Mus musculus

62 known processes

Hsd17b4

hydroxysteroid (17-beta) dehydrogenase 4

(Aliases: 17-beta-HSD,MPF-2,perMFE-2,MFE-2,Mfp-2,MFP2,4,DBP,17[b]-HSD)

Hsd17b4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
small molecule catabolic process GO:0044282 71 0.985
monocarboxylic acid catabolic process GO:0072329 27 0.950
organic acid catabolic process GO:0016054 51 0.942
lipid modification GO:0030258 65 0.935
fatty acid oxidation GO:0019395 28 0.891
lipid oxidation GO:0034440 29 0.887
cellular lipid catabolic process GO:0044242 52 0.864
fatty acid catabolic process GO:0009062 25 0.858
lipid catabolic process GO:0016042 69 0.847
carboxylic acid catabolic process GO:0046395 51 0.833
monocarboxylic acid metabolic process GO:0032787 191 0.792
cellular lipid metabolic process GO:0044255 323 0.785
fatty acid beta oxidation GO:0006635 16 0.740
fatty acid metabolic process GO:0006631 121 0.721
thioester metabolic process GO:0035383 19 0.630
Human
oxidation reduction process GO:0055114 342 0.530
organic hydroxy compound metabolic process GO:1901615 203 0.443
cellular ketone metabolic process GO:0042180 84 0.419
very long chain fatty acid catabolic process GO:0042760 2 0.409
carnitine metabolic process GO:0009437 7 0.329
peroxisome organization GO:0007031 7 0.309
small molecule biosynthetic process GO:0044283 132 0.284
alcohol metabolic process GO:0006066 116 0.254
acyl coa metabolic process GO:0006637 19 0.242
Human
cellular amino acid metabolic process GO:0006520 103 0.214
lipid localization GO:0010876 126 0.192
Worm
acylglycerol metabolic process GO:0006639 55 0.156
carboxylic acid biosynthetic process GO:0046394 86 0.151
regulation of cellular ketone metabolic process GO:0010565 66 0.145
protein homooligomerization GO:0051260 43 0.135
steroid metabolic process GO:0008202 119 0.123
Human
cellular amine metabolic process GO:0044106 44 0.120
amino acid betaine metabolic process GO:0006577 7 0.113
protein oligomerization GO:0051259 67 0.112
very long chain fatty acid metabolic process GO:0000038 8 0.103
lipid biosynthetic process GO:0008610 179 0.102
lipid transport GO:0006869 98 0.096
sterol metabolic process GO:0016125 58 0.093
membrane organization GO:0061024 245 0.088
cellular aldehyde metabolic process GO:0006081 12 0.084
cofactor metabolic process GO:0051186 80 0.083
Human
fatty acid alpha oxidation GO:0001561 2 0.083
coenzyme metabolic process GO:0006732 52 0.083
Human
aldehyde catabolic process GO:0046185 4 0.072
organic cyclic compound catabolic process GO:1901361 295 0.069
medium chain fatty acid metabolic process GO:0051791 1 0.068
regulation of hormone levels GO:0010817 211 0.067
Human
nucleobase containing small molecule metabolic process GO:0055086 352 0.065
organonitrogen compound catabolic process GO:1901565 264 0.064
maintenance of location GO:0051235 89 0.063
Worm
amine metabolic process GO:0009308 45 0.063
anion transport GO:0006820 177 0.062
ketone catabolic process GO:0042182 3 0.060
response to organic cyclic compound GO:0014070 198 0.060
regulation of cellular amino acid metabolic process GO:0006521 5 0.059
alpha amino acid biosynthetic process GO:1901607 15 0.053
organic acid biosynthetic process GO:0016053 86 0.052
cellular modified amino acid metabolic process GO:0006575 63 0.051
glycerolipid metabolic process GO:0046486 122 0.051
organic anion transport GO:0015711 137 0.049
protein tetramerization GO:0051262 23 0.048
organic hydroxy compound biosynthetic process GO:1901617 77 0.048
nucleoside phosphate metabolic process GO:0006753 338 0.047
organonitrogen compound biosynthetic process GO:1901566 192 0.047
defense response to other organism GO:0098542 197 0.047
Worm
regulation of cellular catabolic process GO:0031329 242 0.046
progesterone biosynthetic process GO:0006701 1 0.044
endomembrane system organization GO:0010256 147 0.044
cellular amino acid catabolic process GO:0009063 25 0.043
