Mus musculus

90 known processes

Chd8

chromodomain helicase DNA binding protein 8

(Aliases: Duplin,mKIAA1564,HELSNF1,AU015341,5830451P18Rik)

Chd8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amine metabolic process GO:0044106 44 0.183
dna metabolic process GO:0006259 303 0.119
Human
cellular amino acid metabolic process GO:0006520 103 0.118
amine metabolic process GO:0009308 45 0.105
cellular ketone metabolic process GO:0042180 84 0.100
methylation GO:0032259 134 0.086
regulation of cellular amino acid metabolic process GO:0006521 5 0.084
dna packaging GO:0006323 30 0.083
regulation of cellular amine metabolic process GO:0033238 20 0.080
regulation of organelle organization GO:0033043 289 0.073
regulation of cellular ketone metabolic process GO:0010565 66 0.073
dna alkylation GO:0006305 43 0.064
histone methylation GO:0016571 71 0.059
dna methylation involved in gamete generation GO:0043046 15 0.052
dna methylation GO:0006306 43 0.052
protein alkylation GO:0008213 81 0.051
chromatin organization GO:0006325 206 0.051
Human
chromatin modification GO:0016568 187 0.051
Human
regulation of chromatin organization GO:1902275 57 0.050
regulation of histone methylation GO:0031060 30 0.049
histone modification GO:0016570 159 0.048
compound eye development GO:0048749 1 0.042
nuclear transport GO:0051169 139 0.040
dna conformation change GO:0071103 37 0.039
Human
covalent chromatin modification GO:0016569 163 0.039
chemotaxis GO:0006935 247 0.037
Fly
internal protein amino acid acetylation GO:0006475 42 0.036
regulation of histone modification GO:0031056 56 0.035
dna modification GO:0006304 50 0.034
peptidyl amino acid modification GO:0018193 336 0.034
regulation of chromosome organization GO:0033044 83 0.033
protein localization to organelle GO:0033365 185 0.033
protein methylation GO:0006479 81 0.032
leukocyte differentiation GO:0002521 342 0.031
chromatin assembly GO:0031497 13 0.031
epithalamus development GO:0021538 2 0.030
genetic imprinting GO:0071514 27 0.029
macromolecule methylation GO:0043414 120 0.029
purine nucleoside metabolic process GO:0042278 241 0.028
Human
negative regulation of molecular function GO:0044092 258 0.028
internal peptidyl lysine acetylation GO:0018393 42 0.027
regulation of purine nucleotide catabolic process GO:0033121 122 0.026
transmission of nerve impulse GO:0019226 76 0.025
regionalization GO:0003002 337 0.024
Fly
homeostasis of number of cells GO:0048872 210 0.024
blastocyst growth GO:0001832 23 0.024
histone acetylation GO:0016573 41 0.024
regulation of cell cycle GO:0051726 281 0.023
blastocyst development GO:0001824 80 0.023
nucleoside phosphate metabolic process GO:0006753 338 0.022
Human
spermatogenesis GO:0007283 284 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.022
cellular response to dna damage stimulus GO:0006974 207 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
nucleocytoplasmic transport GO:0006913 139 0.022
regulation of chromatin modification GO:1903308 57 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
male gamete generation GO:0048232 285 0.021
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.021
endocytosis GO:0006897 168 0.020
aromatic compound catabolic process GO:0019439 286 0.020
Human
regulation of cell projection organization GO:0031344 206 0.020
regulation of transcription during meiosis GO:0051037 1 0.020
posttranscriptional regulation of gene expression GO:0010608 155 0.019
multicellular organismal signaling GO:0035637 91 0.019
chromatin assembly or disassembly GO:0006333 16 0.019
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
small molecule biosynthetic process GO:0044283 132 0.019
dna repair GO:0006281 107 0.019
regulation of protein localization GO:0032880 231 0.019
nucleotide catabolic process GO:0009166 217 0.019
Human
segmentation GO:0035282 93 0.019
Fly
purine containing compound metabolic process GO:0072521 311 0.019
Human
protein acylation GO:0043543 64 0.019
ribonucleotide metabolic process GO:0009259 291 0.019
Human
hematopoietic progenitor cell differentiation GO:0002244 143 0.019
lymphocyte differentiation GO:0030098 242 0.018
skeletal system development GO:0001501 356 0.018
