Mus musculus

29 known processes

Txnrd1

thioredoxin reductase 1

(Aliases: TR1,TrxR1,TR)

Txnrd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.175
Rat
mitochondrion organization GO:0007005 134 0.107
oxidation reduction process GO:0055114 342 0.092
response to oxidative stress GO:0006979 123 0.089
Rat
spermatogenesis GO:0007283 284 0.079
cellular amine metabolic process GO:0044106 44 0.057
amine metabolic process GO:0009308 45 0.057
glutathione metabolic process GO:0006749 16 0.057
Rat
regulation of cellular ketone metabolic process GO:0010565 66 0.055
response to organonitrogen compound GO:0010243 246 0.055
protein modification by small protein conjugation or removal GO:0070647 207 0.050
dna metabolic process GO:0006259 303 0.048
cellular response to dna damage stimulus GO:0006974 207 0.046
protein localization to organelle GO:0033365 185 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
regulation of protein localization GO:0032880 231 0.044
protein ubiquitination GO:0016567 171 0.044
cytoplasmic transport GO:0016482 234 0.044
response to inorganic substance GO:0010035 96 0.044
Rat
posttranscriptional regulation of gene expression GO:0010608 155 0.043
male gamete generation GO:0048232 285 0.043
protein modification by small protein conjugation GO:0032446 187 0.043
apoptotic signaling pathway GO:0097190 306 0.043
maintenance of location GO:0051235 89 0.042
aromatic compound catabolic process GO:0019439 286 0.042
regulation of apoptotic signaling pathway GO:2001233 197 0.042
organic cyclic compound catabolic process GO:1901361 295 0.041
intrinsic apoptotic signaling pathway GO:0097193 132 0.041
positive regulation of cellular amine metabolic process GO:0033240 5 0.040
transmembrane transport GO:0055085 412 0.040
small molecule biosynthetic process GO:0044283 132 0.039
regulation of cellular amino acid metabolic process GO:0006521 5 0.038
neural tube formation GO:0001841 108 0.037
cation homeostasis GO:0055080 212 0.037
regulation of organelle organization GO:0033043 289 0.037
cellular protein complex assembly GO:0043623 116 0.036
cellular response to lipid GO:0071396 145 0.036
sensory perception GO:0007600 245 0.036
response to oxygen radical GO:0000305 16 0.036
cellular ketone metabolic process GO:0042180 84 0.036
peptide metabolic process GO:0006518 46 0.035
Rat
ras protein signal transduction GO:0007265 77 0.035
response to organic cyclic compound GO:0014070 198 0.035
translation GO:0006412 93 0.035
response to acid chemical GO:0001101 111 0.034
translational initiation GO:0006413 24 0.034
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.033
microtubule based process GO:0007017 236 0.033
protein alkylation GO:0008213 81 0.033
purine nucleotide catabolic process GO:0006195 211 0.032
methylation GO:0032259 134 0.032
purine containing compound metabolic process GO:0072521 311 0.032
establishment of protein localization to organelle GO:0072594 118 0.031
cellular homeostasis GO:0019725 240 0.031
heterocycle catabolic process GO:0046700 280 0.031
regulation of cellular amine metabolic process GO:0033238 20 0.030
nucleobase containing small molecule metabolic process GO:0055086 352 0.030
Rat
inflammatory response GO:0006954 244 0.030
response to radiation GO:0009314 165 0.030
organelle fission GO:0048285 170 0.029
myeloid cell differentiation GO:0030099 233 0.029
embryonic organ morphogenesis GO:0048562 276 0.028
organonitrogen compound catabolic process GO:1901565 264 0.028
cellular amide metabolic process GO:0043603 58 0.028
Rat
muscle tissue development GO:0060537 308 0.028
regulation of cellular catabolic process GO:0031329 242 0.028
protein targeting GO:0006605 143 0.028
response to reactive oxygen species GO:0000302 56 0.028
Rat
regulation of protein transport GO:0051223 163 0.027
epithelial tube morphogenesis GO:0060562 303 0.027
regulation of membrane potential GO:0042391 192 0.027
locomotory behavior GO:0007626 195 0.026
positive regulation of cellular catabolic process GO:0031331 148 0.026
regulation of transferase activity GO:0051338 263 0.026
nitrogen compound transport GO:0071705 271 0.026
protein methylation GO:0006479 81 0.026
peptidyl amino acid modification GO:0018193 336 0.026
ion transmembrane transport GO:0034220 361 0.026
cellular lipid metabolic process GO:0044255 323 0.026
positive regulation of cell death GO:0010942 224 0.026
Rat
cellular macromolecule catabolic process GO:0044265 206 0.026
mapk cascade GO:0000165 281 0.025
positive regulation of protein modification process GO:0031401 299 0.025
