Mus musculus

24 known processes

Dctn2

dynactin 2

(Aliases: GMP23-48K,C130077D06Rik,RBP50,DCTN-50,2310042E05Rik,p50,C87049)

Dctn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic transmission GO:0007268 329 0.357
macroautophagy GO:0016236 21 0.321
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.280
vesicle localization GO:0051648 86 0.253
modification dependent macromolecule catabolic process GO:0043632 133 0.222
membrane organization GO:0061024 245 0.218
regulation of protein localization GO:0032880 231 0.195
establishment of melanosome localization GO:0032401 11 0.195
regulation of neuron projection development GO:0010975 169 0.184
regulation of establishment of protein localization GO:0070201 181 0.168
regulation of secretion GO:0051046 274 0.156
cellular protein catabolic process GO:0044257 155 0.147
microtubule based process GO:0007017 236 0.122
melanosome localization GO:0032400 12 0.122
protein localization to membrane GO:0072657 108 0.121
cytoplasmic transport GO:0016482 234 0.116
glycerolipid metabolic process GO:0046486 122 0.115
virion assembly GO:0019068 1 0.108
regulation of neuron differentiation GO:0045664 281 0.107
intracellular protein transport GO:0006886 204 0.107
positive regulation of apoptotic process GO:0043065 217 0.105
modification dependent protein catabolic process GO:0019941 133 0.105
organelle localization GO:0051640 179 0.101
ras protein signal transduction GO:0007265 77 0.099
regulation of secretion by cell GO:1903530 249 0.098
pigmentation GO:0043473 71 0.095
regulation of proteolysis GO:0030162 164 0.093
purine nucleoside triphosphate catabolic process GO:0009146 203 0.092
protein localization to organelle GO:0033365 185 0.092
nuclear division GO:0000280 158 0.088
regulation of cell projection organization GO:0031344 206 0.085
histone modification GO:0016570 159 0.085
meiotic cell cycle process GO:1903046 77 0.084
spermatogenesis GO:0007283 284 0.083
organophosphate catabolic process GO:0046434 232 0.080
nucleobase containing small molecule metabolic process GO:0055086 352 0.080
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.078
microtubule cytoskeleton organization GO:0000226 157 0.076
heterocycle catabolic process GO:0046700 280 0.076
small gtpase mediated signal transduction GO:0007264 97 0.074
cellular response to nutrient levels GO:0031669 64 0.069
retrograde transport endosome to golgi GO:0042147 2 0.068
protein catabolic process GO:0030163 221 0.068
multicellular organism growth GO:0035264 161 0.065
cellular amino acid metabolic process GO:0006520 103 0.063
organelle fission GO:0048285 170 0.063
regulation of vesicle mediated transport GO:0060627 139 0.062
nucleotide metabolic process GO:0009117 332 0.059
histone acetylation GO:0016573 41 0.057
synaptic vesicle transport GO:0048489 57 0.057
meiotic nuclear division GO:0007126 115 0.057
nucleoside phosphate metabolic process GO:0006753 338 0.056
dendrite development GO:0016358 115 0.056
establishment of organelle localization GO:0051656 122 0.055
positive regulation of cell death GO:0010942 224 0.055
protein maturation GO:0051604 176 0.054
mitotic cell cycle GO:0000278 195 0.053
peptidyl lysine modification GO:0018205 77 0.053
male gamete generation GO:0048232 285 0.053
regulation of cellular component biogenesis GO:0044087 181 0.053
purine ribonucleoside metabolic process GO:0046128 241 0.053
macromolecule catabolic process GO:0009057 281 0.052
glycosyl compound catabolic process GO:1901658 206 0.052
cellular macromolecule catabolic process GO:0044265 206 0.051
locomotory behavior GO:0007626 195 0.051
cellular pigmentation GO:0033059 20 0.050
positive regulation of cell development GO:0010720 237 0.049
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.048
positive regulation of organelle organization GO:0010638 128 0.046
rho protein signal transduction GO:0007266 32 0.046
regulation of cell cycle process GO:0010564 160 0.046
ubiquitin dependent protein catabolic process GO:0006511 129 0.046
regulation of cell cycle GO:0051726 281 0.046
ribonucleoside metabolic process GO:0009119 245 0.045
axonogenesis GO:0007409 274 0.045
organelle assembly GO:0070925 177 0.045
purine nucleotide metabolic process GO:0006163 302 0.044
ribose phosphate metabolic process GO:0019693 291 0.044
cellular homeostasis GO:0019725 240 0.043
