Mus musculus

49 known processes

Pcsk4

proprotein convertase subtilisin/kexin type 4

(Aliases: MGC63195,NEC 3,PC4,AI647044,L21221,SPC5,NEC3)

Pcsk4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane transport GO:0055085 412 0.594
sperm motility GO:0030317 47 0.556
negative regulation of hormone metabolic process GO:0032351 4 0.543
ion transmembrane transport GO:0034220 361 0.532
metal ion homeostasis GO:0055065 189 0.409
cation homeostasis GO:0055080 212 0.343
negative regulation of hormone biosynthetic process GO:0032353 4 0.305
nucleobase containing small molecule metabolic process GO:0055086 352 0.298
cation transport GO:0006812 399 0.283
inorganic ion transmembrane transport GO:0098660 234 0.275
dephosphorylation GO:0016311 129 0.265
inorganic cation transmembrane transport GO:0098662 207 0.263
cation transmembrane transport GO:0098655 266 0.260
sodium ion transport GO:0006814 73 0.255
glutamate receptor signaling pathway GO:0007215 35 0.242
cellular ion homeostasis GO:0006873 165 0.231
regulation of muscle system process GO:0090257 80 0.199
developmental maturation GO:0021700 193 0.196
steroid metabolic process GO:0008202 119 0.180
negative regulation of molecular function GO:0044092 258 0.144
potassium ion transport GO:0006813 52 0.136
adult behavior GO:0030534 135 0.133
potassium ion transmembrane transport GO:0071805 43 0.114
regulation of hormone levels GO:0010817 211 0.109
Mouse Worm
muscle contraction GO:0006936 101 0.105
sodium ion transmembrane transport GO:0035725 49 0.104
cell type specific apoptotic process GO:0097285 268 0.103
potassium ion homeostasis GO:0055075 4 0.102
cellular homeostasis GO:0019725 240 0.102
cofactor metabolic process GO:0051186 80 0.102
purine ribonucleoside catabolic process GO:0046130 205 0.101
ribonucleotide metabolic process GO:0009259 291 0.100
ribonucleoside triphosphate metabolic process GO:0009199 220 0.094
regulation of ion transmembrane transport GO:0034765 119 0.089
regulation of cellular amino acid metabolic process GO:0006521 5 0.089
germ cell development GO:0007281 185 0.088
regulation of system process GO:0044057 200 0.087
lipid transport GO:0006869 98 0.083
camera type eye development GO:0043010 266 0.083
muscle system process GO:0003012 141 0.082
hormone secretion GO:0046879 128 0.082
cellular calcium ion homeostasis GO:0006874 119 0.080
determination of left right symmetry GO:0007368 80 0.079
Mouse
blood circulation GO:0008015 195 0.076
lipid biosynthetic process GO:0008610 179 0.076
male gamete generation GO:0048232 285 0.075
locomotory behavior GO:0007626 195 0.075
cellular amino acid metabolic process GO:0006520 103 0.075
organic cyclic compound catabolic process GO:1901361 295 0.074
spermatid differentiation GO:0048515 115 0.074
sensory perception GO:0007600 245 0.073
sensory organ morphogenesis GO:0090596 242 0.071
multicellular organismal homeostasis GO:0048871 164 0.070
monovalent inorganic cation homeostasis GO:0055067 33 0.070
purine ribonucleotide metabolic process GO:0009150 290 0.070
nucleoside monophosphate metabolic process GO:0009123 85 0.069
heterocycle catabolic process GO:0046700 280 0.069
atp metabolic process GO:0046034 75 0.068
cellular potassium ion transport GO:0071804 43 0.067
fat cell differentiation GO:0045444 160 0.066
ribonucleoside catabolic process GO:0042454 206 0.066
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.066
nucleoside triphosphate catabolic process GO:0009143 205 0.065
cerebellum development GO:0021549 77 0.065
organic anion transport GO:0015711 137 0.065
spermatogenesis GO:0007283 284 0.064
cellular metal ion homeostasis GO:0006875 151 0.064
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.063
