Mus musculus

142 known processes

Sh2d1b2

SH2 domain protein 1B2

(Aliases: Ert,EAT-2B,Sh2d1c,Eat2b)

Sh2d1b2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular amine metabolic process GO:0033238 20 0.120
cytokine production GO:0001816 319 0.107
amine metabolic process GO:0009308 45 0.107
regulation of secretion GO:0051046 274 0.089
t cell activation GO:0042110 289 0.088
positive regulation of cellular amine metabolic process GO:0033240 5 0.075
cellular amino acid metabolic process GO:0006520 103 0.074
cation transport GO:0006812 399 0.068
sensory perception GO:0007600 245 0.067
positive regulation of secretion GO:0051047 130 0.062
leukocyte activation involved in immune response GO:0002366 126 0.062
Mouse
cellular amine metabolic process GO:0044106 44 0.061
regulation of leukocyte mediated immunity GO:0002703 104 0.060
cellular response to biotic stimulus GO:0071216 92 0.052
anion transport GO:0006820 177 0.051
innate immune response GO:0045087 157 0.049
immune effector process GO:0002252 321 0.049
positive regulation of innate immune response GO:0045089 80 0.048
membrane organization GO:0061024 245 0.047
detection of fungus GO:0016046 2 0.046
cellular response to lipopolysaccharide GO:0071222 77 0.044
macromolecule catabolic process GO:0009057 281 0.044
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.043
reactive oxygen species metabolic process GO:0072593 84 0.043
negative regulation of immune system process GO:0002683 209 0.042
regulation of defense response GO:0031347 233 0.041
regulation of cytokine production GO:0001817 266 0.040
regulation of cellular amino acid metabolic process GO:0006521 5 0.040
ion transmembrane transport GO:0034220 361 0.040
response to molecule of bacterial origin GO:0002237 143 0.039
divalent inorganic cation transport GO:0072511 178 0.039
cell adhesion GO:0007155 329 0.039
regulation of cellular ketone metabolic process GO:0010565 66 0.038
leukocyte differentiation GO:0002521 342 0.037
sequestering of calcium ion GO:0051208 18 0.037
reactive oxygen species biosynthetic process GO:1903409 8 0.036
g protein coupled receptor signaling pathway GO:0007186 243 0.036
regulation of lymphocyte activation GO:0051249 240 0.036
mapk cascade GO:0000165 281 0.036
regulation of organelle organization GO:0033043 289 0.035
regulation of cell activation GO:0050865 289 0.035
immune response regulating signaling pathway GO:0002764 125 0.035
cation transmembrane transport GO:0098655 266 0.035
nucleotide metabolic process GO:0009117 332 0.035
positive regulation of immune effector process GO:0002699 107 0.034
divalent metal ion transport GO:0070838 172 0.033
detection of yeast GO:0001879 2 0.033
cellular response to lipid GO:0071396 145 0.033
detection of stimulus GO:0051606 84 0.033
oxidation reduction process GO:0055114 342 0.033
synaptic transmission GO:0007268 329 0.033
response to molecule of fungal origin GO:0002238 4 0.033
cell activation involved in immune response GO:0002263 126 0.033
Mouse
protein secretion GO:0009306 111 0.032
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.032
natural killer cell activation GO:0030101 44 0.032
cellular response to molecule of bacterial origin GO:0071219 83 0.032
transmembrane transport GO:0055085 412 0.032
regulation of system process GO:0044057 200 0.031
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.031
reactive nitrogen species metabolic process GO:2001057 0 0.031
epithelial tube morphogenesis GO:0060562 303 0.029
positive regulation of defense response GO:0031349 124 0.029
regulation of cell cycle GO:0051726 281 0.029
regulation of response to wounding GO:1903034 189 0.029
regulation of secretion by cell GO:1903530 249 0.028
regulation of protein localization GO:0032880 231 0.028
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.028
activation of immune response GO:0002253 138 0.028
protein catabolic process GO:0030163 221 0.028
b cell activation GO:0042113 161 0.028
cellular ketone metabolic process GO:0042180 84 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
nucleobase containing small molecule metabolic process GO:0055086 352 0.028
regulation of ion homeostasis GO:2000021 64 0.027
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.027
regulation of ion transport GO:0043269 215 0.027
