Mus musculus

5 known processes

Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

(Aliases: Ahr-1,ALR2,Ahr1,Aldr1,AR,Akr1b1,Aldor1)

Akr1b3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleotide metabolic process GO:0009117 332 0.095
nucleobase containing small molecule metabolic process GO:0055086 352 0.094
negative regulation of phosphorylation GO:0042326 166 0.066
nucleoside phosphate metabolic process GO:0006753 338 0.062
cellular amino acid metabolic process GO:0006520 103 0.057
male gamete generation GO:0048232 285 0.057
regulation of cellular amino acid metabolic process GO:0006521 5 0.055
purine containing compound metabolic process GO:0072521 311 0.055
circulatory system process GO:0003013 197 0.055
nucleoside monophosphate metabolic process GO:0009123 85 0.054
purine nucleotide metabolic process GO:0006163 302 0.053
negative regulation of protein phosphorylation GO:0001933 126 0.049
regulation of system process GO:0044057 200 0.048
negative regulation of phosphate metabolic process GO:0045936 184 0.047
organonitrogen compound biosynthetic process GO:1901566 192 0.047
negative regulation of protein metabolic process GO:0051248 282 0.047
peptidyl amino acid modification GO:0018193 336 0.047
cellular amine metabolic process GO:0044106 44 0.047
heart contraction GO:0060047 93 0.046
regulation of membrane potential GO:0042391 192 0.046
urogenital system development GO:0001655 261 0.044
renal system development GO:0072001 225 0.043
transmembrane transport GO:0055085 412 0.041
kidney development GO:0001822 213 0.040
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.040
spermatogenesis GO:0007283 284 0.040
negative regulation of cellular protein metabolic process GO:0032269 247 0.038
negative regulation of protein modification process GO:0031400 163 0.037
peptidyl serine modification GO:0018209 83 0.037
inorganic cation transmembrane transport GO:0098662 207 0.036
negative regulation of phosphorus metabolic process GO:0010563 184 0.035
regulation of blood circulation GO:1903522 93 0.035
nucleoside triphosphate metabolic process GO:0009141 230 0.035
cellular ketone metabolic process GO:0042180 84 0.035
Human Mouse
heart process GO:0003015 94 0.035
dna metabolic process GO:0006259 303 0.034
peptidyl serine phosphorylation GO:0018105 74 0.034
regulation of cellular ketone metabolic process GO:0010565 66 0.034
purine ribonucleotide metabolic process GO:0009150 290 0.033
intrinsic apoptotic signaling pathway GO:0097193 132 0.033
purine containing compound biosynthetic process GO:0072522 70 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.033
g protein coupled receptor signaling pathway GO:0007186 243 0.033
inflammatory response GO:0006954 244 0.033
regulation of inflammatory response GO:0050727 147 0.033
cation transport GO:0006812 399 0.032
apoptotic signaling pathway GO:0097190 306 0.032
regulation of transmembrane transport GO:0034762 128 0.032
organophosphate biosynthetic process GO:0090407 122 0.031
cytokine production GO:0001816 319 0.031
hypotonic response GO:0006971 3 0.031
atp metabolic process GO:0046034 75 0.030
positive regulation of cellular amine metabolic process GO:0033240 5 0.030
heterocycle catabolic process GO:0046700 280 0.030
aromatic compound catabolic process GO:0019439 286 0.029
cation transmembrane transport GO:0098655 266 0.029
multicellular organismal signaling GO:0035637 91 0.029
positive regulation of programmed cell death GO:0043068 218 0.029
purine nucleoside metabolic process GO:0042278 241 0.029
nitrogen compound transport GO:0071705 271 0.028
carbohydrate derivative biosynthetic process GO:1901137 183 0.028
amine metabolic process GO:0009308 45 0.028
oxidation reduction process GO:0055114 342 0.028
blood circulation GO:0008015 195 0.028
ribonucleoside metabolic process GO:0009119 245 0.028
regulation of ion transmembrane transporter activity GO:0032412 54 0.027
response to organic cyclic compound GO:0014070 198 0.027
regulation of apoptotic signaling pathway GO:2001233 197 0.027
