Mus musculus

17 known processes

Dub1

deubiquitinating enzyme 1

Dub1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell recognition GO:0008037 83 0.100
positive regulation of nervous system development GO:0051962 221 0.093
regulation of cell motility GO:2000145 236 0.082
positive regulation of innate immune response GO:0045089 80 0.071
negative regulation of cellular protein metabolic process GO:0032269 247 0.070
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 40 0.068
mitotic cell cycle GO:0000278 195 0.068
Mouse
regulation of neural precursor cell proliferation GO:2000177 70 0.065
negative regulation of protein metabolic process GO:0051248 282 0.061
Mouse
regulation of kinase activity GO:0043549 249 0.059
multicellular organismal homeostasis GO:0048871 164 0.059
blastocyst development GO:0001824 80 0.058
spermatogenesis GO:0007283 284 0.054
epidermis development GO:0008544 187 0.054
negative regulation of cell proliferation GO:0008285 296 0.053
protein catabolic process GO:0030163 221 0.051
Mouse
gland development GO:0048732 330 0.048
positive regulation of programmed cell death GO:0043068 218 0.048
negative regulation of phosphorus metabolic process GO:0010563 184 0.047
mapk cascade GO:0000165 281 0.046
digestive system development GO:0055123 200 0.045
regulation of transferase activity GO:0051338 263 0.043
female sex differentiation GO:0046660 84 0.043
cellular lipid metabolic process GO:0044255 323 0.042
regulation of protein localization GO:0032880 231 0.041
developmental maturation GO:0021700 193 0.041
cellular response to inorganic substance GO:0071241 37 0.041
development of primary sexual characteristics GO:0045137 143 0.041
regulation of stem cell proliferation GO:0072091 78 0.041
positive regulation of keratinocyte proliferation GO:0010838 4 0.040
anion transmembrane transport GO:0098656 71 0.040
single fertilization GO:0007338 82 0.040
regulation of hydrolase activity GO:0051336 246 0.040
small gtpase mediated signal transduction GO:0007264 97 0.040
adult locomotory behavior GO:0008344 91 0.039
digestive tract development GO:0048565 190 0.038
amine metabolic process GO:0009308 45 0.038
fat cell differentiation GO:0045444 160 0.037
anion transport GO:0006820 177 0.036
cellular ketone metabolic process GO:0042180 84 0.036
protein maturation GO:0051604 176 0.036
cellular amino acid metabolic process GO:0006520 103 0.036
ion transmembrane transport GO:0034220 361 0.036
regulation of membrane potential GO:0042391 192 0.036
innate immune response GO:0045087 157 0.036
apoptotic signaling pathway GO:0097190 306 0.035
defense response to other organism GO:0098542 197 0.035
regulation of protein serine threonine kinase activity GO:0071900 157 0.035
extracellular matrix organization GO:0030198 147 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
gonad development GO:0008406 141 0.035
regulation of hormone secretion GO:0046883 88 0.034
stem cell proliferation GO:0072089 117 0.034
ovulation cycle GO:0042698 59 0.034
chemotaxis GO:0006935 247 0.034
reactive oxygen species metabolic process GO:0072593 84 0.034
response to acid chemical GO:0001101 111 0.033
development of primary female sexual characteristics GO:0046545 73 0.033
response to lipopolysaccharide GO:0032496 128 0.032
positive regulation of cell development GO:0010720 237 0.032
positive regulation of cell death GO:0010942 224 0.032
cellular response to gonadotropin stimulus GO:0071371 4 0.032
protein modification by small protein conjugation or removal GO:0070647 207 0.031
regulation of cellular amino acid metabolic process GO:0006521 5 0.031
positive regulation of defense response GO:0031349 124 0.031
negative regulation of phosphorylation GO:0042326 166 0.031
regulation of proteolysis GO:0030162 164 0.031
Mouse
modification dependent macromolecule catabolic process GO:0043632 133 0.031
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.031
female gonad development GO:0008585 71 0.031
rhythmic process GO:0048511 174 0.030
regulation of cell migration GO:0030334 219 0.030
male sex differentiation GO:0046661 109 0.030
regulation of defense response GO:0031347 233 0.030
