Mus musculus

41 known processes

Birc3

baculoviral IAP repeat-containing 3

(Aliases: MIHB,MIHC,MIAP2,HIAP2,Api2,MIAP1,cIAP-2,cIAP-1,IAP2,Birc2,cIAP2,IAP1,RNF49,cIAP1,AW107670,Api1)

Birc3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of defense response GO:0031347 233 0.964
defense response to other organism GO:0098542 197 0.958
Mouse
positive regulation of cytokine production GO:0001819 174 0.956
i kappab kinase nf kappab signaling GO:0007249 85 0.950
activation of innate immune response GO:0002218 56 0.937
response to molecule of bacterial origin GO:0002237 143 0.932
t cell proliferation GO:0042098 120 0.926
positive regulation of innate immune response GO:0045089 80 0.924
cellular response to biotic stimulus GO:0071216 92 0.917
cytokine biosynthetic process GO:0042089 68 0.916
cytokine production GO:0001816 319 0.912
regulation of innate immune response GO:0045088 91 0.899
immune response regulating signaling pathway GO:0002764 125 0.896
immune effector process GO:0002252 321 0.895
positive regulation of cytokine biosynthetic process GO:0042108 40 0.893
cellular response to lipopolysaccharide GO:0071222 77 0.887
inflammatory response GO:0006954 244 0.884
Mouse
lymphocyte proliferation GO:0046651 164 0.882
t cell activation GO:0042110 289 0.881
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.875
response to lipopolysaccharide GO:0032496 128 0.868
pattern recognition receptor signaling pathway GO:0002221 47 0.856
adaptive immune response GO:0002250 155 0.854
regulation of cytokine biosynthetic process GO:0042035 59 0.843
regulation of cytokine production GO:0001817 266 0.835
leukocyte proliferation GO:0070661 172 0.814
cellular response to molecule of bacterial origin GO:0071219 83 0.812
toll like receptor signaling pathway GO:0002224 38 0.807
cellular response to cytokine stimulus GO:0071345 189 0.804
activation of immune response GO:0002253 138 0.799
regulation of cell activation GO:0050865 289 0.797
cellular response to lipid GO:0071396 145 0.792
Mouse
negative regulation of molecular function GO:0044092 258 0.783
Mouse
immune response activating signal transduction GO:0002757 116 0.781
innate immune response activating signal transduction GO:0002758 50 0.769
positive regulation of defense response GO:0031349 124 0.754
regulation of leukocyte proliferation GO:0070663 121 0.753
innate immune response GO:0045087 157 0.732
regulation of lymphocyte activation GO:0051249 240 0.727
cytokine metabolic process GO:0042107 71 0.724
regulation of lymphocyte proliferation GO:0050670 117 0.679
negative regulation of immune system process GO:0002683 209 0.675
myeloid leukocyte activation GO:0002274 83 0.660
regulation of response to biotic stimulus GO:0002831 38 0.635
production of molecular mediator of immune response GO:0002440 103 0.635
regulation of inflammatory response GO:0050727 147 0.617
regulation of interleukin 6 production GO:0032675 55 0.613
negative regulation of cytokine production GO:0001818 84 0.609
response to interleukin 1 GO:0070555 11 0.605
type i interferon production GO:0032606 29 0.591
immunoglobulin mediated immune response GO:0016064 69 0.582
regulation of establishment of protein localization GO:0070201 181 0.578
lymphocyte mediated immunity GO:0002449 139 0.577
leukocyte mediated immunity GO:0002443 174 0.568
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.566
regulation of t cell activation GO:0050863 170 0.563
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.561
myeloid leukocyte differentiation GO:0002573 119 0.554
positive regulation of programmed cell death GO:0043068 218 0.552
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.532
t helper 1 type immune response GO:0042088 25 0.528
positive regulation of cell activation GO:0050867 158 0.525
regulation of protein kinase activity GO:0045859 232 0.521
interferon beta production GO:0032608 16 0.512
cellular response to oxidative stress GO:0034599 76 0.480
leukocyte differentiation GO:0002521 342 0.479
regulation of t cell proliferation GO:0042129 92 0.467
programmed necrotic cell death GO:0097300 28 0.457
regulation of protein transport GO:0051223 163 0.453