cellular response to molecule of bacterial origin GO:0071219 83 0.025
sensory organ morphogenesis GO:0090596 242 0.025
neural tube development GO:0021915 160 0.025
cation transport GO:0006812 399 0.025
regulation of cytoskeleton organization GO:0051493 122 0.024
nucleoside metabolic process GO:0009116 246 0.024
peptidyl tyrosine phosphorylation GO:0018108 143 0.024
response to superoxide GO:0000303 16 0.024
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.024
nucleoside phosphate metabolic process GO:0006753 338 0.024
Rat
negative regulation of cellular component organization GO:0051129 194 0.024
t cell activation GO:0042110 289 0.024
regionalization GO:0003002 337 0.023
regulation of lymphocyte activation GO:0051249 240 0.023
organelle disassembly GO:1903008 2 0.023
monocarboxylic acid metabolic process GO:0032787 191 0.023
ossification GO:0001503 216 0.023
nuclear division GO:0000280 158 0.023
oocyte axis specification GO:0007309 2 0.022
regulation of anatomical structure size GO:0090066 178 0.022
oocyte anterior posterior axis specification GO:0007314 2 0.022
regulation of intracellular transport GO:0032386 159 0.022
regulation of proteolysis GO:0030162 164 0.022
carboxylic acid biosynthetic process GO:0046394 86 0.022
blood vessel morphogenesis GO:0048514 285 0.022
organic acid biosynthetic process GO:0016053 86 0.022
regulation of defense response GO:0031347 233 0.022
angiogenesis GO:0001525 201 0.022
cellular response to organonitrogen compound GO:0071417 145 0.021
regulation of cell activation GO:0050865 289 0.021
mitotic cell cycle GO:0000278 195 0.021
protein import GO:0017038 101 0.021
myeloid leukocyte differentiation GO:0002573 119 0.021
lipid localization GO:0010876 126 0.021
organophosphate catabolic process GO:0046434 232 0.021
reactive oxygen species metabolic process GO:0072593 84 0.021
Rat
morphogenesis of embryonic epithelium GO:0016331 159 0.021
cellular nitrogen compound catabolic process GO:0044270 280 0.021
leukocyte differentiation GO:0002521 342 0.021
cellular ion homeostasis GO:0006873 165 0.021
actin cytoskeleton organization GO:0030036 220 0.021
regulation of secretion by cell GO:1903530 249 0.021
microtubule cytoskeleton organization GO:0000226 157 0.021
regulation of kinase activity GO:0043549 249 0.021
forebrain development GO:0030900 302 0.021
embryonic epithelial tube formation GO:0001838 130 0.021
nucleoside triphosphate metabolic process GO:0009141 230 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
skeletal system development GO:0001501 356 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.020
regulation of mapk cascade GO:0043408 248 0.020
negative regulation of protein metabolic process GO:0051248 282 0.020
cellular response to biotic stimulus GO:0071216 92 0.020
regulation of hydrolase activity GO:0051336 246 0.020
cellular chemical homeostasis GO:0055082 215 0.020
negative regulation of apoptotic signaling pathway GO:2001234 104 0.020
single organism cell adhesion GO:0098602 156 0.020
tube formation GO:0035148 140 0.020
urogenital system development GO:0001655 261 0.020
response to lipopolysaccharide GO:0032496 128 0.019
response to extracellular stimulus GO:0009991 127 0.019
circulatory system process GO:0003013 197 0.019
membrane organization GO:0061024 245 0.019
oocyte construction GO:0007308 2 0.019
regulation of secretion GO:0051046 274 0.019
peptidyl tyrosine modification GO:0018212 145 0.019
negative regulation of intracellular signal transduction GO:1902532 167 0.019
positive regulation of cell development GO:0010720 237 0.019
cellular metal ion homeostasis GO:0006875 151 0.019
cellular protein complex disassembly GO:0043624 36 0.019
cellular response to lipopolysaccharide GO:0071222 77 0.019
positive regulation of programmed cell death GO:0043068 218 0.018
stem cell development GO:0048864 219 0.018
cellularization GO:0007349 1 0.018
response to endoplasmic reticulum stress GO:0034976 53 0.018
purine ribonucleoside metabolic process GO:0046128 241 0.018
protein localization to nucleus GO:0034504 121 0.018
organic anion transport GO:0015711 137 0.018
response to molecule of bacterial origin GO:0002237 143 0.018
purine nucleotide metabolic process GO:0006163 302 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
muscle cell differentiation GO:0042692 261 0.018
innate immune response GO:0045087 157 0.018
negative regulation of cellular amine metabolic process GO:0033239 1 0.018
cytokine production GO:0001816 319 0.018
epithelial cell development GO:0002064 159 0.018
