Mus musculus

3 known processes

Sh2d2a

SH2 domain protein 2A

(Aliases: Lad,Ribp,Tsad)

Sh2d2a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
interleukin 12 secretion GO:0072610 3 0.898
cytokine production GO:0001816 319 0.885
t cell activation GO:0042110 289 0.875
Mouse
adaptive immune response GO:0002250 155 0.867
leukocyte mediated immunity GO:0002443 174 0.842
positive regulation of lymphocyte proliferation GO:0050671 70 0.814
regulation of lymphocyte activation GO:0051249 240 0.786
positive regulation of leukocyte mediated immunity GO:0002705 70 0.776
regulation of cytokine production GO:0001817 266 0.775
immune effector process GO:0002252 321 0.731
apoptotic signaling pathway GO:0097190 306 0.708
positive regulation of t cell activation GO:0050870 101 0.698
positive regulation of t cell proliferation GO:0042102 52 0.693
positive regulation of leukocyte proliferation GO:0070665 73 0.685
leukocyte differentiation GO:0002521 342 0.685
lymphocyte mediated immunity GO:0002449 139 0.681
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.676
positive regulation of cellular amine metabolic process GO:0033240 5 0.674
alpha beta t cell activation GO:0046631 91 0.674
positive regulation of cytokine production GO:0001819 174 0.668
response to lipopolysaccharide GO:0032496 128 0.663
production of molecular mediator of immune response GO:0002440 103 0.644
positive regulation of lymphocyte activation GO:0051251 140 0.635
t cell proliferation GO:0042098 120 0.621
regulation of cell activation GO:0050865 289 0.602
regulation of alpha beta t cell proliferation GO:0046640 18 0.594
lymphocyte proliferation GO:0046651 164 0.584
mature dendritic cell differentiation GO:0097029 3 0.569
lymphocyte differentiation GO:0030098 242 0.556
extrinsic apoptotic signaling pathway GO:0097191 126 0.549
regulation of t cell activation GO:0050863 170 0.540
regulation of t cell proliferation GO:0042129 92 0.531
positive regulation of immune effector process GO:0002699 107 0.528
positive regulation of protein phosphorylation GO:0001934 242 0.526
regulation of adaptive immune response GO:0002819 90 0.524
regulation of defense response GO:0031347 233 0.520
myeloid leukocyte differentiation GO:0002573 119 0.520
positive regulation of monocyte chemotaxis GO:0090026 2 0.518
leukocyte proliferation GO:0070661 172 0.515
regulation of leukocyte proliferation GO:0070663 121 0.506
cytokine mediated signaling pathway GO:0019221 115 0.489
regulation of secretion by cell GO:1903530 249 0.487
amine metabolic process GO:0009308 45 0.485
regulation of cytokine secretion GO:0050707 61 0.478
interleukin 10 secretion GO:0072608 4 0.473
leukocyte migration GO:0050900 124 0.466
response to molecule of bacterial origin GO:0002237 143 0.466
positive regulation of programmed cell death GO:0043068 218 0.464
t cell differentiation GO:0030217 174 0.462
positive regulation of cell activation GO:0050867 158 0.459
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.459
regulation of alpha beta t cell activation GO:0046634 53 0.454
regulation of cellular amino acid metabolic process GO:0006521 5 0.451
antigen receptor mediated signaling pathway GO:0050851 64 0.451
regulation of apoptotic signaling pathway GO:2001233 197 0.445
inflammatory response GO:0006954 244 0.440
cation homeostasis GO:0055080 212 0.436
positive regulation of protein modification process GO:0031401 299 0.422
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.415
regulation of lymphocyte proliferation GO:0050670 117 0.414
cellular amine metabolic process GO:0044106 44 0.412
regulation of protein transport GO:0051223 163 0.407
cytokine secretion GO:0050663 72 0.397
positive regulation of t cell costimulation GO:2000525 2 0.396
cellular response to lipopolysaccharide GO:0071222 77 0.391
positive regulation of cell death GO:0010942 224 0.390
peptidyl tyrosine modification GO:0018212 145 0.377
regulation of protein kinase activity GO:0045859 232 0.373
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.371
