Mus musculus

0 known processes

Top1mt

DNA topoisomerase 1, mitochondrial

(Aliases: 2900052H09Rik)

Top1mt biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.088
transmembrane transport GO:0055085 412 0.051
cellular nitrogen compound catabolic process GO:0044270 280 0.048
aromatic compound catabolic process GO:0019439 286 0.047
cellular ketone metabolic process GO:0042180 84 0.046
positive regulation of cellular amine metabolic process GO:0033240 5 0.046
regulation of cellular ketone metabolic process GO:0010565 66 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.044
heterocycle catabolic process GO:0046700 280 0.044
organonitrogen compound catabolic process GO:1901565 264 0.044
purine ribonucleoside metabolic process GO:0046128 241 0.043
cellular amine metabolic process GO:0044106 44 0.043
organic cyclic compound catabolic process GO:1901361 295 0.042
regulation of cellular amine metabolic process GO:0033238 20 0.042
amine metabolic process GO:0009308 45 0.041
regulation of cellular amino acid metabolic process GO:0006521 5 0.038
nucleobase containing small molecule metabolic process GO:0055086 352 0.037
ribonucleoside metabolic process GO:0009119 245 0.034
purine nucleoside metabolic process GO:0042278 241 0.033
dna metabolic process GO:0006259 303 0.033
glycosyl compound metabolic process GO:1901657 246 0.033
purine nucleotide metabolic process GO:0006163 302 0.032
oxidation reduction process GO:0055114 342 0.032
nucleotide metabolic process GO:0009117 332 0.032
purine containing compound metabolic process GO:0072521 311 0.031
ion transmembrane transport GO:0034220 361 0.031
nucleoside phosphate metabolic process GO:0006753 338 0.031
regulation of membrane potential GO:0042391 192 0.031
mitochondrion organization GO:0007005 134 0.029
macromolecule catabolic process GO:0009057 281 0.028
carbohydrate derivative catabolic process GO:1901136 231 0.027
regulation of organelle organization GO:0033043 289 0.027
nucleoside metabolic process GO:0009116 246 0.027
cytokine production GO:0001816 319 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
carbohydrate derivative biosynthetic process GO:1901137 183 0.025
purine nucleoside catabolic process GO:0006152 205 0.024
peptidyl amino acid modification GO:0018193 336 0.024
purine ribonucleoside catabolic process GO:0046130 205 0.024
response to organonitrogen compound GO:0010243 246 0.024
ribonucleotide metabolic process GO:0009259 291 0.023
cell type specific apoptotic process GO:0097285 268 0.023
nitrogen compound transport GO:0071705 271 0.023
negative regulation of protein metabolic process GO:0051248 282 0.023
organonitrogen compound biosynthetic process GO:1901566 192 0.023
nucleotide catabolic process GO:0009166 217 0.022
nucleoside catabolic process GO:0009164 206 0.022
spermatogenesis GO:0007283 284 0.022
cellular response to dna damage stimulus GO:0006974 207 0.022
cation transport GO:0006812 399 0.022
cation transmembrane transport GO:0098655 266 0.022
organic hydroxy compound metabolic process GO:1901615 203 0.022
regulation of cytokine production GO:0001817 266 0.022
cytoplasmic transport GO:0016482 234 0.022
regulation of cell activation GO:0050865 289 0.022
purine ribonucleotide metabolic process GO:0009150 290 0.022
ribonucleoside catabolic process GO:0042454 206 0.022
male gamete generation GO:0048232 285 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.022
purine nucleotide catabolic process GO:0006195 211 0.021
immune effector process GO:0002252 321 0.021
apoptotic signaling pathway GO:0097190 306 0.021
cofactor metabolic process GO:0051186 80 0.020
neuronal action potential GO:0019228 54 0.020
ribonucleoside triphosphate metabolic process GO:0009199 220 0.020
carbohydrate metabolic process GO:0005975 230 0.020
cofactor transport GO:0051181 4 0.020
intracellular protein transport GO:0006886 204 0.019
purine nucleoside triphosphate metabolic process GO:0009144 226 0.019
inorganic cation transmembrane transport GO:0098662 207 0.019
cellular homeostasis GO:0019725 240 0.019
nucleoside triphosphate catabolic process GO:0009143 205 0.019
purine containing compound catabolic process GO:0072523 213 0.019
glycosyl compound catabolic process GO:1901658 206 0.019
purine ribonucleotide catabolic process GO:0009154 208 0.019
cell adhesion GO:0007155 329 0.019
regulation of protein localization GO:0032880 231 0.019
cellular lipid metabolic process GO:0044255 323 0.019
protein maturation GO:0051604 176 0.018
cellular macromolecule catabolic process GO:0044265 206 0.018
regulation of ion transport GO:0043269 215 0.018
positive regulation of cell death GO:0010942 224 0.018
ribonucleotide catabolic process GO:0009261 208 0.018
regulation of transferase activity GO:0051338 263 0.018
transmission of nerve impulse GO:0019226 76 0.018
regulation of establishment of protein localization GO:0070201 181 0.018
