|
|
ripoptosome assembly involved in necroptotic process
|
GO:1901026 |
6 |
0.997
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
28 |
0.991
|
|
|
|
regulation of necroptotic process
|
GO:0060544 |
10 |
0.978
|
|
|
|
negative regulation of necroptotic process
|
GO:0060546 |
9 |
0.976
|
|
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.967
|
|
|
|
interleukin 10 secretion
|
GO:0072608 |
4 |
0.951
|
|
|
|
negative regulation of necrotic cell death
|
GO:0060547 |
11 |
0.933
|
|
|
|
necroptotic process
|
GO:0070266 |
21 |
0.928
|
|
|
|
interleukin 5 secretion
|
GO:0072603 |
2 |
0.928
|
|
|
|
germinal center formation
|
GO:0002467 |
16 |
0.917
|
|
|
|
negative regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902443 |
3 |
0.882
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.867
|
Human |
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.853
|
Mouse |
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.851
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.816
|
Human Mouse |
|
|
negative regulation of interleukin 10 secretion
|
GO:2001180 |
2 |
0.760
|
|
|
|
immunoglobulin production
|
GO:0002377 |
73 |
0.752
|
|
|
|
regulation of interleukin 13 secretion
|
GO:2000665 |
2 |
0.746
|
|
|
|
regulation of interleukin 5 secretion
|
GO:2000662 |
2 |
0.742
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.737
|
Human |
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.690
|
Mouse |
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.678
|
Mouse |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.649
|
Mouse |
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.631
|
Mouse |
|
|
regulation of necrotic cell death
|
GO:0010939 |
13 |
0.617
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.594
|
Mouse |
|
|
lymphocyte apoptotic process
|
GO:0070227 |
54 |
0.548
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.543
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.543
|
Human |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.531
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.507
|
Mouse |
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.504
|
Mouse |
|
|
activation of immune response
|
GO:0002253 |
138 |
0.502
|
Mouse |
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.501
|
Mouse |
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.501
|
Human |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.500
|
Human |
|
|
jnk cascade
|
GO:0007254 |
72 |
0.498
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.493
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.493
|
Mouse |
|
|
positive regulation of fever generation by positive regulation of prostaglandin secretion
|
GO:0071812 |
2 |
0.484
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.473
|
Mouse |
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.468
|
Human |
|
|
negative regulation of interleukin 5 secretion
|
GO:2000663 |
1 |
0.468
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.466
|
Mouse |
|
|
somatic recombination of immunoglobulin gene segments
|
GO:0016447 |
42 |
0.461
|
|
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.459
|
Mouse |
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.454
|
|
|
|
negative regulation of interleukin 13 production
|
GO:0032696 |
2 |
0.441
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.439
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.435
|
Human Mouse |
|
|
negative regulation of interleukin 13 secretion
|
GO:2000666 |
1 |
0.433
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
10 |
0.428
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.427
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.422
|
Mouse |
|
|
protein polyubiquitination
|
GO:0000209 |
33 |
0.411
|
Human Mouse |
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.401
|
|
|
|
myd88 independent toll like receptor signaling pathway
|
GO:0002756 |
3 |
0.388
|
|
|
|
somatic diversification of immune receptors via germline recombination within a single locus
|
GO:0002562 |
51 |
0.383
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
26 |
0.356
|
Human Mouse |
|
|
regulation of cd8 positive alpha beta cytotoxic t cell extravasation
|
GO:2000452 |
2 |
0.349
|
|
|
|
regulation of cytokine secretion involved in immune response
|
GO:0002739 |
4 |
0.346
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.335
|
Mouse |
|
|
myeloid dendritic cell differentiation
|
GO:0043011 |
16 |
0.334
|
Mouse |
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.331
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.314
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.308
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
142 |
0.306
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
6 |
0.305
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.300
|
|
|
|
circadian temperature homeostasis
|
GO:0060086 |
2 |
0.299
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.298
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.293
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.292
|
Human Mouse |
|
|
glial cell apoptotic process
|
GO:0034349 |
3 |
0.290
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.289
|
Mouse |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.288
