Mus musculus

136 known processes

Pbk

PDZ binding kinase

(Aliases: TOPK,AW538537,D14Ertd732e,2810434B10Rik)

Pbk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
meiotic cell cycle GO:0051321 122 0.488
dna metabolic process GO:0006259 303 0.302
spindle assembly involved in mitosis GO:0090307 4 0.297
asymmetric stem cell division GO:0098722 3 0.296
protein modification by small protein conjugation or removal GO:0070647 207 0.274
cellular response to dna damage stimulus GO:0006974 207 0.247
asymmetric neuroblast division GO:0055059 1 0.245
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.225
organelle fission GO:0048285 170 0.218
covalent chromatin modification GO:0016569 163 0.217
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.211
regulation of spindle organization GO:0090224 2 0.186
mitotic cell cycle GO:0000278 195 0.154
mitotic cell cycle process GO:1903047 159 0.149
regulation of cell cycle GO:0051726 281 0.142
meiotic cell cycle process GO:1903046 77 0.139
microtubule cytoskeleton organization GO:0000226 157 0.132
nuclear division GO:0000280 158 0.132
meiotic nuclear division GO:0007126 115 0.113
cytokinesis GO:0000910 17 0.112
chromatin modification GO:0016568 187 0.111
mitotic cytokinesis GO:0000281 4 0.109
histone serine phosphorylation GO:0035404 5 0.108
nucleotide metabolic process GO:0009117 332 0.104
attachment of spindle microtubules to kinetochore GO:0008608 4 0.099
microtubule based process GO:0007017 236 0.097
regulation of microtubule cytoskeleton organization GO:0070507 37 0.097
regulation of exit from mitosis GO:0007096 1 0.088
organelle assembly GO:0070925 177 0.084
regulation of cellular catabolic process GO:0031329 242 0.082
cytokinetic process GO:0032506 2 0.079
regulation of microtubule based process GO:0032886 52 0.071
response to oxidative stress GO:0006979 123 0.070
male meiosis GO:0007140 37 0.070
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.068
ribonucleoside triphosphate catabolic process GO:0009203 199 0.067
positive regulation of cellular catabolic process GO:0031331 148 0.066
germ cell development GO:0007281 185 0.066
protein catabolic process GO:0030163 221 0.062
spindle assembly GO:0051225 13 0.061
nucleoside phosphate metabolic process GO:0006753 338 0.061
chromosome segregation GO:0007059 48 0.060
mitotic nuclear division GO:0007067 48 0.060
peptidyl amino acid modification GO:0018193 336 0.059
cellular amine metabolic process GO:0044106 44 0.057
male gamete generation GO:0048232 285 0.057
chromatin organization GO:0006325 206 0.056
sister chromatid segregation GO:0000819 20 0.054
ubiquitin dependent protein catabolic process GO:0006511 129 0.053
cellular nitrogen compound catabolic process GO:0044270 280 0.052
cellular homeostasis GO:0019725 240 0.051
regulation of cellular ketone metabolic process GO:0010565 66 0.051
muscle tissue development GO:0060537 308 0.051
microtubule based movement GO:0007018 84 0.049
cell division GO:0051301 120 0.049
female meiotic division GO:0007143 21 0.049
cellular amino acid metabolic process GO:0006520 103 0.049
ras protein signal transduction GO:0007265 77 0.048
amine metabolic process GO:0009308 45 0.048
cellular protein catabolic process GO:0044257 155 0.047
positive regulation of intracellular transport GO:0032388 70 0.047
response to inorganic substance GO:0010035 96 0.045
cyclin catabolic process GO:0008054 1 0.045
positive regulation of nfat protein import into nucleus GO:0051533 1 0.045
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.044
regulation of organelle organization GO:0033043 289 0.044
nucleobase containing small molecule metabolic process GO:0055086 352 0.043
cellular ketone metabolic process GO:0042180 84 0.042
nucleoside triphosphate metabolic process GO:0009141 230 0.042
response to reactive oxygen species GO:0000302 56 0.042
regulation of cellular amine metabolic process GO:0033238 20 0.042
regulation of cellular amino acid metabolic process GO:0006521 5 0.042
aromatic compound catabolic process GO:0019439 286 0.041
oxidation reduction process GO:0055114 342 0.041
lateral inhibition GO:0046331 1 0.041
maintenance of location GO:0051235 89 0.041
