Mus musculus

31 known processes

Sirt6

sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)

(Aliases: AI043036,Sir2l6,2810449N18Rik)

Sirt6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.058
Human
cellular amine metabolic process GO:0044106 44 0.043
organic cyclic compound catabolic process GO:1901361 295 0.041
amine metabolic process GO:0009308 45 0.040
cellular amino acid metabolic process GO:0006520 103 0.040
cellular ketone metabolic process GO:0042180 84 0.039
macromolecule catabolic process GO:0009057 281 0.038
nucleoside phosphate metabolic process GO:0006753 338 0.036
cellular nitrogen compound catabolic process GO:0044270 280 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.035
regulation of organelle organization GO:0033043 289 0.034
heterocycle catabolic process GO:0046700 280 0.034
regulation of cellular ketone metabolic process GO:0010565 66 0.034
immune effector process GO:0002252 321 0.033
nucleoside metabolic process GO:0009116 246 0.033
ras protein signal transduction GO:0007265 77 0.033
aromatic compound catabolic process GO:0019439 286 0.032
negative regulation of protein metabolic process GO:0051248 282 0.032
regulation of cellular amino acid metabolic process GO:0006521 5 0.032
response to organonitrogen compound GO:0010243 246 0.030
carbohydrate derivative catabolic process GO:1901136 231 0.030
nucleobase containing small molecule metabolic process GO:0055086 352 0.028
nucleotide catabolic process GO:0009166 217 0.028
purine nucleoside triphosphate metabolic process GO:0009144 226 0.028
nucleotide metabolic process GO:0009117 332 0.028
glycosyl compound metabolic process GO:1901657 246 0.028
cellular response to dna damage stimulus GO:0006974 207 0.028
Human
regulation of cellular amine metabolic process GO:0033238 20 0.028
ribose phosphate metabolic process GO:0019693 291 0.028
regulation of cellular catabolic process GO:0031329 242 0.027
cellular lipid metabolic process GO:0044255 323 0.027
nucleoside phosphate catabolic process GO:1901292 222 0.027
cellular macromolecule catabolic process GO:0044265 206 0.027
ribonucleoside metabolic process GO:0009119 245 0.027
leukocyte differentiation GO:0002521 342 0.027
ribonucleotide metabolic process GO:0009259 291 0.026
organonitrogen compound catabolic process GO:1901565 264 0.026
purine containing compound metabolic process GO:0072521 311 0.025
regulation of hydrolase activity GO:0051336 246 0.025
homeostasis of number of cells GO:0048872 210 0.025
organophosphate catabolic process GO:0046434 232 0.025
ribonucleoside triphosphate metabolic process GO:0009199 220 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.024
purine nucleoside triphosphate catabolic process GO:0009146 203 0.024
carbohydrate metabolic process GO:0005975 230 0.024
cytokine production GO:0001816 319 0.024
striated muscle tissue development GO:0014706 293 0.023
organonitrogen compound biosynthetic process GO:1901566 192 0.023
negative regulation of cellular protein metabolic process GO:0032269 247 0.023
cell adhesion GO:0007155 329 0.023
regulation of cell activation GO:0050865 289 0.023
purine ribonucleotide metabolic process GO:0009150 290 0.023
purine nucleotide catabolic process GO:0006195 211 0.023
carbohydrate derivative biosynthetic process GO:1901137 183 0.022
purine nucleotide metabolic process GO:0006163 302 0.022
purine ribonucleoside metabolic process GO:0046128 241 0.022
negative regulation of protein modification process GO:0031400 163 0.022
nucleoside triphosphate catabolic process GO:0009143 205 0.022
purine nucleoside metabolic process GO:0042278 241 0.021
positive regulation of protein modification process GO:0031401 299 0.021
rho protein signal transduction GO:0007266 32 0.021
regulation of lymphocyte activation GO:0051249 240 0.021
regulation of cell cycle GO:0051726 281 0.021
purine ribonucleotide catabolic process GO:0009154 208 0.021
nucleoside triphosphate metabolic process GO:0009141 230 0.020
myeloid cell differentiation GO:0030099 233 0.020
regulation of cytokine production GO:0001817 266 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.020
muscle tissue development GO:0060537 308 0.020
regulation of transferase activity GO:0051338 263 0.020
ribonucleotide catabolic process GO:0009261 208 0.020
oxidation reduction process GO:0055114 342 0.020
small gtpase mediated signal transduction GO:0007264 97 0.020
