Mus musculus

122 known processes

Pcsk9

proprotein convertase subtilisin/kexin type 9

(Aliases: PC9,AI747682,MGC47409,HCHOLA3,Narc1,FH3,AI415265)

Pcsk9 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane transport GO:0055085 412 0.114
amine metabolic process GO:0009308 45 0.099
ion transmembrane transport GO:0034220 361 0.093
cellular amino acid metabolic process GO:0006520 103 0.086
cellular ketone metabolic process GO:0042180 84 0.078
regulation of cellular amine metabolic process GO:0033238 20 0.078
apoptotic signaling pathway GO:0097190 306 0.076
regulation of cellular amino acid metabolic process GO:0006521 5 0.074
skeletal system development GO:0001501 356 0.071
cellular amine metabolic process GO:0044106 44 0.070
small molecule biosynthetic process GO:0044283 132 0.066
organic hydroxy compound metabolic process GO:1901615 203 0.064
regulation of cellular ketone metabolic process GO:0010565 66 0.063
cation transport GO:0006812 399 0.057
regulation of secretion GO:0051046 274 0.057
sensory perception GO:0007600 245 0.055
developmental maturation GO:0021700 193 0.052
ribonucleotide metabolic process GO:0009259 291 0.051
purine ribonucleotide metabolic process GO:0009150 290 0.051
purine containing compound metabolic process GO:0072521 311 0.049
regulation of membrane potential GO:0042391 192 0.048
purine nucleotide metabolic process GO:0006163 302 0.046
cation homeostasis GO:0055080 212 0.046
regulation of homeostatic process GO:0032844 182 0.046
ras protein signal transduction GO:0007265 77 0.045
oxidation reduction process GO:0055114 342 0.045
nitrogen compound transport GO:0071705 271 0.044
regulation of protein localization GO:0032880 231 0.043
embryonic organ morphogenesis GO:0048562 276 0.043
cellular chemical homeostasis GO:0055082 215 0.042
nucleoside phosphate metabolic process GO:0006753 338 0.041
nucleobase containing small molecule metabolic process GO:0055086 352 0.041
sensory organ morphogenesis GO:0090596 242 0.040
male gamete generation GO:0048232 285 0.040
cellular homeostasis GO:0019725 240 0.040
anion transport GO:0006820 177 0.040
steroid metabolic process GO:0008202 119 0.040
gland development GO:0048732 330 0.040
ossification GO:0001503 216 0.039
skin development GO:0043588 220 0.039
synaptic transmission GO:0007268 329 0.039
cholesterol metabolic process GO:0008203 56 0.039
ribose phosphate metabolic process GO:0019693 291 0.038
cation transmembrane transport GO:0098655 266 0.038
ribonucleoside metabolic process GO:0009119 245 0.038
metal ion homeostasis GO:0055065 189 0.038
organic cyclic compound catabolic process GO:1901361 295 0.037
regulation of secretion by cell GO:1903530 249 0.037
cellular lipid metabolic process GO:0044255 323 0.037
forebrain development GO:0030900 302 0.036
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.036
regulation of cell cycle GO:0051726 281 0.036
positive regulation of cellular amine metabolic process GO:0033240 5 0.036
regulation of mapk cascade GO:0043408 248 0.035
locomotory behavior GO:0007626 195 0.035
nucleotide metabolic process GO:0009117 332 0.035
negative regulation of protein metabolic process GO:0051248 282 0.035
heterocycle catabolic process GO:0046700 280 0.035
hematopoietic progenitor cell differentiation GO:0002244 143 0.035
cell adhesion GO:0007155 329 0.035
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
cell type specific apoptotic process GO:0097285 268 0.034
regulation of body fluid levels GO:0050878 162 0.034
regulation of system process GO:0044057 200 0.034
response to organic cyclic compound GO:0014070 198 0.034
cellular response to lipid GO:0071396 145 0.034
regionalization GO:0003002 337 0.034
ribonucleoside triphosphate metabolic process GO:0009199 220 0.034
cellular ion homeostasis GO:0006873 165 0.034
calcium ion homeostasis GO:0055074 127 0.033
connective tissue development GO:0061448 179 0.033
epidermis development GO:0008544 187 0.033
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.033
renal system development GO:0072001 225 0.033
cellular metal ion homeostasis GO:0006875 151 0.033
peptidyl amino acid modification GO:0018193 336 0.033
regulation of nucleotide metabolic process GO:0006140 169 0.032
bone development GO:0060348 120 0.032
lipid biosynthetic process GO:0008610 179 0.032