negative regulation of transferase activity GO:0051348 85 0.029
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.029
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.029
methylation GO:0032259 134 0.029
morphogenesis of a branching structure GO:0001763 203 0.029
action potential GO:0001508 78 0.029
regulation of organ morphogenesis GO:2000027 144 0.029
cell maturation GO:0048469 127 0.029
locomotory behavior GO:0007626 195 0.028
response to oxidative stress GO:0006979 123 0.028
organelle fission GO:0048285 170 0.028
protein kinase b signaling GO:0043491 74 0.028
response to molecule of bacterial origin GO:0002237 143 0.028
negative regulation of proteolysis GO:0045861 74 0.028
Mouse
defense response to bacterium GO:0042742 119 0.028
positive regulation of t cell activation GO:0050870 101 0.028
macromolecule methylation GO:0043414 120 0.028
cellular response to molecule of bacterial origin GO:0071219 83 0.028
carbohydrate homeostasis GO:0033500 128 0.028
cell type specific apoptotic process GO:0097285 268 0.027
regulation of microvillus organization GO:0032530 3 0.027
negative regulation of cellular component organization GO:0051129 194 0.027
Mouse
oxidation reduction process GO:0055114 342 0.027
positive regulation of transferase activity GO:0051347 167 0.027
male gonad development GO:0008584 88 0.026
regulation of neuroblast proliferation GO:1902692 27 0.026
muscle cell differentiation GO:0042692 261 0.026
striated muscle tissue development GO:0014706 293 0.026
binding of sperm to zona pellucida GO:0007339 34 0.026
cell division GO:0051301 120 0.026
muscle tissue development GO:0060537 308 0.026
extracellular structure organization GO:0043062 148 0.026
cellular macromolecule catabolic process GO:0044265 206 0.025
Mouse
regulation of organelle organization GO:0033043 289 0.025
Mouse
regulation of microvillus assembly GO:0032534 3 0.025
regulation of vasculature development GO:1901342 88 0.025
cation transport GO:0006812 399 0.025
regulation of anatomical structure size GO:0090066 178 0.025
multicellular organism growth GO:0035264 161 0.025
regulation of vesicle mediated transport GO:0060627 139 0.025
regulation of cellular ketone metabolic process GO:0010565 66 0.024
regulation of innate immune response GO:0045088 91 0.024
cellular nitrogen compound catabolic process GO:0044270 280 0.024
regulation of cellular amine metabolic process GO:0033238 20 0.024
endocrine process GO:0050886 39 0.024
segmentation GO:0035282 93 0.024
neuron death GO:0070997 154 0.024
somite development GO:0061053 81 0.024
regulation of lipid metabolic process GO:0019216 118 0.023
erk1 and erk2 cascade GO:0070371 77 0.023
regulation of protein kinase activity GO:0045859 232 0.023
cellular amine metabolic process GO:0044106 44 0.023
neuronal action potential GO:0019228 54 0.023
negative regulation of kinase activity GO:0033673 81 0.023
negative regulation of nervous system development GO:0051961 156 0.023
sperm egg recognition GO:0035036 37 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.022
regulation of leukocyte differentiation GO:1902105 159 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
regulation of cellular component biogenesis GO:0044087 181 0.022
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.022
neuron projection guidance GO:0097485 141 0.022
regulation of chromosome organization GO:0033044 83 0.021
Mouse
glucose homeostasis GO:0042593 128 0.021
cellular response to lipopolysaccharide GO:0071222 77 0.021
regulation of angiogenesis GO:0045765 81 0.021
membrane organization GO:0061024 245 0.020
male gamete generation GO:0048232 285 0.020
positive regulation of cellular amine metabolic process GO:0033240 5 0.020
spermatid development GO:0007286 108 0.020
fertilization GO:0009566 127 0.020
negative regulation of cell cycle GO:0045786 123 0.020
Mouse
central nervous system neuron differentiation GO:0021953 162 0.020
oocyte development GO:0048599 33 0.020
regulation of secretion GO:0051046 274 0.019
steroid metabolic process GO:0008202 119 0.019
skin development GO:0043588 220 0.019
regulation of protein transport GO:0051223 163 0.019