central nervous system neuron differentiation GO:0021953 162 0.018
segment specification GO:0007379 15 0.018
Fly
nucleosome positioning GO:0016584 4 0.018
respiratory tube development GO:0030323 167 0.018
chromatin silencing at rdna GO:0000183 3 0.017
cytokine production GO:0001816 319 0.017
rap protein signal transduction GO:0032486 3 0.017
rho protein signal transduction GO:0007266 32 0.017
lung development GO:0030324 164 0.017
immune effector process GO:0002252 321 0.017
exocytosis GO:0006887 121 0.017
purine ribonucleoside metabolic process GO:0046128 241 0.017
Human
asymmetric stem cell division GO:0098722 3 0.017
ras protein signal transduction GO:0007265 77 0.017
nucleoside metabolic process GO:0009116 246 0.017
Human
meiotic cell cycle process GO:1903046 77 0.016
forebrain development GO:0030900 302 0.016
Mouse
nitrogen compound transport GO:0071705 271 0.016
negative regulation of synapse assembly GO:0051964 3 0.016
mapk cascade GO:0000165 281 0.016
blood circulation GO:0008015 195 0.016
Mouse
cell activation involved in immune response GO:0002263 126 0.016
cognition GO:0050890 149 0.016
Fly
gene silencing GO:0016458 38 0.016
negative regulation of protein modification process GO:0031400 163 0.016
cellular chemical homeostasis GO:0055082 215 0.016
neuronal action potential GO:0019228 54 0.016
purine containing compound catabolic process GO:0072523 213 0.016
Human
heart morphogenesis GO:0003007 178 0.015
Mouse
positive regulation of dna templated transcription elongation GO:0032786 2 0.015
regulation of membrane potential GO:0042391 192 0.015
regulation of cell motility GO:2000145 236 0.015
innate immune response GO:0045087 157 0.015
protein dna complex subunit organization GO:0071824 28 0.015
nucleoside catabolic process GO:0009164 206 0.015
Human
ribonucleoside metabolic process GO:0009119 245 0.015
Human
purine ribonucleoside catabolic process GO:0046130 205 0.015
Human
small gtpase mediated signal transduction GO:0007264 97 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.015
cell division GO:0051301 120 0.015
positive regulation of protein phosphorylation GO:0001934 242 0.015
purine nucleotide catabolic process GO:0006195 211 0.015
Human
organic cyclic compound catabolic process GO:1901361 295 0.015
Human
gland development GO:0048732 330 0.014
organonitrogen compound catabolic process GO:1901565 264 0.014
Human
mitotic cell cycle GO:0000278 195 0.014
neuron projection guidance GO:0097485 141 0.014
Fly
regulation of system process GO:0044057 200 0.014
negative regulation of organelle organization GO:0010639 90 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
Human
negative regulation of chromosome organization GO:2001251 30 0.014
regulation of transferase activity GO:0051338 263 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
sensory system development GO:0048880 3 0.014
organelle localization GO:0051640 179 0.014
positive regulation of protein modification process GO:0031401 299 0.014
cell recognition GO:0008037 83 0.014
vesicle localization GO:0051648 86 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
Human
erythrocyte differentiation GO:0030218 88 0.013
ear development GO:0043583 200 0.013
Mouse
action potential GO:0001508 78 0.013
regulation of kinase activity GO:0043549 249 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
gonad development GO:0008406 141 0.013
peptidyl lysine acetylation GO:0018394 45 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
Human
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
regulation of cell cycle process GO:0010564 160 0.013
regulation of actin filament based process GO:0032970 99 0.013
protein ubiquitination GO:0016567 171 0.013
regulation of cell migration GO:0030334 219 0.013
anatomical structure homeostasis GO:0060249 145 0.013
regulation of gene expression by genetic imprinting GO:0006349 15 0.013
cytoplasmic transport GO:0016482 234 0.013
protein localization to nucleus GO:0034504 121 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.013
Human
histone lysine methylation GO:0034968 50 0.013
ribose phosphate metabolic process GO:0019693 291 0.013
Human