epithelial cell development GO:0002064 159 0.031
action potential GO:0001508 78 0.031
spermatogenesis GO:0007283 284 0.031
camera type eye development GO:0043010 266 0.031
kidney development GO:0001822 213 0.031
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.031
regulation of organ morphogenesis GO:2000027 144 0.031
cytokine production GO:0001816 319 0.031
sterol metabolic process GO:0016125 58 0.031
homeostasis of number of cells GO:0048872 210 0.031
neuronal action potential GO:0019228 54 0.031
nucleoside triphosphate catabolic process GO:0009143 205 0.030
cellular divalent inorganic cation homeostasis GO:0072503 127 0.030
b cell activation GO:0042113 161 0.030
skeletal system morphogenesis GO:0048705 203 0.030
regulation of anatomical structure size GO:0090066 178 0.030
divalent inorganic cation transport GO:0072511 178 0.030
blood circulation GO:0008015 195 0.030
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.030
epithelial tube morphogenesis GO:0060562 303 0.029
nuclear division GO:0000280 158 0.029
mapk cascade GO:0000165 281 0.029
response to extracellular stimulus GO:0009991 127 0.029
carbohydrate derivative catabolic process GO:1901136 231 0.029
adult behavior GO:0030534 135 0.029
cellular response to hormone stimulus GO:0032870 150 0.029
cellular calcium ion homeostasis GO:0006874 119 0.029
urogenital system development GO:0001655 261 0.029
regulation of transmembrane transport GO:0034762 128 0.029
anatomical structure homeostasis GO:0060249 145 0.029
transmission of nerve impulse GO:0019226 76 0.029
limb morphogenesis GO:0035108 149 0.029
wound healing GO:0042060 157 0.029
inorganic cation transmembrane transport GO:0098662 207 0.029
dna metabolic process GO:0006259 303 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.028
multicellular organismal signaling GO:0035637 91 0.028
axonogenesis GO:0007409 274 0.028
organonitrogen compound biosynthetic process GO:1901566 192 0.028
peptide transport GO:0015833 133 0.028
digestive system development GO:0055123 200 0.028
amide transport GO:0042886 138 0.028
inorganic ion transmembrane transport GO:0098660 234 0.028
positive regulation of protein modification process GO:0031401 299 0.028
negative regulation of cellular amine metabolic process GO:0033239 1 0.028
circulatory system process GO:0003013 197 0.027
cytoplasmic transport GO:0016482 234 0.027
regulation of ossification GO:0030278 112 0.027
regulation of ion transport GO:0043269 215 0.027
regulation of ion transmembrane transport GO:0034765 119 0.027
cellular response to cytokine stimulus GO:0071345 189 0.027
regulation of cell motility GO:2000145 236 0.026
organelle fission GO:0048285 170 0.026
posttranscriptional regulation of gene expression GO:0010608 155 0.026
organonitrogen compound catabolic process GO:1901565 264 0.026
negative regulation of phosphorylation GO:0042326 166 0.026
divalent inorganic cation homeostasis GO:0072507 138 0.026
leukocyte differentiation GO:0002521 342 0.026
regulation of organelle organization GO:0033043 289 0.026
g protein coupled receptor signaling pathway GO:0007186 243 0.026
purine ribonucleotide catabolic process GO:0009154 208 0.026
neuron migration GO:0001764 122 0.026
purine nucleoside metabolic process GO:0042278 241 0.026
positive regulation of apoptotic process GO:0043065 217 0.025
regulation of neuron differentiation GO:0045664 281 0.025
placenta development GO:0001890 140 0.025
developmental growth involved in morphogenesis GO:0060560 138 0.025
cellular nitrogen compound catabolic process GO:0044270 280 0.025
aromatic compound catabolic process GO:0019439 286 0.025
nucleoside triphosphate metabolic process GO:0009141 230 0.025
cellular response to organonitrogen compound GO:0071417 145 0.025
negative regulation of molecular function GO:0044092 258 0.025
glycosyl compound metabolic process GO:1901657 246 0.024
regulation of cellular component biogenesis GO:0044087 181 0.024
negative regulation of cell proliferation GO:0008285 296 0.024
regulation of cell cycle process GO:0010564 160 0.024
alcohol metabolic process GO:0006066 116 0.024
regulation of apoptotic signaling pathway GO:2001233 197 0.024
response to inorganic substance GO:0010035 96 0.024
myeloid cell differentiation GO:0030099 233 0.024
