Mus musculus

140 known processes

Socs3

suppressor of cytokine signaling 3

(Aliases: Cish3,Ef10,EF-10,Cis3,Ssi3,SSI-3)

Socs3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
t cell differentiation GO:0030217 174 0.954
Mouse
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.953
Mouse
regulation of t cell differentiation GO:0045580 83 0.951
Mouse
immune effector process GO:0002252 321 0.941
Mouse
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.934
Mouse
leukocyte differentiation GO:0002521 342 0.931
Mouse
regulation of t helper 1 cell differentiation GO:0045625 7 0.928
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.896
cellular response to cytokine stimulus GO:0071345 189 0.863
Mouse
amine metabolic process GO:0009308 45 0.823
cellular amino acid metabolic process GO:0006520 103 0.818
activation of janus kinase activity GO:0042976 2 0.813
Mouse
negative regulation of immune system process GO:0002683 209 0.808
Mouse
regulation of cytokine production GO:0001817 266 0.796
Mouse
alpha beta t cell differentiation GO:0046632 69 0.741
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.730
regulation of lymphocyte differentiation GO:0045619 107 0.728
Mouse
adaptive immune response GO:0002250 155 0.721
Mouse
cellular response to biotic stimulus GO:0071216 92 0.703
negative regulation of t cell differentiation GO:0045581 23 0.695
Mouse
t helper 1 type immune response GO:0042088 25 0.693
Mouse
t cell activation involved in immune response GO:0002286 43 0.691
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.682
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.680
positive regulation of cell death GO:0010942 224 0.678
positive regulation of t cell differentiation GO:0045582 52 0.664
Mouse
myeloid cell differentiation GO:0030099 233 0.664
positive regulation of cytokine production GO:0001819 174 0.663
cellular response to molecule of bacterial origin GO:0071219 83 0.663
regulation of inflammatory response GO:0050727 147 0.660
b cell mediated immunity GO:0019724 71 0.639
response to molecule of bacterial origin GO:0002237 143 0.633
Rat
regulation of protein kinase activity GO:0045859 232 0.633
Mouse
response to organonitrogen compound GO:0010243 246 0.630
response to lipopolysaccharide GO:0032496 128 0.629
Rat
peptidyl tyrosine phosphorylation GO:0018108 143 0.621
Mouse
peptidyl amino acid modification GO:0018193 336 0.599
Mouse
cd4 positive alpha beta t cell activation GO:0035710 45 0.590
Mouse
alpha beta t cell activation involved in immune response GO:0002287 31 0.576
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.563
Mouse
regulation of defense response GO:0031347 233 0.560
regulation of hydrolase activity GO:0051336 246 0.529
negative regulation of molecular function GO:0044092 258 0.526
Mouse
lymphocyte activation involved in immune response GO:0002285 93 0.526
Mouse
t helper cell differentiation GO:0042093 28 0.511
Mouse
regulation of response to wounding GO:1903034 189 0.503
negative regulation of leukocyte differentiation GO:1902106 51 0.499
Mouse
cytokine production GO:0001816 319 0.498
Mouse
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.496
Mouse
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.486
Mouse
cellular ketone metabolic process GO:0042180 84 0.483
immune response activating signal transduction GO:0002757 116 0.478
cellular response to organonitrogen compound GO:0071417 145 0.476
regulation of t helper 1 type immune response GO:0002825 17 0.469
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.461
Mouse
regulation of antimicrobial humoral response GO:0002759 3 0.444
positive regulation of programmed cell death GO:0043068 218 0.443
cellular amine metabolic process GO:0044106 44 0.441
cellular response to amino acid stimulus GO:0071230 29 0.430
Mouse
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.424
Mouse
interleukin 11 mediated signaling pathway GO:0038154 2 0.413
negative regulation of intracellular signal transduction GO:1902532 167 0.406
Mouse
cellular response to peptide GO:1901653 92 0.398
immunoglobulin mediated immune response GO:0016064 69 0.395
