
nucleotide biosynthetic process GO:0009165 78 0.016
anatomical structure homeostasis GO:0060249 145 0.016
viral transcription GO:0019083 3 0.015
reactive oxygen species metabolic process GO:0072593 84 0.015
entry into cell of other organism involved in symbiotic interaction GO:0051806 15 0.015
immune response activating signal transduction GO:0002757 116 0.015
response to oxygen levels GO:0070482 62 0.015
myeloid leukocyte differentiation GO:0002573 119 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
antimicrobial peptide biosynthetic process GO:0002777 2 0.015
regulation of leukocyte proliferation GO:0070663 121 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.015
regulation of action potential GO:0098900 4 0.015
cellular amide metabolic process GO:0043603 58 0.015
female gamete generation GO:0007292 74 0.015
innate immune response activating signal transduction GO:0002758 50 0.015
negative regulation of inflammatory response GO:0050728 61 0.015
blood vessel morphogenesis GO:0048514 285 0.015
positive regulation of cell division GO:0051781 31 0.014
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.014
apoptotic signaling pathway GO:0097190 306 0.014
response to molecule of bacterial origin GO:0002237 143 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
positive regulation of glial cell differentiation GO:0045687 21 0.014
antimicrobial peptide production GO:0002775 2 0.014
rna processing GO:0006396 105 0.014
myelination GO:0042552 74 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
positive regulation of immune effector process GO:0002699 107 0.014
response to organonitrogen compound GO:0010243 246 0.014
production of molecular mediator of immune response GO:0002440 103 0.014
spinal cord development GO:0021510 81 0.014
interleukin 6 production GO:0032635 58 0.014
regulation of protein complex assembly GO:0043254 83 0.014
tumor necrosis factor production GO:0032640 50 0.014
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure GO:0001988 1 0.014
proteasomal protein catabolic process GO:0010498 98 0.014
axon ensheathment GO:0008366 76 0.014
carbohydrate transport GO:0008643 62 0.014
regulation of protein kinase activity GO:0045859 232 0.014
angiogenesis GO:0001525 201 0.014
regulation of body fluid levels GO:0050878 162 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
odontogenesis GO:0042476 78 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
regulation of nlrp3 inflammasome complex assembly GO:1900225 4 0.013
activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 3 0.013
positive regulation of viral entry into host cell GO:0046598 3 0.013
response to extracellular stimulus GO:0009991 127 0.013
protein import into nucleus GO:0006606 95 0.013
sensory organ morphogenesis GO:0090596 242 0.013
positive regulation of kinase activity GO:0033674 155 0.013
digestive tract development GO:0048565 190 0.013
negative regulation of nervous system development GO:0051961 156 0.013
regulation of b cell activation GO:0050864 81 0.013
mesodermal cell migration GO:0008078 4 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
oligodendrocyte differentiation GO:0048709 53 0.013
membrane organization GO:0061024 245 0.013
b cell activation involved in immune response GO:0002312 50 0.013
ensheathment of neurons GO:0007272 76 0.013
regulation of t cell differentiation GO:0045580 83 0.013
wnt signaling pathway GO:0016055 188 0.013
placenta development GO:0001890 140 0.013
regulation of muscle tissue development GO:1901861 97 0.013
regulation of nucleotide metabolic process GO:0006140 169 0.013
morphogenesis of a branching epithelium GO:0061138 193 0.013
development of primary male sexual characteristics GO:0046546 88 0.013
regulation of saliva secretion GO:0046877 2 0.013
sequestering of calcium ion GO:0051208 18 0.013
leukocyte proliferation GO:0070661 172 0.013
respiratory gaseous exchange GO:0007585 43 0.013
regulation of chemotaxis GO:0050920 53 0.013
rhythmic process GO:0048511 174 0.013
stem cell proliferation GO:0072089 117 0.013
paramesonephric duct development GO:0061205 3 0.013
male sex differentiation GO:0046661 109 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
astrocyte fate commitment GO:0060018 4 0.013
single fertilization GO:0007338 82 0.013
sodium ion transport GO:0006814 73 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.012
mitotic cell cycle process GO:1903047 159 0.012
lymphocyte activation involved in immune response GO:0002285 93 0.012
limbic system development GO:0021761 72 0.012
negative regulation of immune effector process GO:0002698 55 0.012
cell activation involved in immune response GO:0002263 126 0.012
positive regulation of nuclear division GO:0051785 27 0.012
regulation of vasculature development GO:1901342 88 0.012
chromatin organization GO:0006325 206 0.012
detection of external stimulus GO:0009581 61 0.012
protein import GO:0017038 101 0.012
germ cell development GO:0007281 185 0.012
cytokine metabolic process GO:0042107 71 0.012
glycosyl compound metabolic process GO:1901657 246 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
