Mus musculus

102 known processes

Insig2

insulin induced gene 2

(Aliases: Insig-2,2900053I11Rik,C730043J18Rik)

Insig2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organophosphate catabolic process GO:0046434 232 0.092
alcohol metabolic process GO:0006066 116 0.083
cellular lipid metabolic process GO:0044255 323 0.080
organic cyclic compound catabolic process GO:1901361 295 0.073
nucleobase containing small molecule metabolic process GO:0055086 352 0.064
cellular amine metabolic process GO:0044106 44 0.062
organic hydroxy compound metabolic process GO:1901615 203 0.061
lipid biosynthetic process GO:0008610 179 0.060
ubiquitin dependent protein catabolic process GO:0006511 129 0.058
amine metabolic process GO:0009308 45 0.058
glycerolipid metabolic process GO:0046486 122 0.057
cellular ketone metabolic process GO:0042180 84 0.056
glycerophospholipid metabolic process GO:0006650 71 0.054
small molecule biosynthetic process GO:0044283 132 0.050
cellular amino acid metabolic process GO:0006520 103 0.049
carbohydrate derivative catabolic process GO:1901136 231 0.049
macromolecule catabolic process GO:0009057 281 0.046
nucleotide metabolic process GO:0009117 332 0.045
nucleoside metabolic process GO:0009116 246 0.043
nucleoside phosphate metabolic process GO:0006753 338 0.043
glycosyl compound metabolic process GO:1901657 246 0.043
ribonucleoside metabolic process GO:0009119 245 0.042
phosphatidylethanolamine metabolic process GO:0046337 2 0.042
immune effector process GO:0002252 321 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.039
organonitrogen compound catabolic process GO:1901565 264 0.039
intracellular protein transport GO:0006886 204 0.038
monocarboxylic acid metabolic process GO:0032787 191 0.038
aromatic compound catabolic process GO:0019439 286 0.037
ribonucleotide catabolic process GO:0009261 208 0.036
protein catabolic process GO:0030163 221 0.036
protein targeting GO:0006605 143 0.036
nitrogen compound transport GO:0071705 271 0.035
purine nucleoside metabolic process GO:0042278 241 0.035
ribonucleoside triphosphate metabolic process GO:0009199 220 0.035
regulation of cellular ketone metabolic process GO:0010565 66 0.034
purine ribonucleotide catabolic process GO:0009154 208 0.034
phospholipid metabolic process GO:0006644 87 0.034
cellular nitrogen compound catabolic process GO:0044270 280 0.033
cellular biogenic amine metabolic process GO:0006576 28 0.033
purine containing compound metabolic process GO:0072521 311 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
nucleotide catabolic process GO:0009166 217 0.030
purine ribonucleoside metabolic process GO:0046128 241 0.030
membrane organization GO:0061024 245 0.030
leukocyte differentiation GO:0002521 342 0.029
regulation of intracellular transport GO:0032386 159 0.029
protein modification by small protein conjugation or removal GO:0070647 207 0.029
organic anion transport GO:0015711 137 0.028
regulation of cellular catabolic process GO:0031329 242 0.028
glycosyl compound catabolic process GO:1901658 206 0.028
heterocycle catabolic process GO:0046700 280 0.028
cellular protein catabolic process GO:0044257 155 0.027
transmembrane transport GO:0055085 412 0.027
regulation of defense response GO:0031347 233 0.026
cytokine production GO:0001816 319 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
regulation of cytokine production GO:0001817 266 0.025
nucleoside triphosphate catabolic process GO:0009143 205 0.025
cellular macromolecule catabolic process GO:0044265 206 0.025
response to organonitrogen compound GO:0010243 246 0.025
modification dependent macromolecule catabolic process GO:0043632 133 0.024
negative regulation of protein metabolic process GO:0051248 282 0.024
purine nucleotide metabolic process GO:0006163 302 0.024
nucleoside triphosphate metabolic process GO:0009141 230 0.024
positive regulation of cellular amine metabolic process GO:0033240 5 0.024