regulation of hormone levels GO:0010817 211 0.018
negative regulation of molecular function GO:0044092 258 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
immune effector process GO:0002252 321 0.018
regulation of nucleotide metabolic process GO:0006140 169 0.018
regulation of neuron differentiation GO:0045664 281 0.018
small gtpase mediated signal transduction GO:0007264 97 0.018
renal system development GO:0072001 225 0.018
macromolecule catabolic process GO:0009057 281 0.018
skeletal system morphogenesis GO:0048705 203 0.018
purine ribonucleotide metabolic process GO:0009150 290 0.018
metal ion homeostasis GO:0055065 189 0.017
organonitrogen compound biosynthetic process GO:1901566 192 0.017
intracellular protein transport GO:0006886 204 0.017
negative regulation of cellular protein metabolic process GO:0032269 247 0.017
regulation of purine nucleotide metabolic process GO:1900542 169 0.017
positive regulation of kinase activity GO:0033674 155 0.017
camera type eye development GO:0043010 266 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
response to alkaloid GO:0043279 34 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
wound healing GO:0042060 157 0.017
homeostasis of number of cells GO:0048872 210 0.017
rhythmic process GO:0048511 174 0.017
cellular response to hormone stimulus GO:0032870 150 0.017
gland development GO:0048732 330 0.017
female gamete generation GO:0007292 74 0.017
germ cell development GO:0007281 185 0.017
multi multicellular organism process GO:0044706 109 0.017
regulation of cell cycle process GO:0010564 160 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
protein import into nucleus GO:0006606 95 0.017
positive regulation of peptidase activity GO:0010952 49 0.016
lipid biosynthetic process GO:0008610 179 0.016
compound eye development GO:0048749 1 0.016
regulation of cytokine production GO:0001817 266 0.016
regulation of leukocyte differentiation GO:1902105 159 0.016
carbohydrate derivative biosynthetic process GO:1901137 183 0.016
negative regulation of phosphate metabolic process GO:0045936 184 0.016
positive regulation of protein transport GO:0051222 93 0.016
single organism nuclear import GO:1902593 95 0.016
negative regulation of phosphorus metabolic process GO:0010563 184 0.016
nucleocytoplasmic transport GO:0006913 139 0.016
blood circulation GO:0008015 195 0.016
regulation of establishment of protein localization GO:0070201 181 0.016
endocytosis GO:0006897 168 0.016
generation of precursor metabolites and energy GO:0006091 103 0.016
engulfment of apoptotic cell GO:0043652 3 0.016
cellular carbohydrate metabolic process GO:0044262 119 0.016
negative regulation of protein modification process GO:0031400 163 0.016
ribonucleoside catabolic process GO:0042454 206 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
maternal determination of anterior posterior axis embryo GO:0008358 2 0.016
positive regulation of apoptotic process GO:0043065 217 0.016
organophosphate biosynthetic process GO:0090407 122 0.016
organism emergence from protective structure GO:0071684 4 0.016
inorganic ion transmembrane transport GO:0098660 234 0.016
regulation of inflammatory response GO:0050727 147 0.016
actin filament organization GO:0007015 113 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
positive regulation of hydrolase activity GO:0051345 148 0.015
glucose homeostasis GO:0042593 128 0.015
anatomical structure homeostasis GO:0060249 145 0.015
regulation of cell adhesion GO:0030155 154 0.015
cellular response to acid chemical GO:0071229 68 0.015
response to oxygen levels GO:0070482 62 0.015
Rat
ribonucleotide metabolic process GO:0009259 291 0.015
regulation of homeostatic process GO:0032844 182 0.015
leukocyte proliferation GO:0070661 172 0.015
carbohydrate metabolic process GO:0005975 230 0.015
stem cell differentiation GO:0048863 268 0.015
inorganic cation transmembrane transport GO:0098662 207 0.015
positive regulation of protein phosphorylation GO:0001934 242 0.015
ribose phosphate metabolic process GO:0019693 291 0.015
neural tube closure GO:0001843 90 0.015
response to light stimulus GO:0009416 135 0.015
epidermis development GO:0008544 187 0.015
kidney development GO:0001822 213 0.015
regulation of reactive oxygen species metabolic process GO:2000377 40 0.015
ribonucleoprotein complex disassembly GO:0032988 3 0.015
regulation of cell cycle GO:0051726 281 0.014
cellular response to cytokine stimulus GO:0071345 189 0.014
respiratory system development GO:0060541 190 0.014