defense response to virus GO:0051607 68 0.445
b cell mediated immunity GO:0019724 71 0.445
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.435
myeloid cell differentiation GO:0030099 233 0.433
leukocyte activation involved in immune response GO:0002366 126 0.423
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 9 0.406
cytokine mediated signaling pathway GO:0019221 115 0.405
interleukin 12 biosynthetic process GO:0042090 8 0.391
regulation of hydrolase activity GO:0051336 246 0.391
Mouse
interleukin 6 biosynthetic process GO:0042226 12 0.379
interferon beta biosynthetic process GO:0045350 4 0.379
regulation of production of molecular mediator of immune response GO:0002700 65 0.375
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.374
protein secretion GO:0009306 111 0.370
regulation of interferon beta biosynthetic process GO:0045357 4 0.361
b cell activation GO:0042113 161 0.361
regulation of secretion by cell GO:1903530 249 0.359
positive regulation of interleukin 6 production GO:0032755 37 0.354
stress activated protein kinase signaling cascade GO:0031098 81 0.348
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.342
homeostasis of number of cells GO:0048872 210 0.340
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.336
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.332
necrotic cell death GO:0070265 30 0.329
morphogenesis of embryonic epithelium GO:0016331 159 0.324
positive regulation of lymphocyte activation GO:0051251 140 0.324
regulation of b cell proliferation GO:0030888 39 0.324
t cell mediated immunity GO:0002456 50 0.321
negative regulation of necroptotic process GO:0060546 9 0.320
negative regulation of protein metabolic process GO:0051248 282 0.320
Mouse
regulation of multi organism process GO:0043900 111 0.319
negative regulation of cell proliferation GO:0008285 296 0.317
positive regulation of hydrolase activity GO:0051345 148 0.308
regulation of response to wounding GO:1903034 189 0.308
positive regulation of interferon alpha production GO:0032727 4 0.307
positive regulation of immune effector process GO:0002699 107 0.307
regulation of leukocyte mediated immunity GO:0002703 104 0.305
regulation of leukocyte differentiation GO:1902105 159 0.300
regulation of type i interferon production GO:0032479 22 0.295
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.294
negative regulation of cell activation GO:0050866 111 0.293
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.291
negative regulation of t cell activation GO:0050868 65 0.285
myeloid dendritic cell activation GO:0001773 25 0.284
positive regulation of interleukin 12 production GO:0032735 21 0.276
positive regulation of apoptotic signaling pathway GO:2001235 95 0.269
epithelial tube morphogenesis GO:0060562 303 0.267
lymphocyte activation involved in immune response GO:0002285 93 0.266
regulation of protein serine threonine kinase activity GO:0071900 157 0.265
regulation of secretion GO:0051046 274 0.265
regulation of transferase activity GO:0051338 263 0.263
regulation of proteolysis GO:0030162 164 0.256
Mouse
regulation of stress activated mapk cascade GO:0032872 69 0.253
protein catabolic process GO:0030163 221 0.250
response to organic cyclic compound GO:0014070 198 0.247
Mouse
apoptotic signaling pathway GO:0097190 306 0.247
positive regulation of apoptotic process GO:0043065 217 0.246
cell activation involved in immune response GO:0002263 126 0.239
heterocycle catabolic process GO:0046700 280 0.239
macromolecule catabolic process GO:0009057 281 0.237
regulation of interleukin 12 production GO:0032655 30 0.233
negative regulation of cellular protein metabolic process GO:0032269 247 0.232
Mouse
jnk cascade GO:0007254 72 0.229
defense response to protozoan GO:0042832 25 0.228
negative regulation of lymphocyte proliferation GO:0050672 45 0.225
protein modification by small protein conjugation GO:0032446 187 0.224
Human
regulation of necroptotic process GO:0060544 10 0.224
t cell activation involved in immune response GO:0002286 43 0.221
regulation of immunoglobulin production GO:0002637 42 0.214
antigen processing and presentation of exogenous antigen GO:0019884 26 0.213