negative regulation of cellular protein metabolic process GO:0032269 247 0.018
homeostasis of number of cells GO:0048872 210 0.018
nucleoside phosphate catabolic process GO:1901292 222 0.018
protein localization to organelle GO:0033365 185 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
gland development GO:0048732 330 0.017
action potential GO:0001508 78 0.017
cellular metal ion homeostasis GO:0006875 151 0.017
organophosphate catabolic process GO:0046434 232 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
positive regulation of protein modification process GO:0031401 299 0.017
metal ion homeostasis GO:0055065 189 0.017
response to inorganic substance GO:0010035 96 0.017
response to organic cyclic compound GO:0014070 198 0.017
striated muscle tissue development GO:0014706 293 0.017
reactive oxygen species metabolic process GO:0072593 84 0.017
regulation of hormone levels GO:0010817 211 0.017
ribonucleoside triphosphate catabolic process GO:0009203 199 0.017
small gtpase mediated signal transduction GO:0007264 97 0.017
regulation of secretion by cell GO:1903530 249 0.017
multicellular organismal signaling GO:0035637 91 0.017
inorganic ion transmembrane transport GO:0098660 234 0.016
g protein coupled receptor signaling pathway GO:0007186 243 0.016
protein processing GO:0016485 163 0.016
anion transport GO:0006820 177 0.016
cellular chemical homeostasis GO:0055082 215 0.016
regulation of hydrolase activity GO:0051336 246 0.016
nucleoside triphosphate metabolic process GO:0009141 230 0.016
muscle tissue development GO:0060537 308 0.016
positive regulation of protein phosphorylation GO:0001934 242 0.015
anatomical structure homeostasis GO:0060249 145 0.015
skin development GO:0043588 220 0.015
cofactor biosynthetic process GO:0051188 41 0.015
positive regulation of programmed cell death GO:0043068 218 0.015
muscle system process GO:0003012 141 0.015
sensory perception GO:0007600 245 0.015
leukocyte differentiation GO:0002521 342 0.015
alpha amino acid metabolic process GO:1901605 59 0.015
regulation of secretion GO:0051046 274 0.015
nucleocytoplasmic transport GO:0006913 139 0.015
regulation of system process GO:0044057 200 0.015
negative regulation of phosphorus metabolic process GO:0010563 184 0.015
organic acid biosynthetic process GO:0016053 86 0.015
carboxylic acid biosynthetic process GO:0046394 86 0.015
divalent inorganic cation transport GO:0072511 178 0.015
t cell activation GO:0042110 289 0.015
monosaccharide metabolic process GO:0005996 106 0.015
cation homeostasis GO:0055080 212 0.015
neuron apoptotic process GO:0051402 142 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
membrane organization GO:0061024 245 0.014
myeloid cell differentiation GO:0030099 233 0.014
synaptic transmission GO:0007268 329 0.014
cellular response to lipid GO:0071396 145 0.014
intrinsic apoptotic signaling pathway GO:0097193 132 0.014
sulfur compound metabolic process GO:0006790 100 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
regulation of kinase activity GO:0043549 249 0.014
coenzyme metabolic process GO:0006732 52 0.014
nuclear transport GO:0051169 139 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
cellular carbohydrate metabolic process GO:0044262 119 0.014
regulation of anatomical structure size GO:0090066 178 0.014
response to radiation GO:0009314 165 0.014
circulatory system process GO:0003013 197 0.014
divalent metal ion transport GO:0070838 172 0.014
alcohol metabolic process GO:0006066 116 0.014
cellular ion homeostasis GO:0006873 165 0.014
organic hydroxy compound transport GO:0015850 93 0.013
regulation of transmembrane transport GO:0034762 128 0.013
locomotory behavior GO:0007626 195 0.013
positive regulation of cell development GO:0010720 237 0.013
regulation of defense response GO:0031347 233 0.013
inflammatory response GO:0006954 244 0.013
response to oxidative stress GO:0006979 123 0.013
negative regulation of immune system process GO:0002683 209 0.013
muscle cell differentiation GO:0042692 261 0.013
organic anion transport GO:0015711 137 0.013
positive regulation of cytokine production GO:0001819 174 0.013
protein targeting GO:0006605 143 0.013
regulation of protein transport GO:0051223 163 0.013
translation GO:0006412 93 0.013
cell substrate adhesion GO:0031589 130 0.013
fat cell differentiation GO:0045444 160 0.013
lateral inhibition GO:0046331 1 0.013
regulation of intracellular transport GO:0032386 159 0.013
cellular protein complex assembly GO:0043623 116 0.013
neuron death GO:0070997 154 0.013
renal system development GO:0072001 225 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
blood circulation GO:0008015 195 0.013
chromatin organization GO:0006325 206 0.013
positive regulation of hydrolase activity GO:0051345 148 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