cellular response to organonitrogen compound GO:0071417 145 0.020
camera type eye development GO:0043010 266 0.020
protein maturation GO:0051604 176 0.020
protein modification by small protein conjugation or removal GO:0070647 207 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
glycosyl compound catabolic process GO:1901658 206 0.019
negative regulation of molecular function GO:0044092 258 0.019
ribonucleoside catabolic process GO:0042454 206 0.019
dna repair GO:0006281 107 0.019
Human
regulation of cellular response to stress GO:0080135 159 0.019
Human
purine ribonucleoside catabolic process GO:0046130 205 0.019
organelle localization GO:0051640 179 0.019
positive regulation of programmed cell death GO:0043068 218 0.019
glycoprotein metabolic process GO:0009100 116 0.019
regulation of protein localization GO:0032880 231 0.019
regulation of neuron differentiation GO:0045664 281 0.018
microtubule based process GO:0007017 236 0.018
cellular homeostasis GO:0019725 240 0.018
histone modification GO:0016570 159 0.018
Human
apoptotic signaling pathway GO:0097190 306 0.018
negative regulation of cell proliferation GO:0008285 296 0.018
compound eye development GO:0048749 1 0.018
g protein coupled receptor signaling pathway GO:0007186 243 0.018
intracellular protein transport GO:0006886 204 0.018
regulation of cell cycle process GO:0010564 160 0.018
chromatin organization GO:0006325 206 0.018
Human
cellular chemical homeostasis GO:0055082 215 0.018
actin cytoskeleton organization GO:0030036 220 0.018
protein modification by small protein conjugation GO:0032446 187 0.018
t cell activation GO:0042110 289 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
negative regulation of immune system process GO:0002683 209 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
ribonucleoside triphosphate catabolic process GO:0009203 199 0.017
muscle cell differentiation GO:0042692 261 0.017
cation transmembrane transport GO:0098655 266 0.017
digestive system development GO:0055123 200 0.017
peptidyl amino acid modification GO:0018193 336 0.017
regulation of purine nucleotide catabolic process GO:0033121 122 0.017
mitochondrion organization GO:0007005 134 0.017
protein catabolic process GO:0030163 221 0.017
response to peptide GO:1901652 136 0.016
positive regulation of nervous system development GO:0051962 221 0.016
regulation of nucleotide metabolic process GO:0006140 169 0.016
purine nucleoside catabolic process GO:0006152 205 0.016
reactive oxygen species metabolic process GO:0072593 84 0.016
nucleoside catabolic process GO:0009164 206 0.016
regulation of proteolysis GO:0030162 164 0.016
purine containing compound catabolic process GO:0072523 213 0.016
positive regulation of cytokine production GO:0001819 174 0.016
mapk cascade GO:0000165 281 0.016
regulation of feeding behavior GO:0060259 3 0.016
positive regulation of cell death GO:0010942 224 0.016
b cell activation GO:0042113 161 0.016
regulation of purine nucleotide metabolic process GO:1900542 169 0.015
regulation of secretion by cell GO:1903530 249 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
positive regulation of neuron differentiation GO:0045666 141 0.015
regulation of cell migration GO:0030334 219 0.015
negative regulation of cellular amine metabolic process GO:0033239 1 0.015
small molecule biosynthetic process GO:0044283 132 0.015
positive regulation of cell activation GO:0050867 158 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.015
myeloid leukocyte differentiation GO:0002573 119 0.015
guanosine containing compound catabolic process GO:1901069 144 0.015
gtp catabolic process GO:0006184 143 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
positive regulation of cell development GO:0010720 237 0.015
lipid biosynthetic process GO:0008610 179 0.015
membrane organization GO:0061024 245 0.015
regulation of nucleoside metabolic process GO:0009118 130 0.015
embryonic organ morphogenesis GO:0048562 276 0.015
ossification GO:0001503 216 0.015
axonogenesis GO:0007409 274 0.015
nitrogen compound transport GO:0071705 271 0.015
cell type specific apoptotic process GO:0097285 268 0.015
lymphocyte differentiation GO:0030098 242 0.014
regulation of response to wounding GO:1903034 189 0.014
mitotic cell cycle GO:0000278 195 0.014
regulation of defense response GO:0031347 233 0.014
stem cell differentiation GO:0048863 268 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
