Mus musculus

7 known processes

Mvk

mevalonate kinase

(Aliases: AI414037,2310010A05Rik,AI256848,MK)

Mvk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sterol metabolic process GO:0016125 58 0.457
Human
cellular alcohol metabolic process GO:0044107 3 0.400
lipid biosynthetic process GO:0008610 179 0.239
Human
cellular lipid metabolic process GO:0044255 323 0.230
Human
cellular alcohol biosynthetic process GO:0044108 3 0.156
sterol biosynthetic process GO:0016126 17 0.123
Human
cholesterol metabolic process GO:0008203 56 0.121
Human
cholesterol biosynthetic process GO:0006695 15 0.105
Human
regulation of organelle organization GO:0033043 289 0.096
alcohol biosynthetic process GO:0046165 43 0.089
Human
cellular amino acid metabolic process GO:0006520 103 0.082
steroid metabolic process GO:0008202 119 0.076
Human
circulatory system process GO:0003013 197 0.072
regulation of secretion GO:0051046 274 0.066
regulation of cellular ketone metabolic process GO:0010565 66 0.063
regulation of cellular amino acid metabolic process GO:0006521 5 0.057
negative regulation of cellular protein metabolic process GO:0032269 247 0.056
carbohydrate derivative biosynthetic process GO:1901137 183 0.055
isoprenoid biosynthetic process GO:0008299 9 0.053
Human
negative regulation of protein metabolic process GO:0051248 282 0.052
regulation of cellular response to stress GO:0080135 159 0.051
synaptic transmission GO:0007268 329 0.051
cellular ketone metabolic process GO:0042180 84 0.049
sulfur compound biosynthetic process GO:0044272 37 0.046
compound eye development GO:0048749 1 0.044
negative regulation of molecular function GO:0044092 258 0.044
response to radiation GO:0009314 165 0.043
nucleobase containing small molecule metabolic process GO:0055086 352 0.043
regulation of protein kinase activity GO:0045859 232 0.042
liver development GO:0001889 66 0.041
mapk cascade GO:0000165 281 0.039
skin development GO:0043588 220 0.039
amine metabolic process GO:0009308 45 0.039
oxidation reduction process GO:0055114 342 0.039
stress activated protein kinase signaling cascade GO:0031098 81 0.038
alcohol metabolic process GO:0006066 116 0.038
Human
muscle cell differentiation GO:0042692 261 0.038
ribonucleotide metabolic process GO:0009259 291 0.037
microtubule based process GO:0007017 236 0.036
protein maturation GO:0051604 176 0.035
organelle localization GO:0051640 179 0.035
positive regulation of cellular amine metabolic process GO:0033240 5 0.035
positive regulation of apoptotic process GO:0043065 217 0.033
cytoplasmic transport GO:0016482 234 0.033
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.033
response to light stimulus GO:0009416 135 0.032
positive regulation of nervous system development GO:0051962 221 0.032
blood vessel morphogenesis GO:0048514 285 0.032
cellular amine metabolic process GO:0044106 44 0.031
striated muscle tissue development GO:0014706 293 0.031
steroid biosynthetic process GO:0006694 47 0.031
Human
regulation of purine nucleotide metabolic process GO:1900542 169 0.031
cellular response to lipid GO:0071396 145 0.030
positive regulation of organelle organization GO:0010638 128 0.030
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.029
skeletal system development GO:0001501 356 0.029
regulation of cellular amine metabolic process GO:0033238 20 0.029
nucleotide metabolic process GO:0009117 332 0.029
apoptotic signaling pathway GO:0097190 306 0.028
aromatic compound catabolic process GO:0019439 286 0.028
protein processing GO:0016485 163 0.028
regulation of transferase activity GO:0051338 263 0.028
gland development GO:0048732 330 0.028
response to nutrient levels GO:0031667 109 0.028
cellular nitrogen compound catabolic process GO:0044270 280 0.028
germ cell development GO:0007281 185 0.028
peptidyl amino acid modification GO:0018193 336 0.028
positive regulation of cell development GO:0010720 237 0.028
isoprenoid metabolic process GO:0006720 29 0.027
Human