negative regulation of intracellular signal transduction GO:1902532 167 0.027
apoptotic signaling pathway GO:0097190 306 0.026
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.026
leukocyte mediated cytotoxicity GO:0001909 62 0.026
regulation of innate immune response GO:0045088 91 0.026
skeletal system development GO:0001501 356 0.026
regulation of reactive oxygen species metabolic process GO:2000377 40 0.026
response to acid chemical GO:0001101 111 0.026
alcohol metabolic process GO:0006066 116 0.025
regulation of protein secretion GO:0050708 82 0.025
response to organonitrogen compound GO:0010243 246 0.025
inorganic ion transmembrane transport GO:0098660 234 0.024
negative regulation of immune effector process GO:0002698 55 0.024
regulation of wnt signaling pathway GO:0030111 123 0.024
response to drug GO:0042493 75 0.024
regulation of membrane potential GO:0042391 192 0.024
cellular response to dna damage stimulus GO:0006974 207 0.023
cellular response to organonitrogen compound GO:0071417 145 0.023
regulation of establishment of protein localization GO:0070201 181 0.023
organic hydroxy compound metabolic process GO:1901615 203 0.023
response to organic cyclic compound GO:0014070 198 0.023
negative regulation of cellular component organization GO:0051129 194 0.023
ras protein signal transduction GO:0007265 77 0.023
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.023
regulation of apoptotic signaling pathway GO:2001233 197 0.022
wnt signaling pathway GO:0016055 188 0.022
dna metabolic process GO:0006259 303 0.022
peptidyl amino acid modification GO:0018193 336 0.022
response to lipopolysaccharide GO:0032496 128 0.022
positive regulation of protein transport GO:0051222 93 0.022
regulation of actin filament based process GO:0032970 99 0.022
small gtpase mediated signal transduction GO:0007264 97 0.022
sensory perception of chemical stimulus GO:0007606 51 0.021
interferon gamma production GO:0032609 67 0.021
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.021
inorganic cation transmembrane transport GO:0098662 207 0.021
regulation of lymphocyte mediated immunity GO:0002706 84 0.021
leukocyte mediated immunity GO:0002443 174 0.021
natural killer cell mediated cytotoxicity GO:0042267 29 0.021
immune response activating signal transduction GO:0002757 116 0.021
regulation of vesicle mediated transport GO:0060627 139 0.021
regulation of mapk cascade GO:0043408 248 0.021
lymphocyte activation involved in immune response GO:0002285 93 0.021
circulatory system process GO:0003013 197 0.020
organonitrogen compound catabolic process GO:1901565 264 0.020
cellular response to acid chemical GO:0071229 68 0.020
positive regulation of leukocyte mediated immunity GO:0002705 70 0.020
cellular lipid metabolic process GO:0044255 323 0.020
negative regulation of cell proliferation GO:0008285 296 0.020
regulation of hydrolase activity GO:0051336 246 0.020
response to growth factor GO:0070848 198 0.020
nucleoside phosphate metabolic process GO:0006753 338 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.020
sequestering of metal ion GO:0051238 19 0.020
lymphocyte proliferation GO:0046651 164 0.020
cation homeostasis GO:0055080 212 0.020
single organism cell adhesion GO:0098602 156 0.020
purine containing compound metabolic process GO:0072521 311 0.020
exocytosis GO:0006887 121 0.019
defense response to bacterium GO:0042742 119 0.019
regulation of angiotensin levels in blood GO:0002002 4 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
carboxylic acid transport GO:0046942 100 0.019
positive regulation of secretion by cell GO:1903532 114 0.019
endocytosis GO:0006897 168 0.019
leukocyte proliferation GO:0070661 172 0.019
negative regulation of phosphorus metabolic process GO:0010563 184 0.018
transmission of nerve impulse GO:0019226 76 0.018
regulation of anatomical structure size GO:0090066 178 0.018
negative regulation of protein metabolic process GO:0051248 282 0.018
myeloid cell differentiation GO:0030099 233 0.018
sensory perception of mechanical stimulus GO:0050954 107 0.018
positive regulation of cytokine production GO:0001819 174 0.018
striated muscle tissue development GO:0014706 293 0.018
positive regulation of protein modification process GO:0031401 299 0.018