lymphocyte differentiation GO:0030098 242 0.213
regulation of apoptotic signaling pathway GO:2001233 197 0.212
interleukin 6 production GO:0032635 58 0.212
regulation of adaptive immune response GO:0002819 90 0.212
regulation of cytokine production involved in immune response GO:0002718 26 0.211
interleukin 1 mediated signaling pathway GO:0070498 4 0.209
positive regulation of kinase activity GO:0033674 155 0.205
regulation of interferon beta production GO:0032648 13 0.205
regulation of cytokine secretion GO:0050707 61 0.202
regulation of cellular amino acid metabolic process GO:0006521 5 0.200
regulation of antimicrobial humoral response GO:0002759 3 0.197
cellular amine metabolic process GO:0044106 44 0.196
b cell proliferation GO:0042100 53 0.193
immunoglobulin production GO:0002377 73 0.193
positive regulation of cell death GO:0010942 224 0.193
t cell differentiation GO:0030217 174 0.192
positive regulation of cytokine production involved in immune response GO:0002720 19 0.191
negative regulation of phosphorus metabolic process GO:0010563 184 0.191
ossification GO:0001503 216 0.190
intrinsic apoptotic signaling pathway GO:0097193 132 0.190
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.187
epithelial tube formation GO:0072175 130 0.186
organic cyclic compound catabolic process GO:1901361 295 0.183
interleukin 1 beta production GO:0032611 30 0.182
embryonic epithelial tube formation GO:0001838 130 0.180
interleukin 10 secretion GO:0072608 4 0.177
positive regulation of protein phosphorylation GO:0001934 242 0.175
regulation of lymphocyte mediated immunity GO:0002706 84 0.175
positive regulation of antimicrobial humoral response GO:0002760 2 0.174
negative regulation of necrotic cell death GO:0060547 11 0.172
multicellular organismal homeostasis GO:0048871 164 0.172
positive regulation of jnk cascade GO:0046330 46 0.170
regulation of mapk cascade GO:0043408 248 0.169
regulation of protein localization GO:0032880 231 0.169
interleukin 2 production GO:0032623 33 0.169
regulation of defense response to virus GO:0050688 18 0.168
cd4 positive alpha beta t cell activation GO:0035710 45 0.168
positive regulation of leukocyte proliferation GO:0070665 73 0.168
nik nf kappab signaling GO:0038061 14 0.167
amine metabolic process GO:0009308 45 0.167
positive regulation of lymphocyte proliferation GO:0050671 70 0.166
skin development GO:0043588 220 0.165
cellular response to abiotic stimulus GO:0071214 56 0.164
positive regulation of t cell activation GO:0050870 101 0.164
t helper cell differentiation GO:0042093 28 0.164
cytokine production involved in immune response GO:0002367 34 0.164
antigen processing and presentation GO:0019882 47 0.163
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.162
mapk cascade GO:0000165 281 0.161
regulation of alpha beta t cell activation GO:0046634 53 0.160
b cell activation involved in immune response GO:0002312 50 0.160
establishment of protein localization to organelle GO:0072594 118 0.160
positive regulation of mapk cascade GO:0043410 170 0.159
neural tube formation GO:0001841 108 0.159
positive regulation of antimicrobial peptide production GO:0002225 1 0.155
neural tube development GO:0021915 160 0.154
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.153
tumor necrosis factor production GO:0032640 50 0.153
regulation of kinase activity GO:0043549 249 0.152
regulation of t cell differentiation GO:0045580 83 0.152
dendritic cell differentiation GO:0097028 26 0.152
regulation of t cell mediated immunity GO:0002709 34 0.151
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.150
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.150
Mouse
response to organonitrogen compound GO:0010243 246 0.150
negative regulation of lymphocyte activation GO:0051250 91 0.149
negative regulation of b cell proliferation GO:0030889 13 0.149
protein ubiquitination GO:0016567 171 0.148
Human
cytokine secretion GO:0050663 72 0.147
cellular amino acid metabolic process GO:0006520 103 0.147
protein processing GO:0016485 163 0.146
Mouse
leukocyte apoptotic process GO:0071887 71 0.145
cellular nitrogen compound catabolic process GO:0044270 280 0.145