cell type specific apoptotic process GO:0097285 268 0.027
response to starvation GO:0042594 65 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
regulation of neuron differentiation GO:0045664 281 0.026
positive regulation of protein modification process GO:0031401 299 0.026
male gamete generation GO:0048232 285 0.026
glycoprotein metabolic process GO:0009100 116 0.026
positive regulation of mapk cascade GO:0043410 170 0.026
respiratory tube development GO:0030323 167 0.026
regulation of kinase activity GO:0043549 249 0.025
regulation of mapk cascade GO:0043408 248 0.025
regulation of proteolysis GO:0030162 164 0.025
spermatogenesis GO:0007283 284 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
ribonucleoside triphosphate metabolic process GO:0009199 220 0.025
posttranscriptional regulation of gene expression GO:0010608 155 0.025
nucleoside phosphate metabolic process GO:0006753 338 0.025
protein targeting GO:0006605 143 0.024
positive regulation of protein phosphorylation GO:0001934 242 0.024
oocyte axis specification GO:0007309 2 0.024
molting cycle GO:0042303 90 0.024
lung development GO:0030324 164 0.024
regulation of cysteine type endopeptidase activity GO:2000116 65 0.024
protein catabolic process GO:0030163 221 0.024
regulation of cytoskeleton organization GO:0051493 122 0.024
regulation of cellular response to growth factor stimulus GO:0090287 82 0.023
regulation of secretion by cell GO:1903530 249 0.023
purine containing compound metabolic process GO:0072521 311 0.023
skeletal muscle organ development GO:0060538 163 0.023
positive regulation of transferase activity GO:0051347 167 0.023
regulation of protein serine threonine kinase activity GO:0071900 157 0.023
ras protein signal transduction GO:0007265 77 0.023
angiogenesis GO:0001525 201 0.023
positive regulation of cell death GO:0010942 224 0.023
oocyte construction GO:0007308 2 0.023
response to testosterone GO:0033574 3 0.022
regulation of cell cycle process GO:0010564 160 0.022
positive regulation of secretion by cell GO:1903532 114 0.022
membrane organization GO:0061024 245 0.022
microtubule cytoskeleton organization GO:0000226 157 0.022
actin cytoskeleton organization GO:0030036 220 0.022
muscle tissue development GO:0060537 308 0.022
zymogen activation GO:0031638 41 0.022
regulation of hormone levels GO:0010817 211 0.022
regulation of endopeptidase activity GO:0052548 89 0.022
t cell activation GO:0042110 289 0.022
epithelial tube morphogenesis GO:0060562 303 0.022
purine ribonucleotide metabolic process GO:0009150 290 0.021
small molecule biosynthetic process GO:0044283 132 0.021
Human
regulation of cell projection organization GO:0031344 206 0.021
glycoprotein biosynthetic process GO:0009101 89 0.021
purine nucleoside metabolic process GO:0042278 241 0.021
rho protein signal transduction GO:0007266 32 0.020
sulfur compound metabolic process GO:0006790 100 0.020
positive regulation of secretion GO:0051047 130 0.020
learning or memory GO:0007611 148 0.020
regulation of peptidase activity GO:0052547 96 0.020
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.020
organelle assembly GO:0070925 177 0.020
regulation of cell motility GO:2000145 236 0.020
positive regulation of peptide secretion GO:0002793 33 0.020
regulation of anatomical structure size GO:0090066 178 0.020
blood circulation GO:0008015 195 0.019
leukocyte differentiation GO:0002521 342 0.019
inorganic ion transmembrane transport GO:0098660 234 0.019
organophosphate biosynthetic process GO:0090407 122 0.019
regulation of lipid metabolic process GO:0019216 118 0.019
nitrogen compound transport GO:0071705 271 0.019
acetylcholine transport GO:0015870 2 0.019
peptide hormone secretion GO:0030072 109 0.019
organonitrogen compound biosynthetic process GO:1901566 192 0.019
regulation of cell cycle GO:0051726 281 0.018
nucleoside phosphate biosynthetic process GO:1901293 79 0.018
hormone secretion GO:0046879 128 0.018
heart contraction GO:0060047 93 0.018
response to extracellular stimulus GO:0009991 127 0.018