|
Human |
|
|
negative regulation of inflammatory response
|
GO:0050728 |
61 |
0.277
|
|
|
|
regulation of anion transport
|
GO:0044070 |
27 |
0.277
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.277
|
Mouse |
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
38 |
0.273
|
Mouse |
|
|
regulation of immunoglobulin secretion
|
GO:0051023 |
12 |
0.273
|
|
|
|
regulation of b cell activation
|
GO:0050864 |
81 |
0.270
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.266
|
Human |
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.261
|
Mouse |
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.260
|
|
|
|
interleukin 13 secretion
|
GO:0072611 |
2 |
0.253
|
|
|
|
regulation of hepatocyte proliferation
|
GO:2000345 |
6 |
0.252
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.251
|
Mouse |
|
|
neuron death
|
GO:0070997 |
154 |
0.249
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.248
|
Mouse |
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.247
|
Mouse |
|
|
nik nf kappab signaling
|
GO:0038061 |
14 |
0.246
|
Human |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.241
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.238
|
Human |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.235
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.232
|
Mouse |
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.229
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
40 |
0.229
|
Mouse |
|
|
b cell apoptotic process
|
GO:0001783 |
19 |
0.227
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
40 |
0.226
|
Mouse |
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
84 |
0.225
|
Human |
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.223
|
Mouse |
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.220
|
Mouse |
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.217
|
Mouse |
|
|
immunoglobulin secretion
|
GO:0048305 |
17 |
0.214
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.210
|
Human Mouse |
|
|
nucleotide binding oligomerization domain containing 1 signaling pathway
|
GO:0070427 |
5 |
0.207
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.206
|
Human |
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
13 |
0.204
|
Human Mouse |
|
|
immune effector process
|
GO:0002252 |
321 |
0.204
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.195
|
|
|
|
protein secretion
|
GO:0009306 |
111 |
0.195
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.186
|
Mouse |
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
41 |
0.183
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
62 |
0.183
|
Human |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
65 |
0.181
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.181
|
Mouse |
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.181
|
Human |
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
28 |
0.180
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
21 |
0.180
|
Human Mouse |
|
|
positive regulation of interleukin 12 production
|
GO:0032735 |
21 |
0.175
|
Mouse |
|
|
negative regulation of odontogenesis of dentin containing tooth
|
GO:0042489 |
1 |
0.172
|
|
|
|
ripoptosome assembly
|
GO:0097343 |
6 |
0.172
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
71 |
0.166
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.165
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.165
|
Human |
|
|
negative regulation of odontogenesis
|
GO:0042483 |
3 |
0.163
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.162
|
Human Mouse |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.161
|
|
|
|
negative regulation of interleukin 5 production
|
GO:0032714 |
4 |
0.157
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.157
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.157
|
Human |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.156
|
Mouse |
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.155
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.150
|
Mouse |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.149
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.149
|
Mouse |
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.147
|
Human Mouse |
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.146
|
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.145
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
96 |
0.144
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.144
|
|
|
|
anion transport
|
GO:0006820 |
177 |
0.144
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.143
|
|
|
|
t helper cell differentiation
|
GO:0042093 |
28 |
0.141
|
|
|
|
myeloid dendritic cell activation
|
GO:0001773 |
25 |
0.136
|
Mouse |
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
104 |
0.136
|
Human |
|
|
positive regulation of b cell activation
|
GO:0050871 |
49 |
0.135
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
9 |
0.134
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.134
|
Human Mouse |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.133
|
Human |
|
|
negative regulation of protein processing
|
GO:0010955 |
79 |
0.131
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.130
|
Mouse |
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.129
|
|