leukocyte apoptotic process GO:0071887 71 0.394
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.392
regulation of leukocyte differentiation GO:1902105 159 0.391
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.378
nitrogen compound transport GO:0071705 271 0.375
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.373
positive regulation of apoptotic process GO:0043065 217 0.371
cell activation involved in immune response GO:0002263 126 0.360
Mouse
peptidyl tyrosine modification GO:0018212 145 0.357
Mouse
regulation of lymphocyte activation GO:0051249 240 0.353
Mouse
lymphocyte differentiation GO:0030098 242 0.353
Mouse
negative regulation of multi organism process GO:0043901 68 0.351
positive regulation of cellular amine metabolic process GO:0033240 5 0.350
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.349
Mouse
phagocytosis GO:0006909 66 0.338
activation of mapk activity involved in innate immune response GO:0035419 2 0.338
carbohydrate metabolic process GO:0005975 230 0.336
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.335
Mouse
positive regulation of peptidase activity GO:0010952 49 0.333
defense response to virus GO:0051607 68 0.326
regulation of t cell activation GO:0050863 170 0.325
Mouse
peptide transport GO:0015833 133 0.313
cellular response to interleukin 6 GO:0071354 9 0.311
b cell activation GO:0042113 161 0.308
regulation of kinase activity GO:0043549 249 0.307
Mouse
regulation of adaptive immune response GO:0002819 90 0.306
Mouse
axon regeneration GO:0031103 12 0.304
Zebrafish
interleukin 6 mediated signaling pathway GO:0070102 6 0.303
segmentation GO:0035282 93 0.302
t cell activation GO:0042110 289 0.299
Mouse
cell type specific apoptotic process GO:0097285 268 0.298
response to organic cyclic compound GO:0014070 198 0.292
Rat
t cell differentiation involved in immune response GO:0002292 30 0.288
Mouse
regulation of mapk cascade GO:0043408 248 0.287
type i interferon signaling pathway GO:0060337 10 0.287
inflammatory response GO:0006954 244 0.287
response to peptide GO:1901652 136 0.284
leukocyte mediated immunity GO:0002443 174 0.279
negative regulation of myeloid cell differentiation GO:0045638 38 0.276
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.276
regulation of cellular response to stress GO:0080135 159 0.275
Zebrafish
neuron projection regeneration GO:0031102 14 0.274
Zebrafish
regulation of transferase activity GO:0051338 263 0.267
Mouse
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.266
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.265
cellular chemical homeostasis GO:0055082 215 0.263
cellular calcium ion homeostasis GO:0006874 119 0.262
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.257
Mouse
positive regulation of mapk cascade GO:0043410 170 0.257
response to radiation GO:0009314 165 0.249
Rat
cellular response to lipid GO:0071396 145 0.249
cellular response to type i interferon GO:0071357 10 0.244
organonitrogen compound biosynthetic process GO:1901566 192 0.243
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.243
regulation of leukocyte apoptotic process GO:2000106 56 0.241
positive regulation of protein kinase activity GO:0045860 144 0.240
Mouse
production of molecular mediator of immune response GO:0002440 103 0.238
regulation of jak stat cascade GO:0046425 34 0.234
Mouse
interleukin 8 production GO:0032637 4 0.233
negative regulation of interleukin 8 production GO:0032717 1 0.232
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.225
Mouse
regulation of cell motility GO:2000145 236 0.224
t cell differentiation in thymus GO:0033077 77 0.223
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.222
Mouse
immune response regulating signaling pathway GO:0002764 125 0.221
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.218
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.213
Mouse
notch signaling pathway GO:0007219 71 0.213
positive regulation of nucleotide metabolic process GO:0045981 114 0.212
regulation of endopeptidase activity GO:0052548 89 0.210
nucleocytoplasmic transport GO:0006913 139 0.209
response to interleukin 6 GO:0070741 10 0.209