regulation of protein localization GO:0032880 231 0.018
wnt signaling pathway GO:0016055 188 0.018
mitochondrion organization GO:0007005 134 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
appendage development GO:0048736 166 0.017
neuron death GO:0070997 154 0.017
regulation of jnk cascade GO:0046328 62 0.017
glucose homeostasis GO:0042593 128 0.017
purine nucleotide metabolic process GO:0006163 302 0.017
ketone body metabolic process GO:1902224 3 0.017
urogenital system development GO:0001655 261 0.017
regulation of satellite cell activation involved in skeletal muscle regeneration GO:0014717 3 0.017
protein modification by small protein conjugation or removal GO:0070647 207 0.017
positive regulation of programmed cell death GO:0043068 218 0.017
alpha amino acid metabolic process GO:1901605 59 0.017
intrinsic apoptotic signaling pathway GO:0097193 132 0.017
regulation of peptide transport GO:0090087 91 0.017
response to acid chemical GO:0001101 111 0.017
ribonucleoside metabolic process GO:0009119 245 0.017
stem cell development GO:0048864 219 0.017
carbohydrate homeostasis GO:0033500 128 0.017
nuclear transport GO:0051169 139 0.017
jnk cascade GO:0007254 72 0.016
limb development GO:0060173 166 0.016
negative regulation of hydrolase activity GO:0051346 71 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
neural tube development GO:0021915 160 0.016
regulation of actin filament based process GO:0032970 99 0.016
regulation of protein maturation GO:1903317 96 0.016
regulation of homeostatic process GO:0032844 182 0.016
regulation of response to wounding GO:1903034 189 0.016
Human
regulation of establishment of protein localization GO:0070201 181 0.016
kidney development GO:0001822 213 0.016
stress activated mapk cascade GO:0051403 80 0.016
cellular response to dna damage stimulus GO:0006974 207 0.016
connective tissue development GO:0061448 179 0.016
establishment of organelle localization GO:0051656 122 0.016
cell growth GO:0016049 130 0.015
regulation of peptide secretion GO:0002791 77 0.015
vesicle localization GO:0051648 86 0.015
iron ion homeostasis GO:0055072 36 0.015
transmembrane transport GO:0055085 412 0.015
single organism cell adhesion GO:0098602 156 0.015
ossification GO:0001503 216 0.015
positive regulation of neuron differentiation GO:0045666 141 0.015
anatomical structure homeostasis GO:0060249 145 0.015
male sex differentiation GO:0046661 109 0.015
heart process GO:0003015 94 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
negative regulation of protein modification process GO:0031400 163 0.015
satellite cell activation involved in skeletal muscle regeneration GO:0014901 3 0.015
forebrain development GO:0030900 302 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
ameboidal type cell migration GO:0001667 128 0.015
exocytosis GO:0006887 121 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.015
intracellular protein transport GO:0006886 204 0.015
sensory perception GO:0007600 245 0.015
response to oxidative stress GO:0006979 123 0.015
cellular response to extracellular stimulus GO:0031668 81 0.015
positive regulation of jnk cascade GO:0046330 46 0.015
fatty acid metabolic process GO:0006631 121 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
response to growth factor GO:0070848 198 0.015
regulation of protein catabolic process GO:0042176 108 0.014
response to organonitrogen compound GO:0010243 246 0.014
midgut development GO:0007494 4 0.014
peptidyl tyrosine modification GO:0018212 145 0.014
cellular response to cytokine stimulus GO:0071345 189 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
learning GO:0007612 98 0.014
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.014
organic hydroxy compound biosynthetic process GO:1901617 77 0.014
Human
negative regulation of protein processing GO:0010955 79 0.014
positive regulation of kinase activity GO:0033674 155 0.014
actin filament organization GO:0007015 113 0.014