development of primary male sexual characteristics GO:0046546 88 0.062
regulation of neurotransmitter levels GO:0001505 87 0.062
ribonucleoside monophosphate metabolic process GO:0009161 80 0.062
gland development GO:0048732 330 0.062
nucleoside triphosphate metabolic process GO:0009141 230 0.062
sensory perception of sound GO:0007605 97 0.061
purine nucleotide metabolic process GO:0006163 302 0.061
regulation of steroid biosynthetic process GO:0050810 26 0.061
purine ribonucleotide catabolic process GO:0009154 208 0.061
regulation of steroid metabolic process GO:0019218 39 0.060
peptide secretion GO:0002790 114 0.060
cellular response to hormone stimulus GO:0032870 150 0.058
urogenital system development GO:0001655 261 0.056
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.056
negative regulation of lipid metabolic process GO:0045833 30 0.056
epithelial tube morphogenesis GO:0060562 303 0.056
heart morphogenesis GO:0003007 178 0.055
calcium ion homeostasis GO:0055074 127 0.055
insulin secretion GO:0030073 89 0.055
negative regulation of steroid biosynthetic process GO:0010894 8 0.055
ribonucleoside metabolic process GO:0009119 245 0.054
heart contraction GO:0060047 93 0.054
divalent inorganic cation homeostasis GO:0072507 138 0.054
peptide transport GO:0015833 133 0.054
fluid transport GO:0042044 14 0.053
carbohydrate derivative catabolic process GO:1901136 231 0.053
regulation of peptide secretion GO:0002791 77 0.053
cellular amine metabolic process GO:0044106 44 0.052
regulation of cellular amine metabolic process GO:0033238 20 0.052
atp catabolic process GO:0006200 55 0.051
regulation of peptide hormone secretion GO:0090276 75 0.051
nucleoside monophosphate catabolic process GO:0009125 59 0.051
microtubule based process GO:0007017 236 0.051
regulation of organ morphogenesis GO:2000027 144 0.051
purine ribonucleoside metabolic process GO:0046128 241 0.051
regulation of ion transport GO:0043269 215 0.051
adult locomotory behavior GO:0008344 91 0.051
regulation of cell cycle GO:0051726 281 0.050
regulation of ph GO:0006885 26 0.050
response to organic cyclic compound GO:0014070 198 0.050
cellular lipid metabolic process GO:0044255 323 0.050
skeletal system development GO:0001501 356 0.049
Mouse
ribonucleoside monophosphate catabolic process GO:0009158 57 0.049
steroid biosynthetic process GO:0006694 47 0.048
striated muscle tissue development GO:0014706 293 0.048
carboxylic acid transport GO:0046942 100 0.048
spermatid development GO:0007286 108 0.048
purine containing compound metabolic process GO:0072521 311 0.047
embryonic organ morphogenesis GO:0048562 276 0.047
reactive oxygen species metabolic process GO:0072593 84 0.047
carbohydrate metabolic process GO:0005975 230 0.047
cilium morphogenesis GO:0060271 102 0.046
purine containing compound catabolic process GO:0072523 213 0.046
hydrogen ion transmembrane transport GO:1902600 25 0.046
aromatic compound catabolic process GO:0019439 286 0.046
epithelial cell development GO:0002064 159 0.045
retina development in camera type eye GO:0060041 119 0.044
regulation of hormone secretion GO:0046883 88 0.044
response to light stimulus GO:0009416 135 0.044
t cell activation GO:0042110 289 0.043
regulation of membrane potential GO:0042391 192 0.042
nucleoside phosphate catabolic process GO:1901292 222 0.042
meiotic nuclear division GO:0007126 115 0.042
kidney development GO:0001822 213 0.041
Mouse
neuron death GO:0070997 154 0.041
regionalization GO:0003002 337 0.040
Mouse
nitrogen compound transport GO:0071705 271 0.040
neurotransmitter transport GO:0006836 76 0.040
mesenchyme development GO:0060485 152 0.039
ribonucleoside triphosphate catabolic process GO:0009203 199 0.039
epidermis development GO:0008544 187 0.039