ribonucleotide metabolic process GO:0009259 291 0.024
purine containing compound catabolic process GO:0072523 213 0.024
regulation of cellular amine metabolic process GO:0033238 20 0.024
anion transport GO:0006820 177 0.024
negative regulation of cellular component organization GO:0051129 194 0.023
lipid transport GO:0006869 98 0.023
carbohydrate metabolic process GO:0005975 230 0.023
intra golgi vesicle mediated transport GO:0006891 1 0.023
cell activation involved in immune response GO:0002263 126 0.022
purine nucleotide catabolic process GO:0006195 211 0.022
leukocyte mediated immunity GO:0002443 174 0.022
apoptotic signaling pathway GO:0097190 306 0.022
purine nucleoside triphosphate metabolic process GO:0009144 226 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.022
endomembrane system organization GO:0010256 147 0.021
purine nucleoside triphosphate catabolic process GO:0009146 203 0.021
organonitrogen compound biosynthetic process GO:1901566 192 0.021
regulation of protein localization GO:0032880 231 0.021
purine ribonucleotide metabolic process GO:0009150 290 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.021
regulation of nucleotide metabolic process GO:0006140 169 0.021
adaptive immune response GO:0002250 155 0.021
carboxylic acid biosynthetic process GO:0046394 86 0.021
regulation of cellular amino acid metabolic process GO:0006521 5 0.020
regulation of organelle organization GO:0033043 289 0.020
t cell activation GO:0042110 289 0.020
organophosphate biosynthetic process GO:0090407 122 0.020
positive regulation of nervous system development GO:0051962 221 0.020
negative regulation of immune system process GO:0002683 209 0.020
small gtpase mediated signal transduction GO:0007264 97 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.020
regulation of hormone levels GO:0010817 211 0.019
organophosphate ester transport GO:0015748 28 0.019
ribonucleoside triphosphate catabolic process GO:0009203 199 0.019
leukocyte activation involved in immune response GO:0002366 126 0.019
regulation of apoptotic signaling pathway GO:2001233 197 0.019
positive regulation of protein modification process GO:0031401 299 0.019
nucleocytoplasmic transport GO:0006913 139 0.019
positive regulation of hydrolase activity GO:0051345 148 0.018
organic acid biosynthetic process GO:0016053 86 0.018
cell type specific apoptotic process GO:0097285 268 0.018
cellular homeostasis GO:0019725 240 0.018
regulation of neuron projection development GO:0010975 169 0.018
phosphatidylethanolamine biosynthetic process GO:0006646 2 0.018
neuron death GO:0070997 154 0.018
lipid localization GO:0010876 126 0.017
regulation of anatomical structure size GO:0090066 178 0.017
small molecule catabolic process GO:0044282 71 0.017
cell growth GO:0016049 130 0.017
inflammatory response GO:0006954 244 0.017
protein import GO:0017038 101 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
leukocyte proliferation GO:0070661 172 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
establishment of protein localization to vacuole GO:0072666 4 0.016
negative regulation of cellular protein metabolic process GO:0032269 247 0.016
response to radiation GO:0009314 165 0.016
response to oxidative stress GO:0006979 123 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
reactive oxygen species metabolic process GO:0072593 84 0.016
regulation of leukocyte proliferation GO:0070663 121 0.016
activation of immune response GO:0002253 138 0.016
lipoprotein metabolic process GO:0042157 43 0.016
regulation of neuron apoptotic process GO:0043523 122 0.016
b cell activation GO:0042113 161 0.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
ossification GO:0001503 216 0.016
guanosine containing compound catabolic process GO:1901069 144 0.016
nucleoside catabolic process GO:0009164 206 0.016
regulation of cellular response to stress GO:0080135 159 0.015
cdp choline pathway GO:0006657 2 0.015
regulation of leukocyte mediated immunity GO:0002703 104 0.015