amide transport GO:0042886 138 0.014
response to temperature stimulus GO:0009266 55 0.014
nucleotide biosynthetic process GO:0009165 78 0.014
cellular macromolecule catabolic process GO:0044265 206 0.014
purine nucleotide biosynthetic process GO:0006164 65 0.014
locomotory behavior GO:0007626 195 0.014
canonical wnt signaling pathway GO:0060070 130 0.014
neuron apoptotic process GO:0051402 142 0.014
negative regulation of proteolysis GO:0045861 74 0.014
regulation of autophagic vacuole assembly GO:2000785 4 0.014
dna metabolic process GO:0006259 303 0.014
heterocycle catabolic process GO:0046700 280 0.014
positive regulation of protein kinase activity GO:0045860 144 0.014
ion transmembrane transport GO:0034220 361 0.014
regulation of cell growth GO:0001558 91 0.014
macromolecule catabolic process GO:0009057 281 0.014
cognition GO:0050890 149 0.014
regulation of hydrolase activity GO:0051336 246 0.014
glycerolipid metabolic process GO:0046486 122 0.014
regulation of mitochondrion organization GO:0010821 27 0.014
regulation of system process GO:0044057 200 0.014
organonitrogen compound catabolic process GO:1901565 264 0.014
tissue migration GO:0090130 68 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.014
rap protein signal transduction GO:0032486 3 0.014
regulation of vesicle mediated transport GO:0060627 139 0.013
response to inorganic substance GO:0010035 96 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
organelle fission GO:0048285 170 0.013
regulation of cell activation GO:0050865 289 0.013
regulation of cell migration GO:0030334 219 0.013
gtp catabolic process GO:0006184 143 0.013
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.013
regulation of protein processing GO:0070613 96 0.013
lateral inhibition GO:0046331 1 0.013
organic hydroxy compound transport GO:0015850 93 0.013
oocyte anterior posterior axis specification GO:0007314 2 0.013
tissue homeostasis GO:0001894 115 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
response to transforming growth factor beta GO:0071559 88 0.013
regulation of blood pressure GO:0008217 93 0.013
purine containing compound biosynthetic process GO:0072522 70 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
cellular response to nutrient levels GO:0031669 64 0.013
bone development GO:0060348 120 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.013
regulation of nucleotide biosynthetic process GO:0030808 34 0.013
organic acid biosynthetic process GO:0016053 86 0.013
negative regulation of organelle organization GO:0010639 90 0.012
cellular homeostasis GO:0019725 240 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.012
cation transport GO:0006812 399 0.012
cellular response to external stimulus GO:0071496 88 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
regulation of membrane potential GO:0042391 192 0.012
cell division GO:0051301 120 0.012
regulation of map kinase activity GO:0043405 120 0.012
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.012
morphogenesis of a polarized epithelium GO:0001738 37 0.012
regulation of blood vessel size GO:0050880 56 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
cell adhesion GO:0007155 329 0.012
regulation of epithelial cell proliferation GO:0050678 141 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
regulation of neuron death GO:1901214 134 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
carbohydrate metabolic process GO:0005975 230 0.012
positive regulation of apoptotic signaling pathway GO:2001235 95 0.012
tube formation GO:0035148 140 0.012
protein localization to nucleus GO:0034504 121 0.012
fat cell differentiation GO:0045444 160 0.012
macromolecule glycosylation GO:0043413 55 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
innate immune response GO:0045087 157 0.012
regulation of interleukin 8 secretion GO:2000482 2 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.012
cellular chemical homeostasis GO:0055082 215 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
