Mus musculus

0 known processes

Gen1

Gen homolog 1, endonuclease (Drosophila)

(Aliases: 5830483C08Rik,MGC115970)

Gen1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.112
Human Fly
meiotic cell cycle process GO:1903046 77 0.104
male gamete generation GO:0048232 285 0.102
negative regulation of fibroblast apoptotic process GO:2000270 6 0.100
protein catabolic process GO:0030163 221 0.089
meiotic cell cycle GO:0051321 122 0.084
meiotic nuclear division GO:0007126 115 0.075
organelle fission GO:0048285 170 0.068
regulation of organelle organization GO:0033043 289 0.064
Human
spermatid differentiation GO:0048515 115 0.056
cellular amine metabolic process GO:0044106 44 0.054
microtubule based process GO:0007017 236 0.053
Human
cellular response to gamma radiation GO:0071480 4 0.052
chromosome segregation GO:0007059 48 0.044
microtubule cytoskeleton organization GO:0000226 157 0.044
Human
regulation of cell cycle GO:0051726 281 0.044
Human
cellular ketone metabolic process GO:0042180 84 0.041
amine metabolic process GO:0009308 45 0.040
double strand break repair GO:0006302 48 0.039
Human Fly
dna repair GO:0006281 107 0.039
Human Fly
mitotic cell cycle process GO:1903047 159 0.037
Human
cilium assembly GO:0042384 81 0.037
regulation of cellular amino acid metabolic process GO:0006521 5 0.034
regulation of cell cycle process GO:0010564 160 0.033
Human
meiosis i GO:0007127 60 0.033
germ cell development GO:0007281 185 0.033
negative regulation of cellular protein metabolic process GO:0032269 247 0.032
Human
negative regulation of cellular component organization GO:0051129 194 0.032
Human
intrinsic apoptotic signaling pathway GO:0097193 132 0.031
centrosome organization GO:0051297 26 0.031
Human
protein modification by small protein conjugation or removal GO:0070647 207 0.029
spermatid development GO:0007286 108 0.029
protein maturation GO:0051604 176 0.027
regulation of protein catabolic process GO:0042176 108 0.027
Human
protein methylation GO:0006479 81 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
regulation of cellular amine metabolic process GO:0033238 20 0.025
regulation of protein maturation GO:1903317 96 0.025
Human
spermatogenesis GO:0007283 284 0.025
negative regulation of cell division GO:0051782 24 0.025
Human
protein modification by small protein conjugation GO:0032446 187 0.025
establishment of organelle localization GO:0051656 122 0.025
nucleobase containing small molecule metabolic process GO:0055086 352 0.024
negative regulation of protein catabolic process GO:0042177 36 0.024
Human
nuclear division GO:0000280 158 0.024
lateral inhibition GO:0046331 1 0.024
dna recombination GO:0006310 92 0.024
Human
macromolecule catabolic process GO:0009057 281 0.022
Human Fly
cellular amino acid metabolic process GO:0006520 103 0.021
regulation of cellular protein catabolic process GO:1903362 61 0.021
Human
regulation of cellular ketone metabolic process GO:0010565 66 0.021
regulation of mitotic cell cycle phase transition GO:1901990 73 0.021
Human
protein polyubiquitination GO:0000209 33 0.020
negative regulation of ubiquitin protein transferase activity GO:0051444 3 0.020
organelle assembly GO:0070925 177 0.020
synapsis GO:0007129 34 0.020
carbohydrate derivative catabolic process GO:1901136 231 0.020
regulation of chromosome organization GO:0033044 83 0.019
Human
nucleotide metabolic process GO:0009117 332 0.019
negative regulation of transferase activity GO:0051348 85 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019
Human
mitotic cell cycle GO:0000278 195 0.018
Human
male meiosis i GO:0007141 16 0.018
nucleoside phosphate metabolic process GO:0006753 338 0.018
modification dependent macromolecule catabolic process GO:0043632 133 0.018
chromosome organization involved in meiosis GO:0070192 39 0.018
dna metabolic process GO:0006259 303 0.017
Human Fly
positive regulation of mitotic cell cycle GO:0045931 41 0.017
Human
methylation GO:0032259 134 0.017
regulation of microtubule based process GO:0032886 52 0.017
Human
negative regulation of organelle organization GO:0010639 90 0.017
Human
purine nucleoside metabolic process GO:0042278 241 0.017
response to uv GO:0009411 44 0.016
negative regulation of cell cycle GO:0045786 123 0.016
Human
negative regulation of cell cycle phase transition GO:1901988 48 0.016
Human
cell division GO:0051301 120 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
positive regulation of nfat protein import into nucleus GO:0051533 1 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
telencephalon development GO:0021537 186 0.016
lymphocyte mediated immunity GO:0002449 139 0.016
negative regulation of cellular protein catabolic process GO:1903363 22 0.016
Human
positive regulation of cell death GO:0010942 224 0.015
negative regulation of ligase activity GO:0051352 3 0.015
organophosphate catabolic process GO:0046434 232 0.015