tube formation GO:0035148 140 0.143
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.143
bone resorption GO:0045453 38 0.141
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.141
positive regulation of cytokine secretion GO:0050715 41 0.140
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.140
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.139
respiratory tube development GO:0030323 167 0.138
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.138
extrinsic apoptotic signaling pathway GO:0097191 126 0.137
antimicrobial peptide production GO:0002775 2 0.136
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.135
regulation of protein secretion GO:0050708 82 0.134
cellular ketone metabolic process GO:0042180 84 0.131
positive regulation of protein kinase activity GO:0045860 144 0.131
regulation of chemokine production GO:0032642 30 0.130
myeloid dendritic cell differentiation GO:0043011 16 0.130
acute inflammatory response GO:0002526 41 0.130
positive regulation of response to biotic stimulus GO:0002833 15 0.129
positive regulation of leukocyte mediated immunity GO:0002705 70 0.129
positive regulation of multi organism process GO:0043902 26 0.128
response to oxidative stress GO:0006979 123 0.128
positive regulation of inflammatory response GO:0050729 47 0.127
positive regulation of jun kinase activity GO:0043507 30 0.124
negative regulation of b cell activation GO:0050869 27 0.123
odontogenesis of dentin containing tooth GO:0042475 66 0.122
type i interferon biosynthetic process GO:0045351 9 0.121
positive regulation of cellular catabolic process GO:0031331 148 0.121
alpha beta t cell activation involved in immune response GO:0002287 31 0.121
interleukin 1 production GO:0032612 31 0.121
positive regulation of cellular amine metabolic process GO:0033240 5 0.121
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.118
negative regulation of intracellular signal transduction GO:1902532 167 0.118
negative regulation of defense response GO:0031348 77 0.117
positive regulation of map kinase activity GO:0043406 84 0.116
regulation of interleukin 2 production GO:0032663 28 0.114
positive regulation of transferase activity GO:0051347 167 0.114
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.112
epidermis development GO:0008544 187 0.112
leukocyte homeostasis GO:0001776 79 0.111
positive regulation of interleukin 2 production GO:0032743 19 0.110
lymphocyte apoptotic process GO:0070227 54 0.110
activation of nf kappab inducing kinase activity GO:0007250 4 0.109
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.109
regulation of interleukin 10 production GO:0032653 21 0.108
cellular response to nitric oxide GO:0071732 4 0.108
regulation of cellular amine metabolic process GO:0033238 20 0.107
regulation of interleukin 1 production GO:0032652 26 0.107
antigen processing and presentation of exogenous peptide antigen GO:0002478 21 0.106
regulation of lymphocyte differentiation GO:0045619 107 0.106
interleukin 12 production GO:0032615 32 0.106
cellular protein complex assembly GO:0043623 116 0.106
positive regulation of type i interferon production GO:0032481 14 0.105
regulation of necrotic cell death GO:0010939 13 0.105
positive regulation of interleukin 6 biosynthetic process GO:0045410 6 0.104
cellular response to peptidoglycan GO:0071224 4 0.104
t cell differentiation involved in immune response GO:0002292 30 0.103
regulation of cysteine type endopeptidase activity GO:2000116 65 0.099
Mouse
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.098
regulation of cellular response to stress GO:0080135 159 0.098
positive regulation of secretion GO:0051047 130 0.097
regulation of interleukin 8 production GO:0032677 3 0.096
epithelial cell proliferation GO:0050673 174 0.094
cell type specific apoptotic process GO:0097285 268 0.094
Mouse
protein maturation GO:0051604 176 0.093
Mouse
positive regulation of protein transport GO:0051222 93 0.093
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.093
positive regulation of proteolysis GO:0045862 85 0.092
spermatogenesis GO:0007283 284 0.091
positive regulation of secretion by cell GO:1903532 114 0.091