telencephalon development GO:0021537 186 0.012
microtubule polymerization or depolymerization GO:0031109 26 0.012
regulation of stress activated mapk cascade GO:0032872 69 0.012
hair follicle development GO:0001942 85 0.012
myeloid cell differentiation GO:0030099 233 0.012
axon guidance GO:0007411 141 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.011
positive regulation of neuron projection development GO:0010976 79 0.011
peptidyl serine phosphorylation GO:0018105 74 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
negative regulation of cellular catabolic process GO:0031330 47 0.011
acyl coa metabolic process GO:0006637 19 0.011
regulation of cellular catabolic process GO:0031329 242 0.011
regulation of vacuole organization GO:0044088 4 0.011
organ growth GO:0035265 117 0.011
response to peptide GO:1901652 136 0.011
negative regulation of protein maturation GO:1903318 79 0.011
ribonucleotide biosynthetic process GO:0009260 59 0.011
organic anion transport GO:0015711 137 0.011
monosaccharide metabolic process GO:0005996 106 0.011
regulation of t cell activation GO:0050863 170 0.011
developmental cell growth GO:0048588 84 0.011
regulation of ossification GO:0030278 112 0.011
insulin secretion GO:0030073 89 0.011
acyl coa biosynthetic process GO:0071616 7 0.011
nucleoside metabolic process GO:0009116 246 0.011
small gtpase mediated signal transduction GO:0007264 97 0.011
monocarboxylic acid biosynthetic process GO:0072330 61 0.011
maintenance of location GO:0051235 89 0.011
chemotaxis GO:0006935 247 0.011
appendage morphogenesis GO:0035107 149 0.011
neural precursor cell proliferation GO:0061351 121 0.011
cation homeostasis GO:0055080 212 0.011
spermatid differentiation GO:0048515 115 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
detection of abiotic stimulus GO:0009582 60 0.011
myotube differentiation GO:0014902 105 0.011
hindbrain formation GO:0021576 1 0.011
positive regulation of stress activated mapk cascade GO:0032874 48 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
proteasomal protein catabolic process GO:0010498 98 0.011
immune effector process GO:0002252 321 0.011
embryonic skeletal system development GO:0048706 120 0.011
cartilage development GO:0051216 140 0.011
protein glycosylation GO:0006486 55 0.011
epithelial cell proliferation GO:0050673 174 0.011
female gamete generation GO:0007292 74 0.011
modification dependent protein catabolic process GO:0019941 133 0.011
embryonic limb morphogenesis GO:0030326 126 0.011
response to insulin GO:0032868 100 0.011
modification dependent macromolecule catabolic process GO:0043632 133 0.011
cell substrate adhesion GO:0031589 130 0.010
purine nucleoside triphosphate catabolic process GO:0009146 203 0.010
regulation of defense response GO:0031347 233 0.010
Human
mitotic cell cycle process GO:1903047 159 0.010
regulation of heart contraction GO:0008016 77 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.010
glycosylation GO:0070085 62 0.010
epithelial cell migration GO:0010631 63 0.010
embryonic organ morphogenesis GO:0048562 276 0.010
mesenchymal cell differentiation GO:0048762 107 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.010
respiratory system development GO:0060541 190 0.010
coenzyme biosynthetic process GO:0009108 23 0.010
monosaccharide transport GO:0015749 58 0.010
cellular response to peptide GO:1901653 92 0.010
regulation of protein transport GO:0051223 163 0.010
cell maturation GO:0048469 127 0.010
smoothened signaling pathway GO:0007224 105 0.010
organophosphate catabolic process GO:0046434 232 0.010
negative regulation of neuron death GO:1901215 98 0.010

Mvk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
inherited metabolic disorder DOID:655 0 0.024
Human
disease of metabolism DOID:0014667 0 0.024
Human
nervous system disease DOID:863 0 0.021
disease of anatomical entity DOID:7 0 0.021
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.017
cancer DOID:162 0 0.017