Mus musculus

16 known processes

Tnks2

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

(Aliases: AA517131,AI662480,5430432P15Rik,Tank2)

Tnks2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of phosphorylation GO:0042326 166 0.176
cellular ketone metabolic process GO:0042180 84 0.152
peptidyl amino acid modification GO:0018193 336 0.145
stem cell differentiation GO:0048863 268 0.125
protein ubiquitination GO:0016567 171 0.119
Human
regulation of cellular amine metabolic process GO:0033238 20 0.114
peptidyl serine modification GO:0018209 83 0.105
cytoplasmic transport GO:0016482 234 0.104
dna metabolic process GO:0006259 303 0.100
macromolecule catabolic process GO:0009057 281 0.095
peptidyl serine phosphorylation GO:0018105 74 0.093
regulation of cellular amino acid metabolic process GO:0006521 5 0.093
regulation of organelle organization GO:0033043 289 0.087
regulation of cell cycle GO:0051726 281 0.085
multicellular organism growth GO:0035264 161 0.084
chromatin organization GO:0006325 206 0.078
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.076
stem cell development GO:0048864 219 0.076
regionalization GO:0003002 337 0.072
amine metabolic process GO:0009308 45 0.071
modification dependent protein catabolic process GO:0019941 133 0.071
cellular amine metabolic process GO:0044106 44 0.069
wnt signaling pathway GO:0016055 188 0.068
Human
regulation of canonical wnt signaling pathway GO:0060828 82 0.063
Human
negative regulation of protein modification process GO:0031400 163 0.063
ribonucleotide catabolic process GO:0009261 208 0.062
protein modification by small protein conjugation GO:0032446 187 0.059
Human
covalent chromatin modification GO:0016569 163 0.059
cellular response to growth factor stimulus GO:0071363 197 0.058
endocytosis GO:0006897 168 0.058
cell adhesion GO:0007155 329 0.057
negative regulation of cell proliferation GO:0008285 296 0.055
regulation of cell migration GO:0030334 219 0.054
purine ribonucleotide catabolic process GO:0009154 208 0.053
negative regulation of nervous system development GO:0051961 156 0.052
regulation of protein localization GO:0032880 231 0.052
regulation of cell cycle process GO:0010564 160 0.052
regulation of chromosome organization GO:0033044 83 0.052
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.050
learning or memory GO:0007611 148 0.050
regulation of exocytosis GO:0017157 61 0.050
protein modification by small protein conjugation or removal GO:0070647 207 0.050
Human
inorganic cation transmembrane transport GO:0098662 207 0.049
chromosome segregation GO:0007059 48 0.048
protein polyubiquitination GO:0000209 33 0.048
Human
peptidyl threonine phosphorylation GO:0018107 31 0.047
regulation of mapk cascade GO:0043408 248 0.047
regulation of establishment of protein localization GO:0070201 181 0.047
male gamete generation GO:0048232 285 0.046
protein localization to organelle GO:0033365 185 0.046
Human
germ cell development GO:0007281 185 0.046
nitrogen compound transport GO:0071705 271 0.045
nucleoside phosphate catabolic process GO:1901292 222 0.045
cellular amino acid metabolic process GO:0006520 103 0.045
posttranscriptional regulation of gene expression GO:0010608 155 0.044
negative regulation of synapse assembly GO:0051964 3 0.044
mapk cascade GO:0000165 281 0.044
chromatin modification GO:0016568 187 0.044
cation transmembrane transport GO:0098655 266 0.043
small gtpase mediated signal transduction GO:0007264 97 0.043
negative regulation of intracellular signal transduction GO:1902532 167 0.042
negative regulation of cell cycle GO:0045786 123 0.041
carbohydrate metabolic process GO:0005975 230 0.040
Human
negative regulation of phosphate metabolic process GO:0045936 184 0.040
negative regulation of cellular component organization GO:0051129 194 0.038
regulation of secretion GO:0051046 274 0.038
ribose phosphate metabolic process GO:0019693 291 0.037
synaptic transmission GO:0007268 329 0.036
ras protein signal transduction GO:0007265 77 0.036
regulation of kinase activity GO:0043549 249 0.036
negative regulation of protein metabolic process GO:0051248 282 0.035
negative regulation of cellular protein metabolic process GO:0032269 247 0.035
positive regulation of neuron differentiation GO:0045666 141 0.034
actin cytoskeleton organization GO:0030036 220 0.034
oocyte construction GO:0007308 2 0.034
aromatic compound catabolic process GO:0019439 286 0.034
