Mus musculus

72 known processes

Mre11a

meiotic recombination 11 homolog A (S. cerevisiae)

(Aliases: Mre11b,Mre11)

Mre11a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.769
dna repair GO:0006281 107 0.451
double strand break repair GO:0006302 48 0.392
telomere capping GO:0016233 4 0.359
Fly
meiotic cell cycle process GO:1903046 77 0.285
nuclear division GO:0000280 158 0.228
mitotic cell cycle process GO:1903047 159 0.175
meiotic cell cycle GO:0051321 122 0.172
regulation of protein autophosphorylation GO:0031952 8 0.163
Human
telomere maintenance GO:0000723 19 0.159
Fly
organelle fission GO:0048285 170 0.155
dna replication GO:0006260 52 0.149
Human
mitotic recombination GO:0006312 3 0.148
microtubule based process GO:0007017 236 0.138
chromosome organization involved in meiosis GO:0070192 39 0.136
dna conformation change GO:0071103 37 0.126
Human
synapsis GO:0007129 34 0.125
anatomical structure homeostasis GO:0060249 145 0.115
Fly
cellular hyperosmotic salinity response GO:0071475 0 0.115
dna recombination GO:0006310 92 0.110
Yeast
heterocycle catabolic process GO:0046700 280 0.095
Human Yeast
negative regulation of cell cycle GO:0045786 123 0.093
aromatic compound catabolic process GO:0019439 286 0.090
Human Yeast
microtubule organizing center organization GO:0031023 28 0.084
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.078
positive regulation of protein phosphorylation GO:0001934 242 0.073
Human
microtubule cytoskeleton organization GO:0000226 157 0.071
chromosome segregation GO:0007059 48 0.067
Human Worm
positive regulation of protein modification process GO:0031401 299 0.066
Human
rna dependent dna replication GO:0006278 3 0.065
organic cyclic compound catabolic process GO:1901361 295 0.063
Human Yeast
dna duplex unwinding GO:0032508 7 0.060
Human
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.058
cellular amino acid metabolic process GO:0006520 103 0.056
cellular macromolecule catabolic process GO:0044265 206 0.055
Yeast
regulation of transferase activity GO:0051338 263 0.055
Human
organelle assembly GO:0070925 177 0.055
regulation of mitotic cell cycle GO:0007346 126 0.053
cellular nitrogen compound catabolic process GO:0044270 280 0.050
Human Yeast
cellular response to dna damage stimulus GO:0006974 207 0.047
nuclear transport GO:0051169 139 0.046
mitotic cell cycle GO:0000278 195 0.045
negative regulation of cell cycle process GO:0010948 69 0.044
cytoplasmic transport GO:0016482 234 0.042
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.040
Yeast
somatic cell dna recombination GO:0016444 51 0.039
meiotic nuclear division GO:0007126 115 0.039
nuclear dna replication GO:0033260 3 0.039
regulation of cell cycle GO:0051726 281 0.038
gene silencing GO:0016458 38 0.038
establishment of organelle localization GO:0051656 122 0.038
chromatin organization GO:0006325 206 0.038
negative regulation of mitotic cell cycle GO:0045930 58 0.037
mitotic nuclear division GO:0007067 48 0.036
regulation of cell cycle process GO:0010564 160 0.035
meiosis i GO:0007127 60 0.035
apoptotic signaling pathway GO:0097190 306 0.034
organelle localization GO:0051640 179 0.033
peptidyl amino acid modification GO:0018193 336 0.033
blastocyst development GO:0001824 80 0.032
regulation of organelle organization GO:0033043 289 0.032
regulation of cellular ketone metabolic process GO:0010565 66 0.032
response to x ray GO:0010165 11 0.032
reciprocal dna recombination GO:0035825 16 0.032
Yeast
cellular ketone metabolic process GO:0042180 84 0.032
nucleocytoplasmic transport GO:0006913 139 0.031
positive regulation of protein autophosphorylation GO:0031954 4 0.030
Human
intracellular protein transport GO:0006886 204 0.030
ribose phosphate metabolic process GO:0019693 291 0.029
Human
telomere maintenance via telomerase GO:0007004 1 0.029
organonitrogen compound catabolic process GO:1901565 264 0.028
Human
negative regulation of cellular component organization GO:0051129 194 0.028
cellular amine metabolic process GO:0044106 44 0.027
cell cycle checkpoint GO:0000075 47 0.026
dna geometric change GO:0032392 7 0.026
Human
positive regulation of hydrolase activity GO:0051345 148 0.026
endocytosis GO:0006897 168 0.026
nucleobase containing small molecule metabolic process GO:0055086 352 0.025
Human Yeast
glycosyl compound metabolic process GO:1901657 246 0.025
Human
somatic diversification of immunoglobulins GO:0016445 43 0.025
cell activation involved in immune response GO:0002263 126 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.024
Human
regulation of protein localization GO:0032880 231 0.024
synaptonemal complex assembly GO:0007130 13 0.024
regulation of mitotic cell cycle phase transition GO:1901990 73 0.024