meiotic cell cycle GO:0051321 122 0.043
ribonucleoside triphosphate metabolic process GO:0009199 220 0.043
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.043
mitotic cell cycle process GO:1903047 159 0.042
regulation of transposition GO:0010528 2 0.042
positive regulation of nervous system development GO:0051962 221 0.041
regulation of organelle organization GO:0033043 289 0.041
viral budding GO:0046755 1 0.040
endomembrane system organization GO:0010256 147 0.040
positive regulation of programmed cell death GO:0043068 218 0.040
purine containing compound metabolic process GO:0072521 311 0.040
vacuole organization GO:0007033 38 0.039
camera type eye development GO:0043010 266 0.039
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.039
response to metal ion GO:0010038 47 0.038
cellular response to dna damage stimulus GO:0006974 207 0.038
cellular response to extracellular stimulus GO:0031668 81 0.037
cell fate commitment GO:0045165 210 0.037
response to inorganic substance GO:0010035 96 0.037
nucleoside triphosphate catabolic process GO:0009143 205 0.037
autophagy GO:0006914 45 0.037
chromatin organization GO:0006325 206 0.037
regulation of mitotic cell cycle GO:0007346 126 0.036
melanosome transport GO:0032402 11 0.036
positive regulation of secretion GO:0051047 130 0.036
purine ribonucleotide metabolic process GO:0009150 290 0.036
regulation of binding GO:0051098 111 0.036
nitrogen compound transport GO:0071705 271 0.035
positive regulation of hormone secretion GO:0046887 38 0.035
negative regulation of molecular function GO:0044092 258 0.035
positive regulation of neuron differentiation GO:0045666 141 0.034
establishment of vesicle localization GO:0051650 81 0.034
aromatic compound catabolic process GO:0019439 286 0.033
cellular response to starvation GO:0009267 57 0.033
cell type specific apoptotic process GO:0097285 268 0.033
establishment of protein localization to organelle GO:0072594 118 0.033
protein acylation GO:0043543 64 0.033
cilium morphogenesis GO:0060271 102 0.032
exocytosis GO:0006887 121 0.032
glycosyl compound metabolic process GO:1901657 246 0.031
protein processing GO:0016485 163 0.031
positive regulation of secretion by cell GO:1903532 114 0.031
retina development in camera type eye GO:0060041 119 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
cellular ketone metabolic process GO:0042180 84 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.029
cell maturation GO:0048469 127 0.029
ribonucleotide catabolic process GO:0009261 208 0.029
cellular amine metabolic process GO:0044106 44 0.029
regulation of protein transport GO:0051223 163 0.029
purine nucleoside metabolic process GO:0042278 241 0.029
protein targeting GO:0006605 143 0.029
skin development GO:0043588 220 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.029
regulation of cellular amino acid metabolic process GO:0006521 5 0.029
regulation of anatomical structure size GO:0090066 178 0.029
synapsis GO:0007129 34 0.028
regulation of cellular ketone metabolic process GO:0010565 66 0.028
chromatin modification GO:0016568 187 0.028
purine containing compound catabolic process GO:0072523 213 0.028
asymmetric neuroblast division GO:0055059 1 0.027
protein import into nucleus GO:0006606 95 0.027
gtp catabolic process GO:0006184 143 0.027
positive regulation of nucleotide catabolic process GO:0030813 88 0.027
cellular component assembly involved in morphogenesis GO:0010927 139 0.026
negative regulation of synapse assembly GO:0051964 3 0.026
negative regulation of growth GO:0045926 99 0.026
chromosome segregation GO:0007059 48 0.026
oocyte development GO:0048599 33 0.026
vesicle organization GO:0016050 60 0.026
nucleoside catabolic process GO:0009164 206 0.026
mitochondrial membrane organization GO:0007006 26 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
guanosine containing compound catabolic process GO:1901069 144 0.026
internal protein amino acid acetylation GO:0006475 42 0.025
negative regulation of cellular component organization GO:0051129 194 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.025
protein modification by small protein conjugation GO:0032446 187 0.025
amine metabolic process GO:0009308 45 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
protein import GO:0017038 101 0.025