positive regulation of cell migration GO:0030335 109 0.369
regulation of leukocyte mediated immunity GO:0002703 104 0.367
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.365
cell type specific apoptotic process GO:0097285 268 0.361
Mouse
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.360
sequestering of calcium ion GO:0051208 18 0.354
alpha beta t cell proliferation GO:0046633 21 0.354
positive regulation of t cell mediated cytotoxicity GO:0001916 15 0.341
regulation of cell migration GO:0030334 219 0.335
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.332
positive regulation of apoptotic process GO:0043065 217 0.329
regulation of establishment of protein localization GO:0070201 181 0.327
regulation of inflammatory response GO:0050727 147 0.326
g protein coupled receptor signaling pathway GO:0007186 243 0.325
regulation of eosinophil degranulation GO:0043309 1 0.321
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.314
regulation of cellular amine metabolic process GO:0033238 20 0.307
negative regulation of apoptotic signaling pathway GO:2001234 104 0.305
regulation of kinase activity GO:0043549 249 0.296
regulation of response to wounding GO:1903034 189 0.293
negative regulation of immune system process GO:0002683 209 0.290
small gtpase mediated signal transduction GO:0007264 97 0.289
cellular response to cytokine stimulus GO:0071345 189 0.283
t cell costimulation GO:0031295 14 0.283
leukocyte apoptotic process GO:0071887 71 0.279
Mouse
regulation of protein secretion GO:0050708 82 0.277
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.276
morphogenesis of a branching epithelium GO:0061138 193 0.274
negative regulation of macrophage apoptotic process GO:2000110 3 0.270
positive regulation of interferon gamma production GO:0032729 39 0.270
leukocyte activation involved in immune response GO:0002366 126 0.267
positive regulation of inflammatory response GO:0050729 47 0.260
regulation of lymphocyte mediated immunity GO:0002706 84 0.254
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.249
cytokine production involved in immune response GO:0002367 34 0.247
myeloid leukocyte mediated immunity GO:0002444 42 0.239
cellular amino acid metabolic process GO:0006520 103 0.236
regulation of homeostatic process GO:0032844 182 0.235
Mouse
t cell migration GO:0072678 19 0.233
regulation of interleukin 10 secretion GO:2001179 4 0.230
immune complex clearance GO:0002434 2 0.229
glycoprotein metabolic process GO:0009100 116 0.223
defense response to other organism GO:0098542 197 0.223
cdc42 protein signal transduction GO:0032488 0 0.223
morphogenesis of a branching structure GO:0001763 203 0.219
regulation of protein localization GO:0032880 231 0.218
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.216
mapk cascade GO:0000165 281 0.213
epithelial cell proliferation GO:0050673 174 0.213
negative regulation of interleukin 10 secretion GO:2001180 2 0.212
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.211
positive regulation of mapk cascade GO:0043410 170 0.211
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.207
sensory organ morphogenesis GO:0090596 242 0.204
t helper 1 type immune response GO:0042088 25 0.202
activation of immune response GO:0002253 138 0.202
interferon gamma production GO:0032609 67 0.197
positive regulation of adaptive immune response GO:0002821 61 0.196
peptidyl amino acid modification GO:0018193 336 0.196
positive regulation of alpha beta t cell proliferation GO:0046641 12 0.195
cellular response to biotic stimulus GO:0071216 92 0.194
cell adhesion GO:0007155 329 0.193
t cell mediated immunity GO:0002456 50 0.191
positive regulation of behavior GO:0048520 40 0.190
regulation of monocyte chemotaxis GO:0090025 3 0.189
divalent metal ion transport GO:0070838 172 0.187
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.187
positive regulation of protein kinase activity GO:0045860 144 0.186
cation transport GO:0006812 399 0.185
protein secretion GO:0009306 111 0.180