regulation of mitotic cell cycle GO:0007346 126 0.040
cation transport GO:0006812 399 0.040
organic cyclic compound catabolic process GO:1901361 295 0.040
positive regulation of protein modification process GO:0031401 299 0.040
cellular response to oxidative stress GO:0034599 76 0.039
meiosis ii GO:0007135 7 0.039
regulation of chromosome segregation GO:0051983 21 0.039
synaptonemal complex assembly GO:0007130 13 0.039
spindle organization GO:0007051 28 0.039
protein ubiquitination GO:0016567 171 0.038
purine nucleoside triphosphate catabolic process GO:0009146 203 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.038
mitotic chromosome condensation GO:0007076 1 0.037
regulation of protein localization GO:0032880 231 0.037
negative regulation of cellular protein metabolic process GO:0032269 247 0.037
response to radiation GO:0009314 165 0.037
nucleoside phosphate catabolic process GO:1901292 222 0.036
purine nucleotide metabolic process GO:0006163 302 0.036
small gtpase mediated signal transduction GO:0007264 97 0.035
mrna metabolic process GO:0016071 84 0.035
regulation of double strand break repair via homologous recombination GO:0010569 2 0.035
mitotic sister chromatid segregation GO:0000070 14 0.034
positive regulation of protein phosphorylation GO:0001934 242 0.034
cell type specific apoptotic process GO:0097285 268 0.034
regulation of microtubule depolymerization GO:0031114 13 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.033
synapsis GO:0007129 34 0.033
cellular protein complex disassembly GO:0043624 36 0.033
positive regulation of exit from mitosis GO:0031536 1 0.033
regulation of mitotic spindle organization GO:0060236 2 0.032
mitotic cell cycle embryonic GO:0045448 5 0.032
microtubule depolymerization GO:0007019 15 0.032
mitotic spindle organization GO:0007052 10 0.031
regulation of protein complex disassembly GO:0043244 28 0.031
positive regulation of cellular amine metabolic process GO:0033240 5 0.030
regulation of protein kinase activity GO:0045859 232 0.030
chromosome organization involved in meiosis GO:0070192 39 0.029
purine ribonucleoside metabolic process GO:0046128 241 0.029
gonad development GO:0008406 141 0.028
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.028
purine containing compound catabolic process GO:0072523 213 0.028
developmental maturation GO:0021700 193 0.027
regulation of protein serine threonine kinase activity GO:0071900 157 0.027
histone modification GO:0016570 159 0.027
purine containing compound metabolic process GO:0072521 311 0.027
negative regulation of molecular function GO:0044092 258 0.027
regulation of cell cycle process GO:0010564 160 0.027
positive regulation of protein kinase activity GO:0045860 144 0.027
ribonucleoside catabolic process GO:0042454 206 0.027
endocytosis GO:0006897 168 0.027
spermatogenesis GO:0007283 284 0.027
homeostasis of number of cells GO:0048872 210 0.027
regulation of establishment of protein localization GO:0070201 181 0.027
purine ribonucleotide metabolic process GO:0009150 290 0.026
ribonucleotide metabolic process GO:0009259 291 0.026
peptidyl serine phosphorylation GO:0018105 74 0.026
regulation of intracellular protein transport GO:0033157 82 0.026
cell fate commitment GO:0045165 210 0.026
regulation of intracellular transport GO:0032386 159 0.026
regulation of purine nucleotide metabolic process GO:1900542 169 0.026
regulation of wnt signaling pathway GO:0030111 123 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
leukocyte homeostasis GO:0001776 79 0.026
dna packaging GO:0006323 30 0.025
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051439 1 0.025
modification dependent protein catabolic process GO:0019941 133 0.025
organ growth GO:0035265 117 0.025
oogenesis GO:0048477 56 0.024
regulation of neuron projection development GO:0010975 169 0.024
regulation of kinase activity GO:0043549 249 0.024
macromolecule catabolic process GO:0009057 281 0.024
wnt signaling pathway GO:0016055 188 0.024
rho protein signal transduction GO:0007266 32 0.024
spindle assembly involved in meiosis GO:0090306 4 0.024
muscle cell differentiation GO:0042692 261 0.023