|
|
positive regulation of response to cytokine stimulus
|
GO:0060760 |
11 |
0.122
|
|
|
|
defense response to gram positive bacterium
|
GO:0050830 |
50 |
0.122
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.121
|
|
|
|
regulation of germinal center formation
|
GO:0002634 |
10 |
0.120
|
|
|
|
positive regulation of immature t cell proliferation
|
GO:0033091 |
4 |
0.120
|
|
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
53 |
0.118
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.118
|
Human Mouse |
|
|
protein targeting
|
GO:0006605 |
143 |
0.117
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.117
|
|
|
|
somatic diversification of immunoglobulins involved in immune response
|
GO:0002208 |
36 |
0.116
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
34 |
0.115
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.115
|
|
|
|
spleen development
|
GO:0048536 |
39 |
0.115
|
|
|
|
positive regulation of cytokine secretion involved in immune response
|
GO:0002741 |
2 |
0.115
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.114
|
|
|
|
b cell activation involved in immune response
|
GO:0002312 |
50 |
0.113
|
|
|
|
protein processing
|
GO:0016485 |
163 |
0.113
|
|
|
|
regulation of alpha beta t cell proliferation
|
GO:0046640 |
18 |
0.109
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.108
|
|
|
|
interleukin 6 production
|
GO:0032635 |
58 |
0.107
|
Mouse |
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.106
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.106
|
|
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.106
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.106
|
Human |
|
|
positive regulation of t helper 1 cell differentiation
|
GO:0045627 |
4 |
0.105
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.105
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
71 |
0.104
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
3 |
0.104
|
|
|
|
negative regulation of b cell activation
|
GO:0050869 |
27 |
0.102
|
|
|
|
negative regulation of lipopolysaccharide mediated signaling pathway
|
GO:0031665 |
3 |
0.102
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
6 |
0.102
|
|
|
|
alpha beta t cell differentiation involved in immune response
|
GO:0002293 |
30 |
0.102
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.101
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.101
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
55 |
0.100
|
Mouse |
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.098
|
Mouse |
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.098
|
Human |
|
|
response to interleukin 12
|
GO:0070671 |
2 |
0.097
|
|
|
|
regulation of alpha beta t cell differentiation
|
GO:0046637 |
35 |
0.095
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.094
|
|
|
|
positive regulation of b cell proliferation
|
GO:0030890 |
24 |
0.092
|
|
|
|
somatic cell dna recombination
|
GO:0016444 |
51 |
0.091
|
|
|
|
lymph node development
|
GO:0048535 |
18 |
0.091
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.091
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.091
|
Mouse |
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.091
|
|
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.091
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
74 |
0.090
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.089
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.089
|
|
|
|
interleukin 8 production
|
GO:0032637 |
4 |
0.087
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
69 |
0.087
|
|
|
|
type i interferon production
|
GO:0032606 |
29 |
0.086
|
Mouse |
|
|
cytokine secretion involved in immune response
|
GO:0002374 |
6 |
0.085
|
|
|
|
regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902442 |
3 |
0.084
|
|
|
|
protein maturation
|
GO:0051604 |
176 |
0.084
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.084
|
Mouse |
|
|
b cell proliferation
|
GO:0042100 |
53 |
0.084
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.083
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.082
|
Human |
|
|
dna recombination
|
GO:0006310 |
92 |
0.082
|
|
|
|
circadian rhythm
|
GO:0007623 |
114 |
0.080
|
|
|
|
somatic diversification of immunoglobulins
|
GO:0016445 |
43 |
0.079
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
18 |
0.079
|
Mouse |
|
|
cellular response to nitric oxide
|
GO:0071732 |
4 |
0.079
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.079
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.078
|
|
|
|
chromatin modification
|
GO:0016568 |
187 |
0.078
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.077
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
56 |
0.076
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
68 |
0.075
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
45 |
0.075
|
|
|
|
dendritic cell differentiation
|
GO:0097028 |
26 |
0.073
|
Mouse |
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.073
|
Human Mouse |
|
|
histone modification
|
GO:0016570 |
159 |
0.071
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.071
|
Mouse |
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.069
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.069
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.068