regulation of cell motility GO:2000145 236 0.180
exocytosis GO:0006887 121 0.179
regulation of interferon gamma production GO:0032649 57 0.178
regulation of secretion GO:0051046 274 0.176
positive regulation of defense response GO:0031349 124 0.173
regulation of cellular ketone metabolic process GO:0010565 66 0.172
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.171
positive regulation of cell killing GO:0031343 33 0.170
regulation of transferase activity GO:0051338 263 0.167
intrinsic apoptotic signaling pathway GO:0097193 132 0.164
sequestering of metal ion GO:0051238 19 0.164
positive regulation of eosinophil migration GO:2000418 2 0.163
cellular ketone metabolic process GO:0042180 84 0.162
positive regulation of kinase activity GO:0033674 155 0.162
epithelial tube morphogenesis GO:0060562 303 0.161
hematopoietic stem cell migration GO:0035701 1 0.160
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.160
metal ion homeostasis GO:0055065 189 0.160
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.159
cellular response to lipid GO:0071396 145 0.159
leukocyte mediated cytotoxicity GO:0001909 62 0.158
t cell selection GO:0045058 34 0.157
regulation of membrane potential GO:0042391 192 0.157
Mouse
gland development GO:0048732 330 0.154
cell killing GO:0001906 67 0.154
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.151
chemotaxis GO:0006935 247 0.151
positive regulation of cytokine biosynthetic process GO:0042108 40 0.146
regulation of mapk cascade GO:0043408 248 0.146
glycoprotein biosynthetic process GO:0009101 89 0.145
sensory perception of pain GO:0019233 47 0.144
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.144
immune response activating signal transduction GO:0002757 116 0.143
positive regulation of chemotaxis GO:0050921 38 0.142
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.140
regulation of angiogenesis GO:0045765 81 0.140
regulation of interleukin 2 production GO:0032663 28 0.140
interleukin 2 production GO:0032623 33 0.138
astrocyte cell migration GO:0043615 3 0.137
regulation of leukocyte apoptotic process GO:2000106 56 0.136
Mouse
negative regulation of t cell activation GO:0050868 65 0.135
antigen processing and presentation GO:0019882 47 0.135
regulation of lymphocyte anergy GO:0002911 4 0.135
positive regulation of alpha beta t cell activation GO:0046635 39 0.134
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.133
t cell receptor signaling pathway GO:0050852 46 0.133
negative regulation of eosinophil degranulation GO:0043310 1 0.132
positive regulation of cell motility GO:2000147 116 0.131
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.130
eosinophil activation GO:0043307 1 0.129
regulation of erk1 and erk2 cascade GO:0070372 71 0.129
regulation of epithelial cell proliferation GO:0050678 141 0.128
divalent inorganic cation homeostasis GO:0072507 138 0.127
peptidyl tyrosine phosphorylation GO:0018108 143 0.127
regulation of cell killing GO:0031341 40 0.125
negative regulation of growth GO:0045926 99 0.124
eosinophil mediated immunity GO:0002447 1 0.124
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.120
positive t cell selection GO:0043368 23 0.120
lymphocyte apoptotic process GO:0070227 54 0.120
Mouse
cellular ion homeostasis GO:0006873 165 0.120
regulation of t cell costimulation GO:2000523 2 0.119
cellular homeostasis GO:0019725 240 0.118
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.118
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.118
regulation of angiotensin levels in blood GO:0002002 4 0.118
cellular response to molecule of bacterial origin GO:0071219 83 0.118
dna metabolic process GO:0006259 303 0.118
inflammatory response to antigenic stimulus GO:0002437 30 0.116
positive regulation of hydrolase activity GO:0051345 148 0.116
myeloid cell apoptotic process GO:0033028 22 0.116
b cell mediated immunity GO:0019724 71 0.115
t cell differentiation in thymus GO:0033077 77 0.115
lymphocyte activation involved in immune response GO:0002285 93 0.114