striated muscle tissue development GO:0014706 293 0.023
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.023
regulation of hydrolase activity GO:0051336 246 0.023
cell adhesion GO:0007155 329 0.023
cellular lipid metabolic process GO:0044255 323 0.023
female gamete generation GO:0007292 74 0.022
oocyte maturation GO:0001556 18 0.022
regulation of embryonic development GO:0045995 71 0.022
glycosyl compound catabolic process GO:1901658 206 0.022
microtubule anchoring GO:0034453 9 0.022
carbohydrate derivative biosynthetic process GO:1901137 183 0.022
nucleoside metabolic process GO:0009116 246 0.022
neural tube formation GO:0001841 108 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
regulation of protein maturation GO:1903317 96 0.022
purine nucleotide catabolic process GO:0006195 211 0.022
heterocycle catabolic process GO:0046700 280 0.021
positive regulation of chromosome organization GO:2001252 33 0.021
regulation of cell projection organization GO:0031344 206 0.021
carbohydrate derivative catabolic process GO:1901136 231 0.021
dna replication GO:0006260 52 0.021
regulation of secretion GO:0051046 274 0.021
positive regulation of protein transport GO:0051222 93 0.021
regulation of cytoskeleton organization GO:0051493 122 0.020
cellular response to lipid GO:0071396 145 0.020
negative regulation of phosphate metabolic process GO:0045936 184 0.020
nuclear dna replication GO:0033260 3 0.020
mesodermal cell migration GO:0008078 4 0.020
axonogenesis GO:0007409 274 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.020
negative regulation of protein metabolic process GO:0051248 282 0.020
modification dependent macromolecule catabolic process GO:0043632 133 0.020
protein localization to organelle GO:0033365 185 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
purine nucleoside metabolic process GO:0042278 241 0.020
neural tube development GO:0021915 160 0.020
neural precursor cell proliferation GO:0061351 121 0.020
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.019
neuroblast proliferation GO:0007405 49 0.019
positive regulation of apoptotic process GO:0043065 217 0.019
regulation of nucleotide catabolic process GO:0030811 122 0.019
response to organonitrogen compound GO:0010243 246 0.019
chromosome movement towards spindle pole GO:0051305 3 0.019
regulation of lymphocyte activation GO:0051249 240 0.019
posttranscriptional regulation of gene expression GO:0010608 155 0.019
negative regulation of protein phosphorylation GO:0001933 126 0.019
positive regulation of intracellular protein transport GO:0090316 42 0.019
regulation of nucleotide metabolic process GO:0006140 169 0.018
purine ribonucleoside catabolic process GO:0046130 205 0.018
cell maturation GO:0048469 127 0.018
response to organic cyclic compound GO:0014070 198 0.018
dna ligation GO:0006266 3 0.018
regulation of nucleocytoplasmic transport GO:0046822 73 0.018
response to iron ion GO:0010039 4 0.018
rac protein signal transduction GO:0016601 13 0.018
regulation of chromatin binding GO:0035561 7 0.018
myeloid cell differentiation GO:0030099 233 0.018
organophosphate biosynthetic process GO:0090407 122 0.018
regulation of double strand break repair via nonhomologous end joining GO:2001032 2 0.017
spindle assembly involved in female meiosis GO:0007056 3 0.017
glycosyl compound metabolic process GO:1901657 246 0.017
response to oxygen levels GO:0070482 62 0.017
response to acid chemical GO:0001101 111 0.017
regulation of cytoplasmic transport GO:1903649 112 0.017
regulation of secretion by cell GO:1903530 249 0.017
regulation of homeostatic process GO:0032844 182 0.017
positive regulation of nucleotide catabolic process GO:0030813 88 0.017
translesion synthesis GO:0019985 1 0.017
protein modification by small protein conjugation GO:0032446 187 0.017
nucleoside triphosphate catabolic process GO:0009143 205 0.017
negative regulation of protein modification process GO:0031400 163 0.017
cleavage furrow formation GO:0036089 2 0.017
cellular chemical homeostasis GO:0055082 215 0.017
regulation of protein targeting GO:1903533 61 0.017
nucleotide catabolic process GO:0009166 217 0.016