cellular response to growth factor stimulus GO:0071363 197 0.024
reactive oxygen species metabolic process GO:0072593 84 0.024
carbohydrate metabolic process GO:0005975 230 0.024
regulation of cytokine production GO:0001817 266 0.024
ear morphogenesis GO:0042471 118 0.023
cell maturation GO:0048469 127 0.023
blood vessel morphogenesis GO:0048514 285 0.023
negative regulation of cellular protein metabolic process GO:0032269 247 0.023
rho protein signal transduction GO:0007266 32 0.023
regulation of purine nucleotide metabolic process GO:1900542 169 0.023
ribonucleotide catabolic process GO:0009261 208 0.023
morphogenesis of a branching structure GO:0001763 203 0.023
inflammatory response GO:0006954 244 0.023
heart morphogenesis GO:0003007 178 0.023
lymphocyte differentiation GO:0030098 242 0.023
ear development GO:0043583 200 0.023
carbohydrate derivative biosynthetic process GO:1901137 183 0.023
response to peptide hormone GO:0043434 127 0.022
positive regulation of protein phosphorylation GO:0001934 242 0.022
nucleoside metabolic process GO:0009116 246 0.022
cell growth GO:0016049 130 0.022
peptide hormone secretion GO:0030072 109 0.022
regulation of establishment of protein localization GO:0070201 181 0.022
cerebral cortex development GO:0021987 86 0.022
purine nucleotide catabolic process GO:0006195 211 0.022
maintenance of location GO:0051235 89 0.022
response to growth factor GO:0070848 198 0.022
purine nucleoside triphosphate metabolic process GO:0009144 226 0.022
response to nutrient levels GO:0031667 109 0.022
gastrulation GO:0007369 116 0.022
positive regulation of neuron differentiation GO:0045666 141 0.022
sulfur compound metabolic process GO:0006790 100 0.022
fat cell differentiation GO:0045444 160 0.022
purine ribonucleoside catabolic process GO:0046130 205 0.022
digestive tract morphogenesis GO:0048546 147 0.022
organic anion transport GO:0015711 137 0.022
regulation of mitotic cell cycle GO:0007346 126 0.022
divalent metal ion transport GO:0070838 172 0.022
regulation of hydrolase activity GO:0051336 246 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.021
mitotic cell cycle process GO:1903047 159 0.021
embryonic placenta development GO:0001892 98 0.021
organophosphate catabolic process GO:0046434 232 0.021
nucleoside catabolic process GO:0009164 206 0.021
regulation of defense response GO:0031347 233 0.021
regulation of protein transport GO:0051223 163 0.021
negative regulation of intracellular signal transduction GO:1902532 167 0.021
cellular alcohol biosynthetic process GO:0044108 3 0.021
innate immune response GO:0045087 157 0.021
morphogenesis of a branching epithelium GO:0061138 193 0.021
positive regulation of cell development GO:0010720 237 0.021
regulation of response to wounding GO:1903034 189 0.021
regulation of protein kinase activity GO:0045859 232 0.021
regulation of kinase activity GO:0043549 249 0.021
liver development GO:0001889 66 0.021
epithelial cell proliferation GO:0050673 174 0.021
intestinal epithelial structure maintenance GO:0060729 4 0.021
purine ribonucleoside metabolic process GO:0046128 241 0.021
multicellular organismal homeostasis GO:0048871 164 0.021
regulation of hormone levels GO:0010817 211 0.020
cellular response to acid chemical GO:0071229 68 0.020
organic hydroxy compound biosynthetic process GO:1901617 77 0.020
protein localization to organelle GO:0033365 185 0.020
sensory perception of mechanical stimulus GO:0050954 107 0.020
purine containing compound catabolic process GO:0072523 213 0.020
actin filament based movement GO:0030048 23 0.020
regulation of cellular catabolic process GO:0031329 242 0.020
sequestering of calcium ion GO:0051208 18 0.020
regulation of lymphocyte activation GO:0051249 240 0.020
protein modification by small protein conjugation GO:0032446 187 0.020
regulation of transferase activity GO:0051338 263 0.020
cartilage development GO:0051216 140 0.020
appendage morphogenesis GO:0035107 149 0.020
regulation of nucleoside metabolic process GO:0009118 130 0.020
heart process GO:0003015 94 0.020
negative regulation of protein modification process GO:0031400 163 0.020
embryonic appendage morphogenesis GO:0035113 126 0.020
regulation of cell size GO:0008361 72 0.020
stem cell differentiation GO:0048863 268 0.020
protein ubiquitination GO:0016567 171 0.020