organic hydroxy compound biosynthetic process GO:1901617 77 0.015
camera type eye development GO:0043010 266 0.015
hormone secretion GO:0046879 128 0.015
regulation of cell motility GO:2000145 236 0.015
cation homeostasis GO:0055080 212 0.015
mapk cascade GO:0000165 281 0.015
ion transmembrane transport GO:0034220 361 0.015
gtp metabolic process GO:0046039 144 0.015
negative regulation of cytokine production GO:0001818 84 0.015
regulation of neuron death GO:1901214 134 0.015
regulation of purine nucleotide catabolic process GO:0033121 122 0.015
sensory perception GO:0007600 245 0.015
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.015
regulation of hydrolase activity GO:0051336 246 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
regulation of t cell activation GO:0050863 170 0.015
regulation of lipid metabolic process GO:0019216 118 0.015
regulation of cytoplasmic transport GO:1903649 112 0.014
regulation of secretion by cell GO:1903530 249 0.014
protein ubiquitination GO:0016567 171 0.014
establishment of protein localization to organelle GO:0072594 118 0.014
adult behavior GO:0030534 135 0.014
glycerophospholipid biosynthetic process GO:0046474 32 0.014
myeloid cell differentiation GO:0030099 233 0.014
plasma membrane organization GO:0007009 90 0.014
cation transport GO:0006812 399 0.014
chromatin organization GO:0006325 206 0.014
regulation of kinase activity GO:0043549 249 0.014
action potential GO:0001508 78 0.014
negative regulation of molecular function GO:0044092 258 0.013
innate immune response GO:0045087 157 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.013
modification dependent protein catabolic process GO:0019941 133 0.013
neuron apoptotic process GO:0051402 142 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
spermatogenesis GO:0007283 284 0.013
defense response to other organism GO:0098542 197 0.013
negative regulation of defense response GO:0031348 77 0.013
regulation of membrane potential GO:0042391 192 0.013
lipoprotein biosynthetic process GO:0042158 33 0.013
organic acid transport GO:0015849 101 0.013
regulation of lymphocyte proliferation GO:0050670 117 0.013
compound eye development GO:0048749 1 0.013
regulation of secretion GO:0051046 274 0.013
organic acid catabolic process GO:0016054 51 0.013
regulation of purine nucleotide metabolic process GO:1900542 169 0.013
regulation of cell projection organization GO:0031344 206 0.013
regulation of transferase activity GO:0051338 263 0.013
protein localization to vacuole GO:0072665 4 0.013
positive regulation of nucleotide catabolic process GO:0030813 88 0.013
positive regulation of secretion GO:0051047 130 0.013
lymphocyte mediated immunity GO:0002449 139 0.013
protein maturation GO:0051604 176 0.013
response to inorganic substance GO:0010035 96 0.013
regulation of proteolysis GO:0030162 164 0.013
neurotransmitter transport GO:0006836 76 0.013
muscle cell differentiation GO:0042692 261 0.013
regulation of cell migration GO:0030334 219 0.013
regulation of cell activation GO:0050865 289 0.013
lymphocyte activation involved in immune response GO:0002285 93 0.013
positive regulation of secretion by cell GO:1903532 114 0.013
positive regulation of cell development GO:0010720 237 0.013
membrane fusion GO:0061025 38 0.013
response to peptide GO:1901652 136 0.013
cellular protein complex assembly GO:0043623 116 0.013
regulation of protein catabolic process GO:0042176 108 0.012
cellular response to lipid GO:0071396 145 0.012
membrane lipid metabolic process GO:0006643 53 0.012
lymphocyte differentiation GO:0030098 242 0.012
regulation of response to wounding GO:1903034 189 0.012
regulation of protein transport GO:0051223 163 0.012
organelle localization GO:0051640 179 0.012
response to endoplasmic reticulum stress GO:0034976 53 0.012
alcohol biosynthetic process GO:0046165 43 0.012
regulation of inflammatory response GO:0050727 147 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