fertilization GO:0009566 127 0.012
purine ribonucleotide metabolic process GO:0009150 290 0.012
Human
negative regulation of intracellular signal transduction GO:1902532 167 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
protein modification by small protein conjugation or removal GO:0070647 207 0.012
nuclear division GO:0000280 158 0.012
cell adhesion GO:0007155 329 0.012
habenula development GO:0021986 2 0.012
meiotic cell cycle GO:0051321 122 0.012
regulation of mapk cascade GO:0043408 248 0.012
maintenance of location GO:0051235 89 0.012
regulation of neuron differentiation GO:0045664 281 0.012
regulation of inositol trisphosphate biosynthetic process GO:0032960 3 0.012
neural precursor cell proliferation GO:0061351 121 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
purine nucleoside triphosphate metabolic process GO:0009144 226 0.012
Human
cellular response to lipid GO:0071396 145 0.012
mitotic cytokinesis GO:0000281 4 0.012
regulation of cellular response to stress GO:0080135 159 0.012
positive regulation of gtp catabolic process GO:0033126 85 0.012
negative regulation of phosphorylation GO:0042326 166 0.012
respiratory system development GO:0060541 190 0.012
Mouse
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
Human
negative regulation of phosphate metabolic process GO:0045936 184 0.011
regulation of secretion by cell GO:1903530 249 0.011
protein targeting GO:0006605 143 0.011
b cell activation GO:0042113 161 0.011
cellular homeostasis GO:0019725 240 0.011
positive regulation of nucleoside metabolic process GO:0045979 91 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
regulation of defense response GO:0031347 233 0.011
histone h3 acetylation GO:0043966 14 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
terminal button organization GO:0072553 3 0.011
response to inorganic substance GO:0010035 96 0.011
negative regulation of cellular amine metabolic process GO:0033239 1 0.011
alpha beta t cell activation GO:0046631 91 0.011
sensory perception GO:0007600 245 0.011
Mouse
actin cytoskeleton organization GO:0030036 220 0.011
sperm motility GO:0030317 47 0.011
positive regulation of organelle organization GO:0010638 128 0.011
regulation of secretion GO:0051046 274 0.011
mrna transcription from rna polymerase ii promoter GO:0042789 4 0.011
regulation of intracellular transport GO:0032386 159 0.011
intracellular protein transport GO:0006886 204 0.011
germ cell development GO:0007281 185 0.011
Fly
carbohydrate metabolic process GO:0005975 230 0.011
synapse organization GO:0050808 125 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.011
Human
regulation of inositol phosphate biosynthetic process GO:0010919 3 0.010
single fertilization GO:0007338 82 0.010
negative regulation of cell proliferation GO:0008285 296 0.010
cation transmembrane transport GO:0098655 266 0.010
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.010
Human
t cell activation GO:0042110 289 0.010
myeloid cell homeostasis GO:0002262 114 0.010
immunoglobulin production GO:0002377 73 0.010
nucleotide metabolic process GO:0009117 332 0.010
Human
axon ensheathment GO:0008366 76 0.010
epithelial cell development GO:0002064 159 0.010
Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.010
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.010
myeloid cell differentiation GO:0030099 233 0.010
sequestering of metal ion GO:0051238 19 0.010
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
immune response regulating signaling pathway GO:0002764 125 0.010
regulation of cytoplasmic transport GO:1903649 112 0.010
nucleobase containing small molecule metabolic process GO:0055086 352 0.010
Human
purine nucleoside triphosphate catabolic process GO:0009146 203 0.010
Human
ribonucleoside catabolic process GO:0042454 206 0.010
Human
regulation of lymphocyte activation GO:0051249 240 0.010
cation transport GO:0006812 399 0.010
dna recombination GO:0006310 92 0.010

Chd8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.023
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
inherited metabolic disorder DOID:655 0 0.013
central nervous system disease DOID:331 0 0.012