Mus musculus

33 known processes

Pcsk2

proprotein convertase subtilisin/kexin type 2

(Aliases: 6330411F23Rik,Nec-2,PC2,AI839700,Phpp-2,Nec2,SPC2)

Pcsk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic transmission GO:0007268 329 0.955
regulation of neurotransmitter levels GO:0001505 87 0.856
exocytosis GO:0006887 121 0.705
Mouse
ion transmembrane transport GO:0034220 361 0.688
regulation of ion transport GO:0043269 215 0.685
axonogenesis GO:0007409 274 0.651
synaptic vesicle localization GO:0097479 59 0.639
neurotransmitter secretion GO:0007269 62 0.632
synaptic vesicle priming GO:0016082 8 0.606
vesicle localization GO:0051648 86 0.569
inorganic ion transmembrane transport GO:0098660 234 0.564
regulation of secretion by cell GO:1903530 249 0.507
inorganic cation transmembrane transport GO:0098662 207 0.489
organelle localization GO:0051640 179 0.488
circulatory system process GO:0003013 197 0.480
response to growth factor GO:0070848 198 0.468
synaptic transmission glutamatergic GO:0035249 36 0.457
regulation of exocytosis GO:0017157 61 0.456
chemotaxis GO:0006935 247 0.435
regulation of secretion GO:0051046 274 0.435
negative regulation of cell development GO:0010721 169 0.421
cation transport GO:0006812 399 0.413
regulation of cellular amine metabolic process GO:0033238 20 0.395
establishment of synaptic vesicle localization GO:0097480 57 0.382
regulation of synaptic plasticity GO:0048167 87 0.378
transmembrane transport GO:0055085 412 0.365
positive regulation of secretion by cell GO:1903532 114 0.358
cation transmembrane transport GO:0098655 266 0.353
regulation of transmembrane transport GO:0034762 128 0.335
regulation of ion transmembrane transport GO:0034765 119 0.323
membrane organization GO:0061024 245 0.323
regulation of neuron projection development GO:0010975 169 0.321
establishment of vesicle localization GO:0051650 81 0.306
regulation of system process GO:0044057 200 0.301
cell type specific apoptotic process GO:0097285 268 0.289
axon guidance GO:0007411 141 0.270
cellular response to growth factor stimulus GO:0071363 197 0.266
regulation of neuron death GO:1901214 134 0.262
cellular amino acid metabolic process GO:0006520 103 0.247
neuron migration GO:0001764 122 0.246
regulation of ion transmembrane transporter activity GO:0032412 54 0.240
muscle contraction GO:0006936 101 0.240
locomotory behavior GO:0007626 195 0.239
Worm Fly
regulation of cell motility GO:2000145 236 0.234
positive regulation of nervous system development GO:0051962 221 0.233
cellular amine metabolic process GO:0044106 44 0.232
glutamate receptor signaling pathway GO:0007215 35 0.230
catecholamine secretion GO:0050432 15 0.230
establishment of organelle localization GO:0051656 122 0.213
regulation of neuronal synaptic plasticity GO:0048168 30 0.210
catecholamine transport GO:0051937 21 0.205
calcium ion dependent exocytosis GO:0017156 35 0.181
Mouse
ear development GO:0043583 200 0.180
positive regulation of cellular amine metabolic process GO:0033240 5 0.173
neurotransmitter transport GO:0006836 76 0.173
regulation of neuron differentiation GO:0045664 281 0.173
regulation of metal ion transport GO:0010959 106 0.161
positive regulation of secretion GO:0051047 130 0.160
synaptic vesicle transport GO:0048489 57 0.158
cellular potassium ion transport GO:0071804 43 0.156
angiogenesis GO:0001525 201 0.155
anatomical structure homeostasis GO:0060249 145 0.155
regulation of neurotransmitter transport GO:0051588 35 0.152
regulation of hormone levels GO:0010817 211 0.144
nucleoside phosphate metabolic process GO:0006753 338 0.141
synaptic vesicle exocytosis GO:0016079 26 0.139
regulation of cellular ketone metabolic process GO:0010565 66 0.136
cellular ketone metabolic process GO:0042180 84 0.132
multi multicellular organism process GO:0044706 109 0.132
Mouse Worm