multicellular organismal signaling GO:0035637 91 0.012
production of molecular mediator of immune response GO:0002440 103 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.012
oxidation reduction process GO:0055114 342 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
response to light stimulus GO:0009416 135 0.012
regulation of homeostatic process GO:0032844 182 0.012
axonogenesis GO:0007409 274 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.012
somatic diversification of immune receptors GO:0002200 53 0.012
male gamete generation GO:0048232 285 0.012
g protein coupled receptor signaling pathway GO:0007186 243 0.012
protein lipidation GO:0006497 28 0.012
establishment of protein localization to golgi GO:0072600 1 0.012
monocarboxylic acid biosynthetic process GO:0072330 61 0.012
cellular chemical homeostasis GO:0055082 215 0.012
lipid catabolic process GO:0016042 69 0.012
protein modification by small protein conjugation GO:0032446 187 0.012
cytoplasmic transport GO:0016482 234 0.011
metal ion homeostasis GO:0055065 189 0.011
protein targeting to vacuole GO:0006623 3 0.011
skin development GO:0043588 220 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.011
cellular carbohydrate metabolic process GO:0044262 119 0.011
locomotory behavior GO:0007626 195 0.011
peptidyl amino acid modification GO:0018193 336 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
synaptic transmission GO:0007268 329 0.011
golgi to endosome transport GO:0006895 3 0.011
transmission of nerve impulse GO:0019226 76 0.011
ras protein signal transduction GO:0007265 77 0.011
glycoprotein metabolic process GO:0009100 116 0.011
embryonic organ morphogenesis GO:0048562 276 0.011
exocytosis GO:0006887 121 0.011
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.011
regulation of production of molecular mediator of immune response GO:0002700 65 0.011
carboxylic acid transport GO:0046942 100 0.011
fat cell differentiation GO:0045444 160 0.011
Mouse
protein processing GO:0016485 163 0.011
nuclear transport GO:0051169 139 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
positive regulation of monocyte chemotaxis GO:0090026 2 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
response to transforming growth factor beta GO:0071559 88 0.011
renal system development GO:0072001 225 0.011
regulation of cellular response to growth factor stimulus GO:0090287 82 0.011
epithelial cell proliferation GO:0050673 174 0.011
regulation of t cell proliferation GO:0042129 92 0.011
retrograde vesicle mediated transport golgi to er GO:0006890 1 0.011
response to extracellular stimulus GO:0009991 127 0.011
amide transport GO:0042886 138 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.011
positive regulation of cell migration GO:0030335 109 0.011
neuronal action potential GO:0019228 54 0.011
positive regulation of gtp catabolic process GO:0033126 85 0.011
cellular response to hormone stimulus GO:0032870 150 0.010
negative regulation of immune effector process GO:0002698 55 0.010
positive regulation of nucleotide metabolic process GO:0045981 114 0.010
regulation of multi organism process GO:0043900 111 0.010
regulation of leukocyte differentiation GO:1902105 159 0.010
peptide transport GO:0015833 133 0.010
positive regulation of cellular catabolic process GO:0031331 148 0.010
response to oxygen levels GO:0070482 62 0.010
fatty acid metabolic process GO:0006631 121 0.010
localization within membrane GO:0051668 4 0.010
fatty acid alpha oxidation GO:0001561 2 0.010
apoptotic mitochondrial changes GO:0008637 48 0.010
cation transmembrane transport GO:0098655 266 0.010
mitochondrion organization GO:0007005 134 0.010
gtp catabolic process GO:0006184 143 0.010

Insig2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
disease of metabolism DOID:0014667 0 0.022
musculoskeletal system disease DOID:17 0 0.015
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.010