dendritic cell chemotaxis GO:0002407 7 0.114
regulation of hydrolase activity GO:0051336 246 0.114
helper t cell chemotaxis GO:0035704 1 0.113
regulation of interleukin 1 secretion GO:0050704 15 0.112
microglial cell activation involved in immune response GO:0002282 1 0.112
somatic cell dna recombination GO:0016444 51 0.111
protein maturation GO:0051604 176 0.111
eosinophil activation involved in immune response GO:0002278 1 0.111
natural killer cell activation GO:0030101 44 0.110
regulation of t helper 2 cell cytokine production GO:2000551 3 0.110
b cell activation GO:0042113 161 0.110
regulation of eosinophil migration GO:2000416 2 0.109
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.108
branching morphogenesis of an epithelial tube GO:0048754 159 0.108
regulation of cell adhesion GO:0030155 154 0.108
ameboidal type cell migration GO:0001667 128 0.107
immunoglobulin mediated immune response GO:0016064 69 0.106
regulation of innate immune response GO:0045088 91 0.105
skeletal muscle organ development GO:0060538 163 0.105
positive regulation of t cell extravasation GO:2000409 2 0.104
positive regulation of cellular catabolic process GO:0031331 148 0.104
regulation of cellular catabolic process GO:0031329 242 0.102
divalent inorganic cation transport GO:0072511 178 0.102
response to radiation GO:0009314 165 0.102
regulation of cytokine production involved in immune response GO:0002718 26 0.102
myeloid cell differentiation GO:0030099 233 0.102
t cell activation involved in immune response GO:0002286 43 0.102
t cell extravasation GO:0072683 4 0.102
cytokine metabolic process GO:0042107 71 0.100
cellular response to acid chemical GO:0071229 68 0.100
defense response to virus GO:0051607 68 0.100
gliogenesis GO:0042063 141 0.100
t cell differentiation involved in immune response GO:0002292 30 0.100
neuron death GO:0070997 154 0.100
regulation of gtp catabolic process GO:0033124 113 0.099
regulation of leukocyte differentiation GO:1902105 159 0.098
regulation of immunological synapse formation GO:2000520 2 0.098
negative thymic t cell selection GO:0045060 12 0.097
t cell mediated cytotoxicity GO:0001913 26 0.097
regulation of vesicle mediated transport GO:0060627 139 0.096
lymphocyte migration GO:0072676 26 0.096
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.096
growth of symbiont in host GO:0044117 23 0.096
regulation of chemotaxis GO:0050920 53 0.095
positive regulation of response to wounding GO:1903036 66 0.094
tumor necrosis factor production GO:0032640 50 0.094
rho protein signal transduction GO:0007266 32 0.094
forebrain development GO:0030900 302 0.093
positive regulation of cell development GO:0010720 237 0.093
regulation of neutrophil chemotaxis GO:0090022 14 0.093
transmission of nerve impulse GO:0019226 76 0.093
negative regulation of defense response GO:0031348 77 0.093
regulation of neuron differentiation GO:0045664 281 0.092
regulation of dendritic cell chemotaxis GO:2000508 1 0.092
interleukin 1 beta production GO:0032611 30 0.092
regulation of t helper 1 cell cytokine production GO:2000554 1 0.092
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.090
action potential GO:0001508 78 0.090
positive regulation of monocyte extravasation GO:2000439 1 0.090
dna recombination GO:0006310 92 0.090
calcium ion transport into cytosol GO:0060402 48 0.090
positive regulation of protein secretion GO:0050714 52 0.089
regulation of production of molecular mediator of immune response GO:0002700 65 0.089
regulation of peptidase activity GO:0052547 96 0.089
positive regulation of thymocyte migration GO:2000412 2 0.089
neuron apoptotic process GO:0051402 142 0.089
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.089
cell fate commitment GO:0045165 210 0.088
molting cycle GO:0042303 90 0.088
cytokine biosynthetic process GO:0042089 68 0.088
immunoglobulin production GO:0002377 73 0.088
calcium ion homeostasis GO:0055074 127 0.088
regulation of acute inflammatory response GO:0002673 27 0.087