protein secretion GO:0009306 111 0.014
pole plasm assembly GO:0007315 2 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.014
cell type specific apoptotic process GO:0097285 268 0.014
regulation of protein catabolic process GO:0042176 108 0.014
response to nutrient levels GO:0031667 109 0.014
extracellular matrix organization GO:0030198 147 0.014
regulation of cell division GO:0051302 76 0.014
muscle system process GO:0003012 141 0.014
striated muscle tissue development GO:0014706 293 0.014
extrinsic apoptotic signaling pathway GO:0097191 126 0.014
regulation of ion transport GO:0043269 215 0.014
purine ribonucleoside catabolic process GO:0046130 205 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
regulation of cell migration GO:0030334 219 0.014
energy derivation by oxidation of organic compounds GO:0015980 77 0.014
mitotic cell cycle process GO:1903047 159 0.014
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.014
positive regulation of nervous system development GO:0051962 221 0.014
positive regulation of lymphocyte activation GO:0051251 140 0.014
regulation of protein serine threonine kinase activity GO:0071900 157 0.014
protein maturation GO:0051604 176 0.014
nucleoside monophosphate metabolic process GO:0009123 85 0.014
response to amino acid GO:0043200 37 0.014
lymphocyte proliferation GO:0046651 164 0.014
response to vitamin a GO:0033189 1 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.013
hormone secretion GO:0046879 128 0.013
cell adhesion GO:0007155 329 0.013
meiotic cell cycle GO:0051321 122 0.013
regulation of system process GO:0044057 200 0.013
negative regulation of synapse assembly GO:0051964 3 0.013
g protein coupled receptor signaling pathway GO:0007186 243 0.013
macromolecule methylation GO:0043414 120 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
molting cycle GO:0042303 90 0.013
lateral inhibition GO:0046331 1 0.013
regulation of protein complex assembly GO:0043254 83 0.013
organic hydroxy compound transport GO:0015850 93 0.013
monosaccharide metabolic process GO:0005996 106 0.013
transmission of nerve impulse GO:0019226 76 0.013
positive regulation of immune effector process GO:0002699 107 0.013
nuclear transport GO:0051169 139 0.013
b cell activation GO:0042113 161 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
mitochondrion degradation GO:0000422 3 0.013
positive regulation of organelle organization GO:0010638 128 0.013
connective tissue development GO:0061448 179 0.013
leukocyte mediated immunity GO:0002443 174 0.013
amide transport GO:0042886 138 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
organic hydroxy compound biosynthetic process GO:1901617 77 0.013
positive regulation of proteolysis GO:0045862 85 0.013
nuclear import GO:0051170 95 0.013
glycosyl compound metabolic process GO:1901657 246 0.013
divalent inorganic cation homeostasis GO:0072507 138 0.013
dna endoreduplication GO:0042023 4 0.013
regulation of response to wounding GO:1903034 189 0.013
action potential GO:0001508 78 0.013
cognition GO:0050890 149 0.013
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
peptide transport GO:0015833 133 0.012
organelle localization GO:0051640 179 0.012
purine nucleoside triphosphate catabolic process GO:0009146 203 0.012
regulation of protein localization to nucleus GO:1900180 60 0.012
morphogenesis of a branching structure GO:0001763 203 0.012
developmental maturation GO:0021700 193 0.012
regulation of asymmetric cell division GO:0009786 4 0.012
cellular response to oxidative stress GO:0034599 76 0.012
Rat
cajal body organization GO:0030576 1 0.012
regulation of protein targeting GO:1903533 61 0.012
dephosphorylation GO:0016311 129 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
epithelial tube formation GO:0072175 130 0.012
ear development GO:0043583 200 0.012
proteasomal protein catabolic process GO:0010498 98 0.012
regulation of body fluid levels GO:0050878 162 0.012
cation transmembrane transport GO:0098655 266 0.012
regulation of ras protein signal transduction GO:0046578 114 0.012
divalent inorganic cation transport GO:0072511 178 0.012
synaptic transmission GO:0007268 329 0.012
regulation of chromosome organization GO:0033044 83 0.012
adult behavior GO:0030534 135 0.012
multicellular organismal signaling GO:0035637 91 0.012
cellular response to organic cyclic compound GO:0071407 87 0.012
chromatin modification GO:0016568 187 0.012
carbohydrate homeostasis GO:0033500 128 0.012
autophagy GO:0006914 45 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