positive regulation of cellular catabolic process GO:0031331 148 0.014
protein targeting GO:0006605 143 0.014
regulation of t cell activation GO:0050863 170 0.014
regulation of cell projection organization GO:0031344 206 0.014
regulation of leukocyte differentiation GO:1902105 159 0.014
regulation of anatomical structure size GO:0090066 178 0.014
cation transport GO:0006812 399 0.014
inflammatory response GO:0006954 244 0.014
forebrain development GO:0030900 302 0.014
regulation of protein transport GO:0051223 163 0.014
carbohydrate homeostasis GO:0033500 128 0.014
sensory perception GO:0007600 245 0.014
glycoprotein biosynthetic process GO:0009101 89 0.014
leukocyte proliferation GO:0070661 172 0.014
regulation of neuron projection development GO:0010975 169 0.014
chromatin modification GO:0016568 187 0.014
Human
maintenance of location GO:0051235 89 0.014
mitotic cell cycle process GO:1903047 159 0.014
methylation GO:0032259 134 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
positive regulation of protein phosphorylation GO:0001934 242 0.014
regulation of cellular component biogenesis GO:0044087 181 0.014
fat cell differentiation GO:0045444 160 0.014
microtubule cytoskeleton organization GO:0000226 157 0.014
regulation of protein kinase activity GO:0045859 232 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
peptide transport GO:0015833 133 0.014
developmental growth involved in morphogenesis GO:0060560 138 0.013
regulation of membrane potential GO:0042391 192 0.013
glucose homeostasis GO:0042593 128 0.013
wound healing GO:0042060 157 0.013
cellular protein catabolic process GO:0044257 155 0.013
protein ubiquitination GO:0016567 171 0.013
leukocyte activation involved in immune response GO:0002366 126 0.013
guanosine containing compound metabolic process GO:1901068 144 0.013
lymphocyte proliferation GO:0046651 164 0.013
regulation of kinase activity GO:0043549 249 0.013
organelle assembly GO:0070925 177 0.013
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.013
response to organic cyclic compound GO:0014070 198 0.013
organelle fission GO:0048285 170 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
epithelial cell development GO:0002064 159 0.013
cell division GO:0051301 120 0.013
lateral inhibition GO:0046331 1 0.013
protein processing GO:0016485 163 0.013
protein localization to organelle GO:0033365 185 0.013
regulation of secretion GO:0051046 274 0.013
cellular response to acid chemical GO:0071229 68 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
regulation of inflammatory response GO:0050727 147 0.013
endocytosis GO:0006897 168 0.013
anatomical structure homeostasis GO:0060249 145 0.013
positive regulation of secretion GO:0051047 130 0.013
response to radiation GO:0009314 165 0.013
cellular protein complex assembly GO:0043623 116 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
regulation of cellular component size GO:0032535 121 0.013
ion transmembrane transport GO:0034220 361 0.013
cytoplasmic transport GO:0016482 234 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
tube formation GO:0035148 140 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
t cell differentiation GO:0030217 174 0.012
regulation of hormone levels GO:0010817 211 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
asymmetric stem cell division GO:0098722 3 0.012
regulation of chromosome organization GO:0033044 83 0.012
dephosphorylation GO:0016311 129 0.012
response to acid chemical GO:0001101 111 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
intrinsic apoptotic signaling pathway GO:0097193 132 0.012
cell activation involved in immune response GO:0002263 126 0.012
response to nutrient levels GO:0031667 109 0.012
nuclear division GO:0000280 158 0.012
negative regulation of nervous system development GO:0051961 156 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
negative regulation of cell development GO:0010721 169 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
gland development GO:0048732 330 0.012
production of molecular mediator of immune response GO:0002440 103 0.012
extracellular structure organization GO:0043062 148 0.012
synaptic transmission GO:0007268 329 0.012
macromolecule methylation GO:0043414 120 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
chemotaxis GO:0006935 247 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