calcium ion transport GO:0006816 159 0.012
activation of immune response GO:0002253 138 0.012
protein catabolic process GO:0030163 221 0.012
mapk cascade GO:0000165 281 0.012
macromolecule methylation GO:0043414 120 0.012
regulation of homeostatic process GO:0032844 182 0.012
negative regulation of protein modification process GO:0031400 163 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
organophosphate biosynthetic process GO:0090407 122 0.012
cellular response to cytokine stimulus GO:0071345 189 0.012
hexose metabolic process GO:0019318 98 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
regulation of cellular catabolic process GO:0031329 242 0.012
compound eye development GO:0048749 1 0.012
methylation GO:0032259 134 0.012
regulation of response to wounding GO:1903034 189 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
negative regulation of molecular function GO:0044092 258 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
ras protein signal transduction GO:0007265 77 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
carboxylic acid transport GO:0046942 100 0.012
establishment of protein localization to organelle GO:0072594 118 0.012
regulation of neuron death GO:1901214 134 0.012
regulation of purine nucleotide metabolic process GO:1900542 169 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
protein import GO:0017038 101 0.012
regulation of cell adhesion GO:0030155 154 0.012
regulation of interleukin 8 production GO:0032677 3 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
positive regulation of lymphocyte activation GO:0051251 140 0.011
lymphocyte proliferation GO:0046651 164 0.011
calcium ion homeostasis GO:0055074 127 0.011
organic acid transport GO:0015849 101 0.011
cellular modified amino acid metabolic process GO:0006575 63 0.011
carbohydrate homeostasis GO:0033500 128 0.011
rho protein signal transduction GO:0007266 32 0.011
regulation of ion transmembrane transport GO:0034765 119 0.011
lymphocyte differentiation GO:0030098 242 0.011
regulation of translation GO:0006417 71 0.011
regulation of cellular response to stress GO:0080135 159 0.011
cellular divalent inorganic cation homeostasis GO:0072503 127 0.011
monocarboxylic acid metabolic process GO:0032787 191 0.011
dephosphorylation GO:0016311 129 0.011
response to lipopolysaccharide GO:0032496 128 0.011
regulation of mapk cascade GO:0043408 248 0.011
regulation of cell motility GO:2000145 236 0.011
regulation of t cell activation GO:0050863 170 0.011
response to molecule of bacterial origin GO:0002237 143 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
cognition GO:0050890 149 0.011
glycoprotein metabolic process GO:0009100 116 0.011
forebrain development GO:0030900 302 0.011
regulation of protein kinase activity GO:0045859 232 0.011
cellular calcium ion homeostasis GO:0006874 119 0.011
regulation of neuron differentiation GO:0045664 281 0.011
epithelial cell development GO:0002064 159 0.011
response to acid chemical GO:0001101 111 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
glucose homeostasis GO:0042593 128 0.011
regulation of proteolysis GO:0030162 164 0.011
adult behavior GO:0030534 135 0.011
regulation of inflammatory response GO:0050727 147 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
b cell activation GO:0042113 161 0.011
negative regulation of phosphorylation GO:0042326 166 0.010
wnt signaling pathway GO:0016055 188 0.010
carboxylic acid catabolic process GO:0046395 51 0.010
epithelial cell proliferation GO:0050673 174 0.010
innate immune response GO:0045087 157 0.010
nucleoside monophosphate metabolic process GO:0009123 85 0.010
lipid biosynthetic process GO:0008610 179 0.010
positive regulation of transferase activity GO:0051347 167 0.010
interleukin 8 production GO:0032637 4 0.010
tissue homeostasis GO:0001894 115 0.010
regulation of neuron apoptotic process GO:0043523 122 0.010
ribonucleoside bisphosphate metabolic process GO:0033875 9 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.010
endomembrane system organization GO:0010256 147 0.010
regulation of cytoplasmic transport GO:1903649 112 0.010
heart process GO:0003015 94 0.010
response to oxygen levels GO:0070482 62 0.010
negative regulation of cellular amine metabolic process GO:0033239 1 0.010
sequestering of calcium ion GO:0051208 18 0.010
urogenital system development GO:0001655 261 0.010
amide transport GO:0042886 138 0.010

Top1mt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
disease of metabolism DOID:0014667 0 0.023
inherited metabolic disorder DOID:655 0 0.017
central nervous system disease DOID:331 0 0.014
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
musculoskeletal system disease DOID:17 0 0.011
neurodegenerative disease DOID:1289 0 0.011
sensory system disease DOID:0050155 0 0.010
eye and adnexa disease DOID:1492 0 0.010
eye disease DOID:5614 0 0.010