hepaticobiliary system development GO:0061008 67 0.042
triglyceride metabolic process GO:0006641 51 0.042
protein localization to plasma membrane GO:0072659 57 0.042
ribonucleoside triphosphate metabolic process GO:0009199 220 0.041
protein localization to membrane GO:0072657 108 0.041
diterpenoid metabolic process GO:0016101 24 0.039
isoprenoid metabolic process GO:0006720 29 0.038
liver development GO:0001889 66 0.038
glycerophospholipid metabolic process GO:0006650 71 0.038
ribose phosphate metabolic process GO:0019693 291 0.038
generation of precursor metabolites and energy GO:0006091 103 0.037
regulation of intracellular transport GO:0032386 159 0.036
glycosyl compound metabolic process GO:1901657 246 0.035
regulation of removal of superoxide radicals GO:2000121 4 0.035
regulation of cellular amine metabolic process GO:0033238 20 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.035
intracellular lipid transport GO:0032365 3 0.035
purine ribonucleotide metabolic process GO:0009150 290 0.035
positive regulation of cellular amine metabolic process GO:0033240 5 0.034
homeostasis of number of cells GO:0048872 210 0.033
purine nucleoside metabolic process GO:0042278 241 0.033
energy derivation by oxidation of organic compounds GO:0015980 77 0.031
cytoplasmic transport GO:0016482 234 0.030
microtubule based process GO:0007017 236 0.030
response to copper ion GO:0046688 3 0.030
ribonucleotide metabolic process GO:0009259 291 0.029
nucleoside metabolic process GO:0009116 246 0.029
alcohol biosynthetic process GO:0046165 43 0.029
response to steroid hormone GO:0048545 56 0.029
alpha amino acid metabolic process GO:1901605 59 0.029
positive regulation of protein modification process GO:0031401 299 0.029
nucleotide metabolic process GO:0009117 332 0.029
retinoid metabolic process GO:0001523 24 0.029
glucose metabolic process GO:0006006 92 0.028
aromatic compound catabolic process GO:0019439 286 0.028
fatty acid transmembrane transport GO:1902001 1 0.028
protein import into peroxisome matrix GO:0016558 3 0.028
neutral lipid metabolic process GO:0006638 57 0.028
gland development GO:0048732 330 0.027
cellular amino acid biosynthetic process GO:0008652 22 0.027
protein targeting to peroxisome GO:0006625 4 0.027
regulation of protein localization GO:0032880 231 0.026
establishment of protein localization to peroxisome GO:0072663 4 0.026
regulation of apoptotic signaling pathway GO:2001233 197 0.026
heterocycle catabolic process GO:0046700 280 0.026
monocarboxylic acid biosynthetic process GO:0072330 61 0.026
c21 steroid hormone biosynthetic process GO:0006700 3 0.026
muscle cell differentiation GO:0042692 261 0.025
protein localization to organelle GO:0033365 185 0.025
organophosphate catabolic process GO:0046434 232 0.025
synaptic transmission GO:0007268 329 0.025
coenzyme biosynthetic process GO:0009108 23 0.025
ribonucleotide catabolic process GO:0009261 208 0.024
glutamine family amino acid biosynthetic process GO:0009084 2 0.024
terpenoid metabolic process GO:0006721 25 0.023
regulation of lipid metabolic process GO:0019216 118 0.023
regulation of secretion by cell GO:1903530 249 0.023
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.023
response to oxidative stress GO:0006979 123 0.023
nitrogen compound transport GO:0071705 271 0.023
regulation of neurotransmitter levels GO:0001505 87 0.022
primary alcohol metabolic process GO:0034308 11 0.022
cellular nitrogen compound catabolic process GO:0044270 280 0.022
monosaccharide biosynthetic process GO:0046364 44 0.022
response to drug GO:0042493 75 0.022
heart morphogenesis GO:0003007 178 0.022
intracellular protein transport GO:0006886 204 0.022
nuclear transport GO:0051169 139 0.022
gonad development GO:0008406 141 0.022
organic hydroxy compound transport GO:0015850 93 0.021
nucleocytoplasmic transport GO:0006913 139 0.021
branched chain amino acid catabolic process GO:0009083 2 0.021