glycosyl compound metabolic process GO:1901657 246 0.091
negative regulation of leukocyte proliferation GO:0070664 46 0.091
neuron death GO:0070997 154 0.091
Mouse
interspecies interaction between organisms GO:0044419 83 0.090
negative regulation of protein modification process GO:0031400 163 0.090
interleukin 5 secretion GO:0072603 2 0.089
positive regulation of t cell proliferation GO:0042102 52 0.089
regulation of b cell activation GO:0050864 81 0.089
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.088
tube closure GO:0060606 91 0.088
regulation of tumor necrosis factor production GO:0032680 49 0.087
aromatic compound catabolic process GO:0019439 286 0.087
response to tumor necrosis factor GO:0034612 26 0.086
positive regulation of interferon gamma production GO:0032729 39 0.086
gland development GO:0048732 330 0.085
regulation of reactive oxygen species metabolic process GO:2000377 40 0.085
regulation of ion transport GO:0043269 215 0.083
regulation of protein targeting GO:1903533 61 0.083
small gtpase mediated signal transduction GO:0007264 97 0.082
rho protein signal transduction GO:0007266 32 0.082
protein import into nucleus GO:0006606 95 0.082
carbohydrate derivative biosynthetic process GO:1901137 183 0.081
positive regulation of intracellular transport GO:0032388 70 0.080
response to molecule of fungal origin GO:0002238 4 0.080
regulation of protein processing GO:0070613 96 0.080
Mouse
regulation of map kinase activity GO:0043405 120 0.079
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.079
negative regulation of hydrolase activity GO:0051346 71 0.079
Mouse
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.078
interleukin 13 secretion GO:0072611 2 0.078
osteoclast differentiation GO:0030316 62 0.078
protein polyubiquitination GO:0000209 33 0.078
response to inorganic substance GO:0010035 96 0.077
cellular response to hormone stimulus GO:0032870 150 0.076
Mouse
response to peptide GO:1901652 136 0.076
regulation of endopeptidase activity GO:0052548 89 0.076
Mouse
anatomical structure homeostasis GO:0060249 145 0.075
interleukin 8 production GO:0032637 4 0.075
regulation of intracellular transport GO:0032386 159 0.074
interferon gamma production GO:0032609 67 0.074
alpha beta t cell activation GO:0046631 91 0.073
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.073
stress activated mapk cascade GO:0051403 80 0.073
glycoprotein metabolic process GO:0009100 116 0.072
regulation of interleukin 1 beta production GO:0032651 25 0.072
tissue remodeling GO:0048771 102 0.072
regulation of interleukin 10 secretion GO:2001179 4 0.072
negative regulation of apoptotic signaling pathway GO:2001234 104 0.071
purine containing compound catabolic process GO:0072523 213 0.070
cation transport GO:0006812 399 0.070
negative regulation of endopeptidase activity GO:0010951 44 0.070
Mouse
regulation of intracellular protein transport GO:0033157 82 0.070
peptidyl amino acid modification GO:0018193 336 0.070
cellular response to interferon beta GO:0035458 21 0.070
regulation of binding GO:0051098 111 0.069
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.069
response to nitric oxide GO:0071731 4 0.069
cation homeostasis GO:0055080 212 0.068
regulation of peptidase activity GO:0052547 96 0.068
Mouse
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 17 0.068
positive regulation of interleukin 1 secretion GO:0050716 14 0.068
protein modification by small protein conjugation or removal GO:0070647 207 0.068
Human
regulation of cellular catabolic process GO:0031329 242 0.068
protein homotrimerization GO:0070207 4 0.068
positive regulation of adaptive immune response GO:0002821 61 0.068
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 17 0.067
mitochondrion organization GO:0007005 134 0.067
nucleobase containing small molecule metabolic process GO:0055086 352 0.066
antigen processing and presentation of peptide antigen GO:0048002 29 0.066
nucleocytoplasmic transport GO:0006913 139 0.066
cellular response to dna damage stimulus GO:0006974 207 0.066
regulation of protein complex assembly GO:0043254 83 0.066
Mouse