sensory organ morphogenesis GO:0090596 242 0.019
organic cyclic compound catabolic process GO:1901361 295 0.019
lipid biosynthetic process GO:0008610 179 0.019
regulation of feeding behavior GO:0060259 3 0.019
ubiquitin dependent protein catabolic process GO:0006511 129 0.019
Mouse
positive regulation of stem cell proliferation GO:2000648 59 0.019
chromatin organization GO:0006325 206 0.019
protein processing GO:0016485 163 0.018
mast cell proliferation GO:0070662 4 0.018
mesoderm formation GO:0001707 62 0.018
defense response to gram positive bacterium GO:0050830 50 0.018
intracellular protein transport GO:0006886 204 0.018
immune effector process GO:0002252 321 0.018
response to inorganic substance GO:0010035 96 0.018
transmission of nerve impulse GO:0019226 76 0.018
negative regulation of molecular function GO:0044092 258 0.018
blood circulation GO:0008015 195 0.018
positive regulation of apoptotic process GO:0043065 217 0.018
negative regulation of cellular amine metabolic process GO:0033239 1 0.018
regulation of neuron differentiation GO:0045664 281 0.018
ossification GO:0001503 216 0.017
immune response activating signal transduction GO:0002757 116 0.017
plasma membrane organization GO:0007009 90 0.017
positive regulation of organelle organization GO:0010638 128 0.017
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.017
heterocycle catabolic process GO:0046700 280 0.017
regulation of mapk cascade GO:0043408 248 0.017
camera type eye development GO:0043010 266 0.017
inflammatory response GO:0006954 244 0.017
aromatic compound catabolic process GO:0019439 286 0.017
canonical wnt signaling pathway GO:0060070 130 0.017
positive regulation of phospholipase activity GO:0010518 3 0.017
body morphogenesis GO:0010171 45 0.017
negative regulation of protein processing GO:0010955 79 0.017
Mouse
progesterone metabolic process GO:0042448 4 0.017
regulation of cellular catabolic process GO:0031329 242 0.017
Mouse
regulation of erk1 and erk2 cascade GO:0070372 71 0.016
regulation of hormone levels GO:0010817 211 0.016
cell cell recognition GO:0009988 44 0.016
regulation of protein maturation GO:1903317 96 0.016
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.016
regulation of ion transport GO:0043269 215 0.016
positive regulation of glial cell proliferation GO:0060252 4 0.016
epithelial cell development GO:0002064 159 0.016
stem cell development GO:0048864 219 0.016
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.016
rho protein signal transduction GO:0007266 32 0.016
single organism cell adhesion GO:0098602 156 0.016
nuclear transport GO:0051169 139 0.016
cell adhesion GO:0007155 329 0.016
response to vitamin d GO:0033280 3 0.016
negative regulation of mapk cascade GO:0043409 65 0.016
regulation of mast cell proliferation GO:0070666 4 0.015
multicellular organismal signaling GO:0035637 91 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.015
epithelial cell morphogenesis GO:0003382 41 0.015
cellular homeostasis GO:0019725 240 0.015
placenta development GO:0001890 140 0.015
negative regulation of cell development GO:0010721 169 0.015
axonogenesis GO:0007409 274 0.015
pattern recognition receptor signaling pathway GO:0002221 47 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.015
Mouse
negative regulation of mitotic cell cycle GO:0045930 58 0.015
Mouse
negative regulation of protein maturation GO:1903318 79 0.015
Mouse
phospholipid metabolic process GO:0006644 87 0.015
regulation of multi organism process GO:0043900 111 0.015
glial cell development GO:0021782 54 0.015
regulation of cell projection organization GO:0031344 206 0.015
transmembrane transport GO:0055085 412 0.015
tumor necrosis factor ligand superfamily member 11 production GO:0072535 1 0.015
calcium ion transport GO:0006816 159 0.015
macromolecule catabolic process GO:0009057 281 0.015
Mouse
positive regulation of neural precursor cell proliferation GO:2000179 42 0.015
nucleoside catabolic process GO:0009164 206 0.015
positive regulation of neuron differentiation GO:0045666 141 0.015
respiratory tube development GO:0030323 167 0.015
cellular response to follicle stimulating hormone stimulus GO:0071372 1 0.015