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.132
regulation of vesicle mediated transport GO:0060627 139 0.131
response to light stimulus GO:0009416 135 0.130
learning GO:0007612 98 0.130
regulation of cell migration GO:0030334 219 0.129
negative regulation of cell proliferation GO:0008285 296 0.128
regulation of cell projection organization GO:0031344 206 0.124
divalent metal ion transport GO:0070838 172 0.122
camera type eye development GO:0043010 266 0.121
action potential GO:0001508 78 0.120
peptidyl amino acid modification GO:0018193 336 0.120
hormone secretion GO:0046879 128 0.117
amine metabolic process GO:0009308 45 0.116
regulation of neuron apoptotic process GO:0043523 122 0.115
neuron neuron synaptic transmission GO:0007270 69 0.114
regulation of cellular amino acid metabolic process GO:0006521 5 0.112
phospholipid metabolic process GO:0006644 87 0.108
synapse organization GO:0050808 125 0.107
sensory perception GO:0007600 245 0.106
developmental maturation GO:0021700 193 0.106
Mouse
blood vessel morphogenesis GO:0048514 285 0.104
digestive system development GO:0055123 200 0.104
Mouse
transmission of nerve impulse GO:0019226 76 0.103
positive regulation of protein kinase activity GO:0045860 144 0.101
diencephalon development GO:0021536 63 0.100
nitrogen compound transport GO:0071705 271 0.098
regulation of blood pressure GO:0008217 93 0.097
learning or memory GO:0007611 148 0.095
neuron projection guidance GO:0097485 141 0.093
regulation of synapse assembly GO:0051963 29 0.093
potassium ion transmembrane transport GO:0071805 43 0.091
cellular protein complex assembly GO:0043623 116 0.090
central nervous system neuron differentiation GO:0021953 162 0.090
sensory perception of mechanical stimulus GO:0050954 107 0.089
ribose phosphate biosynthetic process GO:0046390 59 0.089
regulation of membrane potential GO:0042391 192 0.088
vesicle organization GO:0016050 60 0.087
regulation of cell cycle GO:0051726 281 0.087
stem cell development GO:0048864 219 0.087
spermatid development GO:0007286 108 0.087
Mouse
cell fate commitment GO:0045165 210 0.085
multicellular organismal signaling GO:0035637 91 0.084
cellular response to organonitrogen compound GO:0071417 145 0.084
regulation of blood circulation GO:1903522 93 0.081
regulation of neurotransmitter secretion GO:0046928 29 0.081
organophosphate biosynthetic process GO:0090407 122 0.081
intracellular protein transport GO:0006886 204 0.080
long term synaptic potentiation GO:0060291 25 0.080
nucleoside phosphate biosynthetic process GO:1901293 79 0.079
skeletal system development GO:0001501 356 0.078
Mouse
potassium ion transport GO:0006813 52 0.078
blood circulation GO:0008015 195 0.077
peptide transport GO:0015833 133 0.076
forebrain development GO:0030900 302 0.075
cell adhesion GO:0007155 329 0.074
neuronal action potential GO:0019228 54 0.074
heart process GO:0003015 94 0.073
muscle cell development GO:0055001 133 0.073
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.072
regionalization GO:0003002 337 0.072
Mouse
striated muscle contraction GO:0006941 45 0.072
response to organonitrogen compound GO:0010243 246 0.071
neuron apoptotic process GO:0051402 142 0.071
negative regulation of neuron apoptotic process GO:0043524 92 0.070
somatotropin secreting cell differentiation GO:0060126 4 0.070
oocyte construction GO:0007308 2 0.070
cellular chemical homeostasis GO:0055082 215 0.070
developmental cell growth GO:0048588 84 0.069
purine nucleotide metabolic process GO:0006163 302 0.069
organic hydroxy compound metabolic process GO:1901615 203 0.069
peptidyl tyrosine modification GO:0018212 145 0.068
membrane depolarization GO:0051899 64 0.068
mitochondrion transport along microtubule GO:0047497 3 0.068
spinal cord development GO:0021510 81 0.068
regulation of feeding behavior GO:0060259 3 0.067