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.209
leukocyte activation involved in immune response GO:0002366 126 0.208
Mouse
i kappab kinase nf kappab signaling GO:0007249 85 0.207
regulation of ossification GO:0030278 112 0.207
positive regulation of defense response GO:0031349 124 0.205
negative regulation of lymphocyte differentiation GO:0045620 32 0.205
Mouse
regulation of leukocyte mediated immunity GO:0002703 104 0.204
regulation of osteoblast differentiation GO:0045667 67 0.203
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.200
Mouse
regulation of type 2 immune response GO:0002828 18 0.198
Mouse
hindbrain development GO:0030902 128 0.197
Mouse
positive regulation of growth hormone receptor signaling pathway GO:0060399 3 0.196
negative regulation of cell proliferation GO:0008285 296 0.196
negative regulation of cell activation GO:0050866 111 0.194
Mouse
cellular response to lipopolysaccharide GO:0071222 77 0.194
ossification GO:0001503 216 0.194
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.192
regulation of cellular catabolic process GO:0031329 242 0.192
response to ionizing radiation GO:0010212 42 0.191
Rat
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.190
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.190
mapk cascade GO:0000165 281 0.189
cation homeostasis GO:0055080 212 0.186
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.183
positive regulation of protein modification process GO:0031401 299 0.183
Mouse
regulation of multi organism process GO:0043900 111 0.180
negative regulation of alpha beta t cell activation GO:0046636 18 0.179
Mouse
negative regulation of cytokine production GO:0001818 84 0.178
establishment of protein localization to organelle GO:0072594 118 0.177
t cell apoptotic process GO:0070231 39 0.177
lymphocyte mediated immunity GO:0002449 139 0.176
positive regulation of antimicrobial peptide production GO:0002225 1 0.175
immunoglobulin production GO:0002377 73 0.173
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.171
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.169
response to interleukin 4 GO:0070670 23 0.168
regulation of peptide transport GO:0090087 91 0.164
regionalization GO:0003002 337 0.163
stem cell development GO:0048864 219 0.163
positive regulation of hydrolase activity GO:0051345 148 0.163
cellular carbohydrate metabolic process GO:0044262 119 0.162
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 10 0.162
Mouse
positive regulation of leukocyte differentiation GO:1902107 86 0.162
Mouse
regulation of b cell mediated immunity GO:0002712 37 0.161
positive regulation of epithelial cell proliferation GO:0050679 68 0.161
regulation of interleukin 8 production GO:0032677 3 0.160
gland development GO:0048732 330 0.160
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.160
Mouse
positive regulation of lymphocyte activation GO:0051251 140 0.158
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.157
positive regulation of cell activation GO:0050867 158 0.155
Mouse
regulation of production of molecular mediator of immune response GO:0002700 65 0.155
response to interleukin 12 GO:0070671 2 0.153
embryonic placenta development GO:0001892 98 0.153
myeloid leukocyte differentiation GO:0002573 119 0.151
regulation of peptidase activity GO:0052547 96 0.150
carbohydrate homeostasis GO:0033500 128 0.149
regulation of purine nucleotide metabolic process GO:1900542 169 0.149
negative regulation of cellular amine metabolic process GO:0033239 1 0.148
positive regulation of neuron projection regeneration GO:0070572 2 0.147
fertilization GO:0009566 127 0.147
cellular response to insulin stimulus GO:0032869 78 0.147
nuclear transport GO:0051169 139 0.146
regulation of transforming growth factor beta2 production GO:0032909 2 0.143
cellular response to growth factor stimulus GO:0071363 197 0.142
regulation of secretion GO:0051046 274 0.142
Mouse
lymphocyte apoptotic process GO:0070227 54 0.142
interferon gamma mediated signaling pathway GO:0060333 5 0.142
fat cell differentiation GO:0045444 160 0.141
Mouse