posttranscriptional regulation of gene expression GO:0010608 155 0.024
regulation of cellular amino acid metabolic process GO:0006521 5 0.024
macromolecule catabolic process GO:0009057 281 0.023
Yeast
regulation of cytoskeleton organization GO:0051493 122 0.023
spindle assembly involved in mitosis GO:0090307 4 0.023
protein autophosphorylation GO:0046777 61 0.023
Human
chemotaxis GO:0006935 247 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
positive regulation of kinase activity GO:0033674 155 0.022
Human
ribonucleotide metabolic process GO:0009259 291 0.022
Human
amine metabolic process GO:0009308 45 0.022
positive regulation of transferase activity GO:0051347 167 0.022
Human
regulation of dna recombination GO:0000018 34 0.021
immunoglobulin production GO:0002377 73 0.021
carbohydrate derivative biosynthetic process GO:1901137 183 0.021
regulation of cell cycle phase transition GO:1901987 77 0.021
positive regulation of cellular amine metabolic process GO:0033240 5 0.021
intrinsic apoptotic signaling pathway GO:0097193 132 0.021
immune effector process GO:0002252 321 0.021
organophosphate catabolic process GO:0046434 232 0.020
Human
methylation GO:0032259 134 0.020
non recombinational repair GO:0000726 10 0.020
Yeast
establishment of protein localization to organelle GO:0072594 118 0.020
dna catabolic process endonucleolytic GO:0000737 15 0.020
Yeast
protein import GO:0017038 101 0.020
mrna processing GO:0006397 63 0.020
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.020
nitrogen compound transport GO:0071705 271 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.019
Human
ribonucleoside catabolic process GO:0042454 206 0.019
Human
leukocyte mediated immunity GO:0002443 174 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
Human
regulation of kinase activity GO:0043549 249 0.019
Human
receptor mediated endocytosis GO:0006898 51 0.019
chromatin modification GO:0016568 187 0.019
ras protein signal transduction GO:0007265 77 0.018
protein targeting GO:0006605 143 0.018
dendrite development GO:0016358 115 0.018
centrosome cycle GO:0007098 23 0.018
response to radiation GO:0009314 165 0.018
protein localization to nucleus GO:0034504 121 0.017
nucleoside phosphate metabolic process GO:0006753 338 0.017
Human Yeast
protein alkylation GO:0008213 81 0.017
mitotic cell cycle checkpoint GO:0007093 31 0.017
nuclear import GO:0051170 95 0.017
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
Human
negative regulation of cell proliferation GO:0008285 296 0.017
gonad development GO:0008406 141 0.017
regulation of hydrolase activity GO:0051336 246 0.017
double strand break repair via nonhomologous end joining GO:0006303 10 0.017
Yeast
lymphocyte mediated immunity GO:0002449 139 0.017
purine nucleotide metabolic process GO:0006163 302 0.017
Human
cellular response to organonitrogen compound GO:0071417 145 0.017
negative regulation of dna replication GO:0008156 4 0.016
Human
purine nucleoside catabolic process GO:0006152 205 0.016
Human
negative regulation of cellular protein metabolic process GO:0032269 247 0.016
protein methylation GO:0006479 81 0.016
spindle organization GO:0007051 28 0.016
maintenance of location GO:0051235 89 0.016
Worm
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.016
nucleotide metabolic process GO:0009117 332 0.016
Human Yeast
b cell mediated immunity GO:0019724 71 0.016
positive regulation of nervous system development GO:0051962 221 0.016
negative regulation of cell cycle phase transition GO:1901988 48 0.015
response to inorganic substance GO:0010035 96 0.015
ribonucleoside triphosphate metabolic process GO:0009199 220 0.015
Human
male meiosis GO:0007140 37 0.015
fertilization GO:0009566 127 0.015
metaphase plate congression GO:0051310 2 0.015
neuromuscular process controlling balance GO:0050885 59 0.015
small gtpase mediated signal transduction GO:0007264 97 0.015
dephosphorylation GO:0016311 129 0.015
purine containing compound metabolic process GO:0072521 311 0.015
Human
regulation of protein transport GO:0051223 163 0.015
somatic diversification of immune receptors GO:0002200 53 0.015
glycosyl compound catabolic process GO:1901658 206 0.014
Human
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.014
peptidyl serine modification GO:0018209 83 0.014
dna packaging GO:0006323 30 0.014
protein import into nucleus GO:0006606 95 0.014
skeletal system development GO:0001501 356 0.014
immunoglobulin mediated immune response GO:0016064 69 0.014
cellular protein complex assembly GO:0043623 116 0.014
ribonucleoprotein complex localization GO:0071166 1 0.014
lymphocyte activation involved in immune response GO:0002285 93 0.014
regulation of cell activation GO:0050865 289 0.014