negative regulation of intracellular signal transduction GO:1902532 167 0.067
neuron death GO:0070997 154 0.066
detection of light stimulus GO:0009583 25 0.065
positive regulation of protein phosphorylation GO:0001934 242 0.065
glial cell differentiation GO:0010001 131 0.065
microtubule based process GO:0007017 236 0.065
cyclic nucleotide biosynthetic process GO:0009190 44 0.065
apoptotic signaling pathway GO:0097190 306 0.064
regulation of postsynaptic membrane potential GO:0060078 48 0.064
ribonucleotide metabolic process GO:0009259 291 0.064
positive regulation of neuron differentiation GO:0045666 141 0.063
ribonucleoside triphosphate catabolic process GO:0009203 199 0.063
regulation of protein serine threonine kinase activity GO:0071900 157 0.063
central nervous system neuron development GO:0021954 67 0.063
fast calcium ion dependent exocytosis of neurotransmitter GO:0098746 1 0.063
regulation of systemic arterial blood pressure GO:0003073 61 0.063
calcium ion transport GO:0006816 159 0.062
myeloid leukocyte differentiation GO:0002573 119 0.062
cyclic nucleotide metabolic process GO:0009187 59 0.061
regulation of voltage gated calcium channel activity GO:1901385 4 0.061
second messenger mediated signaling GO:0019932 73 0.061
neuromuscular process GO:0050905 99 0.061
telencephalon development GO:0021537 186 0.061
associative learning GO:0008306 61 0.059
maintenance of presynaptic active zone structure GO:0048790 1 0.057
dendrite development GO:0016358 115 0.056
respiratory tube development GO:0030323 167 0.055
Mouse
divalent inorganic cation transport GO:0072511 178 0.055
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.055
neuromuscular process controlling balance GO:0050885 59 0.054
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.054
negative regulation of nervous system development GO:0051961 156 0.054
cell maturation GO:0048469 127 0.054
Mouse
positive regulation of hormone secretion GO:0046887 38 0.054
homeostasis of number of cells GO:0048872 210 0.053
muscle system process GO:0003012 141 0.053
response to organic cyclic compound GO:0014070 198 0.053
positive regulation of cell cycle GO:0045787 92 0.052
mechanoreceptor differentiation GO:0042490 67 0.052
neuron projection extension GO:1990138 64 0.052
erk1 and erk2 cascade GO:0070371 77 0.052
negative regulation of synapse assembly GO:0051964 3 0.052
stem cell differentiation GO:0048863 268 0.051
regulation of protein kinase activity GO:0045859 232 0.051
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.051
mesenchymal cell differentiation GO:0048762 107 0.050
regulation of cell adhesion GO:0030155 154 0.050
cardiac ventricle development GO:0003231 83 0.050
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.049
cognition GO:0050890 149 0.049
negative regulation of cellular protein metabolic process GO:0032269 247 0.049
g protein coupled receptor signaling pathway GO:0007186 243 0.048
regulation of cellular response to stress GO:0080135 159 0.048
renal system development GO:0072001 225 0.048
Mouse
extracellular matrix organization GO:0030198 147 0.048
amide transport GO:0042886 138 0.048
adult behavior GO:0030534 135 0.048
organonitrogen compound biosynthetic process GO:1901566 192 0.047
Mouse
response to radiation GO:0009314 165 0.047
nucleobase containing small molecule metabolic process GO:0055086 352 0.047
female gamete generation GO:0007292 74 0.047
serotonin transport GO:0006837 11 0.046
mesenchyme development GO:0060485 152 0.046
regulation of axon extension GO:0030516 43 0.046
leukocyte differentiation GO:0002521 342 0.046
optic nerve structural organization GO:0021633 2 0.046
peptide secretion GO:0002790 114 0.046
pole plasm assembly GO:0007315 2 0.046
response to acid chemical GO:0001101 111 0.045
purine ribonucleotide metabolic process GO:0009150 290 0.045
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.045