cellular response to lipid GO:0071396 145 0.027
organic cyclic compound catabolic process GO:1901361 295 0.027
Mouse
regulation of heart contraction GO:0008016 77 0.026
macromolecule catabolic process GO:0009057 281 0.026
reactive oxygen species metabolic process GO:0072593 84 0.026
regulation of muscle system process GO:0090257 80 0.026
regulation of purine nucleotide metabolic process GO:1900542 169 0.026
regulation of transporter activity GO:0032409 57 0.026
regulation of protein localization GO:0032880 231 0.026
transmission of nerve impulse GO:0019226 76 0.026
regulation of defense response GO:0031347 233 0.026
ribonucleotide metabolic process GO:0009259 291 0.025
negative regulation of molecular function GO:0044092 258 0.025
inorganic ion transmembrane transport GO:0098660 234 0.024
cellular response to dna damage stimulus GO:0006974 207 0.024
nucleotide catabolic process GO:0009166 217 0.024
neuronal action potential GO:0019228 54 0.024
glycosyl compound metabolic process GO:1901657 246 0.024
Human
action potential GO:0001508 78 0.024
adult behavior GO:0030534 135 0.024
cation homeostasis GO:0055080 212 0.023
response to oxidative stress GO:0006979 123 0.023
negative regulation of intracellular signal transduction GO:1902532 167 0.023
regulation of hormone levels GO:0010817 211 0.023
Mouse
regulation of secretion GO:0051046 274 0.023
protein localization to organelle GO:0033365 185 0.022
purine nucleoside monophosphate metabolic process GO:0009126 81 0.022
membrane organization GO:0061024 245 0.022
cellular homeostasis GO:0019725 240 0.022
positive regulation of protein modification process GO:0031401 299 0.021
regulation of nucleotide metabolic process GO:0006140 169 0.021
mapk cascade GO:0000165 281 0.021
mrna metabolic process GO:0016071 84 0.021
nucleoside phosphate catabolic process GO:1901292 222 0.021
regulation of transferase activity GO:0051338 263 0.021
cellular divalent inorganic cation homeostasis GO:0072503 127 0.021
regulation of interleukin 8 production GO:0032677 3 0.021
ribose phosphate metabolic process GO:0019693 291 0.020
regulation of blood pressure GO:0008217 93 0.020
regulation of body fluid levels GO:0050878 162 0.020
purine nucleoside triphosphate metabolic process GO:0009144 226 0.020
response to organonitrogen compound GO:0010243 246 0.020
ribonucleotide catabolic process GO:0009261 208 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.020
intracellular protein transport GO:0006886 204 0.020
nucleoside metabolic process GO:0009116 246 0.019
epithelial cell development GO:0002064 159 0.019
muscle system process GO:0003012 141 0.019
positive regulation of cell death GO:0010942 224 0.019
ribonucleoside monophosphate metabolic process GO:0009161 80 0.019
organelle localization GO:0051640 179 0.019
muscle contraction GO:0006936 101 0.019
regulation of hydrolase activity GO:0051336 246 0.019
spermatid differentiation GO:0048515 115 0.019
nucleoside phosphate biosynthetic process GO:1901293 79 0.019
carbohydrate metabolic process GO:0005975 230 0.018
Mouse
regulation of ion transmembrane transport GO:0034765 119 0.018
sensory perception GO:0007600 245 0.018
alpha amino acid biosynthetic process GO:1901607 15 0.018
cell adhesion GO:0007155 329 0.018
carbohydrate derivative catabolic process GO:1901136 231 0.018
regulation of cytokine production GO:0001817 266 0.018
multicellular organism growth GO:0035264 161 0.017
establishment of blood nerve barrier GO:0008065 3 0.017
cellular response to acid chemical GO:0071229 68 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
ribonucleoside triphosphate metabolic process GO:0009199 220 0.017
ion transmembrane transport GO:0034220 361 0.017
cellular nitrogen compound catabolic process GO:0044270 280 0.017
cellular response to oxidative stress GO:0034599 76 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.017
calcium ion homeostasis GO:0055074 127 0.017
multi multicellular organism process GO:0044706 109 0.017
Mouse
regulation of intracellular transport GO:0032386 159 0.017