purine nucleoside triphosphate catabolic process GO:0009146 203 0.020
carboxylic acid biosynthetic process GO:0046394 86 0.020
carbohydrate homeostasis GO:0033500 128 0.020
single organism cell adhesion GO:0098602 156 0.020
digestive tract development GO:0048565 190 0.020
peptide secretion GO:0002790 114 0.019
limb development GO:0060173 166 0.019
cell cell junction organization GO:0045216 72 0.019
chemotaxis GO:0006935 247 0.019
immune effector process GO:0002252 321 0.019
positive regulation of nervous system development GO:0051962 221 0.019
hepaticobiliary system development GO:0061008 67 0.019
cellular alcohol metabolic process GO:0044107 3 0.019
hormone secretion GO:0046879 128 0.019
macromolecule catabolic process GO:0009057 281 0.019
negative regulation of cellular component organization GO:0051129 194 0.019
cellular carbohydrate metabolic process GO:0044262 119 0.019
regulation of cell projection organization GO:0031344 206 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
t cell activation GO:0042110 289 0.019
embryonic limb morphogenesis GO:0030326 126 0.019
cellular protein complex assembly GO:0043623 116 0.019
regulation of osteoblast differentiation GO:0045667 67 0.018
inner ear morphogenesis GO:0042472 101 0.018
sensory perception of sound GO:0007605 97 0.018
purine nucleoside catabolic process GO:0006152 205 0.018
nucleotide catabolic process GO:0009166 217 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.018
cell junction organization GO:0034330 77 0.018
ribonucleoside catabolic process GO:0042454 206 0.018
central nervous system neuron differentiation GO:0021953 162 0.018
central nervous system neuron development GO:0021954 67 0.018
bone morphogenesis GO:0060349 78 0.018
regulation of cell growth GO:0001558 91 0.018
positive regulation of programmed cell death GO:0043068 218 0.018
nucleoside monophosphate metabolic process GO:0009123 85 0.018
neuron apoptotic process GO:0051402 142 0.018
neuromuscular process GO:0050905 99 0.018
respiratory system development GO:0060541 190 0.018
angiogenesis GO:0001525 201 0.018
organic acid transport GO:0015849 101 0.018
intracellular protein transport GO:0006886 204 0.018
calcium ion transport GO:0006816 159 0.018
respiratory tube development GO:0030323 167 0.018
regulation of cell migration GO:0030334 219 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
cellular protein catabolic process GO:0044257 155 0.017
cell division GO:0051301 120 0.017
blastocyst development GO:0001824 80 0.017
regulation of cellular response to stress GO:0080135 159 0.017
protein maturation GO:0051604 176 0.017
extrinsic apoptotic signaling pathway GO:0097191 126 0.017
stem cell development GO:0048864 219 0.017
rhythmic process GO:0048511 174 0.017
regulation of cell activation GO:0050865 289 0.017
endomembrane system organization GO:0010256 147 0.017
mitotic cell cycle GO:0000278 195 0.017
negative regulation of nervous system development GO:0051961 156 0.017
appendage development GO:0048736 166 0.017
fat soluble vitamin biosynthetic process GO:0042362 4 0.017
organic acid biosynthetic process GO:0016053 86 0.017
male sex differentiation GO:0046661 109 0.017
small gtpase mediated signal transduction GO:0007264 97 0.017
membrane depolarization GO:0051899 64 0.017
monocarboxylic acid metabolic process GO:0032787 191 0.017
tissue homeostasis GO:0001894 115 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
organophosphate biosynthetic process GO:0090407 122 0.017
extracellular structure organization GO:0043062 148 0.017
organ growth GO:0035265 117 0.016
response to molecule of bacterial origin GO:0002237 143 0.016
alcohol biosynthetic process GO:0046165 43 0.016
protein catabolic process GO:0030163 221 0.016
mesonephros development GO:0001823 97 0.016
regulation of action potential GO:0098900 4 0.016
endocrine system development GO:0035270 98 0.016
regulation of intracellular transport GO:0032386 159 0.016
positive regulation of mapk cascade GO:0043410 170 0.016
glycoprotein metabolic process GO:0009100 116 0.016
cardiac muscle cell contraction GO:0086003 7 0.016
ribonucleoside monophosphate metabolic process GO:0009161 80 0.016
negative regulation of immune system process GO:0002683 209 0.016
fatty acid metabolic process GO:0006631 121 0.016