regulation of apoptotic signaling pathway GO:2001233 197 0.045
synapse assembly GO:0007416 56 0.045
positive regulation of high voltage gated calcium channel activity GO:1901843 1 0.045
pituitary gland development GO:0021983 38 0.044
regulation of organ morphogenesis GO:2000027 144 0.044
negative regulation of neuron death GO:1901215 98 0.044
inner ear receptor cell differentiation GO:0060113 61 0.044
calcium mediated signaling GO:0019722 46 0.044
asymmetric neuroblast division GO:0055059 1 0.044
carbohydrate derivative catabolic process GO:1901136 231 0.044
protein localization to membrane GO:0072657 108 0.044
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.043
cellular amide metabolic process GO:0043603 58 0.043
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.043
anion transport GO:0006820 177 0.043
somatotropin secreting cell development GO:0060133 2 0.043
urogenital system development GO:0001655 261 0.043
Mouse
regulation of transporter activity GO:0032409 57 0.043
axon cargo transport GO:0008088 33 0.043
peripheral nervous system axon regeneration GO:0014012 2 0.042
appendage development GO:0048736 166 0.042
Mouse
sensory organ morphogenesis GO:0090596 242 0.042
positive regulation of organ growth GO:0046622 29 0.042
sensory perception of pain GO:0019233 47 0.041
negative regulation of phosphate metabolic process GO:0045936 184 0.041
purine ribonucleotide catabolic process GO:0009154 208 0.041
positive regulation of schwann cell proliferation GO:0010625 1 0.041
ensheathment of neurons GO:0007272 76 0.040
positive regulation of exocytosis GO:0045921 20 0.040
semicircular canal fusion GO:0060879 1 0.040
fat cell differentiation GO:0045444 160 0.040
regulation of peptide hormone secretion GO:0090276 75 0.040
positive regulation of necrotic cell death GO:0010940 1 0.040
immune effector process GO:0002252 321 0.039
positive regulation of cell development GO:0010720 237 0.039
endocytosis GO:0006897 168 0.039
mitotic cell cycle GO:0000278 195 0.039
carbohydrate derivative biosynthetic process GO:1901137 183 0.039
negative regulation of apoptotic signaling pathway GO:2001234 104 0.039
macromolecule catabolic process GO:0009057 281 0.039
Worm
digestive tract morphogenesis GO:0048546 147 0.039
negative regulation of protein phosphorylation GO:0001933 126 0.038
detection of stimulus GO:0051606 84 0.038
multi organism behavior GO:0051705 62 0.038
Worm
cellular homeostasis GO:0019725 240 0.038
nucleotide biosynthetic process GO:0009165 78 0.038
oocyte differentiation GO:0009994 35 0.038
positive regulation of neuron projection development GO:0010976 79 0.038
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.038
purine ribonucleoside catabolic process GO:0046130 205 0.037
endomembrane system organization GO:0010256 147 0.037
skeletal system morphogenesis GO:0048705 203 0.037
regulation of lyase activity GO:0051339 13 0.037
mitral valve development GO:0003174 4 0.037
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.037
cellular lipid metabolic process GO:0044255 323 0.037
cytoplasmic transport GO:0016482 234 0.037
negative regulation of phosphorylation GO:0042326 166 0.036
male courtship behavior GO:0008049 2 0.036
cellular component assembly involved in morphogenesis GO:0010927 139 0.036
purine containing compound metabolic process GO:0072521 311 0.036
manganese ion transport GO:0006828 5 0.036
regulation of axon diameter GO:0031133 6 0.036
spermatid differentiation GO:0048515 115 0.036
Mouse
regulation of hormone secretion GO:0046883 88 0.036
oogenesis GO:0048477 56 0.036
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.035
gliogenesis GO:0042063 141 0.035
regulation of ossification GO:0030278 112 0.035
embryonic organ morphogenesis GO:0048562 276 0.035
lateral inhibition GO:0046331 1 0.035
intermediate filament bundle assembly GO:0045110 3 0.035