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.065
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.065
regulation of cytoplasmic transport GO:1903649 112 0.065
purine containing compound metabolic process GO:0072521 311 0.065
negative regulation of nf kappab transcription factor activity GO:0032088 15 0.065
purine nucleoside triphosphate catabolic process GO:0009146 203 0.065
negative regulation of phosphorylation GO:0042326 166 0.065
regulation of cellular ketone metabolic process GO:0010565 66 0.065
positive regulation of interferon beta production GO:0032728 8 0.065
negative regulation of protein phosphorylation GO:0001933 126 0.065
cellular response to interferon gamma GO:0071346 25 0.064
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.064
regulation of leukocyte apoptotic process GO:2000106 56 0.063
negative regulation of cysteine type endopeptidase activity GO:2000117 22 0.063
Mouse
regulation of toll like receptor signaling pathway GO:0034121 20 0.062
purine ribonucleoside metabolic process GO:0046128 241 0.062
dna metabolic process GO:0006259 303 0.062
alpha beta t cell differentiation GO:0046632 69 0.062
purine ribonucleotide metabolic process GO:0009150 290 0.062
cellular chemical homeostasis GO:0055082 215 0.062
cellular ion homeostasis GO:0006873 165 0.062
organonitrogen compound biosynthetic process GO:1901566 192 0.061
positive regulation of protein secretion GO:0050714 52 0.061
peptidyl tyrosine phosphorylation GO:0018108 143 0.061
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.060
Mouse
t cell apoptotic process GO:0070231 39 0.060
notch signaling pathway GO:0007219 71 0.060
cellular metal ion homeostasis GO:0006875 151 0.060
interleukin 10 production GO:0032613 23 0.059
cellular homeostasis GO:0019725 240 0.059
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.059
ribonucleoside metabolic process GO:0009119 245 0.059
antimicrobial peptide biosynthetic process GO:0002777 2 0.058
b cell homeostasis GO:0001782 34 0.058
divalent inorganic cation homeostasis GO:0072507 138 0.057
posttranscriptional regulation of gene expression GO:0010608 155 0.056
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.056
ras protein signal transduction GO:0007265 77 0.056
positive regulation of gtp catabolic process GO:0033126 85 0.056
positive regulation of t cell mediated immunity GO:0002711 24 0.056
regulation of cytokine secretion involved in immune response GO:0002739 4 0.055
protein targeting GO:0006605 143 0.055
reactive oxygen species metabolic process GO:0072593 84 0.055
positive regulation of interleukin 8 production GO:0032757 2 0.055
regulation of antimicrobial peptide production GO:0002784 1 0.055
regulation of defense response to fungus GO:1900150 1 0.054
reactive nitrogen species metabolic process GO:2001057 0 0.054
positive regulation of endopeptidase activity GO:0010950 43 0.054
single organism nuclear import GO:1902593 95 0.053
cellular macromolecule catabolic process GO:0044265 206 0.053
positive regulation of interleukin 1 beta production GO:0032731 16 0.053
regulation of acute inflammatory response GO:0002673 27 0.053
intracellular protein transport GO:0006886 204 0.052
regulation of organelle organization GO:0033043 289 0.052
cellular response to organonitrogen compound GO:0071417 145 0.052
response to reactive oxygen species GO:0000302 56 0.051
regulation of jnk cascade GO:0046328 62 0.051
nucleoside triphosphate metabolic process GO:0009141 230 0.050
purine ribonucleoside catabolic process GO:0046130 205 0.050
positive regulation of protein modification process GO:0031401 299 0.050
Human
regulation of interleukin 6 biosynthetic process GO:0045408 11 0.050
response to acid chemical GO:0001101 111 0.050
positive regulation of stress activated mapk cascade GO:0032874 48 0.049
t cell selection GO:0045058 34 0.049
marginal zone b cell differentiation GO:0002315 2 0.049
positive regulation of b cell activation GO:0050871 49 0.049
negative regulation of immune effector process GO:0002698 55 0.049
negative regulation of innate immune response GO:0045824 17 0.049
negative regulation of cellular amine metabolic process GO:0033239 1 0.049