generation of precursor metabolites and energy GO:0006091 103 0.140
cellular response to hormone stimulus GO:0032870 150 0.140
cellular homeostasis GO:0019725 240 0.138
positive regulation of kinase activity GO:0033674 155 0.137
Mouse
toll like receptor signaling pathway GO:0002224 38 0.135
regulation of alpha beta t cell activation GO:0046634 53 0.135
Mouse
lymphocyte homeostasis GO:0002260 64 0.134
response to tumor necrosis factor GO:0034612 26 0.133
purine containing compound metabolic process GO:0072521 311 0.131
positive regulation of osteoblast differentiation GO:0045669 34 0.131
regulation of erk1 and erk2 cascade GO:0070372 71 0.131
negative regulation of t cell activation GO:0050868 65 0.130
Mouse
regulation of cell migration GO:0030334 219 0.129
interleukin 10 biosynthetic process GO:0042091 1 0.128
defense response to other organism GO:0098542 197 0.128
response to interleukin 15 GO:0070672 3 0.126
marginal zone b cell differentiation GO:0002315 2 0.125
humoral immune response GO:0006959 57 0.123
t cell proliferation GO:0042098 120 0.123
regulation of protein serine threonine kinase activity GO:0071900 157 0.122
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.122
cellular response to peptide hormone stimulus GO:0071375 92 0.122
regulation of cysteine type endopeptidase activity GO:2000116 65 0.121
compound eye development GO:0048749 1 0.121
stem cell differentiation GO:0048863 268 0.121
endocytosis GO:0006897 168 0.121
regulation of t helper cell differentiation GO:0045622 14 0.120
Mouse
epithelial cell development GO:0002064 159 0.119
intrinsic apoptotic signaling pathway GO:0097193 132 0.119
cellular response to interleukin 4 GO:0071353 21 0.118
protein modification by small protein conjugation or removal GO:0070647 207 0.118
Mouse
type 2 immune response GO:0042092 23 0.117
Mouse
positive regulation of inflammatory response GO:0050729 47 0.116
reactive oxygen species metabolic process GO:0072593 84 0.116
regulation of response to biotic stimulus GO:0002831 38 0.114
regulation of myeloid cell differentiation GO:0045637 96 0.114
positive regulation of t cell activation GO:0050870 101 0.113
Mouse
insulin secretion GO:0030073 89 0.112
striated muscle tissue development GO:0014706 293 0.112
skin development GO:0043588 220 0.111
Zebrafish
cellular glucan metabolic process GO:0006073 32 0.111
nucleotide metabolic process GO:0009117 332 0.110
positive regulation of cell development GO:0010720 237 0.110
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 226 0.109
regulation of epithelial cell proliferation GO:0050678 141 0.109
response to protozoan GO:0001562 28 0.109
positive regulation of cellular catabolic process GO:0031331 148 0.108
purine ribonucleotide metabolic process GO:0009150 290 0.108
homeostasis of number of cells GO:0048872 210 0.107
protein maturation GO:0051604 176 0.107
regulation of response to cytokine stimulus GO:0060759 23 0.107
interleukin 27 mediated signaling pathway GO:0070106 1 0.106
glucose homeostasis GO:0042593 128 0.106
cytokine biosynthetic process GO:0042089 68 0.105
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.105
negative regulation of response to cytokine stimulus GO:0060761 9 0.104
metal ion homeostasis GO:0055065 189 0.104
regulation of apoptotic signaling pathway GO:2001233 197 0.103
jnk cascade GO:0007254 72 0.103
extracellular matrix organization GO:0030198 147 0.103
nucleoside phosphate metabolic process GO:0006753 338 0.102
myeloid cell homeostasis GO:0002262 114 0.102
chemotaxis GO:0006935 247 0.102
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.101
regulation of immunoglobulin mediated immune response GO:0002889 37 0.101
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.101
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.101
negative regulation of phosphorylation GO:0042326 166 0.100
Mouse
positive regulation of cell adhesion GO:0045785 80 0.099
negative regulation of t helper 1 type immune response GO:0002826 5 0.099
germ cell development GO:0007281 185 0.099
peptide secretion GO:0002790 114 0.099
fasl biosynthetic process GO:0045210 2 0.098