regulation of anatomical structure size GO:0090066 178 0.035
positive regulation of apoptotic process GO:0043065 217 0.035
regulation of cellular component biogenesis GO:0044087 181 0.035
determination of left right symmetry GO:0007368 80 0.034
Mouse
circadian rhythm GO:0007623 114 0.034
heart morphogenesis GO:0003007 178 0.034
purine nucleoside catabolic process GO:0006152 205 0.034
positive regulation of protein modification process GO:0031401 299 0.034
purine ribonucleoside metabolic process GO:0046128 241 0.033
regulation of homeostatic process GO:0032844 182 0.033
carbohydrate homeostasis GO:0033500 128 0.033
Fly
regulation of purine nucleotide metabolic process GO:1900542 169 0.033
oocyte axis specification GO:0007309 2 0.033
single fertilization GO:0007338 82 0.033
Mouse
sensory perception of sound GO:0007605 97 0.032
germ cell development GO:0007281 185 0.032
Mouse
detection of abiotic stimulus GO:0009582 60 0.032
adult locomotory behavior GO:0008344 91 0.032
regulation of organelle organization GO:0033043 289 0.032
glycosyl compound catabolic process GO:1901658 206 0.032
positive regulation of cell death GO:0010942 224 0.032
lymphocyte differentiation GO:0030098 242 0.032
peptidyl tyrosine phosphorylation GO:0018108 143 0.032
monoamine transport GO:0015844 33 0.032
ribose phosphate metabolic process GO:0019693 291 0.032
ear morphogenesis GO:0042471 118 0.031
regulation of heart contraction GO:0008016 77 0.031
negative regulation of protein modification process GO:0031400 163 0.031
morphogenesis of embryonic epithelium GO:0016331 159 0.031
intraspecies interaction between organisms GO:0051703 21 0.031
cyclic purine nucleotide metabolic process GO:0052652 43 0.031
single organismal cell cell adhesion GO:0016337 131 0.031
wnt signaling pathway GO:0016055 188 0.031
posttranscriptional regulation of gene expression GO:0010608 155 0.031
mating behavior GO:0007617 20 0.030
Worm
somatostatin receptor signaling pathway GO:0038169 2 0.030
regulation of map kinase activity GO:0043405 120 0.030
positive regulation of map kinase activity GO:0043406 84 0.030
positive regulation of insulin secretion GO:0032024 26 0.030
regulation of glutamate receptor signaling pathway GO:1900449 16 0.030
cell division GO:0051301 120 0.029
establishment or maintenance of cell polarity GO:0007163 86 0.029
multi organism reproductive behavior GO:0044705 29 0.029
Worm
rac protein signal transduction GO:0016601 13 0.029
cellular nitrogen compound catabolic process GO:0044270 280 0.029
positive regulation of cell motility GO:2000147 116 0.029
activation of adenylate cyclase activity GO:0007190 4 0.029
heart contraction GO:0060047 93 0.029
endocrine system development GO:0035270 98 0.028
mesenchymal cell development GO:0014031 93 0.028
myeloid cell differentiation GO:0030099 233 0.028
purine nucleotide biosynthetic process GO:0006164 65 0.028
regulation of nucleotide biosynthetic process GO:0030808 34 0.028
negative regulation of cellular component organization GO:0051129 194 0.028
cell cell signaling involved in cell fate commitment GO:0045168 35 0.028
cardiac muscle contraction GO:0060048 32 0.028
maternal determination of anterior posterior axis embryo GO:0008358 2 0.028
striated muscle cell development GO:0055002 125 0.027
positive regulation of potassium ion transport GO:0043268 3 0.027
sensory perception of light stimulus GO:0050953 54 0.027
positive regulation of synaptic plasticity GO:0031915 4 0.027
acetylcholine secretion neurotransmission GO:0014055 2 0.027
cell differentiation in spinal cord GO:0021515 53 0.027
negative regulation of reproductive process GO:2000242 31 0.027
Worm
pallium development GO:0021543 120 0.027
regulation of muscle system process GO:0090257 80 0.027
lens development in camera type eye GO:0002088 62 0.027
sodium ion transport GO:0006814 73 0.027