sequestering of metal ion GO:0051238 19 0.016
organelle localization GO:0051640 179 0.016
regulation of cell adhesion GO:0030155 154 0.016
leukocyte proliferation GO:0070661 172 0.016
biomineral tissue development GO:0031214 64 0.016
striated muscle tissue development GO:0014706 293 0.016
monosaccharide metabolic process GO:0005996 106 0.016
insulin secretion GO:0030073 89 0.015
negative regulation of cell cycle GO:0045786 123 0.015
regulation of protein catabolic process GO:0042176 108 0.015
nuclear transport GO:0051169 139 0.015
cofactor metabolic process GO:0051186 80 0.015
ribonucleoside triphosphate catabolic process GO:0009203 199 0.015
regulation of heart contraction GO:0008016 77 0.015
regulation of peptide transport GO:0090087 91 0.015
chondrocyte differentiation GO:0002062 72 0.015
sulfur compound biosynthetic process GO:0044272 37 0.015
actin cytoskeleton organization GO:0030036 220 0.015
dendrite development GO:0016358 115 0.015
multicellular organism growth GO:0035264 161 0.015
exocytosis GO:0006887 121 0.015
norepinephrine secretion GO:0048243 2 0.015
negative regulation of cytokine production GO:0001818 84 0.015
tube formation GO:0035148 140 0.015
positive regulation of cell death GO:0010942 224 0.015
muscle tissue development GO:0060537 308 0.015
regulation of proteolysis GO:0030162 164 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
glucose homeostasis GO:0042593 128 0.015
lymphocyte proliferation GO:0046651 164 0.015
vitamin d3 metabolic process GO:0070640 3 0.015
heart contraction GO:0060047 93 0.015
spermatid differentiation GO:0048515 115 0.015
tissue remodeling GO:0048771 102 0.015
protein targeting GO:0006605 143 0.015
oocyte construction GO:0007308 2 0.015
neural tube formation GO:0001841 108 0.015
hair follicle development GO:0001942 85 0.015
membrane organization GO:0061024 245 0.015
positive regulation of cellular catabolic process GO:0031331 148 0.015
atp metabolic process GO:0046034 75 0.014
regulation of translation GO:0006417 71 0.014
cellular macromolecule catabolic process GO:0044265 206 0.014
pallium development GO:0021543 120 0.014
cognition GO:0050890 149 0.014
mesenchyme development GO:0060485 152 0.014
regulation of feeding behavior GO:0060259 3 0.014
erk1 and erk2 cascade GO:0070371 77 0.014
regulation of leukocyte proliferation GO:0070663 121 0.014
response to organonitrogen compound GO:0010243 246 0.014
meiotic cell cycle GO:0051321 122 0.014
bone mineralization GO:0030282 54 0.014
muscle contraction GO:0006936 101 0.014
intrinsic apoptotic signaling pathway GO:0097193 132 0.014
testosterone biosynthetic process GO:0061370 2 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
purine nucleoside monophosphate metabolic process GO:0009126 81 0.014
muscle system process GO:0003012 141 0.014
midgut development GO:0007494 4 0.014
cellular response to organic cyclic compound GO:0071407 87 0.014
cardiac ventricle development GO:0003231 83 0.014
cellular modified amino acid metabolic process GO:0006575 63 0.014
regulation of neuron projection development GO:0010975 169 0.014
mesenchymal cell differentiation GO:0048762 107 0.014
germ cell development GO:0007281 185 0.014
positive regulation of growth GO:0045927 104 0.014
neural tube development GO:0021915 160 0.014
synapse organization GO:0050808 125 0.014
regulation of blood circulation GO:1903522 93 0.014
embryonic skeletal system development GO:0048706 120 0.014
axon ensheathment GO:0008366 76 0.014
myeloid leukocyte differentiation GO:0002573 119 0.014
actin mediated cell contraction GO:0070252 15 0.014
regulation of multi organism process GO:0043900 111 0.014
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.014
regulation of endopeptidase activity GO:0052548 89 0.014
multi multicellular organism process GO:0044706 109 0.014
mesenchymal cell development GO:0014031 93 0.013
regulation of protein maturation GO:1903317 96 0.013
ensheathment of neurons GO:0007272 76 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.013
hexose metabolic process GO:0019318 98 0.013
cell fate commitment GO:0045165 210 0.013
molting cycle GO:0042303 90 0.013
glucose metabolic process GO:0006006 92 0.013
positive regulation of secretion GO:0051047 130 0.013
hair cycle GO:0042633 90 0.013
response to starvation GO:0042594 65 0.013