positive regulation of cell motility GO:2000147 116 0.015
spermatid differentiation GO:0048515 115 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
regulation of neuron projection development GO:0010975 169 0.015
sulfate assimilation GO:0000103 3 0.015
dephosphorylation GO:0016311 129 0.015
myeloid leukocyte migration GO:0097529 57 0.015
morphogenesis of a branching epithelium GO:0061138 193 0.015
regulation of nuclear division GO:0051783 56 0.015
Mouse
somitogenesis GO:0001756 69 0.015
cardiac muscle tissue development GO:0048738 130 0.015
positive regulation of protein phosphorylation GO:0001934 242 0.015
embryonic placenta development GO:0001892 98 0.015
multi multicellular organism process GO:0044706 109 0.015
positive regulation of leukocyte differentiation GO:1902107 86 0.014
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.014
neuroblast proliferation GO:0007405 49 0.014
embryonic appendage morphogenesis GO:0035113 126 0.014
hexose transport GO:0008645 56 0.014
neural precursor cell proliferation GO:0061351 121 0.014
hindbrain development GO:0030902 128 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
wound healing GO:0042060 157 0.014
response to reactive oxygen species GO:0000302 56 0.014
dna metabolic process GO:0006259 303 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
ras protein signal transduction GO:0007265 77 0.014
protein ubiquitination GO:0016567 171 0.014
carbohydrate metabolic process GO:0005975 230 0.014
stem cell differentiation GO:0048863 268 0.014
regulation of homeostatic process GO:0032844 182 0.014
positive regulation of growth GO:0045927 104 0.014
positive regulation of cell migration GO:0030335 109 0.014
response to amino acid GO:0043200 37 0.014
negative regulation of growth GO:0045926 99 0.014
regulation of striated muscle cell differentiation GO:0051153 81 0.014
negative regulation of intracellular signal transduction GO:1902532 167 0.014
peptide transport GO:0015833 133 0.014
regulation of cytoplasmic transport GO:1903649 112 0.013
gastrulation GO:0007369 116 0.013
regulation of ras protein signal transduction GO:0046578 114 0.013
positive regulation of protein modification process GO:0031401 299 0.013
carbohydrate derivative catabolic process GO:1901136 231 0.013
positive regulation of inflammatory response GO:0050729 47 0.013
regulation of muscle tissue development GO:1901861 97 0.013
circulatory system process GO:0003013 197 0.013
regulation of myeloid cell differentiation GO:0045637 96 0.013
formation of primary germ layer GO:0001704 77 0.013
germ cell development GO:0007281 185 0.013
synapsis GO:0007129 34 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.013
regulation of peptidase activity GO:0052547 96 0.013
lung development GO:0030324 164 0.013
regulation of neuron apoptotic process GO:0043523 122 0.013
positive regulation of cytokine secretion GO:0050715 41 0.013
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.013
phagocytosis GO:0006909 66 0.013
hormone secretion GO:0046879 128 0.013
regulation of mitosis GO:0007088 29 0.013
Mouse
amide transport GO:0042886 138 0.013
establishment or maintenance of cell polarity GO:0007163 86 0.013
blood vessel morphogenesis GO:0048514 285 0.013
metanephros development GO:0001656 79 0.013
endocytosis GO:0006897 168 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
regulation of t cell activation GO:0050863 170 0.013
insulin secretion GO:0030073 89 0.013
vitamin d biosynthetic process GO:0042368 3 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
mitotic nuclear division GO:0007067 48 0.012
retina development in camera type eye GO:0060041 119 0.012
learning or memory GO:0007611 148 0.012
positive regulation of kinase activity GO:0033674 155 0.012
response to organonitrogen compound GO:0010243 246 0.012
nitrogen compound transport GO:0071705 271 0.012
positive regulation of podosome assembly GO:0071803 3 0.012
midgut development GO:0007494 4 0.012
hexose metabolic process GO:0019318 98 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
innate immune response activating signal transduction GO:0002758 50 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.012