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.025
epidermis development GO:0008544 187 0.025
nucleoside triphosphate metabolic process GO:0009141 230 0.024
regulation of peptide hormone secretion GO:0090276 75 0.024
intrinsic apoptotic signaling pathway GO:0097193 132 0.024
establishment or maintenance of cell polarity GO:0007163 86 0.024
carbohydrate homeostasis GO:0033500 128 0.024
activation of adenylate cyclase activity GO:0007190 4 0.024
ribonucleotide metabolic process GO:0009259 291 0.024
sensory perception GO:0007600 245 0.024
guanosine containing compound metabolic process GO:1901068 144 0.023
regulation of nucleocytoplasmic transport GO:0046822 73 0.023
regulation of exocytosis GO:0017157 61 0.023
positive regulation of cell projection organization GO:0031346 95 0.023
developmental maturation GO:0021700 193 0.023
positive regulation of protein modification process GO:0031401 299 0.023
protein localization to nucleus GO:0034504 121 0.023
transmission of nerve impulse GO:0019226 76 0.023
negative regulation of cellular protein metabolic process GO:0032269 247 0.023
glucose homeostasis GO:0042593 128 0.023
hormone secretion GO:0046879 128 0.023
regulation of protein maturation GO:1903317 96 0.022
regulation of cellular amine metabolic process GO:0033238 20 0.022
mitochondrion degradation GO:0000422 3 0.022
cellular nitrogen compound catabolic process GO:0044270 280 0.022
negative regulation of cell cycle GO:0045786 123 0.022
regulation of cellular catabolic process GO:0031329 242 0.022
positive regulation of peptide secretion GO:0002793 33 0.021
dna metabolic process GO:0006259 303 0.021
cellular divalent inorganic cation homeostasis GO:0072503 127 0.021
nucleocytoplasmic transport GO:0006913 139 0.021
positive regulation of protein transport GO:0051222 93 0.021
central nervous system neuron differentiation GO:0021953 162 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
cation transport GO:0006812 399 0.021
regulation of hormone levels GO:0010817 211 0.021
negative regulation of nervous system development GO:0051961 156 0.021
cell division GO:0051301 120 0.020
regulation of peptide secretion GO:0002791 77 0.020
response to organic cyclic compound GO:0014070 198 0.020
apoptotic signaling pathway GO:0097190 306 0.020
kidney development GO:0001822 213 0.020
cilium assembly GO:0042384 81 0.020
peptidyl amino acid modification GO:0018193 336 0.020
negative regulation of mitotic cell cycle GO:0045930 58 0.020
nucleoside phosphate catabolic process GO:1901292 222 0.020
monocarboxylic acid metabolic process GO:0032787 191 0.020
protein secretion GO:0009306 111 0.020
regulation of nucleotide metabolic process GO:0006140 169 0.020
photoreceptor cell differentiation GO:0046530 52 0.020
establishment of synaptic vesicle localization GO:0097480 57 0.020
rhodopsin mediated signaling pathway GO:0016056 4 0.020
negative regulation of binding GO:0051100 39 0.019
asymmetric stem cell division GO:0098722 3 0.019
cellular lipid metabolic process GO:0044255 323 0.019
actin cytoskeleton organization GO:0030036 220 0.019
ribonucleoside triphosphate catabolic process GO:0009203 199 0.019
nuclear transport GO:0051169 139 0.019
response to starvation GO:0042594 65 0.019
cellular ion homeostasis GO:0006873 165 0.019
endocytosis GO:0006897 168 0.019
protein ubiquitination GO:0016567 171 0.019
regulation of cytoplasmic transport GO:1903649 112 0.019
cellular response to abiotic stimulus GO:0071214 56 0.019
meiosis i GO:0007127 60 0.019
positive regulation of peptide hormone secretion GO:0090277 31 0.018
mitochondrion organization GO:0007005 134 0.018
neurotransmitter secretion GO:0007269 62 0.018
axon cargo transport GO:0008088 33 0.018
plasma membrane organization GO:0007009 90 0.018
peptidyl lysine acetylation GO:0018394 45 0.018
nucleoside metabolic process GO:0009116 246 0.018
regulation of meiotic cell cycle GO:0051445 34 0.018
gonad development GO:0008406 141 0.018
sensory organ morphogenesis GO:0090596 242 0.018
positive regulation of neuron projection development GO:0010976 79 0.018
negative regulation of phosphorus metabolic process GO:0010563 184 0.017
compound eye development GO:0048749 1 0.017
cellular metal ion homeostasis GO:0006875 151 0.017
purine nucleoside catabolic process GO:0006152 205 0.017