negative regulation of nik nf kappab signaling GO:1901223 2 0.098
response to peptide hormone GO:0043434 127 0.098
alpha beta t cell lineage commitment GO:0002363 7 0.097
positive regulation of nucleoside metabolic process GO:0045979 91 0.097
peptide hormone secretion GO:0030072 109 0.096
response to amino acid GO:0043200 37 0.095
Mouse
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.094
positive regulation of leukocyte apoptotic process GO:2000108 21 0.094
ciliary neurotrophic factor mediated signaling pathway GO:0070120 1 0.093
positive regulation of antimicrobial humoral response GO:0002760 2 0.093
carbohydrate derivative biosynthetic process GO:1901137 183 0.093
protein import into nucleus GO:0006606 95 0.092
cellular metal ion homeostasis GO:0006875 151 0.092
wound healing involved in inflammatory response GO:0002246 4 0.091
erk1 and erk2 cascade GO:0070371 77 0.090
leukocyte migration GO:0050900 124 0.089
intracellular receptor signaling pathway GO:0030522 74 0.088
jak stat cascade GO:0007259 42 0.088
Mouse Rat
apoptotic signaling pathway GO:0097190 306 0.087
placenta development GO:0001890 140 0.087
rhombomere formation GO:0021594 1 0.087
cd4 positive alpha beta t cell lineage commitment GO:0043373 6 0.085
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.085
negative regulation of cellular component organization GO:0051129 194 0.084
Zebrafish
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.084
positive regulation of transferase activity GO:0051347 167 0.084
Mouse
chromatin modification GO:0016568 187 0.083
nucleoside triphosphate metabolic process GO:0009141 230 0.083
regulation of eosinophil migration GO:2000416 2 0.083
activation of immune response GO:0002253 138 0.082
leukocyte homeostasis GO:0001776 79 0.082
regulation of t cell differentiation in thymus GO:0033081 24 0.082
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.081
oxidation reduction process GO:0055114 342 0.080
innate immune response GO:0045087 157 0.080
t helper 17 cell lineage commitment GO:0072540 4 0.079
positive regulation of innate immune response GO:0045089 80 0.079
response to interferon gamma GO:0034341 34 0.078
positive regulation of nuclear transcribed mrna poly a tail shortening GO:0060213 4 0.078
stress activated mapk cascade GO:0051403 80 0.078
ribonucleoside metabolic process GO:0009119 245 0.078
divalent inorganic cation homeostasis GO:0072507 138 0.077
cellular response to interferon gamma GO:0071346 25 0.077
ribonucleoside triphosphate metabolic process GO:0009199 220 0.077
leukocyte proliferation GO:0070661 172 0.077
negative regulation of response to wounding GO:1903035 77 0.076
posttranscriptional regulation of gene expression GO:0010608 155 0.075
negative regulation of interferon gamma mediated signaling pathway GO:0060336 1 0.075
regulation of protein targeting GO:1903533 61 0.075
negative regulation of immune effector process GO:0002698 55 0.075
Mouse
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.075
blood vessel morphogenesis GO:0048514 285 0.074
negative regulation of homeostatic process GO:0032845 71 0.073
small gtpase mediated signal transduction GO:0007264 97 0.073
protein ubiquitination GO:0016567 171 0.073
Mouse
locomotory behavior GO:0007626 195 0.073
negative regulation of inflammatory response GO:0050728 61 0.073
tumor necrosis factor production GO:0032640 50 0.073
negative regulation of neuron apoptotic process GO:0043524 92 0.072
energy derivation by oxidation of organic compounds GO:0015980 77 0.072
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.072
regulation of myeloid leukocyte differentiation GO:0002761 58 0.072
syncytium formation GO:0006949 43 0.072
gliogenesis GO:0042063 141 0.071
t cell lineage commitment GO:0002360 13 0.070
polysaccharide metabolic process GO:0005976 39 0.070
interleukin 2 mediated signaling pathway GO:0038110 2 0.070
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 10 0.070
Mouse
response to growth factor GO:0070848 198 0.070
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.069
protein processing GO:0016485 163 0.069
positive regulation of cell motility GO:2000147 116 0.069