skeletal system development GO:0001501 356 0.012
spermatogenesis GO:0007283 284 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
covalent chromatin modification GO:0016569 163 0.012
Human
inorganic ion transmembrane transport GO:0098660 234 0.012
nuclear transport GO:0051169 139 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
male gamete generation GO:0048232 285 0.012
sequestering of calcium ion GO:0051208 18 0.011
protein secretion GO:0009306 111 0.011
transmembrane transport GO:0055085 412 0.011
rhythmic process GO:0048511 174 0.011
myosin filament assembly GO:0031034 2 0.011
oocyte axis specification GO:0007309 2 0.011
regulation of nucleotide catabolic process GO:0030811 122 0.011
germ cell development GO:0007281 185 0.011
retrograde transport endosome to golgi GO:0042147 2 0.011
cellular response to lipid GO:0071396 145 0.011
lymphocyte activation involved in immune response GO:0002285 93 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
sensory organ morphogenesis GO:0090596 242 0.011
cytokinetic process GO:0032506 2 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
regulation of lymphocyte proliferation GO:0050670 117 0.011
establishment of organelle localization GO:0051656 122 0.011
monocarboxylic acid metabolic process GO:0032787 191 0.011
regulation of adrenergic receptor signaling pathway GO:0071877 4 0.011
regulation of ras protein signal transduction GO:0046578 114 0.011
regulation of leukocyte proliferation GO:0070663 121 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
peptide secretion GO:0002790 114 0.011
regulation of mapk cascade GO:0043408 248 0.011
negative regulation of lymphocyte activation GO:0051250 91 0.011
intestinal epithelial structure maintenance GO:0060729 4 0.011
protein localization to nucleus GO:0034504 121 0.011
negative regulation of organelle organization GO:0010639 90 0.011
regulation of mitotic cell cycle GO:0007346 126 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
cell growth GO:0016049 130 0.011
wnt signaling pathway GO:0016055 188 0.011
locomotory behavior GO:0007626 195 0.011
myosin filament organization GO:0031033 3 0.011
endomembrane system organization GO:0010256 147 0.011
mitochondrion distribution GO:0048311 4 0.011
modification dependent protein catabolic process GO:0019941 133 0.011
positive regulation of organelle organization GO:0010638 128 0.011
blood circulation GO:0008015 195 0.011
positive regulation of nucleoside metabolic process GO:0045979 91 0.011
alcohol metabolic process GO:0006066 116 0.011
protein localization to membrane GO:0072657 108 0.011
regulation of protein catabolic process GO:0042176 108 0.011
amide transport GO:0042886 138 0.010
regulation of homeostatic process GO:0032844 182 0.010
response to lipopolysaccharide GO:0032496 128 0.010
cation homeostasis GO:0055080 212 0.010
nucleocytoplasmic transport GO:0006913 139 0.010
neural tube development GO:0021915 160 0.010
tissue homeostasis GO:0001894 115 0.010
leukocyte homeostasis GO:0001776 79 0.010
regulation of cell motility GO:2000145 236 0.010
proteasomal protein catabolic process GO:0010498 98 0.010
cellular ion homeostasis GO:0006873 165 0.010
regulation of peptidase activity GO:0052547 96 0.010
blood vessel morphogenesis GO:0048514 285 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
cellular response to external stimulus GO:0071496 88 0.010
regulation of endopeptidase activity GO:0052548 89 0.010
regulation of transmembrane transport GO:0034762 128 0.010
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.010
regulation of intracellular transport GO:0032386 159 0.010
organic acid biosynthetic process GO:0016053 86 0.010
positive regulation of immune effector process GO:0002699 107 0.010
response to insulin GO:0032868 100 0.010
protein import into nucleus GO:0006606 95 0.010
anion transport GO:0006820 177 0.010
regulation of cytoskeleton organization GO:0051493 122 0.010
renal system development GO:0072001 225 0.010
engulfment of apoptotic cell GO:0043652 3 0.010
response to oxidative stress GO:0006979 123 0.010

Sirt6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.019
disease of anatomical entity DOID:7 0 0.019
disease of cellular proliferation DOID:14566 0 0.016
nervous system disease DOID:863 0 0.015
organ system cancer DOID:0050686 0 0.015
cancer DOID:162 0 0.015
hematopoietic system disease DOID:74 0 0.013
disease of metabolism DOID:0014667 0 0.012