positive regulation of epithelial cell proliferation GO:0050679 68 0.087
regulation of protein serine threonine kinase activity GO:0071900 157 0.087
innate immune response GO:0045087 157 0.087
sensory perception GO:0007600 245 0.087
erk1 and erk2 cascade GO:0070371 77 0.087
angiogenesis GO:0001525 201 0.086
interleukin 1 production GO:0032612 31 0.086
t helper 1 cell cytokine production GO:0035744 1 0.086
acute inflammatory response GO:0002526 41 0.085
positive regulation of gtp catabolic process GO:0033126 85 0.083
learning or memory GO:0007611 148 0.083
reactive oxygen species metabolic process GO:0072593 84 0.083
regulation of b cell activation GO:0050864 81 0.083
negative regulation of phosphorus metabolic process GO:0010563 184 0.082
muscle tissue development GO:0060537 308 0.082
regulation of ion transport GO:0043269 215 0.082
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.082
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.081
positive regulation of neutrophil chemotaxis GO:0090023 12 0.081
norepinephrine secretion GO:0048243 2 0.080
positive regulation of ion transport GO:0043270 65 0.080
positive regulation of protein transport GO:0051222 93 0.080
regulation of ion homeostasis GO:2000021 64 0.079
Mouse
cell cell recognition GO:0009988 44 0.079
regulation of monocyte extravasation GO:2000437 2 0.079
regulation of actin filament based process GO:0032970 99 0.079
regulation of norepinephrine secretion GO:0014061 2 0.079
dendritic cell antigen processing and presentation GO:0002468 7 0.079
positive regulation of gtpase activity GO:0043547 85 0.078
endocytosis GO:0006897 168 0.078
cellular response to dna damage stimulus GO:0006974 207 0.078
regulation of rho protein signal transduction GO:0035023 71 0.078
regulation of t cell extravasation GO:2000407 3 0.077
dendritic cell differentiation GO:0097028 26 0.077
regulation of cytoplasmic transport GO:1903649 112 0.077
positive regulation of transferase activity GO:0051347 167 0.076
gtp catabolic process GO:0006184 143 0.076
cellular divalent inorganic cation homeostasis GO:0072503 127 0.076
chemokine mediated signaling pathway GO:0070098 17 0.076
epidermis development GO:0008544 187 0.076
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.075
eosinophil migration GO:0072677 3 0.075
regulation of map kinase activity GO:0043405 120 0.075
natural killer cell chemotaxis GO:0035747 1 0.075
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.074
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.074
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.073
response to growth factor GO:0070848 198 0.073
regulation of neuron death GO:1901214 134 0.072
positive regulation of b cell activation GO:0050871 49 0.072
synaptic transmission GO:0007268 329 0.071
regulation of natural killer cell mediated immunity GO:0002715 19 0.071
regulation of type 2 immune response GO:0002828 18 0.071
regulation of interleukin 12 production GO:0032655 30 0.071
protein processing GO:0016485 163 0.070
regulation of hematopoietic stem cell migration GO:2000471 1 0.070
regulation of cell projection organization GO:0031344 206 0.070
t helper 17 cell chemotaxis GO:0035705 1 0.070
gtp metabolic process GO:0046039 144 0.069
peptidyl serine modification GO:0018209 83 0.069
eosinophil degranulation GO:0043308 1 0.069
negative regulation of leukocyte apoptotic process GO:2000107 31 0.069
Mouse
striated muscle tissue development GO:0014706 293 0.069
lymphocyte costimulation GO:0031294 15 0.069
nucleoside triphosphate catabolic process GO:0009143 205 0.069
cell recognition GO:0008037 83 0.069
signal transduction in absence of ligand GO:0038034 55 0.069
interleukin 2 mediated signaling pathway GO:0038110 2 0.069
thymic t cell selection GO:0045061 22 0.069
regulation of lymphocyte differentiation GO:0045619 107 0.068
carbohydrate metabolic process GO:0005975 230 0.068
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.068
positive regulation of organelle organization GO:0010638 128 0.068
mature natural killer cell chemotaxis GO:0035782 1 0.068