negative regulation of transposition GO:0010529 2 0.017
glycerophospholipid metabolic process GO:0006650 71 0.017
retina morphogenesis in camera type eye GO:0060042 45 0.017
positive regulation of cellular amine metabolic process GO:0033240 5 0.017
regulation of protein catabolic process GO:0042176 108 0.017
peptide hormone secretion GO:0030072 109 0.017
regulation of nucleoside metabolic process GO:0009118 130 0.017
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.017
protein autophosphorylation GO:0046777 61 0.017
organonitrogen compound catabolic process GO:1901565 264 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.017
positive regulation of cell growth GO:0030307 33 0.017
covalent chromatin modification GO:0016569 163 0.017
development of primary sexual characteristics GO:0045137 143 0.016
synapse organization GO:0050808 125 0.016
positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 13 0.016
microtubule based transport GO:0010970 50 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
gtp metabolic process GO:0046039 144 0.016
positive regulation of nucleotide metabolic process GO:0045981 114 0.016
sensory system development GO:0048880 3 0.016
regulation of synaptic plasticity GO:0048167 87 0.016
cellular response to molecule of bacterial origin GO:0071219 83 0.016
oocyte axis specification GO:0007309 2 0.016
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.016
oocyte differentiation GO:0009994 35 0.016
lipid biosynthetic process GO:0008610 179 0.016
positive regulation of hydrolase activity GO:0051345 148 0.016
single fertilization GO:0007338 82 0.016
oocyte maturation GO:0001556 18 0.016
positive regulation of transferase activity GO:0051347 167 0.016
synaptonemal complex assembly GO:0007130 13 0.015
spermatid differentiation GO:0048515 115 0.015
cell junction maintenance GO:0034331 4 0.015
peptide secretion GO:0002790 114 0.015
regulation of intracellular transport GO:0032386 159 0.015
spermatid development GO:0007286 108 0.015
response to organonitrogen compound GO:0010243 246 0.015
labyrinthine layer development GO:0060711 49 0.015
purine nucleotide catabolic process GO:0006195 211 0.015
regulation of leukocyte differentiation GO:1902105 159 0.015
positive regulation of proteolysis GO:0045862 85 0.015
carbohydrate metabolic process GO:0005975 230 0.015
regulation of hydrolase activity GO:0051336 246 0.015
regulation of nucleotide catabolic process GO:0030811 122 0.015
negative regulation of protein processing GO:0010955 79 0.015
cellular response to cytokine stimulus GO:0071345 189 0.015
neural retina development GO:0003407 41 0.015
cellular response to external stimulus GO:0071496 88 0.015
negative regulation of cell development GO:0010721 169 0.014
regulation of cell size GO:0008361 72 0.014
positive regulation of protein kinase activity GO:0045860 144 0.014
regulation of purine nucleotide catabolic process GO:0033121 122 0.014
pigment granule transport GO:0051904 12 0.014
fertilization GO:0009566 127 0.014
negative regulation of gene silencing GO:0060969 2 0.014
response to radiation GO:0009314 165 0.014
response to extracellular stimulus GO:0009991 127 0.014
negative regulation of protein modification process GO:0031400 163 0.014
germ cell development GO:0007281 185 0.014
positive regulation of phospholipase activity GO:0010518 3 0.014
positive regulation of cell cycle GO:0045787 92 0.014
positive regulation of insulin secretion GO:0032024 26 0.014
eye photoreceptor cell differentiation GO:0001754 41 0.014
positive regulation of synaptic plasticity GO:0031915 4 0.013
pigment granule localization GO:0051875 13 0.013
protein localization to plasma membrane GO:0072659 57 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
adult behavior GO:0030534 135 0.013
response to light stimulus GO:0009416 135 0.013
positive regulation of kinase activity GO:0033674 155 0.013
maintenance of location GO:0051235 89 0.013
purine ribonucleotide catabolic process GO:0009154 208 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
regulation of polyamine transmembrane transport GO:1902267 5 0.013
positive regulation of protein catabolic process GO:0045732 60 0.013
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.013
proteasomal protein catabolic process GO:0010498 98 0.013
nucleotide catabolic process GO:0009166 217 0.013