acetylcholine transport GO:0015870 2 0.026
glucose homeostasis GO:0042593 128 0.026
alcohol metabolic process GO:0006066 116 0.026
intracellular mrna localization GO:0008298 4 0.026
positive regulation of transferase activity GO:0051347 167 0.026
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.026
positive regulation of cell cycle process GO:0090068 61 0.026
male sex differentiation GO:0046661 109 0.026
positive regulation of synapse assembly GO:0051965 18 0.026
epithelial cell development GO:0002064 159 0.026
skeletal muscle organ development GO:0060538 163 0.026
positive regulation of mitotic cell cycle GO:0045931 41 0.026
cell cell signaling involved in lung development GO:0060495 1 0.026
response to corticosterone GO:0051412 1 0.026
negative regulation of adenylate cyclase activity GO:0007194 1 0.026
regulation of protein transport GO:0051223 163 0.026
cerebellum development GO:0021549 77 0.026
nucleotide metabolic process GO:0009117 332 0.026
small gtpase mediated signal transduction GO:0007264 97 0.026
nucleoside triphosphate metabolic process GO:0009141 230 0.026
hippocampus development GO:0021766 52 0.025
muscle cell differentiation GO:0042692 261 0.025
kidney development GO:0001822 213 0.025
Mouse
peptide hormone secretion GO:0030072 109 0.025
regulation of cellular component size GO:0032535 121 0.025
regulation of cell cycle process GO:0010564 160 0.025
palate development GO:0060021 76 0.025
cardiac muscle cell contraction GO:0086003 7 0.025
negative regulation of neuron differentiation GO:0045665 101 0.025
connective tissue development GO:0061448 179 0.025
feeding behavior GO:0007631 62 0.024
protein kinase b signaling GO:0043491 74 0.024
regulation of response to wounding GO:1903034 189 0.024
amine transport GO:0015837 21 0.024
mitochondrion organization GO:0007005 134 0.024
cell growth GO:0016049 130 0.024
negative regulation of cellular amine metabolic process GO:0033239 1 0.024
cellular metal ion homeostasis GO:0006875 151 0.024
regulation of angiogenesis GO:0045765 81 0.024
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.024
visual behavior GO:0007632 45 0.024
regulation of protein kinase b signaling GO:0051896 56 0.024
regulation of ovulation GO:0060278 3 0.024
regulation of schwann cell proliferation GO:0010624 2 0.024
mrna transcription from rna polymerase ii promoter GO:0042789 4 0.024
canonical wnt signaling pathway GO:0060070 130 0.024
positive regulation of fat cell proliferation GO:0070346 1 0.024
positive regulation of cell adhesion GO:0045785 80 0.024
regulation of kinase activity GO:0043549 249 0.024
peptidyl serine modification GO:0018209 83 0.024
glial cell development GO:0021782 54 0.024
compound eye development GO:0048749 1 0.023
synaptic vesicle fusion to presynaptic membrane GO:0031629 3 0.023
positive regulation of mapk cascade GO:0043410 170 0.023
inner ear morphogenesis GO:0042472 101 0.023
fear response GO:0042596 33 0.023
cellular response to hexose stimulus GO:0071331 47 0.023
regulation of renin secretion into blood stream GO:1900133 4 0.023
regulation of cell activation GO:0050865 289 0.023
camp metabolic process GO:0046058 40 0.023
purine containing compound catabolic process GO:0072523 213 0.023
regulation of osteoblast differentiation GO:0045667 67 0.023
positive regulation of cellular component biogenesis GO:0044089 94 0.023
regulation of white fat cell proliferation GO:0070350 2 0.023
regulation of multi organism process GO:0043900 111 0.023
Worm
glycerolipid metabolic process GO:0046486 122 0.023
metanephros development GO:0001656 79 0.023
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.023
organ growth GO:0035265 117 0.023
regulation of wnt signaling pathway GO:0030111 123 0.023
negative regulation of molecular function GO:0044092 258 0.023
synaptic transmission cholinergic GO:0007271 7 0.023