ribose phosphate metabolic process GO:0019693 291 0.069
neuron death GO:0070997 154 0.069
cytokine metabolic process GO:0042107 71 0.068
positive regulation of ossification GO:0045778 47 0.067
chromatin organization GO:0006325 206 0.067
glial cell differentiation GO:0010001 131 0.067
cellular divalent inorganic cation homeostasis GO:0072503 127 0.067
response to nutrient levels GO:0031667 109 0.067
Rat
alpha beta t cell activation GO:0046631 91 0.067
Mouse
regulation of tumor necrosis factor production GO:0032680 49 0.067
calcium ion homeostasis GO:0055074 127 0.066
regulation of map kinase activity GO:0043405 120 0.066
digestive system development GO:0055123 200 0.066
hexose biosynthetic process GO:0019319 39 0.065
monosaccharide metabolic process GO:0005996 106 0.064
b cell differentiation GO:0030183 78 0.064
mammary gland epithelium development GO:0061180 65 0.064
myotube differentiation GO:0014902 105 0.064
regulation of ovulation GO:0060278 3 0.063
heterocycle catabolic process GO:0046700 280 0.063
cellular response to dna damage stimulus GO:0006974 207 0.063
negative regulation of adaptive immune response GO:0002820 25 0.063
defense response to protozoan GO:0042832 25 0.063
regulation of cell activation GO:0050865 289 0.063
Mouse
wound healing GO:0042060 157 0.062
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.062
mesonephric tubule development GO:0072164 94 0.062
reactive nitrogen species metabolic process GO:2001057 0 0.062
nucleobase containing small molecule metabolic process GO:0055086 352 0.062
cognition GO:0050890 149 0.061
regulation of nucleotide metabolic process GO:0006140 169 0.061
regulation of lymphocyte mediated immunity GO:0002706 84 0.060
b cell activation involved in immune response GO:0002312 50 0.060
regulation of b cell activation GO:0050864 81 0.059
innate immune response activating signal transduction GO:0002758 50 0.059
ribonucleotide metabolic process GO:0009259 291 0.058
negative regulation of nf kappab transcription factor activity GO:0032088 15 0.058
purine ribonucleoside metabolic process GO:0046128 241 0.058
regulation of activation of jak2 kinase activity GO:0010534 1 0.058
Mouse
negative regulation of glycoprotein metabolic process GO:1903019 3 0.058
regulation of notch signaling pathway GO:0008593 35 0.058
epithelial cell proliferation GO:0050673 174 0.058
regulation of vesicle mediated transport GO:0060627 139 0.058
positive regulation of eosinophil migration GO:2000418 2 0.057
positive regulation of nervous system development GO:0051962 221 0.057
Mouse
carbohydrate biosynthetic process GO:0016051 74 0.057
isotype switching GO:0045190 36 0.057
regulation of binding GO:0051098 111 0.057
acute inflammatory response GO:0002526 41 0.057
positive regulation of adaptive immune response GO:0002821 61 0.057
Mouse
eosinophil migration GO:0072677 3 0.057
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.057
connective tissue development GO:0061448 179 0.056
reactive oxygen species biosynthetic process GO:1903409 8 0.056
regeneration GO:0031099 38 0.056
Zebrafish Rat
regulation of glucose metabolic process GO:0010906 60 0.056
amide transport GO:0042886 138 0.056
chemokine production GO:0032602 34 0.056
protein localization to organelle GO:0033365 185 0.055
regulation of dendritic cell cytokine production GO:0002730 2 0.055
regulation of nucleoside metabolic process GO:0009118 130 0.055
cellular response to organic cyclic compound GO:0071407 87 0.055
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.055
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.055
regulation of protein import into nucleus GO:0042306 52 0.055
glycoprotein biosynthetic process GO:0009101 89 0.055
neural tube development GO:0021915 160 0.055
defense response to gram positive bacterium GO:0050830 50 0.054
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.054
Mouse
regulation of establishment of protein localization GO:0070201 181 0.054
Mouse
negative regulation of t helper cell differentiation GO:0045623 9 0.054
Mouse
t helper 1 cell differentiation GO:0045063 13 0.054
Mouse