renal system development GO:0072001 225 0.039
Mouse
glycosyl compound metabolic process GO:1901657 246 0.039
negative regulation of cell proliferation GO:0008285 296 0.039
cellular chemical homeostasis GO:0055082 215 0.039
cerebellum morphogenesis GO:0021587 42 0.039
peptide hormone secretion GO:0030072 109 0.039
embryonic heart tube morphogenesis GO:0003143 51 0.039
skin development GO:0043588 220 0.039
anion transport GO:0006820 177 0.039
protein localization to nucleus GO:0034504 121 0.038
actin cytoskeleton organization GO:0030036 220 0.038
organelle assembly GO:0070925 177 0.038
nucleocytoplasmic transport GO:0006913 139 0.038
synaptic transmission GO:0007268 329 0.038
organophosphate catabolic process GO:0046434 232 0.038
nuclear transport GO:0051169 139 0.038
organelle fission GO:0048285 170 0.037
cop9 signalosome assembly GO:0010387 2 0.036
regulation of body fluid levels GO:0050878 162 0.036
organic hydroxy compound metabolic process GO:1901615 203 0.036
nucleotide metabolic process GO:0009117 332 0.036
germ line stem cell division GO:0042078 2 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.035
male meiosis GO:0007140 37 0.035
regulation of cellular ketone metabolic process GO:0010565 66 0.035
cellular response to lipid GO:0071396 145 0.035
anatomical structure homeostasis GO:0060249 145 0.035
cofactor transport GO:0051181 4 0.035
fat soluble vitamin biosynthetic process GO:0042362 4 0.035
glycosyl compound catabolic process GO:1901658 206 0.034
cellular component assembly involved in morphogenesis GO:0010927 139 0.034
skeletal muscle cell differentiation GO:0035914 66 0.034
cell maturation GO:0048469 127 0.033
regulation of striated muscle contraction GO:0006942 25 0.033
regulation of transporter activity GO:0032409 57 0.033
nephric duct formation GO:0072179 4 0.032
cellular divalent inorganic cation homeostasis GO:0072503 127 0.032
hormone biosynthetic process GO:0042446 16 0.032
regulation of cardioblast differentiation GO:0051890 3 0.032
hormone metabolic process GO:0042445 86 0.032
Mouse Worm
response to radiation GO:0009314 165 0.032
regulation of heart contraction GO:0008016 77 0.032
purine nucleoside metabolic process GO:0042278 241 0.032
cellular ketone metabolic process GO:0042180 84 0.032
response to glycoside GO:1903416 2 0.031
amide transport GO:0042886 138 0.031
generation of precursor metabolites and energy GO:0006091 103 0.031
determination of heart left right asymmetry GO:0061371 48 0.031
sensory perception of mechanical stimulus GO:0050954 107 0.031
purine nucleoside triphosphate catabolic process GO:0009146 203 0.030
hepaticobiliary system development GO:0061008 67 0.030
transition metal ion transport GO:0000041 38 0.030
embryonic epithelial tube formation GO:0001838 130 0.030
actin filament organization GO:0007015 113 0.030
purine nucleoside monophosphate metabolic process GO:0009126 81 0.030
regulation of neuron apoptotic process GO:0043523 122 0.030
glucocorticoid biosynthetic process GO:0006704 5 0.030
iron ion homeostasis GO:0055072 36 0.029
cellular response to organic cyclic compound GO:0071407 87 0.029
response to oxidative stress GO:0006979 123 0.029
purine nucleoside triphosphate metabolic process GO:0009144 226 0.029
muscle tissue development GO:0060537 308 0.029
amine metabolic process GO:0009308 45 0.029
response to temperature stimulus GO:0009266 55 0.029
negative regulation of steroid metabolic process GO:0045939 8 0.029
triglyceride metabolic process GO:0006641 51 0.029
metencephalon development GO:0022037 89 0.029
ribose phosphate metabolic process GO:0019693 291 0.029
nucleoside metabolic process GO:0009116 246 0.029
regulation of anatomical structure size GO:0090066 178 0.029