regulation of purine nucleotide catabolic process GO:0033121 122 0.068
homeostasis of number of cells GO:0048872 210 0.068
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.067
inflammatory cell apoptotic process GO:0006925 11 0.067
regulation of cytokine biosynthetic process GO:0042035 59 0.067
single organism cell adhesion GO:0098602 156 0.067
regulation of proteolysis GO:0030162 164 0.067
positive regulation of immunological synapse formation GO:2000522 1 0.067
cellular calcium ion homeostasis GO:0006874 119 0.067
calcium ion transport GO:0006816 159 0.066
regulation of t helper 1 type immune response GO:0002825 17 0.066
single organismal cell cell adhesion GO:0016337 131 0.066
monocyte extravasation GO:0035696 2 0.066
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.066
positive regulation of leukocyte differentiation GO:1902107 86 0.066
positive regulation of nervous system development GO:0051962 221 0.066
negative regulation of molecular function GO:0044092 258 0.065
cell activation involved in immune response GO:0002263 126 0.065
myotube cell development GO:0014904 60 0.065
guanosine containing compound metabolic process GO:1901068 144 0.065
regulation of t cell anergy GO:0002667 4 0.065
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000526 1 0.065
regulation of cysteine type endopeptidase activity GO:2000116 65 0.064
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.064
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.064
nucleoside phosphate catabolic process GO:1901292 222 0.064
release of sequestered calcium ion into cytosol GO:0051209 42 0.064
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.063
regulation of immunoglobulin production GO:0002637 42 0.063
negative regulation of phosphorylation GO:0042326 166 0.063
neuronal action potential GO:0019228 54 0.063
regulation of thymocyte migration GO:2000410 2 0.063
immune complex clearance by monocytes and macrophages GO:0002436 2 0.063
positive regulation of angiogenesis GO:0045766 46 0.062
purine containing compound metabolic process GO:0072521 311 0.062
positive regulation of nucleotide catabolic process GO:0030813 88 0.062
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.062
positive regulation of jun kinase activity GO:0043507 30 0.062
regulation of natural killer cell chemotaxis GO:2000501 1 0.062
tolerance induction GO:0002507 14 0.062
cytosolic calcium ion transport GO:0060401 48 0.061
regulation of dendritic cell dendrite assembly GO:2000547 2 0.061
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.061
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.060
myeloid leukocyte activation GO:0002274 83 0.060
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.060
cellular response to organonitrogen compound GO:0071417 145 0.060
negative regulation of cell proliferation GO:0008285 296 0.059
negative regulation of homeostatic process GO:0032845 71 0.059
regulation of exocytosis GO:0017157 61 0.059
regulation of myoblast differentiation GO:0045661 29 0.058
negative regulation of myeloid cell apoptotic process GO:0033033 11 0.058
camera type eye development GO:0043010 266 0.058
defense response to gram positive bacterium GO:0050830 50 0.057
positive regulation of lymphocyte migration GO:2000403 11 0.057
somatic diversification of immunoglobulins GO:0016445 43 0.057
interleukin 12 production GO:0032615 32 0.057
type 2 immune response GO:0042092 23 0.057
cellular response to growth factor stimulus GO:0071363 197 0.056
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.056
ras protein signal transduction GO:0007265 77 0.056
circulatory system process GO:0003013 197 0.056
jak stat cascade GO:0007259 42 0.056
positive regulation of cellular component biogenesis GO:0044089 94 0.055
nucleotide catabolic process GO:0009166 217 0.055
protein localization to nucleus GO:0034504 121 0.055
glial cell differentiation GO:0010001 131 0.055
positive regulation of t cell mediated immunity GO:0002711 24 0.055