glucose homeostasis GO:0042593 128 0.016
cell type specific apoptotic process GO:0097285 268 0.016
nuclear transport GO:0051169 139 0.016
cytoplasmic transport GO:0016482 234 0.016
positive regulation of apoptotic process GO:0043065 217 0.016
regulation of reactive oxygen species metabolic process GO:2000377 40 0.016
regulation of mapk cascade GO:0043408 248 0.016
protein modification by small protein conjugation GO:0032446 187 0.016
organophosphate catabolic process GO:0046434 232 0.016
protein catabolic process GO:0030163 221 0.016
regulation of ion transport GO:0043269 215 0.016
chromatin organization GO:0006325 206 0.016
cellular macromolecule catabolic process GO:0044265 206 0.016
ensheathment of neurons GO:0007272 76 0.016
mitotic cell cycle GO:0000278 195 0.016
epithelial tube morphogenesis GO:0060562 303 0.016
nucleotide biosynthetic process GO:0009165 78 0.015
divalent inorganic cation homeostasis GO:0072507 138 0.015
regulation of organelle organization GO:0033043 289 0.015
purine nucleotide catabolic process GO:0006195 211 0.015
cellular response to biotic stimulus GO:0071216 92 0.015
cellular amino acid biosynthetic process GO:0008652 22 0.015
gland development GO:0048732 330 0.015
lateral inhibition GO:0046331 1 0.015
positive regulation of protein phosphorylation GO:0001934 242 0.015
cellular response to osmotic stress GO:0071470 7 0.015
second messenger mediated signaling GO:0019932 73 0.015
positive regulation of apoptotic signaling pathway GO:2001235 95 0.015
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.015
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.015
muscle adaptation GO:0043500 39 0.015
negative regulation of potassium ion transmembrane transporter activity GO:1901017 3 0.015
interleukin 8 production GO:0032637 4 0.015
carboxylic acid biosynthetic process GO:0046394 86 0.015
Mouse
regulation of protein kinase activity GO:0045859 232 0.015
synaptic transmission GO:0007268 329 0.014
developmental growth involved in morphogenesis GO:0060560 138 0.014
response to osmotic stress GO:0006970 21 0.014
rna processing GO:0006396 105 0.014
mitochondrion distribution GO:0048311 4 0.014
tissue homeostasis GO:0001894 115 0.014
actin cytoskeleton organization GO:0030036 220 0.014
striated muscle tissue development GO:0014706 293 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
engulfment of apoptotic cell GO:0043652 3 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.014
mitochondrion organization GO:0007005 134 0.014
wound healing GO:0042060 157 0.014
regulation of kinase activity GO:0043549 249 0.014
divalent metal ion transport GO:0070838 172 0.014
neurotransmitter transport GO:0006836 76 0.013
cellular response to peptide GO:1901653 92 0.013
protein processing GO:0016485 163 0.013
small gtpase mediated signal transduction GO:0007264 97 0.013
ribonucleoside catabolic process GO:0042454 206 0.013
cellular ion homeostasis GO:0006873 165 0.013
ketone catabolic process GO:0042182 3 0.013
Mouse
regulation of cellular response to stress GO:0080135 159 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.013
methylation GO:0032259 134 0.013
positive regulation of nucleotide metabolic process GO:0045981 114 0.013
locomotory behavior GO:0007626 195 0.013
skin development GO:0043588 220 0.013
positive regulation of monooxygenase activity GO:0032770 2 0.013
anatomical structure homeostasis GO:0060249 145 0.013
regulation of secretion by cell GO:1903530 249 0.013
response to acid chemical GO:0001101 111 0.013
regulation of ion homeostasis GO:2000021 64 0.013
regulation of cell projection organization GO:0031344 206 0.013
regulation of protein transport GO:0051223 163 0.013
striated muscle contraction GO:0006941 45 0.013
organic acid biosynthetic process GO:0016053 86 0.013
Mouse
cellular response to hormone stimulus GO:0032870 150 0.012
protein targeting GO:0006605 143 0.012
regulation of neurotransmitter levels GO:0001505 87 0.012
cellular protein catabolic process GO:0044257 155 0.012