regulation of cellular catabolic process GO:0031329 242 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.018
muscle contraction GO:0006936 101 0.018
protein maturation GO:0051604 176 0.018
cellular divalent inorganic cation homeostasis GO:0072503 127 0.018
purine ribonucleotide metabolic process GO:0009150 290 0.018
inflammatory response GO:0006954 244 0.018
regulation of blood pressure GO:0008217 93 0.018
organophosphate catabolic process GO:0046434 232 0.018
ribose phosphate metabolic process GO:0019693 291 0.018
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.017
purine nucleotide metabolic process GO:0006163 302 0.017
detection of chemical stimulus involved in sensory perception of taste GO:0050912 3 0.017
positive regulation of cell death GO:0010942 224 0.017
regulation of b cell activation GO:0050864 81 0.017
transepithelial chloride transport GO:0030321 4 0.017
multicellular organismal homeostasis GO:0048871 164 0.017
alpha beta t cell activation GO:0046631 91 0.017
negative regulation of defense response GO:0031348 77 0.017
ribonucleotide metabolic process GO:0009259 291 0.017
compound eye development GO:0048749 1 0.017
calcium ion homeostasis GO:0055074 127 0.017
ear development GO:0043583 200 0.017
positive regulation of nervous system development GO:0051962 221 0.017
calcium ion transport GO:0006816 159 0.017
blood vessel morphogenesis GO:0048514 285 0.017
negative regulation of growth GO:0045926 99 0.017
glycosyl compound metabolic process GO:1901657 246 0.017
organic anion transport GO:0015711 137 0.016
innate immune response activating signal transduction GO:0002758 50 0.016
pattern recognition receptor signaling pathway GO:0002221 47 0.016
t cell differentiation GO:0030217 174 0.016
cellular alcohol biosynthetic process GO:0044108 3 0.016
lymphocyte mediated immunity GO:0002449 139 0.016
positive regulation of apoptotic process GO:0043065 217 0.016
regulation of cellular component biogenesis GO:0044087 181 0.016
activation of innate immune response GO:0002218 56 0.016
regulation of leukocyte proliferation GO:0070663 121 0.016
blood circulation GO:0008015 195 0.016
cellular calcium ion homeostasis GO:0006874 119 0.016
rho protein signal transduction GO:0007266 32 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
negative regulation of cell activation GO:0050866 111 0.015
negative regulation of cellular amine metabolic process GO:0033239 1 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.015
regulation of homeostatic process GO:0032844 182 0.015
cellular protein catabolic process GO:0044257 155 0.015
endodermal cell fate specification GO:0001714 4 0.015
action potential GO:0001508 78 0.015
response to inorganic substance GO:0010035 96 0.015
protein localization to organelle GO:0033365 185 0.015
positive regulation of interleukin 8 production GO:0032757 2 0.015
morphogenesis of a branching structure GO:0001763 203 0.015
regulation of cell migration GO:0030334 219 0.015
muscle tissue development GO:0060537 308 0.015
regulation of proteolysis GO:0030162 164 0.015
purine ribonucleoside metabolic process GO:0046128 241 0.015
aromatic compound catabolic process GO:0019439 286 0.015
cell killing GO:0001906 67 0.015
placenta development GO:0001890 140 0.015
nucleoside phosphate catabolic process GO:1901292 222 0.015
cytoplasmic transport GO:0016482 234 0.015
nuclear division GO:0000280 158 0.015
negative regulation of phosphate metabolic process GO:0045936 184 0.015
purine nucleoside triphosphate metabolic process GO:0009144 226 0.015
phagocytosis GO:0006909 66 0.015
cell type specific apoptotic process GO:0097285 268 0.015
regulation of cytokine secretion GO:0050707 61 0.014
adaptive immune response GO:0002250 155 0.014
digestive tract development GO:0048565 190 0.014
anatomical structure homeostasis GO:0060249 145 0.014
regulation of action potential GO:0098900 4 0.014
regulation of cell cycle process GO:0010564 160 0.014
organic cyclic compound catabolic process GO:1901361 295 0.014
purine nucleotide catabolic process GO:0006195 211 0.014
positive regulation of cell killing GO:0031343 33 0.014
camera type eye development GO:0043010 266 0.014
single organismal cell cell adhesion GO:0016337 131 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.014
positive regulation of hydrolase activity GO:0051345 148 0.014