i kappab kinase nf kappab signaling GO:0007249 85 0.012
digestive system development GO:0055123 200 0.012
regulation of cell projection organization GO:0031344 206 0.012
rho protein signal transduction GO:0007266 32 0.012
regulation of t cell activation GO:0050863 170 0.012
morphogenesis of a branching epithelium GO:0061138 193 0.012
dna repair GO:0006281 107 0.012
regulation of cell motility GO:2000145 236 0.012
fatty acid metabolic process GO:0006631 121 0.011
regulation of tube size GO:0035150 57 0.011
inter male aggressive behavior GO:0002121 3 0.011
divalent metal ion transport GO:0070838 172 0.011
heart morphogenesis GO:0003007 178 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.011
learning or memory GO:0007611 148 0.011
regulation of transmembrane transport GO:0034762 128 0.011
macromolecular complex disassembly GO:0032984 43 0.011
hexose metabolic process GO:0019318 98 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
cellular response to amino acid stimulus GO:0071230 29 0.011
striated muscle cell development GO:0055002 125 0.011
calcium ion homeostasis GO:0055074 127 0.011
alpha amino acid metabolic process GO:1901605 59 0.011
Rat
nucleus organization GO:0006997 45 0.011
dna recombination GO:0006310 92 0.011
chromatin organization GO:0006325 206 0.011
regulation of lamellipodium assembly GO:0010591 3 0.011
regulation of peptidase activity GO:0052547 96 0.011
ribonucleotide catabolic process GO:0009261 208 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.011
muscle cell development GO:0055001 133 0.011
anion transmembrane transport GO:0098656 71 0.011
cellular response to external stimulus GO:0071496 88 0.011
striated muscle myosin thick filament assembly GO:0071688 1 0.011
positive regulation of endopeptidase activity GO:0010950 43 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.011
myosin filament assembly GO:0031034 2 0.011
muscle contraction GO:0006936 101 0.011
t cell differentiation GO:0030217 174 0.011
cellular response to carbohydrate stimulus GO:0071322 50 0.011
purine containing compound catabolic process GO:0072523 213 0.011
retina development in camera type eye GO:0060041 119 0.011
carbohydrate derivative catabolic process GO:1901136 231 0.011
positive regulation of cell activation GO:0050867 158 0.011
fertilization GO:0009566 127 0.011
negative regulation of transferase activity GO:0051348 85 0.011
ribonucleoside triphosphate catabolic process GO:0009203 199 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
protein processing GO:0016485 163 0.011
regulation of myeloid leukocyte differentiation GO:0002761 58 0.011
double strand break repair GO:0006302 48 0.011
primary neural tube formation GO:0014020 95 0.011
skin development GO:0043588 220 0.011
interleukin 8 production GO:0032637 4 0.011
hatching GO:0035188 4 0.011
regulation of organ morphogenesis GO:2000027 144 0.011
extracellular structure organization GO:0043062 148 0.011
mesoderm development GO:0007498 100 0.011
cofactor metabolic process GO:0051186 80 0.011
Rat
nucleoside phosphate biosynthetic process GO:1901293 79 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.010
cellular response to gamma radiation GO:0071480 4 0.010
cellular calcium ion homeostasis GO:0006874 119 0.010
t cell proliferation GO:0042098 120 0.010
negative regulation of nervous system development GO:0051961 156 0.010
multicellular organism growth GO:0035264 161 0.010
regulation of protein kinase activity GO:0045859 232 0.010
endomembrane system organization GO:0010256 147 0.010
ear morphogenesis GO:0042471 118 0.010
regulation of cysteine type endopeptidase activity GO:2000116 65 0.010
regulation of nucleoside metabolic process GO:0009118 130 0.010
adaptive immune response GO:0002250 155 0.010
positive regulation of transferase activity GO:0051347 167 0.010
lipid transport GO:0006869 98 0.010
cellular modified amino acid metabolic process GO:0006575 63 0.010
Rat
regulation of lymphocyte proliferation GO:0050670 117 0.010
negative regulation of organelle organization GO:0010639 90 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.010
neuron death GO:0070997 154 0.010
cytokine mediated signaling pathway GO:0019221 115 0.010
skeletal muscle organ development GO:0060538 163 0.010

Txnrd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.088
nervous system disease DOID:863 0 0.088
central nervous system disease DOID:331 0 0.032
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
neurodegenerative disease DOID:1289 0 0.011