regulation of oxidative phosphorylation GO:0002082 6 0.029
nucleotide catabolic process GO:0009166 217 0.028
regulation of voltage gated calcium channel activity GO:1901385 4 0.028
cytoplasmic transport GO:0016482 234 0.028
organonitrogen compound catabolic process GO:1901565 264 0.028
monocarboxylic acid transport GO:0015718 44 0.028
multi multicellular organism process GO:0044706 109 0.028
Mouse
acylglycerol metabolic process GO:0006639 55 0.028
regulation of actin filament based process GO:0032970 99 0.028
intracellular protein transport GO:0006886 204 0.028
hydrogen transport GO:0006818 35 0.027
nucleoside catabolic process GO:0009164 206 0.027
positive regulation of ion transport GO:0043270 65 0.027
response to peptide hormone GO:0043434 127 0.027
cellular response to dna damage stimulus GO:0006974 207 0.026
synapse organization GO:0050808 125 0.026
heart process GO:0003015 94 0.026
cellular modified amino acid metabolic process GO:0006575 63 0.026
cd4 positive alpha beta t cell activation GO:0035710 45 0.026
positive regulation of striated muscle contraction GO:0045989 3 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.026
regulation of vitamin metabolic process GO:0030656 3 0.026
optic vesicle morphogenesis GO:0003404 2 0.026
cellular response to peptide GO:1901653 92 0.026
anatomical structure maturation GO:0071695 49 0.026
negative regulation of hormone secretion GO:0046888 20 0.026
purine nucleoside catabolic process GO:0006152 205 0.025
meiotic cell cycle GO:0051321 122 0.025
regulation of muscle contraction GO:0006937 49 0.025
regulation of lipid transport GO:0032368 36 0.025
lateral inhibition GO:0046331 1 0.025
regulation of hormone metabolic process GO:0032350 15 0.025
negative regulation of phosphate metabolic process GO:0045936 184 0.025
lipid homeostasis GO:0055088 63 0.025
striated muscle contraction GO:0006941 45 0.025
alpha beta t cell differentiation GO:0046632 69 0.024
l serine metabolic process GO:0006563 2 0.024
liver development GO:0001889 66 0.024
hindbrain morphogenesis GO:0021575 46 0.024
regulation of cellular ph GO:0030641 12 0.024
organic acid transport GO:0015849 101 0.024
regulation of homeostatic process GO:0032844 182 0.023
coenzyme metabolic process GO:0006732 52 0.023
cerebellar cortex morphogenesis GO:0021696 32 0.023
epithelial tube formation GO:0072175 130 0.023
regulation of cell cycle process GO:0010564 160 0.023
regulation of blood circulation GO:1903522 93 0.023
meiotic cell cycle process GO:1903046 77 0.023
respiratory system development GO:0060541 190 0.023
tissue homeostasis GO:0001894 115 0.023
eye photoreceptor cell differentiation GO:0001754 41 0.023
protein catabolic process GO:0030163 221 0.022
morphogenesis of a branching structure GO:0001763 203 0.022
purine nucleoside monophosphate catabolic process GO:0009128 58 0.022
inner medullary collecting duct development GO:0072061 2 0.022
macromolecule catabolic process GO:0009057 281 0.022
establishment of protein localization to organelle GO:0072594 118 0.022
asymmetric stem cell division GO:0098722 3 0.022
regulation of lipid biosynthetic process GO:0046890 54 0.022
learning GO:0007612 98 0.022
response to peptide GO:1901652 136 0.022
negative regulation of cellular protein metabolic process GO:0032269 247 0.022
negative regulation of phosphorus metabolic process GO:0010563 184 0.022
mitochondrion organization GO:0007005 134 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
regulation of neuron death GO:1901214 134 0.021
morphogenesis of embryonic epithelium GO:0016331 159 0.021
apoptotic process involved in mammary gland involution GO:0060057 4 0.021
cartilage development GO:0051216 140 0.021
regulation of secretion GO:0051046 274 0.021