female gamete generation GO:0007292 74 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
protein secretion GO:0009306 111 0.012
glucose transport GO:0015758 56 0.012
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.012
neuron migration GO:0001764 122 0.012
genetic imprinting GO:0071514 27 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
development of primary male sexual characteristics GO:0046546 88 0.012
ensheathment of neurons GO:0007272 76 0.012
cell differentiation involved in kidney development GO:0061005 33 0.012
ribonucleoside catabolic process GO:0042454 206 0.012
tissue homeostasis GO:0001894 115 0.012
fat soluble vitamin biosynthetic process GO:0042362 4 0.012
c21 steroid hormone biosynthetic process GO:0006700 3 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.012
purine nucleotide catabolic process GO:0006195 211 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
regulation of cell cycle process GO:0010564 160 0.012
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 226 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
synaptic transmission GO:0007268 329 0.011
cytokine production GO:0001816 319 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
compound eye development GO:0048749 1 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
positive regulation of proteolysis GO:0045862 85 0.011
protein localization to organelle GO:0033365 185 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
nucleotide catabolic process GO:0009166 217 0.011
anatomical structure homeostasis GO:0060249 145 0.011
nephron development GO:0072006 109 0.011
organophosphate catabolic process GO:0046434 232 0.011
cognition GO:0050890 149 0.011
myeloid cell differentiation GO:0030099 233 0.011
chromosome segregation GO:0007059 48 0.011
homeostasis of number of cells GO:0048872 210 0.011
organic acid transport GO:0015849 101 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
purine containing compound catabolic process GO:0072523 213 0.011
regulation of cell division GO:0051302 76 0.011
Mouse
organelle localization GO:0051640 179 0.011
neuron apoptotic process GO:0051402 142 0.011
myoblast differentiation GO:0045445 52 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.011
negative regulation of leukocyte proliferation GO:0070664 46 0.011
cellular modified amino acid metabolic process GO:0006575 63 0.011
cellular protein catabolic process GO:0044257 155 0.011
Mouse
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.011
ribonucleoside triphosphate metabolic process GO:0009199 220 0.011
peptide hormone secretion GO:0030072 109 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
negative regulation of protein modification process GO:0031400 163 0.010
ribose phosphate metabolic process GO:0019693 291 0.010
nephrogenic mesenchyme development GO:0072076 3 0.010
negative regulation of lymphocyte proliferation GO:0050672 45 0.010
monosaccharide transport GO:0015749 58 0.010
regulation of translation GO:0006417 71 0.010
cellular response to acid chemical GO:0071229 68 0.010
oocyte differentiation GO:0009994 35 0.010
dendrite development GO:0016358 115 0.010
myeloid cell homeostasis GO:0002262 114 0.010
regulation of cell cycle phase transition GO:1901987 77 0.010
Mouse
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.010
nucleobase containing small molecule metabolic process GO:0055086 352 0.010
oocyte construction GO:0007308 2 0.010
purine ribonucleoside metabolic process GO:0046128 241 0.010
glucose metabolic process GO:0006006 92 0.010
regulation of synaptic plasticity GO:0048167 87 0.010
ovarian follicle development GO:0001541 40 0.010
amino acid transport GO:0006865 61 0.010
protein targeting GO:0006605 143 0.010
sclerotome development GO:0061056 4 0.010
regulation of chromatin organization GO:1902275 57 0.010
regulation of antimicrobial peptide production GO:0002784 1 0.010
developmental growth involved in morphogenesis GO:0060560 138 0.010
leukocyte differentiation GO:0002521 342 0.010

Dub1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013
musculoskeletal system disease DOID:17 0 0.013