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.067
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
111 |
0.066
|
Mouse |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.065
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.064
|
Human |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.064
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
3 |
0.063
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
9 |
0.063
|
|
|
|
t cell apoptotic process
|
GO:0070231 |
39 |
0.062
|
|
|
|
alpha beta t cell proliferation
|
GO:0046633 |
21 |
0.062
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.061
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
96 |
0.061
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.061
|
|
|
|
positive regulation of inflammatory response
|
GO:0050729 |
47 |
0.061
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
46 |
0.060
|
|
|
|
positive regulation of type i interferon mediated signaling pathway
|
GO:0060340 |
4 |
0.060
|
|
|
|
cellular response to estrogen stimulus
|
GO:0071391 |
12 |
0.060
|
|
|
|
cd4 positive or cd8 positive alpha beta t cell lineage commitment
|
GO:0043369 |
8 |
0.059
|
|
|
|
b 1 b cell homeostasis
|
GO:0001922 |
4 |
0.059
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.059
|
Mouse |
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.057
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.057
|
Human |
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.057
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
163 |
0.057
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.057
|
|
|
|
negative regulation of alpha beta t cell proliferation
|
GO:0046642 |
5 |
0.056
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
41 |
0.056
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.056
|
Human |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.056
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
2 |
0.055
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.055
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
22 |
0.055
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
84 |
0.055
|
|
|
|
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway
|
GO:0070428 |
3 |
0.055
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.055
|
Human |
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.054
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.053
|
|
|
|
protein methylation
|
GO:0006479 |
81 |
0.053
|
|
|
|
isotype switching
|
GO:0045190 |
36 |
0.053
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.053
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.052
|
Mouse |
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.052
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.052
|
|
|
|
organic anion transport
|
GO:0015711 |
137 |
0.052
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.051
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.051
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.050
|
Human |
|
|
regulation of protein processing
|
GO:0070613 |
96 |
0.049
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.049
|
|
|
|
interleukin 10 production
|
GO:0032613 |
23 |
0.048
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.048
|
Human Mouse |
|
|
fatty acid derivative transport
|
GO:1901571 |
14 |
0.048
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.048
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.048
|
|
|
|
cd8 positive alpha beta cytotoxic t cell extravasation
|
GO:0035698 |
2 |
0.047
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
52 |
0.047
|
|
|
|
positive regulation of antimicrobial peptide production
|
GO:0002225 |
1 |
0.047
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
26 |
0.047
|
Human |
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.046
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
83 |
0.046
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.045
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.045
|
Mouse |
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.045
|
|
|
|
ossification
|
GO:0001503 |
216 |
0.045
|
Mouse |
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
57 |
0.045
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
79 |
0.044
|
|
|
|
toll like receptor 3 signaling pathway
|
GO:0034138 |
4 |
0.044
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.044
|
Human |
|
|
somatic recombination of immunoglobulin genes involved in immune response
|
GO:0002204 |
36 |
0.044
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
18 |
0.044
|
|
|
|
cd4 positive alpha beta t cell lineage commitment
|
GO:0043373 |
6 |
0.044
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.043
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
48 |
0.043
|
Human |
|
|
negative regulation of response to wounding
|
GO:1903035 |
77 |
0.043
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.043
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
44 |
0.043
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.042
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.042
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.041
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.040
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.040