chromosome separation GO:0051304 14 0.014
response to organic cyclic compound GO:0014070 198 0.014
g2 dna damage checkpoint GO:0031572 8 0.014
positive regulation of cell cycle GO:0045787 92 0.013
Worm
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
regulation of cytoplasmic transport GO:1903649 112 0.013
neuron migration GO:0001764 122 0.013
regulation of cell division GO:0051302 76 0.013
locomotory behavior GO:0007626 195 0.013
regulation of protein targeting GO:1903533 61 0.013
cellular response to oxidative stress GO:0034599 76 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
nucleoside catabolic process GO:0009164 206 0.013
Human
skin development GO:0043588 220 0.013
reciprocal meiotic recombination GO:0007131 16 0.013
Yeast
organophosphate biosynthetic process GO:0090407 122 0.013
b cell activation involved in immune response GO:0002312 50 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
oxidation reduction process GO:0055114 342 0.013
mrna metabolic process GO:0016071 84 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
Human
embryonic organ morphogenesis GO:0048562 276 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
Human
muscle tissue development GO:0060537 308 0.012
protein maturation GO:0051604 176 0.012
endomembrane system organization GO:0010256 147 0.012
purine nucleotide catabolic process GO:0006195 211 0.012
Human
nucleoside metabolic process GO:0009116 246 0.012
Human
production of molecular mediator of immune response GO:0002440 103 0.012
cell fate commitment GO:0045165 210 0.012
ribonucleotide catabolic process GO:0009261 208 0.012
Human
glycerophospholipid metabolic process GO:0006650 71 0.012
regulation of centriole replication GO:0046599 1 0.012
leukocyte proliferation GO:0070661 172 0.012
sister chromatid segregation GO:0000819 20 0.012
positive regulation of protein transport GO:0051222 93 0.012
carbohydrate metabolic process GO:0005975 230 0.012
response to organonitrogen compound GO:0010243 246 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.012
Human
negative regulation of organelle organization GO:0010639 90 0.012
nuclear export GO:0051168 34 0.012
purine ribonucleoside metabolic process GO:0046128 241 0.012
Human
purine ribonucleotide catabolic process GO:0009154 208 0.012
Human
mitotic g2 dna damage checkpoint GO:0007095 8 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.011
viral process GO:0016032 41 0.011
single organism nuclear import GO:1902593 95 0.011
regulation of protein stability GO:0031647 52 0.011
muscle cell differentiation GO:0042692 261 0.011
dna modification GO:0006304 50 0.011
protein dna complex subunit organization GO:0071824 28 0.011
protein catabolic process GO:0030163 221 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
blastocyst growth GO:0001832 23 0.011
regulation of cellular catabolic process GO:0031329 242 0.011
regulation of intracellular protein transport GO:0033157 82 0.011
lipid biosynthetic process GO:0008610 179 0.011
positive regulation of organelle organization GO:0010638 128 0.011
regulation of intracellular transport GO:0032386 159 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
cellular chemical homeostasis GO:0055082 215 0.011
protein localization to organelle GO:0033365 185 0.011
regulation of nucleocytoplasmic transport GO:0046822 73 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.011
cellular response to inorganic substance GO:0071241 37 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
cation transport GO:0006812 399 0.010
response to light stimulus GO:0009416 135 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.010
Human
ribonucleoside metabolic process GO:0009119 245 0.010
Human
covalent chromatin modification GO:0016569 163 0.010
positive regulation of cell development GO:0010720 237 0.010
spermatogenesis GO:0007283 284 0.010
rhythmic process GO:0048511 174 0.010
forebrain development GO:0030900 302 0.010
regulation of cellular amine metabolic process GO:0033238 20 0.010
response to drug GO:0042493 75 0.010
striated muscle tissue development GO:0014706 293 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
regulation of lipid metabolic process GO:0019216 118 0.010

Mre11a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.044
disease of cellular proliferation DOID:14566 0 0.044
immune system disease DOID:2914 0 0.030
disease of anatomical entity DOID:7 0 0.030
bone marrow disease DOID:4961 0 0.030
hematopoietic system disease DOID:74 0 0.030
immune system cancer DOID:0060083 0 0.028
hematologic cancer DOID:2531 0 0.028
organ system cancer DOID:0050686 0 0.028
aplastic anemia DOID:12449 0 0.019
anemia DOID:2355 0 0.019
leukemia DOID:1240 0 0.016
nervous system disease DOID:863 0 0.012