negative regulation of protein phosphorylation GO:0001933 126 0.034
response to organic cyclic compound GO:0014070 198 0.033
regulation of protein kinase activity GO:0045859 232 0.032
axonogenesis GO:0007409 274 0.032
microtubule based process GO:0007017 236 0.031
inorganic ion transmembrane transport GO:0098660 234 0.031
regulation of cell motility GO:2000145 236 0.031
transmembrane transport GO:0055085 412 0.030
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.030
carbohydrate derivative catabolic process GO:1901136 231 0.030
compound eye development GO:0048749 1 0.030
organelle assembly GO:0070925 177 0.030
negative regulation of molecular function GO:0044092 258 0.030
digestive system development GO:0055123 200 0.029
fertilization GO:0009566 127 0.029
glycosyl compound metabolic process GO:1901657 246 0.029
phagocytosis GO:0006909 66 0.028
microtubule cytoskeleton organization GO:0000226 157 0.028
purine nucleotide metabolic process GO:0006163 302 0.028
hematopoietic progenitor cell differentiation GO:0002244 143 0.028
histone modification GO:0016570 159 0.027
negative regulation of mapk cascade GO:0043409 65 0.027
negative regulation of phosphorus metabolic process GO:0010563 184 0.027
protein localization to plasma membrane GO:0072659 57 0.027
nucleobase containing small molecule metabolic process GO:0055086 352 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.026
regulation of vesicle mediated transport GO:0060627 139 0.026
dendrite development GO:0016358 115 0.026
neuron projection guidance GO:0097485 141 0.025
protein glycosylation GO:0006486 55 0.025
Human
canonical wnt signaling pathway GO:0060070 130 0.025
Human
regulation of cellular ketone metabolic process GO:0010565 66 0.025
mitotic cell cycle process GO:1903047 159 0.024
spermatogenesis GO:0007283 284 0.024
regulation of wnt signaling pathway GO:0030111 123 0.024
Human
formation of primary germ layer GO:0001704 77 0.024
oocyte axis specification GO:0007309 2 0.024
protein catabolic process GO:0030163 221 0.023
cellular protein catabolic process GO:0044257 155 0.023
endomembrane system organization GO:0010256 147 0.023
nuclear division GO:0000280 158 0.023
oocyte anterior posterior axis specification GO:0007314 2 0.023
smoothened signaling pathway GO:0007224 105 0.023
anatomical structure homeostasis GO:0060249 145 0.023
purine nucleoside triphosphate catabolic process GO:0009146 203 0.023
chemotaxis GO:0006935 247 0.023
immune effector process GO:0002252 321 0.023
purine containing compound metabolic process GO:0072521 311 0.022
negative regulation of mitotic cell cycle GO:0045930 58 0.022
regulation of cellular component size GO:0032535 121 0.022
female gamete generation GO:0007292 74 0.022
cellular macromolecule catabolic process GO:0044265 206 0.022
erk1 and erk2 cascade GO:0070371 77 0.022
golgi vesicle transport GO:0048193 30 0.022
cell growth GO:0016049 130 0.022
purine ribonucleotide metabolic process GO:0009150 290 0.021
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.021
cellular response to hormone stimulus GO:0032870 150 0.021
membrane organization GO:0061024 245 0.021
cellular homeostasis GO:0019725 240 0.021
regulation of protein stability GO:0031647 52 0.021
ribonucleoside metabolic process GO:0009119 245 0.021
negative regulation of cellular amine metabolic process GO:0033239 1 0.021
modification dependent macromolecule catabolic process GO:0043632 133 0.021
synapse organization GO:0050808 125 0.021
meiotic nuclear division GO:0007126 115 0.021
positive regulation of mapk cascade GO:0043410 170 0.020
purine nucleoside metabolic process GO:0042278 241 0.020
cellular lipid metabolic process GO:0044255 323 0.020
stem cell maintenance GO:0019827 130 0.020
organic cyclic compound catabolic process GO:1901361 295 0.020
positive regulation of organelle organization GO:0010638 128 0.020
nucleoside phosphate metabolic process GO:0006753 338 0.020
forebrain development GO:0030900 302 0.019
protein autophosphorylation GO:0046777 61 0.019
organophosphate catabolic process GO:0046434 232 0.019
cytokine production GO:0001816 319 0.019
metencephalon development GO:0022037 89 0.019
nucleotide catabolic process GO:0009166 217 0.019
negative regulation of wnt signaling pathway GO:0030178 73 0.019
response to lipopolysaccharide GO:0032496 128 0.019
learning GO:0007612 98 0.019
digestive tract development GO:0048565 190 0.018