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
45 |
0.040
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.039
|
Mouse |
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
1 |
0.039
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.039
|
|
|
|
extracellular structure organization
|
GO:0043062 |
148 |
0.039
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.039
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.039
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.039
|
|
|
|
defense response to virus
|
GO:0051607 |
68 |
0.039
|
Mouse |
|
|
negative regulation of reactive oxygen species metabolic process
|
GO:2000378 |
10 |
0.038
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
60 |
0.038
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.038
|
Human |
|
|
nucleic acid phosphodiester bond hydrolysis
|
GO:0090305 |
49 |
0.038
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.038
|
|
|
|
regulation of t cell apoptotic process
|
GO:0070232 |
28 |
0.037
|
|
|
|
detection of bacterium
|
GO:0016045 |
7 |
0.037
|
|
|
|
protein homooligomerization
|
GO:0051260 |
43 |
0.037
|
Human |
|
|
gland development
|
GO:0048732 |
330 |
0.037
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
4 |
0.037
|
Human |
|
|
regulation of b cell mediated immunity
|
GO:0002712 |
37 |
0.037
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.037
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.036
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.036
|
Mouse |
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.035
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
64 |
0.035
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.035
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.035
|
|
|
|
regulation of rna stability
|
GO:0043487 |
26 |
0.035
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
34 |
0.035
|
|
|
|
negative regulation of b cell proliferation
|
GO:0030889 |
13 |
0.034
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.034
|
|
|
|
mitochondrion organization
|
GO:0007005 |
134 |
0.034
|
|
|
|
hepaticobiliary system development
|
GO:0061008 |
67 |
0.034
|
|
|
|
regulation of nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070424 |
3 |
0.034
|
|
|
|
negative regulation of toll like receptor signaling pathway
|
GO:0034122 |
14 |
0.033
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
56 |
0.033
|
|
|
|
regulation of myd88 independent toll like receptor signaling pathway
|
GO:0034127 |
1 |
0.033
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.033
|
Human |
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
15 |
0.033
|
Mouse |
|
|
oligodendrocyte apoptotic process
|
GO:0097252 |
1 |
0.033
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.033
|
|
|
|
placenta development
|
GO:0001890 |
140 |
0.033
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.033
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
126 |
0.032
|
|
|
|
cdc42 protein signal transduction
|
GO:0032488 |
0 |
0.032
|
|
|
|
carboxylic acid transport
|
GO:0046942 |
100 |
0.032
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.032
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.032
|
|
|
|
regulation of cd8 positive alpha beta t cell proliferation
|
GO:2000564 |
1 |
0.031
|
|
|
|
negative regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0045736 |
9 |
0.031
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.031
|
|
|
|
somatic diversification of immune receptors
|
GO:0002200 |
53 |
0.031
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.031
|
|
|
|
b cell mediated immunity
|
GO:0019724 |
71 |
0.031
|
|
|
|
regulation of dna recombination
|
GO:0000018 |
34 |
0.031
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
10 |
0.030
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.030
|
|
|
|
liver development
|
GO:0001889 |
66 |
0.030
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.030
|
|
|
|
lipid transport
|
GO:0006869 |
98 |
0.029
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.029
|
Mouse |
|
|
regulation of isotype switching
|
GO:0045191 |
22 |
0.029
|
|
|
|
t cell lineage commitment
|
GO:0002360 |
13 |
0.029
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.029
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.029
|
|
|
|
negative regulation of protein secretion
|
GO:0050709 |
20 |
0.029
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.029
|
|
|
|
establishment of protein localization to vacuole
|
GO:0072666 |
4 |
0.029
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
26 |
0.028
|
|
|
|
regulation of lipid transport
|
GO:0032368 |
36 |
0.028
|
|
|
|
antimicrobial peptide production
|
GO:0002775 |
2 |
0.028
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.028
|
|
|
|
detection of external biotic stimulus
|
GO:0098581 |
9 |
0.028
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.028
|
|
|
|
tyrosine phosphorylation of stat1 protein
|
GO:0042508 |
3 |
0.028
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.028
|
Mouse |
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
61 |
0.027
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.027
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
70 |
0.027
|