extracellular matrix organization GO:0030198 147 0.013
detection of abiotic stimulus GO:0009582 60 0.013
response to light stimulus GO:0009416 135 0.013
kidney epithelium development GO:0072073 121 0.013
lung development GO:0030324 164 0.013
regulation of nucleotide catabolic process GO:0030811 122 0.013
negative regulation of phosphorus metabolic process GO:0010563 184 0.013
protein processing GO:0016485 163 0.013
cell substrate adhesion GO:0031589 130 0.013
glycerolipid metabolic process GO:0046486 122 0.013
septum primum development GO:0003284 4 0.013
cellular response to external stimulus GO:0071496 88 0.013
organelle assembly GO:0070925 177 0.013
response to radiation GO:0009314 165 0.013
adult locomotory behavior GO:0008344 91 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
neutral lipid metabolic process GO:0006638 57 0.013
regulation of muscle system process GO:0090257 80 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.013
protein secretion GO:0009306 111 0.013
regulation of protein secretion GO:0050708 82 0.013
defecation GO:0030421 1 0.013
glycerophospholipid metabolic process GO:0006650 71 0.013
anion transmembrane transport GO:0098656 71 0.013
phenol containing compound metabolic process GO:0018958 60 0.013
vitamin d biosynthetic process GO:0042368 3 0.013
axon guidance GO:0007411 141 0.012
cellular response to peptide hormone stimulus GO:0071375 92 0.012
response to lipopolysaccharide GO:0032496 128 0.012
lipid transport GO:0006869 98 0.012
actin filament organization GO:0007015 113 0.012
regulation of actin filament based process GO:0032970 99 0.012
regulation of reproductive process GO:2000241 66 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.012
cell junction assembly GO:0034329 52 0.012
regulation of fat cell differentiation GO:0045598 81 0.012
diencephalon development GO:0021536 63 0.012
meiotic nuclear division GO:0007126 115 0.012
cellular response to starvation GO:0009267 57 0.012
regulation of blood pressure GO:0008217 93 0.012
response to acid chemical GO:0001101 111 0.012
cytokine mediated signaling pathway GO:0019221 115 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
renal system process GO:0003014 48 0.012
lateral inhibition GO:0046331 1 0.012
single organismal cell cell adhesion GO:0016337 131 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
establishment of blood nerve barrier GO:0008065 3 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
mesoderm development GO:0007498 100 0.012
ubiquitin dependent protein catabolic process GO:0006511 129 0.012
protein import GO:0017038 101 0.012
regulation of renin secretion into blood stream GO:1900133 4 0.012
developmental cell growth GO:0048588 84 0.012
norepinephrine transport GO:0015874 2 0.012
glycoprotein biosynthetic process GO:0009101 89 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
regulation of extent of cell growth GO:0061387 52 0.012
negative regulation of growth GO:0045926 99 0.012
regulation of erk1 and erk2 cascade GO:0070372 71 0.012
cardiac muscle tissue development GO:0048738 130 0.012
regulation of peptidase activity GO:0052547 96 0.012
androgen biosynthetic process GO:0006702 4 0.012
regulation of epithelial cell proliferation GO:0050678 141 0.012
coenzyme metabolic process GO:0006732 52 0.012
regulation of cytoplasmic transport GO:1903649 112 0.012
primary neural tube formation GO:0014020 95 0.012
modification dependent macromolecule catabolic process GO:0043632 133 0.012
regulation of cellular component size GO:0032535 121 0.012
regulation of lipid metabolic process GO:0019216 118 0.012
lipid localization GO:0010876 126 0.012
regulation of neurotransmitter levels GO:0001505 87 0.012
dephosphorylation GO:0016311 129 0.012
response to peptide GO:1901652 136 0.012
gliogenesis GO:0042063 141 0.012
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.011
tube closure GO:0060606 91 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
wnt signaling pathway GO:0016055 188 0.011

Pcsk9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.023
disease of anatomical entity DOID:7 0 0.023
disease of metabolism DOID:0014667 0 0.017
immune system disease DOID:2914 0 0.015
inherited metabolic disorder DOID:655 0 0.014
musculoskeletal system disease DOID:17 0 0.013