lateral inhibition GO:0046331 1 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
positive regulation of atpase activity GO:0032781 3 0.012
skin development GO:0043588 220 0.012
engulfment of apoptotic cell GO:0043652 3 0.012
nucleotide metabolic process GO:0009117 332 0.012
forebrain development GO:0030900 302 0.012
regulation of antimicrobial humoral response GO:0002759 3 0.012
cyclic nucleotide biosynthetic process GO:0009190 44 0.012
regulation of muscle system process GO:0090257 80 0.012
negative regulation of viral transcription GO:0032897 3 0.012
adaptive immune response GO:0002250 155 0.012
nuclear division GO:0000280 158 0.012
positive regulation of dopamine secretion GO:0033603 2 0.012
purine containing compound catabolic process GO:0072523 213 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
regulation of neural precursor cell proliferation GO:2000177 70 0.012
regulation of acetylcholine secretion neurotransmission GO:0014056 2 0.012
entry into host cell GO:0030260 15 0.011
negative regulation of multi organism process GO:0043901 68 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
regulation of cellular catabolic process GO:0031329 242 0.011
regulation of myeloid leukocyte differentiation GO:0002761 58 0.011
activation of adenylate cyclase activity GO:0007190 4 0.011
positive regulation of nucleotide metabolic process GO:0045981 114 0.011
ribonucleotide metabolic process GO:0009259 291 0.011
regulation of t cell proliferation GO:0042129 92 0.011
synaptic transmission involved in micturition GO:0060084 3 0.011
detection of stimulus involved in sensory perception GO:0050906 44 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
regulation of cell cycle process GO:0010564 160 0.011
response to peptide GO:1901652 136 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
regulation of cytokine secretion GO:0050707 61 0.011
heterocycle catabolic process GO:0046700 280 0.011
compound eye development GO:0048749 1 0.011
striated muscle cell development GO:0055002 125 0.011
purine nucleoside metabolic process GO:0042278 241 0.011
regulation of hydrolase activity GO:0051336 246 0.011
locomotory behavior GO:0007626 195 0.011
positive regulation of viral genome replication GO:0045070 2 0.011
positive regulation of cell activation GO:0050867 158 0.011
detection of abiotic stimulus GO:0009582 60 0.011
mesenchyme development GO:0060485 152 0.011
asymmetric stem cell division GO:0098722 3 0.011
negative regulation of hydrolase activity GO:0051346 71 0.011
multi multicellular organism process GO:0044706 109 0.011
visceral motor neuron differentiation GO:0021524 3 0.011
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.011
regulation of circadian sleep wake cycle GO:0042749 3 0.011
synapse organization GO:0050808 125 0.011
protein processing GO:0016485 163 0.011
body morphogenesis GO:0010171 45 0.011
retina development in camera type eye GO:0060041 119 0.011
gonad development GO:0008406 141 0.011
small gtpase mediated signal transduction GO:0007264 97 0.011
activation of immune response GO:0002253 138 0.011
telencephalon development GO:0021537 186 0.011
neural tube formation GO:0001841 108 0.011
mitotic cell cycle GO:0000278 195 0.011
heart morphogenesis GO:0003007 178 0.011
t cell differentiation in thymus GO:0033077 77 0.011
regulation of viral transcription GO:0046782 3 0.010
dendrite development GO:0016358 115 0.010
regulation of interleukin 8 production GO:0032677 3 0.010
positive regulation of stem cell proliferation GO:2000648 59 0.010
response to decreased oxygen levels GO:0036293 59 0.010
metencephalon development GO:0022037 89 0.010
regulation of actin filament based process GO:0032970 99 0.010
developmental growth involved in morphogenesis GO:0060560 138 0.010
central nervous system projection neuron axonogenesis GO:0021952 21 0.010
negative regulation of action potential GO:0045759 1 0.010
positive regulation of cell motility GO:2000147 116 0.010
regulation of nucleotide catabolic process GO:0030811 122 0.010
positive regulation of cell cycle GO:0045787 92 0.010
regulation of apoptotic signaling pathway GO:2001233 197 0.010
biomineral tissue development GO:0031214 64 0.010
pattern recognition receptor signaling pathway GO:0002221 47 0.010
specification of organ identity GO:0010092 30 0.010
positive regulation of interleukin 12 production GO:0032735 21 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.010
protein localization to nucleus GO:0034504 121 0.010
conditioned taste aversion GO:0001661 4 0.010
negative regulation of leukocyte mediated immunity GO:0002704 29 0.010
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.010

Tmc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
gastrointestinal system disease DOID:77 0 0.024
disease of cellular proliferation DOID:14566 0 0.022
bone disease DOID:0080001 0 0.017
musculoskeletal system disease DOID:17 0 0.017
connective tissue disease DOID:65 0 0.017
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
nervous system disease DOID:863 0 0.012
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011