response to copper ion GO:0046688 3 0.013
cellular carbohydrate metabolic process GO:0044262 119 0.013
regulation of microtubule based process GO:0032886 52 0.013
attachment of spindle microtubules to kinetochore GO:0008608 4 0.013
regulation of kinase activity GO:0043549 249 0.013
small molecule catabolic process GO:0044282 71 0.013
nuclear import GO:0051170 95 0.013
peptide transport GO:0015833 133 0.013
regulation of dna binding GO:0051101 39 0.013
renal system development GO:0072001 225 0.013
regulation of lymphocyte activation GO:0051249 240 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
phospholipid metabolic process GO:0006644 87 0.012
leukocyte differentiation GO:0002521 342 0.012
cellular response to hexose stimulus GO:0071331 47 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
phosphatidic acid metabolic process GO:0046473 2 0.012
regulation of intracellular protein transport GO:0033157 82 0.012
cellular modified amino acid metabolic process GO:0006575 63 0.012
divalent metal ion transport GO:0070838 172 0.012
synaptic vesicle localization GO:0097479 59 0.012
ear development GO:0043583 200 0.012
gene silencing GO:0016458 38 0.012
protein modification by small protein conjugation or removal GO:0070647 207 0.012
muscle tissue development GO:0060537 308 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
regulation of hormone secretion GO:0046883 88 0.012
regulation of cellular component size GO:0032535 121 0.012
cellular glucose homeostasis GO:0001678 52 0.012
neuronal action potential GO:0019228 54 0.012
female gamete generation GO:0007292 74 0.012
negative regulation of protein maturation GO:1903318 79 0.012
synapse assembly GO:0007416 56 0.012
camera type eye photoreceptor cell differentiation GO:0060219 15 0.011
adult locomotory behavior GO:0008344 91 0.011
cell adhesion GO:0007155 329 0.011
regulation of metal ion transport GO:0010959 106 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
golgi vesicle transport GO:0048193 30 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
striated muscle tissue development GO:0014706 293 0.011
maintenance of location in cell GO:0051651 24 0.011
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 3 0.011
response to alkaloid GO:0043279 34 0.011
negative regulation of cellular amine metabolic process GO:0033239 1 0.011
negative regulation of phosphate metabolic process GO:0045936 184 0.011
skeletal muscle organ development GO:0060538 163 0.011
establishment of pigment granule localization GO:0051905 12 0.011
regulation of cysteine type endopeptidase activity GO:2000116 65 0.011
regulation of peptidase activity GO:0052547 96 0.011
cellular response to oxidative stress GO:0034599 76 0.011
regulation of cell activation GO:0050865 289 0.011
regulation of response to wounding GO:1903034 189 0.011
response to monosaccharide GO:0034284 67 0.011
placenta development GO:0001890 140 0.011
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.011
histone h2a ubiquitination GO:0033522 3 0.011
adherens junction maintenance GO:0034334 1 0.011
nuclear export GO:0051168 34 0.011
cellular response to biotic stimulus GO:0071216 92 0.010
regulation of cellular protein catabolic process GO:1903362 61 0.010
glucose transport GO:0015758 56 0.010
calcium ion transport GO:0006816 159 0.010
ribonucleoside catabolic process GO:0042454 206 0.010
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
regulation of peptide transport GO:0090087 91 0.010
extracellular matrix organization GO:0030198 147 0.010
microtubule based movement GO:0007018 84 0.010
regulation of bmp signaling pathway GO:0030510 60 0.010
hair cell differentiation GO:0035315 40 0.010
regulation of endocytosis GO:0030100 69 0.010
sequestering of calcium ion GO:0051208 18 0.010
regulation of protein secretion GO:0050708 82 0.010
lipid localization GO:0010876 126 0.010

Dctn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
neuromuscular disease DOID:440 0 0.020
disease of anatomical entity DOID:7 0 0.020
charcot marie tooth disease DOID:10595 0 0.020
nervous system disease DOID:863 0 0.020
neuropathy DOID:870 0 0.020
immune system disease DOID:2914 0 0.017
hematopoietic system disease DOID:74 0 0.017
central nervous system disease DOID:331 0 0.016
neurodegenerative disease DOID:1289 0 0.011