regulation of kinase activity GO:0043549 249 0.021
lipid storage GO:0019915 36 0.021
Worm
peptidyl amino acid modification GO:0018193 336 0.021
purine nucleotide metabolic process GO:0006163 302 0.021
carbohydrate metabolic process GO:0005975 230 0.021
response to inorganic substance GO:0010035 96 0.021
response to organonitrogen compound GO:0010243 246 0.021
purine ribonucleoside metabolic process GO:0046128 241 0.020
apoptotic signaling pathway GO:0097190 306 0.020
ion transmembrane transport GO:0034220 361 0.020
regulation of fatty acid beta oxidation GO:0031998 1 0.020
skin development GO:0043588 220 0.020
response to oxygen radical GO:0000305 16 0.020
response to acid chemical GO:0001101 111 0.020
leukocyte differentiation GO:0002521 342 0.020
regulation of mitochondrion organization GO:0010821 27 0.020
nucleoside triphosphate metabolic process GO:0009141 230 0.019
response to nutrient levels GO:0031667 109 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
ossification GO:0001503 216 0.019
Human
regulation of response to wounding GO:1903034 189 0.019
negative regulation of molecular function GO:0044092 258 0.019
succinyl coa metabolic process GO:0006104 1 0.019
negative regulation of immune system process GO:0002683 209 0.019
glutamate biosynthetic process GO:0006537 2 0.019
cellular homeostasis GO:0019725 240 0.018
phospholipid metabolic process GO:0006644 87 0.018
tricarboxylic acid metabolic process GO:0072350 5 0.018
plasma membrane organization GO:0007009 90 0.018
regulation of interleukin 8 production GO:0032677 3 0.018
cytokine production GO:0001816 319 0.018
neuron apoptotic process GO:0051402 142 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
purine nucleotide catabolic process GO:0006195 211 0.018
regulation of transferase activity GO:0051338 263 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
renal system development GO:0072001 225 0.017
positive regulation of cholesterol transport GO:0032376 9 0.017
regulation of cell activation GO:0050865 289 0.017
hormone metabolic process GO:0042445 86 0.017
Human
reactive oxygen species metabolic process GO:0072593 84 0.017
ribonucleoside metabolic process GO:0009119 245 0.017
innate immune response GO:0045087 157 0.017
Worm
sulfur compound metabolic process GO:0006790 100 0.017
Human
response to starvation GO:0042594 65 0.017
multicellular organismal signaling GO:0035637 91 0.017
nucleotide catabolic process GO:0009166 217 0.017
striated muscle tissue development GO:0014706 293 0.017
interleukin 8 production GO:0032637 4 0.017
cellular macromolecule catabolic process GO:0044265 206 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.016
glycerol ether metabolic process GO:0006662 2 0.016
positive regulation of intracellular transport GO:0032388 70 0.016
action potential GO:0001508 78 0.016
regulation of cytokine production GO:0001817 266 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
cellular chemical homeostasis GO:0055082 215 0.016
protein localization to nucleus GO:0034504 121 0.016
positive regulation of lipid metabolic process GO:0045834 40 0.016
purine containing compound catabolic process GO:0072523 213 0.016
regulation of nucleotide metabolic process GO:0006140 169 0.016
immune effector process GO:0002252 321 0.016
cholesterol metabolic process GO:0008203 56 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
t cell activation GO:0042110 289 0.015
response to lipopolysaccharide GO:0032496 128 0.015
myeloid cell differentiation GO:0030099 233 0.015
positive regulation of interleukin 8 production GO:0032757 2 0.015
progesterone metabolic process GO:0042448 4 0.015
forebrain development GO:0030900 302 0.015
response to reactive oxygen species GO:0000302 56 0.015
positive regulation of secretion by cell GO:1903532 114 0.015
neuron death GO:0070997 154 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
sterol transport GO:0015918 38 0.015