negative regulation of cell development GO:0010721 169 0.012
regulation of binding GO:0051098 111 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.012
carbohydrate homeostasis GO:0033500 128 0.012
response to lipopolysaccharide GO:0032496 128 0.012
camera type eye development GO:0043010 266 0.012
cellular response to peptide hormone stimulus GO:0071375 92 0.012
positive regulation of ion transport GO:0043270 65 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
organelle fission GO:0048285 170 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.012
regulation of protein localization to nucleus GO:1900180 60 0.012
regulation of homeostatic process GO:0032844 182 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
cellular chemical homeostasis GO:0055082 215 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
metal ion homeostasis GO:0055065 189 0.011
monocarboxylic acid metabolic process GO:0032787 191 0.011
Mouse
cognition GO:0050890 149 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
dna repair GO:0006281 107 0.011
superoxide metabolic process GO:0006801 27 0.011
negative regulation of camp mediated signaling GO:0043951 3 0.011
potassium ion transmembrane transport GO:0071805 43 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.011
retina development in camera type eye GO:0060041 119 0.011
cellular calcium ion homeostasis GO:0006874 119 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
angiotensin activated signaling pathway GO:0038166 4 0.011
cellular lipid metabolic process GO:0044255 323 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
cellular response to abiotic stimulus GO:0071214 56 0.011
meiotic nuclear division GO:0007126 115 0.011
generation of precursor metabolites and energy GO:0006091 103 0.011
negative regulation of transferase activity GO:0051348 85 0.011
purine containing compound catabolic process GO:0072523 213 0.011
striated muscle hypertrophy GO:0014897 24 0.011
organic hydroxy compound transport GO:0015850 93 0.011
myotube differentiation GO:0014902 105 0.011
nucleoside catabolic process GO:0009164 206 0.011
positive regulation of cardiac muscle contraction GO:0060452 2 0.011
calcium ion transport GO:0006816 159 0.011
alpha amino acid metabolic process GO:1901605 59 0.011
learning or memory GO:0007611 148 0.011
regulation of protein processing GO:0070613 96 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
cellular component assembly involved in morphogenesis GO:0010927 139 0.011
chloride transport GO:0006821 32 0.011
positive regulation of cytokine production GO:0001819 174 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.011
response to inorganic substance GO:0010035 96 0.010
positive regulation of nervous system development GO:0051962 221 0.010
protein localization to nucleus GO:0034504 121 0.010
negative regulation of cell proliferation GO:0008285 296 0.010
regulation of cytoplasmic transport GO:1903649 112 0.010
calcium independent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016338 4 0.010
negative regulation of cellular component organization GO:0051129 194 0.010
forebrain development GO:0030900 302 0.010
muscle tissue development GO:0060537 308 0.010
regulation of androgen receptor signaling pathway GO:0060765 3 0.010
endomembrane system organization GO:0010256 147 0.010
cellular response to lipopolysaccharide GO:0071222 77 0.010
angiogenesis GO:0001525 201 0.010
organonitrogen compound catabolic process GO:1901565 264 0.010
regulation of muscle adaptation GO:0043502 31 0.010
cyclic nucleotide metabolic process GO:0009187 59 0.010
regulation of cellular catabolic process GO:0031329 242 0.010
response to growth factor GO:0070848 198 0.010
modification dependent protein catabolic process GO:0019941 133 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
chromatin modification GO:0016568 187 0.010

Akr1b3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
central nervous system disease DOID:331 0 0.012
cardiovascular system disease DOID:1287 0 0.011
disease of metabolism DOID:0014667 0 0.011