mitotic cell cycle arrest GO:0071850 4 0.015
leukocyte mediated immunity GO:0002443 174 0.015
negative regulation of proteolysis GO:0045861 74 0.015
Human
cytoplasmic transport GO:0016482 234 0.015
nucleotide catabolic process GO:0009166 217 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
Human Fly
b cell activation GO:0042113 161 0.015
mitotic sister chromatid segregation GO:0000070 14 0.015
positive regulation of apoptotic process GO:0043065 217 0.015
protein ubiquitination GO:0016567 171 0.015
microtubule organizing center organization GO:0031023 28 0.015
Human
protein processing GO:0016485 163 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
histone h3 k9 dimethylation GO:0036123 4 0.015
purine nucleoside monophosphate metabolic process GO:0009126 81 0.014
regulation of nuclear division GO:0051783 56 0.014
Human
positive regulation of cellular amine metabolic process GO:0033240 5 0.014
stem cell differentiation GO:0048863 268 0.014
glycosyl compound metabolic process GO:1901657 246 0.014
adaptive immune response GO:0002250 155 0.014
ribonucleoside metabolic process GO:0009119 245 0.014
nucleoside phosphate catabolic process GO:1901292 222 0.014
stem cell maintenance GO:0019827 130 0.014
protein alkylation GO:0008213 81 0.014
ribose phosphate metabolic process GO:0019693 291 0.014
blastocyst development GO:0001824 80 0.014
response to nutrient levels GO:0031667 109 0.013
ubiquitin dependent protein catabolic process GO:0006511 129 0.013
regulation of adaptive immune response GO:0002819 90 0.013
cell cycle switching GO:0060184 1 0.013
spindle assembly involved in meiosis GO:0090306 4 0.013
forebrain development GO:0030900 302 0.013
purine nucleoside monophosphate catabolic process GO:0009128 58 0.013
production of molecular mediator of immune response GO:0002440 103 0.013
intracellular protein transport GO:0006886 204 0.013
nitrogen compound transport GO:0071705 271 0.013
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.012
Human
purine nucleoside triphosphate catabolic process GO:0009146 203 0.012
nucleoside metabolic process GO:0009116 246 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
negative regulation of mitotic cell cycle GO:0045930 58 0.012
Human
stem cell development GO:0048864 219 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
Human
regulation of cell cycle g2 m phase transition GO:1902749 10 0.012
negative regulation of protein processing GO:0010955 79 0.012
Human
regulation of lymphocyte activation GO:0051249 240 0.012
regulation of cell cycle phase transition GO:1901987 77 0.012
Human
mitotic sister chromatid cohesion GO:0007064 1 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
macromolecule methylation GO:0043414 120 0.011
bone development GO:0060348 120 0.011
glucose homeostasis GO:0042593 128 0.011
nucleoside catabolic process GO:0009164 206 0.011
purine containing compound metabolic process GO:0072521 311 0.011
regulation of apoptotic signaling pathway GO:2001233 197 0.011
ribonucleotide catabolic process GO:0009261 208 0.011
response to gamma radiation GO:0010332 22 0.011
apoptotic signaling pathway GO:0097190 306 0.011
atp metabolic process GO:0046034 75 0.011
cilium morphogenesis GO:0060271 102 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
positive regulation of lymphocyte activation GO:0051251 140 0.011
regulation of microtubule cytoskeleton organization GO:0070507 37 0.011
Human
response to hydroperoxide GO:0033194 6 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
regulation of cell activation GO:0050865 289 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
nuclear transport GO:0051169 139 0.011
divalent metal ion transport GO:0070838 172 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
negative regulation of cell cycle process GO:0010948 69 0.011
Human
somatic diversification of immune receptors GO:0002200 53 0.010
regulation of leukocyte mediated immunity GO:0002703 104 0.010
ribonucleoside triphosphate metabolic process GO:0009199 220 0.010
heterochromatin organization GO:0070828 4 0.010
cellular protein complex assembly GO:0043623 116 0.010
cellular response to hydroperoxide GO:0071447 4 0.010
protein localization to organelle GO:0033365 185 0.010
negative regulation of chromosome organization GO:2001251 30 0.010
Human

Gen1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.164
disease of anatomical entity DOID:7 0 0.164
hematopoietic system disease DOID:74 0 0.164
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.025
anemia DOID:2355 0 0.025
congenital hypoplastic anemia DOID:1342 0 0.024
aplastic anemia DOID:12449 0 0.024
bone marrow disease DOID:4961 0 0.024
breast cancer DOID:1612 0 0.023
thoracic cancer DOID:5093 0 0.023
blood platelet disease DOID:2218 0 0.013
hemorrhagic disease DOID:2213 0 0.013
blood coagulation disease DOID:1247 0 0.013
fanconi s anemia DOID:13636 0 0.011
nervous system disease DOID:863 0 0.010