regulation of hydrolase activity GO:0051336 246 0.021
ionotropic glutamate receptor signaling pathway GO:0035235 29 0.021
neuromuscular process GO:0050905 99 0.021
purine nucleotide catabolic process GO:0006195 211 0.021
positive regulation of cell death GO:0010942 224 0.021
body fluid secretion GO:0007589 53 0.021
positive regulation of hydrolase activity GO:0051345 148 0.021
response to organonitrogen compound GO:0010243 246 0.021
closure of optic fissure GO:0061386 2 0.021
neuron apoptotic process GO:0051402 142 0.021
glucose metabolic process GO:0006006 92 0.021
regulation of tube size GO:0035150 57 0.020
ossification GO:0001503 216 0.020
muscle adaptation GO:0043500 39 0.020
monosaccharide metabolic process GO:0005996 106 0.020
negative regulation of phosphorylation GO:0042326 166 0.020
cellular response to peptide hormone stimulus GO:0071375 92 0.020
ribonucleotide catabolic process GO:0009261 208 0.020
small molecule biosynthetic process GO:0044283 132 0.020
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.020
dendrite development GO:0016358 115 0.020
Worm
regulation of lipid metabolic process GO:0019216 118 0.020
cellular nitrogen compound catabolic process GO:0044270 280 0.020
response to insulin GO:0032868 100 0.020
hexose metabolic process GO:0019318 98 0.020
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.020
regulation of transferase activity GO:0051338 263 0.020
regulation of cellular catabolic process GO:0031329 242 0.020
renal inner medulla development GO:0072053 3 0.020
carbohydrate homeostasis GO:0033500 128 0.020
cellular response to insulin stimulus GO:0032869 78 0.020
hypophysis morphogenesis GO:0048850 3 0.019
intrinsic apoptotic signaling pathway GO:0097193 132 0.019
apoptotic signaling pathway GO:0097190 306 0.019
positive regulation of programmed cell death GO:0043068 218 0.019
memory GO:0007613 58 0.019
regulation of sodium ion transport GO:0002028 29 0.019
regulation of lymphocyte activation GO:0051249 240 0.019
cell recognition GO:0008037 83 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019
male meiosis i GO:0007141 16 0.019
regulation of ion transmembrane transporter activity GO:0032412 54 0.019
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.019
smooth muscle contraction GO:0006939 44 0.019
microtubule based movement GO:0007018 84 0.019
cell activation involved in immune response GO:0002263 126 0.019
circulatory system process GO:0003013 197 0.019
regulation of peptide transport GO:0090087 91 0.019
regulation of organ growth GO:0046620 61 0.019
neural tube development GO:0021915 160 0.018
nuclear division GO:0000280 158 0.018
regulation of calcium ion transmembrane transporter activity GO:1901019 20 0.018
spemann organizer formation GO:0060061 2 0.018
positive regulation of growth hormone secretion GO:0060124 3 0.018
tube closure GO:0060606 91 0.018
t cell differentiation GO:0030217 174 0.018
connective tissue development GO:0061448 179 0.018
response to extracellular stimulus GO:0009991 127 0.018
cholesterol metabolic process GO:0008203 56 0.017
proton transport GO:0015992 35 0.017
positive regulation of mitotic cell cycle GO:0045931 41 0.017
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.017
skeletal muscle organ development GO:0060538 163 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
male sex differentiation GO:0046661 109 0.017
leukocyte activation involved in immune response GO:0002366 126 0.017
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.017
regulation of translation GO:0006417 71 0.017
negative regulation of muscle contraction GO:0045932 12 0.017
lipid localization GO:0010876 126 0.017
regulation of interleukin 8 secretion GO:2000482 2 0.017