cellular response to abiotic stimulus GO:0071214 56 0.023
positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway GO:0010579 3 0.023
wound healing GO:0042060 157 0.023
meiotic cell cycle GO:0051321 122 0.023
regulation of cation channel activity GO:2001257 22 0.022
regeneration GO:0031099 38 0.022
regulation of body fluid levels GO:0050878 162 0.022
habituation GO:0046959 3 0.022
regulation of cell substrate adhesion GO:0010810 73 0.022
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.022
phosphatidylinositol metabolic process GO:0046488 45 0.022
striated muscle tissue development GO:0014706 293 0.022
organic hydroxy compound transport GO:0015850 93 0.022
regulation of proteolysis GO:0030162 164 0.022
protein catabolic process GO:0030163 221 0.022
Worm
regulation of leukocyte differentiation GO:1902105 159 0.022
positive regulation of chemotaxis GO:0050921 38 0.022
regulation of purine nucleotide catabolic process GO:0033121 122 0.022
positive regulation of cell migration GO:0030335 109 0.021
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.021
sulfur compound metabolic process GO:0006790 100 0.021
metanephric dct cell differentiation GO:0072240 3 0.021
respiratory system development GO:0060541 190 0.021
regulation of acetylcholine secretion neurotransmission GO:0014056 2 0.021
endocrine process GO:0050886 39 0.021
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.021
digestive tract development GO:0048565 190 0.021
Mouse
positive regulation of lyase activity GO:0051349 11 0.021
camp biosynthetic process GO:0006171 31 0.021
response to oxidative stress GO:0006979 123 0.021
regulation of g protein activated inward rectifier potassium channel activity GO:1900128 1 0.021
positive regulation of kinase activity GO:0033674 155 0.021
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.021
cardiocyte differentiation GO:0035051 87 0.021
mitochondrion distribution GO:0048311 4 0.021
white fat cell proliferation GO:0070343 2 0.021
myelination GO:0042552 74 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.020
regulation of erk1 and erk2 cascade GO:0070372 71 0.020
positive regulation of vesicle fusion GO:0031340 2 0.020
sensory system development GO:0048880 3 0.020
nucleoside phosphate catabolic process GO:1901292 222 0.020
regulation of receptor activity GO:0010469 41 0.020
regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway GO:0010578 3 0.020
negative regulation of neuron projection development GO:0010977 50 0.020
lung development GO:0030324 164 0.020
membrane fusion GO:0061025 38 0.020
organophosphate catabolic process GO:0046434 232 0.020
visual perception GO:0007601 52 0.020
regulation of mapk cascade GO:0043408 248 0.020
organelle fusion GO:0048284 28 0.020
response to amphetamine GO:0001975 16 0.020
positive regulation of homeostatic process GO:0032846 64 0.020
lipid catabolic process GO:0016042 69 0.019
cardiac chamber development GO:0003205 108 0.019
glycoprotein metabolic process GO:0009100 116 0.019
positive regulation of ion transport GO:0043270 65 0.019
asymmetric stem cell division GO:0098722 3 0.019
positive regulation of peptide hormone secretion GO:0090277 31 0.019
epithalamus development GO:0021538 2 0.019
short chain fatty acid catabolic process GO:0019626 2 0.019
cerebral cortex development GO:0021987 86 0.019
ossification GO:0001503 216 0.019
oocyte anterior posterior axis specification GO:0007314 2 0.019
multicellular organismal homeostasis GO:0048871 164 0.019
regulation of neural precursor cell proliferation GO:2000177 70 0.019
embryonic genitalia morphogenesis GO:0030538 4 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019

Pcsk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.059
nervous system disease DOID:863 0 0.059
central nervous system disease DOID:331 0 0.037
neurodegenerative disease DOID:1289 0 0.024