cellular homeostasis GO:0019725 240 0.014
response to radiation GO:0009314 165 0.014
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.014
regulation of neurotransmitter levels GO:0001505 87 0.014
b cell differentiation GO:0030183 78 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.014
negative regulation of cytokine production GO:0001818 84 0.014
regulation of lymphocyte proliferation GO:0050670 117 0.014
negative regulation of cell development GO:0010721 169 0.014
multicellular organismal signaling GO:0035637 91 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
alcohol biosynthetic process GO:0046165 43 0.013
negative regulation of molecular function GO:0044092 258 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
actin filament organization GO:0007015 113 0.013
embryonic placenta development GO:0001892 98 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
negative regulation of secretion GO:0051048 61 0.013
mitotic cell cycle process GO:1903047 159 0.013
cellular alcohol metabolic process GO:0044107 3 0.013
cartilage development GO:0051216 140 0.013
striated muscle contraction GO:0006941 45 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
cellular macromolecule catabolic process GO:0044265 206 0.013
regulation of transferase activity GO:0051338 263 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
nitrogen compound transport GO:0071705 271 0.013
regulation of protein catabolic process GO:0042176 108 0.013
purine nucleoside triphosphate catabolic process GO:0009146 203 0.013
stem cell differentiation GO:0048863 268 0.013
positive regulation of cell development GO:0010720 237 0.013
nucleoside metabolic process GO:0009116 246 0.013
metal ion homeostasis GO:0055065 189 0.013
vesicle organization GO:0016050 60 0.013
peptidyl tyrosine phosphorylation GO:0018108 143 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
positive regulation of neuron projection development GO:0010976 79 0.013
regulation of cellular response to stress GO:0080135 159 0.013
cellular chemical homeostasis GO:0055082 215 0.013
ossification GO:0001503 216 0.013
calcium ion transmembrane transport GO:0070588 85 0.013
regulation of interferon gamma production GO:0032649 57 0.013
i kappab kinase nf kappab signaling GO:0007249 85 0.013
cytokine secretion GO:0050663 72 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
modification dependent protein catabolic process GO:0019941 133 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
regulation of neuron differentiation GO:0045664 281 0.013
axonogenesis GO:0007409 274 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.013
regulation of cytoskeleton organization GO:0051493 122 0.013
mitotic cell cycle GO:0000278 195 0.013
regulation of interferon beta biosynthetic process GO:0045357 4 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
negative regulation of t cell activation GO:0050868 65 0.012
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.012
cellular response to organic cyclic compound GO:0071407 87 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
cellular response to molecule of fungal origin GO:0071226 2 0.012
chemotaxis GO:0006935 247 0.012
protein processing GO:0016485 163 0.012
modification dependent macromolecule catabolic process GO:0043632 133 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
connective tissue development GO:0061448 179 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
detection of external stimulus GO:0009581 61 0.012
lipid transport GO:0006869 98 0.012
myeloid leukocyte activation GO:0002274 83 0.012
negative regulation of lymphocyte activation GO:0051250 91 0.012
humoral immune response GO:0006959 57 0.012
Mouse
fat cell differentiation GO:0045444 160 0.012
amino acid transport GO:0006865 61 0.012
regulation of cell killing GO:0031341 40 0.012
ribonucleoside triphosphate metabolic process GO:0009199 220 0.012
organelle assembly GO:0070925 177 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
regulation of cell projection organization GO:0031344 206 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.012
regulation of endocytosis GO:0030100 69 0.012
lymphocyte differentiation GO:0030098 242 0.012
cellular nitrogen compound catabolic process GO:0044270 280 0.012
appendage development GO:0048736 166 0.012