protein processing GO:0016485 163 0.015
adult behavior GO:0030534 135 0.015
regulation of protein transport GO:0051223 163 0.015
regulation of protein kinase activity GO:0045859 232 0.015
response to extracellular stimulus GO:0009991 127 0.015
defense response to bacterium GO:0042742 119 0.015
Worm
peroxisomal transport GO:0043574 4 0.015
establishment of protein localization to vacuole GO:0072666 4 0.015
neuronal action potential GO:0019228 54 0.015
macromolecule catabolic process GO:0009057 281 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
nucleoside monophosphate metabolic process GO:0009123 85 0.015
lipid homeostasis GO:0055088 63 0.014
response to epidermal growth factor GO:0070849 4 0.014
regulation of membrane potential GO:0042391 192 0.014
positive regulation of cell activation GO:0050867 158 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
citrate metabolic process GO:0006101 3 0.014
cellular response to molecule of bacterial origin GO:0071219 83 0.014
response to molecule of bacterial origin GO:0002237 143 0.014
nucleoside catabolic process GO:0009164 206 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
synapse organization GO:0050808 125 0.014
positive regulation of steroid biosynthetic process GO:0010893 4 0.014
locomotory behavior GO:0007626 195 0.014
hair follicle development GO:0001942 85 0.014
telencephalon development GO:0021537 186 0.014
positive regulation of protein phosphorylation GO:0001934 242 0.014
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
mapk cascade GO:0000165 281 0.014
transmission of nerve impulse GO:0019226 76 0.014
ribonucleoside triphosphate catabolic process GO:0009203 199 0.014
purine nucleoside catabolic process GO:0006152 205 0.014
tissue homeostasis GO:0001894 115 0.014
small gtpase mediated signal transduction GO:0007264 97 0.014
regulation of secretion GO:0051046 274 0.014
regulation of reactive oxygen species metabolic process GO:2000377 40 0.014
atp metabolic process GO:0046034 75 0.014
sensory perception GO:0007600 245 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
muscle tissue development GO:0060537 308 0.013
hexose metabolic process GO:0019318 98 0.013
positive regulation of secretion GO:0051047 130 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
t cell differentiation GO:0030217 174 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
dicarboxylic acid metabolic process GO:0043648 18 0.013
protein localization to peroxisome GO:0072662 4 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.013
steroid biosynthetic process GO:0006694 47 0.013
glycogen metabolic process GO:0005977 32 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
gluconeogenesis GO:0006094 39 0.013
positive regulation of cell death GO:0010942 224 0.013
endocytosis GO:0006897 168 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
energy reserve metabolic process GO:0006112 39 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
ensheathment of neurons GO:0007272 76 0.013
negative regulation of protein modification process GO:0031400 163 0.013
urogenital system development GO:0001655 261 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
spermatogenesis GO:0007283 284 0.013
cell type specific apoptotic process GO:0097285 268 0.013
cellularization GO:0007349 1 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
purine containing compound metabolic process GO:0072521 311 0.013
regulation of steroid metabolic process GO:0019218 39 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.013
phospholipid transport GO:0015914 21 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
regulation of defense response GO:0031347 233 0.012
development of primary male sexual characteristics GO:0046546 88 0.012
ribonucleoside catabolic process GO:0042454 206 0.012
glycogen biosynthetic process GO:0005978 14 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