regulation of anion transport GO:0044070 27 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.017
response to inorganic substance GO:0010035 96 0.017
negative regulation of stem cell maintenance GO:1902455 4 0.017
ear morphogenesis GO:0042471 118 0.017
energy derivation by oxidation of organic compounds GO:0015980 77 0.016
regulation of transmembrane transport GO:0034762 128 0.016
cholesterol transport GO:0030301 38 0.016
regulation of mitotic cell cycle GO:0007346 126 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.016
small molecule catabolic process GO:0044282 71 0.016
multicellular organismal aging GO:0010259 24 0.016
cellular transition metal ion homeostasis GO:0046916 32 0.016
ph reduction GO:0045851 8 0.016
positive regulation of apoptotic process GO:0043065 217 0.016
monocarboxylic acid catabolic process GO:0072329 27 0.016
oocyte axis specification GO:0007309 2 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
Mouse
lipid catabolic process GO:0016042 69 0.016
vitamin d biosynthetic process GO:0042368 3 0.016
regulation of protein kinase activity GO:0045859 232 0.016
negative regulation of peptide secretion GO:0002792 16 0.016
compound eye development GO:0048749 1 0.016
somatotropin secreting cell differentiation GO:0060126 4 0.016
response to decreased oxygen levels GO:0036293 59 0.016
oviduct epithelium development GO:0035846 1 0.016
forebrain generation of neurons GO:0021872 63 0.016
negative regulation of neuron death GO:1901215 98 0.016
sterol metabolic process GO:0016125 58 0.016
regulation of binding GO:0051098 111 0.015
response to camp GO:0051591 14 0.015
regulation of blood pressure GO:0008217 93 0.015
regulation of nucleocytoplasmic transport GO:0046822 73 0.015
clara cell differentiation GO:0060486 4 0.015
regulation of smooth muscle contraction GO:0006940 22 0.015
protein targeting GO:0006605 143 0.015
leukocyte proliferation GO:0070661 172 0.015
alpha amino acid biosynthetic process GO:1901607 15 0.015
regulation of cell cycle phase transition GO:1901987 77 0.015
male gonad development GO:0008584 88 0.015
establishment of tissue polarity GO:0007164 28 0.015
purkinje myocyte differentiation GO:0003168 1 0.015
divalent inorganic cation transport GO:0072511 178 0.015
regulation of defense response GO:0031347 233 0.015
epithelial cell morphogenesis GO:0003382 41 0.015
actomyosin structure organization GO:0031032 56 0.015
lens development in camera type eye GO:0002088 62 0.015
ras protein signal transduction GO:0007265 77 0.015
protein localization to organelle GO:0033365 185 0.015
cellular response to oxidative stress GO:0034599 76 0.015
oocyte construction GO:0007308 2 0.015
organic acid biosynthetic process GO:0016053 86 0.015
cell fate commitment GO:0045165 210 0.015
regulation of organelle organization GO:0033043 289 0.015
inner ear morphogenesis GO:0042472 101 0.015
positive regulation of sodium ion transmembrane transport GO:1902307 4 0.015
positive regulation of muscle contraction GO:0045933 10 0.015
visual learning GO:0008542 44 0.015
regulation of proteolysis GO:0030162 164 0.015
cytosolic calcium ion homeostasis GO:0051480 70 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.015
negative regulation of cellular amine metabolic process GO:0033239 1 0.015
sterol transport GO:0015918 38 0.015
response to copper ion GO:0046688 3 0.014
synapse assembly GO:0007416 56 0.014
limb morphogenesis GO:0035108 149 0.014
Mouse
embryonic placenta development GO:0001892 98 0.014
positive regulation of cardioblast differentiation GO:0051891 3 0.014
regulation of isoprenoid metabolic process GO:0019747 1 0.014
cervix development GO:0060067 2 0.014
negative regulation of testosterone biosynthetic process GO:2000225 1 0.014