embryonic epithelial tube formation GO:0001838 130 0.016
positive regulation of cytoplasmic transport GO:1903651 40 0.016
nucleoside phosphate biosynthetic process GO:1901293 79 0.016
dendrite development GO:0016358 115 0.016
nucleotide biosynthetic process GO:0009165 78 0.016
hematopoietic progenitor cell differentiation GO:0002244 143 0.016
apoptotic signaling pathway GO:0097190 306 0.016
regulation of binding GO:0051098 111 0.016
intracellular protein transport GO:0006886 204 0.016
development of primary sexual characteristics GO:0045137 143 0.016
positive regulation of nucleoside metabolic process GO:0045979 91 0.016
regulation of protein transport GO:0051223 163 0.016
peptidyl serine modification GO:0018209 83 0.015
dephosphorylation GO:0016311 129 0.015
regulation of cellular response to stress GO:0080135 159 0.015
regulation of nucleoside metabolic process GO:0009118 130 0.015
dna recombination GO:0006310 92 0.015
regulation of ras protein signal transduction GO:0046578 114 0.015
chromosome condensation GO:0030261 10 0.015
neuron death GO:0070997 154 0.015
ribose phosphate metabolic process GO:0019693 291 0.015
striated muscle cell development GO:0055002 125 0.015
response to light stimulus GO:0009416 135 0.015
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.015
positive regulation of kinase activity GO:0033674 155 0.015
stem cell division GO:0017145 30 0.015
epithelial cell proliferation GO:0050673 174 0.015
cellular macromolecule catabolic process GO:0044265 206 0.014
regulation of cellular protein catabolic process GO:1903362 61 0.014
positive regulation of organelle organization GO:0010638 128 0.014
wound healing GO:0042060 157 0.014
positive regulation of cell cycle GO:0045787 92 0.014
positive regulation of transferase activity GO:0051347 167 0.014
regulation of hormone levels GO:0010817 211 0.014
regulation of muscle tissue development GO:1901861 97 0.014
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.014
muscle cell development GO:0055001 133 0.014
positive regulation of nucleotide metabolic process GO:0045981 114 0.014
genitalia development GO:0048806 37 0.014
cell cycle g2 m phase transition GO:0044839 20 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.014
intrinsic apoptotic signaling pathway GO:0097193 132 0.014
regulation of rho gtpase activity GO:0032319 58 0.014
positive regulation of nervous system development GO:0051962 221 0.014
ribonucleotide catabolic process GO:0009261 208 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
double strand break repair via homologous recombination GO:0000724 21 0.014
rna processing GO:0006396 105 0.014
circulatory system process GO:0003013 197 0.014
synapse organization GO:0050808 125 0.014
anatomical structure homeostasis GO:0060249 145 0.014
regulation of neuron differentiation GO:0045664 281 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
metaphase plate congression GO:0051310 2 0.013
carbohydrate metabolic process GO:0005975 230 0.013
mapk cascade GO:0000165 281 0.013
nucleoside catabolic process GO:0009164 206 0.013
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.013
generation of precursor metabolites and energy GO:0006091 103 0.013
regulation of cell activation GO:0050865 289 0.013
negative regulation of neuron death GO:1901215 98 0.013
ribonucleoside monophosphate metabolic process GO:0009161 80 0.013
protein targeting GO:0006605 143 0.013
carbohydrate homeostasis GO:0033500 128 0.013
regulation of chromatin organization GO:1902275 57 0.013
regulation of rho protein signal transduction GO:0035023 71 0.013
dna endoreduplication GO:0042023 4 0.013
negative regulation of protein complex disassembly GO:0043242 22 0.013
chromosome separation GO:0051304 14 0.013
actin cytoskeleton organization GO:0030036 220 0.013
positive regulation of mitotic cell cycle GO:0045931 41 0.013
dna replication independent nucleosome assembly GO:0006336 1 0.013
lipid biosynthetic process GO:0008610 179 0.013
maintenance of location in cell GO:0051651 24 0.013
peptidyl tyrosine phosphorylation GO:0018108 143 0.013
meiotic cytokinesis GO:0033206 5 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