memory GO:0007613 58 0.054
multicellular organismal signaling GO:0035637 91 0.054
regulation of b cell mediated immunity GO:0002712 37 0.054
alpha beta t cell activation involved in immune response GO:0002287 31 0.054
smooth muscle contraction GO:0006939 44 0.054
protein kinase b signaling GO:0043491 74 0.054
regulation of reactive oxygen species metabolic process GO:2000377 40 0.053
cell chemotaxis GO:0060326 81 0.053
nucleobase containing small molecule metabolic process GO:0055086 352 0.053
macrophage apoptotic process GO:0071888 7 0.052
nuclear transport GO:0051169 139 0.052
ribonucleotide metabolic process GO:0009259 291 0.052
developmental maturation GO:0021700 193 0.052
regulation of purine nucleotide metabolic process GO:1900542 169 0.052
regulation of b cell chemotaxis GO:2000537 2 0.052
b cell activation involved in immune response GO:0002312 50 0.051
telencephalon cell migration GO:0022029 55 0.051
defense response to bacterium GO:0042742 119 0.051
killing of cells in other organism involved in symbiotic interaction GO:0051883 13 0.051
organophosphate catabolic process GO:0046434 232 0.050
cerebral cortex development GO:0021987 86 0.050
negative regulation of protein metabolic process GO:0051248 282 0.050
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.050
positive regulation of cytokine secretion GO:0050715 41 0.050
protein localization to organelle GO:0033365 185 0.049
organelle fission GO:0048285 170 0.049
positive regulation of secretion by cell GO:1903532 114 0.049
stress activated protein kinase signaling cascade GO:0031098 81 0.049
neuron migration GO:0001764 122 0.049
calcium mediated signaling GO:0019722 46 0.049
regulation of skeletal muscle fiber development GO:0048742 36 0.049
regulation of cellular component biogenesis GO:0044087 181 0.048
negative regulation of secretion by cell GO:1903531 54 0.048
ribonucleoside metabolic process GO:0009119 245 0.048
axonogenesis GO:0007409 274 0.048
regulation of ras protein signal transduction GO:0046578 114 0.048
positive regulation of calcium mediated signaling GO:0050850 15 0.048
granulocyte chemotaxis GO:0071621 39 0.048
urogenital system development GO:0001655 261 0.047
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.047
regulation of multi organism process GO:0043900 111 0.047
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.047
isotype switching GO:0045190 36 0.047
thymocyte migration GO:0072679 2 0.047
blood circulation GO:0008015 195 0.047
positive regulation of immune complex clearance by monocytes and macrophages GO:0090265 2 0.047
retina development in camera type eye GO:0060041 119 0.047
antigen processing and presentation of exogenous antigen GO:0019884 26 0.046
positive regulation of secretion GO:0051047 130 0.046
positive regulation of innate immune response GO:0045089 80 0.046
cellular chemical homeostasis GO:0055082 215 0.046
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.046
negative t cell selection GO:0043383 13 0.046
germ cell development GO:0007281 185 0.046
signal transduction by p53 class mediator GO:0072331 51 0.045
organic cyclic compound catabolic process GO:1901361 295 0.045
lymphocyte homeostasis GO:0002260 64 0.045
regulation of nucleotide metabolic process GO:0006140 169 0.045
interspecies interaction between organisms GO:0044419 83 0.045
natural killer cell inhibitory signaling pathway GO:0002769 2 0.045
heterocycle catabolic process GO:0046700 280 0.045
leukocyte degranulation GO:0043299 27 0.045
regulation of nucleotide catabolic process GO:0030811 122 0.045
mammary gland epithelium development GO:0061180 65 0.045
leukocyte chemotaxis GO:0030595 69 0.045
negative regulation of lymphocyte activation GO:0051250 91 0.045
positive regulation of glial cell differentiation GO:0045687 21 0.045
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.045
nucleoside phosphate metabolic process GO:0006753 338 0.045

Sh2d2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.049
musculoskeletal system disease DOID:17 0 0.049