purine nucleoside metabolic process GO:0042278 241 0.012
regulation of interleukin 8 production GO:0032677 3 0.012
membrane fusion GO:0061025 38 0.012
neurotransmitter transport GO:0006836 76 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
cellular ion homeostasis GO:0006873 165 0.011
nucleotide catabolic process GO:0009166 217 0.011
nucleoside catabolic process GO:0009164 206 0.011
neural tube development GO:0021915 160 0.011
homeostasis of number of cells GO:0048872 210 0.011
monocarboxylic acid metabolic process GO:0032787 191 0.011
positive regulation of interleukin 18 production GO:0032741 2 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
digestive tract morphogenesis GO:0048546 147 0.011
cellularization GO:0007349 1 0.011
cardiac chamber morphogenesis GO:0003206 93 0.011
positive regulation of endocytosis GO:0045807 42 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
protein localization to nucleus GO:0034504 121 0.011
glycosyl compound catabolic process GO:1901658 206 0.011
extracellular matrix organization GO:0030198 147 0.011
purine nucleoside catabolic process GO:0006152 205 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
plasma membrane organization GO:0007009 90 0.011
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.011
regulation of neuron projection development GO:0010975 169 0.011
detection of abiotic stimulus GO:0009582 60 0.011
regulation of canonical wnt signaling pathway GO:0060828 82 0.011
germ cell development GO:0007281 185 0.011
oocyte construction GO:0007308 2 0.011
erk1 and erk2 cascade GO:0070371 77 0.011
cofactor metabolic process GO:0051186 80 0.011
synapse organization GO:0050808 125 0.011
chloride transport GO:0006821 32 0.011
regulation of erk1 and erk2 cascade GO:0070372 71 0.011
regulation of cell motility GO:2000145 236 0.011
lipid biosynthetic process GO:0008610 179 0.011
epidermis development GO:0008544 187 0.011
regulation of body fluid levels GO:0050878 162 0.011
maintenance of location GO:0051235 89 0.011
organelle fission GO:0048285 170 0.011
meiotic nuclear division GO:0007126 115 0.011
forebrain development GO:0030900 302 0.011
regulation of actin cytoskeleton organization GO:0032956 84 0.011
ubiquitin dependent protein catabolic process GO:0006511 129 0.010
tissue homeostasis GO:0001894 115 0.010
regulation of blood circulation GO:1903522 93 0.010
embryonic organ morphogenesis GO:0048562 276 0.010
sulfur compound metabolic process GO:0006790 100 0.010
response to light stimulus GO:0009416 135 0.010
ribonucleotide catabolic process GO:0009261 208 0.010
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
defense response to other organism GO:0098542 197 0.010
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.010
organ growth GO:0035265 117 0.010
positive regulation of protein oligomerization GO:0032461 4 0.010
positive regulation of neuron differentiation GO:0045666 141 0.010
stem cell development GO:0048864 219 0.010
purine ribonucleotide catabolic process GO:0009154 208 0.010
cell growth GO:0016049 130 0.010
production of molecular mediator of immune response GO:0002440 103 0.010
carbohydrate metabolic process GO:0005975 230 0.010
regulation of angiotensin metabolic process GO:0060177 4 0.010
hormone secretion GO:0046879 128 0.010
proteasomal protein catabolic process GO:0010498 98 0.010
small molecule biosynthetic process GO:0044283 132 0.010
muscle cell differentiation GO:0042692 261 0.010
heterocycle catabolic process GO:0046700 280 0.010
developmental growth involved in morphogenesis GO:0060560 138 0.010
regulation of cell adhesion GO:0030155 154 0.010
regulation of transmembrane transport GO:0034762 128 0.010
single fertilization GO:0007338 82 0.010
regulation of t cell proliferation GO:0042129 92 0.010
tissue remodeling GO:0048771 102 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.010

Sh2d1b2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019
sensory system disease DOID:0050155 0 0.014
connective tissue disease DOID:65 0 0.013
musculoskeletal system disease DOID:17 0 0.013
disease of metabolism DOID:0014667 0 0.012
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
eye and adnexa disease DOID:1492 0 0.011
bone disease DOID:0080001 0 0.011
inherited metabolic disorder DOID:655 0 0.010