regulation of neuron differentiation GO:0045664 281 0.054
Zebrafish Mouse
regulation of proteolysis GO:0030162 164 0.054
syncytium formation by plasma membrane fusion GO:0000768 42 0.054
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.053
regulation of innate immune response GO:0045088 91 0.053
protein secretion GO:0009306 111 0.053
Mouse
jak stat cascade involved in growth hormone signaling pathway GO:0060397 4 0.052
cation transport GO:0006812 399 0.052
regulation of antimicrobial peptide production GO:0002784 1 0.052
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.052
negative regulation of type 2 immune response GO:0002829 8 0.052
Mouse
positive regulation of tumor necrosis factor production GO:0032760 30 0.052
regulation of homeostatic process GO:0032844 182 0.052
regulation of lymphocyte apoptotic process GO:0070228 41 0.051
neuron apoptotic process GO:0051402 142 0.051
regulation of thymocyte migration GO:2000410 2 0.051
response to extracellular stimulus GO:0009991 127 0.051
Rat
regulation of leukocyte proliferation GO:0070663 121 0.051
glycoprotein metabolic process GO:0009100 116 0.051
hormone secretion GO:0046879 128 0.051
response to insulin GO:0032868 100 0.051
muscle cell differentiation GO:0042692 261 0.050
regulation of neuron death GO:1901214 134 0.050
regulation of embryonic development GO:0045995 71 0.050
male sex differentiation GO:0046661 109 0.050
response to type i interferon GO:0034340 12 0.050
regulation of cytokine biosynthetic process GO:0042035 59 0.050
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.050
negative regulation of cell adhesion mediated by integrin GO:0033629 2 0.050
glycogen metabolic process GO:0005977 32 0.050
positive regulation of dna templated transcription elongation GO:0032786 2 0.049
cerebral cortex radially oriented cell migration GO:0021799 31 0.049
Mouse
cellular response to carbohydrate stimulus GO:0071322 50 0.049
ovulation cycle GO:0042698 59 0.049
regulation of defense response to bacterium GO:1900424 3 0.049
digestive tract development GO:0048565 190 0.049
negative regulation of ovulation GO:0060280 1 0.048
cellular response to gamma radiation GO:0071480 4 0.048
single organism nuclear import GO:1902593 95 0.048
acylglycerol metabolic process GO:0006639 55 0.048
cellular response to interleukin 15 GO:0071350 2 0.047
nucleoside metabolic process GO:0009116 246 0.047
antimicrobial peptide biosynthetic process GO:0002777 2 0.047
response to corticosteroid GO:0031960 20 0.047
Rat
radial glia guided migration of purkinje cell GO:0021942 6 0.046
Mouse
regulation of protein processing GO:0070613 96 0.046
digestive tract morphogenesis GO:0048546 147 0.046
negative regulation of cellular protein metabolic process GO:0032269 247 0.046
Mouse
negative regulation of lymphocyte activation GO:0051250 91 0.046
Mouse
response to interleukin 1 GO:0070555 11 0.046
glucan metabolic process GO:0044042 32 0.045
protein localization to nucleus GO:0034504 121 0.045
cytoplasmic transport GO:0016482 234 0.045
positive regulation of jnk cascade GO:0046330 46 0.045
gastrulation GO:0007369 116 0.045
positive regulation of neuron apoptotic process GO:0043525 25 0.045
skeletal muscle cell differentiation GO:0035914 66 0.045
positive regulation of secretion by cell GO:1903532 114 0.044
regulation of cell adhesion GO:0030155 154 0.044

Socs3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.187
disease of cellular proliferation DOID:14566 0 0.187
organ system cancer DOID:0050686 0 0.187
immune system cancer DOID:0060083 0 0.141
hematologic cancer DOID:2531 0 0.141
diabetes mellitus DOID:9351 0 0.084
type 2 diabetes mellitus DOID:9352 0 0.084
disease of metabolism DOID:0014667 0 0.084
carbohydrate metabolism disease DOID:0050013 0 0.084
glucose metabolism disease DOID:4194 0 0.084
acquired metabolic disease DOID:0060158 0 0.084
disease of anatomical entity DOID:7 0 0.076
nervous system disease DOID:863 0 0.076
neuropathy DOID:870 0 0.076
neuromuscular disease DOID:440 0 0.075
charcot marie tooth disease DOID:10595 0 0.075
immune system disease DOID:2914 0 0.062
hematopoietic system disease DOID:74 0 0.062