regulation of intracellular transport GO:0032386 159 0.014
regulation of steroid hormone biosynthetic process GO:0090030 4 0.014
asymmetric neuroblast division GO:0055059 1 0.014
protein localization to vacuole GO:0072665 4 0.014
atrial cardiac muscle cell development GO:0055014 2 0.014
placenta development GO:0001890 140 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
ventricular cardiac myofibril assembly GO:0055005 3 0.014
protein targeting to vacuole GO:0006623 3 0.014
regulation of circadian rhythm GO:0042752 58 0.014
regulation of ossification GO:0030278 112 0.014
testosterone biosynthetic process GO:0061370 2 0.014
organic hydroxy compound biosynthetic process GO:1901617 77 0.014
regulation of fat cell differentiation GO:0045598 81 0.013
transition metal ion homeostasis GO:0055076 54 0.013
mrna metabolic process GO:0016071 84 0.013
vitamin metabolic process GO:0006766 23 0.013
intracellular mrna localization GO:0008298 4 0.013
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.013
regulation of metal ion transport GO:0010959 106 0.013
visual behavior GO:0007632 45 0.013
spinal cord development GO:0021510 81 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
developmental cell growth GO:0048588 84 0.013
cerebellar purkinje cell layer development GO:0021680 26 0.013
atrial septum primum morphogenesis GO:0003289 3 0.013
protein import into nucleus GO:0006606 95 0.013
regulation of stem cell differentiation GO:2000736 50 0.013
epithelial cell fate commitment GO:0072148 13 0.013
epithelial cell migration GO:0010631 63 0.013
single organism nuclear import GO:1902593 95 0.013
regulation of activation of jak2 kinase activity GO:0010534 1 0.013
hair follicle development GO:0001942 85 0.013
cerebellar cortex development GO:0021695 48 0.013
hair cycle GO:0042633 90 0.013
monocarboxylic acid metabolic process GO:0032787 191 0.013
adult walking behavior GO:0007628 41 0.013
cell junction organization GO:0034330 77 0.013
limb development GO:0060173 166 0.013
Mouse
superoxide metabolic process GO:0006801 27 0.013
regulation of stress activated mapk cascade GO:0032872 69 0.013
regulation of mapk cascade GO:0043408 248 0.013
brain segmentation GO:0035284 3 0.013
t cell differentiation in thymus GO:0033077 77 0.013
forebrain development GO:0030900 302 0.012
positive regulation of rho gtpase activity GO:0032321 41 0.012
protein import GO:0017038 101 0.012
negative regulation of binding GO:0051100 39 0.012
digestion GO:0007586 40 0.012
translation GO:0006412 93 0.012
glycerolipid metabolic process GO:0046486 122 0.012
chromosome segregation GO:0007059 48 0.012
neurotransmitter uptake GO:0001504 14 0.012
nephron epithelium development GO:0072009 92 0.012
regulation of cell activation GO:0050865 289 0.012
regulation of cytoskeleton organization GO:0051493 122 0.012
establishment of protein localization to vacuole GO:0072666 4 0.012
heart induction GO:0003129 2 0.012
regulation of cysteine type endopeptidase activity GO:2000116 65 0.012
circadian rhythm GO:0007623 114 0.012
hexose biosynthetic process GO:0019319 39 0.012
neurotransmitter secretion GO:0007269 62 0.012
cellular response to steroid hormone stimulus GO:0071383 33 0.012
apoptotic mitochondrial changes GO:0008637 48 0.012
negative chemotaxis GO:0050919 14 0.012
respiratory gaseous exchange GO:0007585 43 0.012

Pcsk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
nervous system disease DOID:863 0 0.027
disease of metabolism DOID:0014667 0 0.020
retinal disease DOID:5679 0 0.019
sensory system disease DOID:0050155 0 0.019
eye and adnexa disease DOID:1492 0 0.019
eye disease DOID:5614 0 0.019
acquired metabolic disease DOID:0060158 0 0.016
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013