regulation of interleukin 1 alpha production GO:0032650 4 0.049
male gamete generation GO:0048232 285 0.048
striated muscle cell development GO:0055002 125 0.048
regulation of alpha beta t cell proliferation GO:0046640 18 0.048
regulation of lymphocyte apoptotic process GO:0070228 41 0.048
ribose phosphate metabolic process GO:0019693 291 0.048
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 14 0.047
regulation of organ morphogenesis GO:2000027 144 0.047
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.047
immunoglobulin secretion GO:0048305 17 0.047
cellular protein catabolic process GO:0044257 155 0.047
tissue homeostasis GO:0001894 115 0.047
positive regulation of nucleotide catabolic process GO:0030813 88 0.047
ribonucleoside catabolic process GO:0042454 206 0.046
primary neural tube formation GO:0014020 95 0.046
regulation of immunoglobulin mediated immune response GO:0002889 37 0.046
regulation of protein maturation GO:1903317 96 0.046
Mouse
regulation of cell motility GO:2000145 236 0.046
t cell differentiation in thymus GO:0033077 77 0.046
antigen receptor mediated signaling pathway GO:0050851 64 0.045
regulation of interferon gamma production GO:0032649 57 0.045
positive regulation of binding GO:0051099 49 0.045
germinal center formation GO:0002467 16 0.045
bone remodeling GO:0046849 53 0.045
cellular response to interleukin 1 GO:0071347 8 0.045
cellular response to type i interferon GO:0071357 10 0.045
sequestering of metal ion GO:0051238 19 0.045
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.045
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.045
rhythmic process GO:0048511 174 0.045
humoral immune response GO:0006959 57 0.045
cytoplasmic transport GO:0016482 234 0.044
odontogenesis GO:0042476 78 0.044
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.044
regulation of rho protein signal transduction GO:0035023 71 0.044
regulation of neuron death GO:1901214 134 0.044
negative regulation of t cell proliferation GO:0042130 38 0.044
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.043
extracellular matrix organization GO:0030198 147 0.043
protein localization to organelle GO:0033365 185 0.043
neural tube closure GO:0001843 90 0.043
negative regulation of peptidase activity GO:0010466 46 0.043
Mouse
regulation of jun kinase activity GO:0043506 40 0.043
regulation of nucleocytoplasmic transport GO:0046822 73 0.042
carbohydrate derivative catabolic process GO:1901136 231 0.042
calcium ion transport GO:0006816 159 0.042
negative regulation of leukocyte differentiation GO:1902106 51 0.042
nucleoside catabolic process GO:0009164 206 0.041
negative regulation of phosphate metabolic process GO:0045936 184 0.041
cdc42 protein signal transduction GO:0032488 0 0.040
defense response to bacterium GO:0042742 119 0.040
Mouse
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.040
antibacterial peptide biosynthetic process GO:0002780 2 0.040
regulation of interleukin 5 secretion GO:2000662 2 0.040
positive regulation of cell motility GO:2000147 116 0.040
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.040
glial cell apoptotic process GO:0034349 3 0.040
purine nucleoside triphosphate metabolic process GO:0009144 226 0.040
positive regulation of interleukin 1 alpha production GO:0032730 4 0.040
cellular response to growth factor stimulus GO:0071363 197 0.039
regulation of membrane potential GO:0042391 192 0.039
glycosyl compound catabolic process GO:1901658 206 0.039
regulation of protein localization to nucleus GO:1900180 60 0.039
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.039
somatic cell dna recombination GO:0016444 51 0.039
reactive oxygen species biosynthetic process GO:1903409 8 0.039
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.039
endocytosis GO:0006897 168 0.038
leukocyte migration GO:0050900 124 0.038
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.038

Birc3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.135
disease of cellular proliferation DOID:14566 0 0.135
organ system cancer DOID:0050686 0 0.135
immune system disease DOID:2914 0 0.065
disease of anatomical entity DOID:7 0 0.065