regulation of proteolysis GO:0030162 164 0.013
negative regulation of protein depolymerization GO:1901880 21 0.013
response to hydrogen peroxide GO:0042542 32 0.013
mrna 3 end processing GO:0031124 16 0.013
centrosome separation GO:0051299 4 0.013
positive regulation of gtp catabolic process GO:0033126 85 0.013
anion transport GO:0006820 177 0.013
ossification GO:0001503 216 0.013
monocarboxylic acid metabolic process GO:0032787 191 0.012
nucleoside monophosphate catabolic process GO:0009125 59 0.012
peptide transport GO:0015833 133 0.012
response to growth factor GO:0070848 198 0.012
protein autophosphorylation GO:0046777 61 0.012
response to copper ion GO:0046688 3 0.012
sensory organ morphogenesis GO:0090596 242 0.012
sensory perception GO:0007600 245 0.012
organelle localization GO:0051640 179 0.012
mitotic sister chromatid separation GO:0051306 9 0.012
peptide hormone secretion GO:0030072 109 0.012
intracellular mrna localization GO:0008298 4 0.012
atp metabolic process GO:0046034 75 0.012
heart growth GO:0060419 45 0.012
digestive system development GO:0055123 200 0.012
regulation of cell division GO:0051302 76 0.012
female meiosis chromosome segregation GO:0016321 1 0.012
regulation of fibroblast proliferation GO:0048145 34 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.012
gtp metabolic process GO:0046039 144 0.012
glucose homeostasis GO:0042593 128 0.012
regulation of chromatin modification GO:1903308 57 0.012
energy derivation by oxidation of organic compounds GO:0015980 77 0.012
blastocyst development GO:0001824 80 0.012
gland development GO:0048732 330 0.012
protein depolymerization GO:0051261 34 0.012
positive regulation of chromosome segregation GO:0051984 4 0.012
purine nucleoside catabolic process GO:0006152 205 0.012
response to ionizing radiation GO:0010212 42 0.011
blood circulation GO:0008015 195 0.011
response to decreased oxygen levels GO:0036293 59 0.011
myeloid cell homeostasis GO:0002262 114 0.011
cofactor metabolic process GO:0051186 80 0.011
positive regulation of gtpase activity GO:0043547 85 0.011
cellular response to inorganic substance GO:0071241 37 0.011
oocyte differentiation GO:0009994 35 0.011
regulation of protein depolymerization GO:1901879 26 0.011
regulation of neuron death GO:1901214 134 0.011
synaptonemal complex organization GO:0070193 15 0.011
negative regulation of protein maturation GO:1903318 79 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
positive regulation of cell death GO:0010942 224 0.011
neuron apoptotic process GO:0051402 142 0.011
nitrogen compound transport GO:0071705 271 0.011
guanosine containing compound metabolic process GO:1901068 144 0.011
nuclear import GO:0051170 95 0.011
helper t cell chemotaxis GO:0035704 1 0.011
lymphocyte homeostasis GO:0002260 64 0.011
protein import GO:0017038 101 0.011
response to metal ion GO:0010038 47 0.011
mrna processing GO:0006397 63 0.011
regulation of histone modification GO:0031056 56 0.011
regulation of protein processing GO:0070613 96 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
response to drug GO:0042493 75 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
protein oligomerization GO:0051259 67 0.010
regulation of protein localization to nucleus GO:1900180 60 0.010
insulin secretion GO:0030073 89 0.010
dna repair GO:0006281 107 0.010
microtubule organizing center organization GO:0031023 28 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
gene silencing GO:0016458 38 0.010
digestive tract development GO:0048565 190 0.010
stem cell differentiation GO:0048863 268 0.010
cardiac muscle tissue development GO:0048738 130 0.010
blood vessel morphogenesis GO:0048514 285 0.010
cardiac muscle cell differentiation GO:0055007 69 0.010
amide transport GO:0042886 138 0.010
negative regulation of apoptotic signaling pathway GO:2001234 104 0.010

Pbk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.232
cancer DOID:162 0 0.075
organ system cancer DOID:0050686 0 0.032
breast cancer DOID:1612 0 0.019
thoracic cancer DOID:5093 0 0.019
gastrointestinal system cancer DOID:3119 0 0.014
intestinal cancer DOID:10155 0 0.014
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012