carbohydrate biosynthetic process GO:0016051 74 0.012
epithelial cell development GO:0002064 159 0.012
circulatory system process GO:0003013 197 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
cellular carbohydrate metabolic process GO:0044262 119 0.012
response to peptide GO:1901652 136 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
response to light stimulus GO:0009416 135 0.012
negative regulation of phosphorylation GO:0042326 166 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
regulation of cytoplasmic transport GO:1903649 112 0.012
response to growth factor GO:0070848 198 0.012
cardiac muscle tissue development GO:0048738 130 0.012
regulation of t cell activation GO:0050863 170 0.012
cofactor biosynthetic process GO:0051188 41 0.011
response to testosterone GO:0033574 3 0.011
regulation of cellular response to stress GO:0080135 159 0.011
axonogenesis GO:0007409 274 0.011
cellular respiration GO:0045333 38 0.011
male gamete generation GO:0048232 285 0.011
cellular ion homeostasis GO:0006873 165 0.011
protein homotetramerization GO:0051289 12 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.011
molting cycle GO:0042303 90 0.011
dna metabolic process GO:0006259 303 0.011
cholesterol transport GO:0030301 38 0.011
cellular response to oxidative stress GO:0034599 76 0.011
kidney development GO:0001822 213 0.011
cellular response to superoxide GO:0071451 14 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.011
neuron migration GO:0001764 122 0.011
metal ion homeostasis GO:0055065 189 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
response to oxygen levels GO:0070482 62 0.011
removal of superoxide radicals GO:0019430 12 0.011
hair cycle GO:0042633 90 0.011
glycosyl compound catabolic process GO:1901658 206 0.011
nephron development GO:0072006 109 0.011
immune response regulating signaling pathway GO:0002764 125 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.011
protein secretion GO:0009306 111 0.011
regulation of homeostatic process GO:0032844 182 0.011
substantia nigra development GO:0021762 2 0.011
cellular response to lipid GO:0071396 145 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
regulation of body fluid levels GO:0050878 162 0.011
exocytosis GO:0006887 121 0.011
camera type eye development GO:0043010 266 0.011
t cell proliferation GO:0042098 120 0.011
multicellular organism growth GO:0035264 161 0.011
sensory organ morphogenesis GO:0090596 242 0.011
male sex differentiation GO:0046661 109 0.011
immune response activating signal transduction GO:0002757 116 0.010
positive regulation of glycolytic process GO:0045821 4 0.010
organic acid transport GO:0015849 101 0.010
response to metal ion GO:0010038 47 0.010
cellular protein complex assembly GO:0043623 116 0.010
multicellular organismal homeostasis GO:0048871 164 0.010
nuclear export GO:0051168 34 0.010
regulation of fatty acid metabolic process GO:0019217 28 0.010
monosaccharide metabolic process GO:0005996 106 0.010
anion transmembrane transport GO:0098656 71 0.010
calcium mediated signaling using intracellular calcium source GO:0035584 3 0.010
posttranscriptional regulation of gene expression GO:0010608 155 0.010
regulation of organelle organization GO:0033043 289 0.010
hexose biosynthetic process GO:0019319 39 0.010
alpha amino acid catabolic process GO:1901606 18 0.010
intrinsic apoptotic signaling pathway GO:0097193 132 0.010
regulation of lymphocyte proliferation GO:0050670 117 0.010

Hsd17b4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.414
inherited metabolic disorder DOID:655 0 0.067
disease of anatomical entity DOID:7 0 0.036
nervous system disease DOID:863 0 0.036
carbohydrate metabolic disorder DOID:2978 0 0.035
hyperinsulinemic hypoglycemia DOID:13317 0 0.034
central nervous system disease DOID:331 0 0.012
sensory system disease DOID:0050155 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011