actin filament organization GO:0007015 113 0.018
organelle localization GO:0051640 179 0.018
intracellular protein transport GO:0006886 204 0.018
regulation of innate immune response GO:0045088 91 0.018
purine containing compound catabolic process GO:0072523 213 0.018
regulation of chromatin modification GO:1903308 57 0.018
positive regulation of wnt signaling pathway GO:0030177 45 0.018
Human
cellular nitrogen compound catabolic process GO:0044270 280 0.018
positive regulation of nervous system development GO:0051962 221 0.018
positive regulation of cellular amine metabolic process GO:0033240 5 0.018
trna wobble base modification GO:0002097 2 0.018
regulation of mitotic cell cycle GO:0007346 126 0.018
cellular component assembly involved in morphogenesis GO:0010927 139 0.018
cellular response to organonitrogen compound GO:0071417 145 0.018
regulation of cellular component biogenesis GO:0044087 181 0.018
nucleoside triphosphate metabolic process GO:0009141 230 0.018
development of primary sexual characteristics GO:0045137 143 0.018
cellular response to lipid GO:0071396 145 0.018
cellularization GO:0007349 1 0.018
developmental growth involved in morphogenesis GO:0060560 138 0.017
negative regulation of cell development GO:0010721 169 0.017
regulation of erk1 and erk2 cascade GO:0070372 71 0.017
ossification GO:0001503 216 0.017
spermatid differentiation GO:0048515 115 0.017
regulation of inflammatory response GO:0050727 147 0.017
regulation of transferase activity GO:0051338 263 0.017
positive regulation of cell motility GO:2000147 116 0.017
cellular chemical homeostasis GO:0055082 215 0.016
regulation of neuron differentiation GO:0045664 281 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
regulation of hydrolase activity GO:0051336 246 0.016
immune response regulating signaling pathway GO:0002764 125 0.016
divalent metal ion transport GO:0070838 172 0.016
carbohydrate homeostasis GO:0033500 128 0.016
camera type eye development GO:0043010 266 0.016
regulation of cell projection organization GO:0031344 206 0.016
homeostasis of number of cells GO:0048872 210 0.016
positive regulation of protein phosphorylation GO:0001934 242 0.016
central nervous system neuron differentiation GO:0021953 162 0.015
apoptotic signaling pathway GO:0097190 306 0.015
cell fate commitment GO:0045165 210 0.015
exocytosis GO:0006887 121 0.015
carbon catabolite regulation of transcription GO:0045990 4 0.015
positive regulation of protein modification process GO:0031401 299 0.015
spermatid development GO:0007286 108 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.015
digestive tract morphogenesis GO:0048546 147 0.015
amide transport GO:0042886 138 0.015
regulation of cytokine production GO:0001817 266 0.015
divalent inorganic cation transport GO:0072511 178 0.015
endodermal cell fate specification GO:0001714 4 0.015
gastrulation GO:0007369 116 0.015
dna recombination GO:0006310 92 0.015
cognition GO:0050890 149 0.014
regulation of histone modification GO:0031056 56 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.014
peptidyl threonine modification GO:0018210 31 0.014
meiotic cell cycle GO:0051321 122 0.014
sequestering of metal ion GO:0051238 19 0.014
heterocycle catabolic process GO:0046700 280 0.014
developmental cell growth GO:0048588 84 0.014
nucleoside metabolic process GO:0009116 246 0.014
cellular ion homeostasis GO:0006873 165 0.014
cellular response to biotic stimulus GO:0071216 92 0.014
single organism cell adhesion GO:0098602 156 0.014
activation of immune response GO:0002253 138 0.014
single organismal cell cell adhesion GO:0016337 131 0.014
response to molecule of bacterial origin GO:0002237 143 0.014
cytokinetic process GO:0032506 2 0.014
regulation of cell growth GO:0001558 91 0.014
respiratory system development GO:0060541 190 0.014
cellular response to lipopolysaccharide GO:0071222 77 0.014
locomotory behavior GO:0007626 195 0.014
internal protein amino acid acetylation GO:0006475 42 0.014
purine nucleotide catabolic process GO:0006195 211 0.014
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.013
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.013
regulation of system process GO:0044057 200 0.013
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.013
immune response activating signal transduction GO:0002757 116 0.013
nucleotide metabolic process GO:0009117 332 0.013
t cell differentiation GO:0030217 174 0.013
sensory perception GO:0007600 245 0.013
rab protein signal transduction GO:0032482 1 0.013
cofactor metabolic process GO:0051186 80 0.013
response to organonitrogen compound GO:0010243 246 0.013
actin polymerization or depolymerization GO:0008154 54 0.013
purine ribonucleoside catabolic process GO:0046130 205 0.013
regulation of chromatin organization GO:1902275 57 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
cation homeostasis GO:0055080 212 0.013
rac protein signal transduction GO:0016601 13 0.013
sensory organ morphogenesis GO:0090596 242 0.013
dephosphorylation GO:0016311 129 0.013
macromolecule glycosylation GO:0043413 55 0.013
Human
purine nucleoside monophosphate metabolic process GO:0009126 81 0.013
regulation of nuclear division GO:0051783 56 0.013
ion transmembrane transport GO:0034220 361 0.012
cellular response to insulin stimulus GO:0032869 78 0.012
glycosylation GO:0070085 62 0.012
Human
regulation of actin filament based process GO:0032970 99 0.012
maternal determination of anterior posterior axis embryo GO:0008358 2 0.012
organelle fission GO:0048285 170 0.012
regulation of voltage gated calcium channel activity GO:1901385 4 0.012
calcium ion transmembrane transport GO:0070588 85 0.012
negative regulation of chromatin modification GO:1903309 19 0.012
regulation of cell adhesion GO:0030155 154 0.012
protein localization to membrane GO:0072657 108 0.012
mitochondrion distribution GO:0048311 4 0.012
stress activated mapk cascade GO:0051403 80 0.012
regulation of secretion by cell GO:1903530 249 0.012
cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 4 0.012
cellular divalent inorganic cation homeostasis GO:0072503 127 0.012
response to growth factor GO:0070848 198 0.012
protein localization to nucleus GO:0034504 121 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
regulation of homeostatic process GO:0032844 182 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
negative regulation of cell cycle process GO:0010948 69 0.011
protein acylation GO:0043543 64 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
skeletal system development GO:0001501 356 0.011
cation transport GO:0006812 399 0.011
associative learning GO:0008306 61 0.011
positive regulation of canonical wnt signaling pathway GO:0090263 29 0.011
Human
meiotic cell cycle process GO:1903046 77 0.011
synapse assembly GO:0007416 56 0.011
response to nutrient levels GO:0031667 109 0.011
hindbrain development GO:0030902 128 0.011
axon target recognition GO:0007412 4 0.011
mitotic cell cycle GO:0000278 195 0.011
establishment of organelle localization GO:0051656 122 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
endoderm development GO:0007492 45 0.011
leukocyte chemotaxis GO:0030595 69 0.011
neural precursor cell proliferation GO:0061351 121 0.011
purine nucleoside triphosphate metabolic process GO:0009144 226 0.011
glycoprotein metabolic process GO:0009100 116 0.011
Human
microtubule based transport GO:0010970 50 0.011
phenol containing compound metabolic process GO:0018958 60 0.011
muscle cell differentiation GO:0042692 261 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
innate immune response GO:0045087 157 0.011
regulation of binding GO:0051098 111 0.010
regulation of cell substrate adhesion GO:0010810 73 0.010
regulation of neuron projection development GO:0010975 169 0.010
visual learning GO:0008542 44 0.010
maintenance of location GO:0051235 89 0.010
calcium ion homeostasis GO:0055074 127 0.010
regulation of lymphocyte activation GO:0051249 240 0.010
cell cell junction organization GO:0045216 72 0.010
regulation of ossification GO:0030278 112 0.010
plasma membrane organization GO:0007009 90 0.010
response to insulin GO:0032868 100 0.010
anion transport GO:0006820 177 0.010
positive regulation of protein kinase activity GO:0045860 144 0.010
regulation of hormone levels GO:0010817 211 0.010
golgi to endosome transport GO:0006895 3 0.010
mrna metabolic process GO:0016071 84 0.010
mitotic sister chromatid cohesion GO:0007064 1 0.010

Tnks2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.063
nervous system disease DOID:863 0 0.063
cancer DOID:162 0 0.036
disease of cellular proliferation DOID:14566 0 0.036
organ system cancer DOID:0050686 0 0.036
endocrine gland cancer DOID:170 0 0.027
sensory system disease DOID:0050155 0 0.014
central nervous system disease DOID:331 0 0.012