Human |
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.027
|
|
|
|
thymus development
|
GO:0048538 |
41 |
0.027
|
|
|
|
regulation of protein deacetylation
|
GO:0090311 |
17 |
0.027
|
|
|
|
interleukin 12 biosynthetic process
|
GO:0042090 |
8 |
0.027
|
Mouse |
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.027
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
52 |
0.027
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.027
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.027
|
|
|
|
mammary gland lobule development
|
GO:0061377 |
22 |
0.027
|
|
|
|
b cell homeostasis
|
GO:0001782 |
34 |
0.027
|
|
|
|
fatty acid transport
|
GO:0015908 |
28 |
0.027
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.027
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.027
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.027
|
|
|
|
icosanoid transport
|
GO:0071715 |
14 |
0.026
|
|
|
|
liver morphogenesis
|
GO:0072576 |
8 |
0.026
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
83 |
0.026
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.026
|
Human |
|
|
inhibition of cysteine type endopeptidase activity involved in apoptotic process
|
GO:1990001 |
1 |
0.026
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.026
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
43 |
0.026
|
|
|
|
regulation of antibacterial peptide biosynthetic process
|
GO:0002808 |
1 |
0.026
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
128 |
0.026
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.026
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
62 |
0.026
|
Mouse |
|
|
regulation of toll like receptor signaling pathway
|
GO:0034121 |
20 |
0.025
|
|
|
|
regulation of icosanoid secretion
|
GO:0032303 |
8 |
0.025
|
|
|
|
regulation of growth of symbiont in host
|
GO:0044126 |
19 |
0.025
|
|
|
|
regulation of heat generation
|
GO:0031650 |
8 |
0.025
|
|
|
|
positive regulation of lipid transport
|
GO:0032370 |
22 |
0.025
|
|
|
|
response to inorganic substance
|
GO:0010035 |
96 |
0.025
|
|
|
|
extracellular matrix organization
|
GO:0030198 |
147 |
0.025
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.024
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.024
|
|
|
|
positive regulation of fatty acid transport
|
GO:2000193 |
8 |
0.024
|
|
|
|
positive regulation of isotype switching
|
GO:0045830 |
15 |
0.024
|
|
|
|
cd8 positive alpha beta t cell proliferation
|
GO:0035740 |
1 |
0.024
|
|
|
|
response to muramyl dipeptide
|
GO:0032495 |
9 |
0.024
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.024
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.024
|
|
|
|
t cell selection
|
GO:0045058 |
34 |
0.024
|
|
|
|
prostaglandin transport
|
GO:0015732 |
7 |
0.023
|
|
|
|
acid secretion
|
GO:0046717 |
33 |
0.023
|
|
|
|
camera type eye development
|
GO:0043010 |
266 |
0.023
|
|
|
|
dna repair
|
GO:0006281 |
107 |
0.023
|
|
|
|
hematopoietic progenitor cell differentiation
|
GO:0002244 |
143 |
0.023
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
22 |
0.023
|
Mouse |
|
|
negative regulation of endothelial cell apoptotic process
|
GO:2000352 |
7 |
0.023
|
|
|
|
negative regulation of interferon beta production
|
GO:0032688 |
3 |
0.023
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.023
|
Human |
|
|
tube formation
|
GO:0035148 |
140 |
0.022
|
Mouse |
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.022
|
|
|
|
heat generation
|
GO:0031649 |
13 |
0.022
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.022
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.022
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
61 |
0.022
|
Human |
|
|
interspecies interaction between organisms
|
GO:0044419 |
83 |
0.022
|
|
|
|
regulation of immunoglobulin production
|
GO:0002637 |
42 |
0.022
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.022
|
|
|
|
positive regulation of icosanoid secretion
|
GO:0032305 |
7 |
0.022
|
|
|
|
growth of symbiont in host
|
GO:0044117 |
23 |
0.022
|
|
|
|
regulation of defense response to virus by host
|
GO:0050691 |
8 |
0.022
|
|
|
|
t helper 17 cell lineage commitment
|
GO:0072540 |
4 |
0.022
|
|
|
|
positive regulation of transcription factor import into nucleus
|
GO:0042993 |
8 |
0.022
|
|
|
|
epithelial tube formation
|
GO:0072175 |
130 |
0.022
|
Mouse |
|
|
regulation of nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070432 |
3 |
0.022
|
|
|
|
positive regulation of interleukin 12 biosynthetic process
|
GO:0045084 |
6 |
0.022
|
Mouse |
|
|
response to interleukin 1
|
GO:0070555 |
11 |
0.021
|
Mouse |
|
|
regulation of odontogenesis of dentin containing tooth
|
GO:0042487 |
11 |
0.021
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
50 |
0.021
|
Human |
|
|
alpha beta t cell lineage commitment
|
GO:0002363 |
7 |
0.021
|
|
|
|
icosanoid secretion
|
GO:0032309 |
12 |
0.021
|
|
|
|
lymphocyte migration
|
GO:0072676 |
26 |
0.021
|
|
|
|
regulation of odontogenesis
|
GO:0042481 |
18 |
0.021
|
|
|
|
nucleobase containing compound transport
|
GO:0015931 |
27 |
0.021
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
68 |
0.021
|
|
|
|
lipid localization
|
GO:0010876 |
126 |
0.020
|
|
|
|
chemokine production
|
GO:0032602 |
34 |
0.020
|
|
|
|
monocarboxylic acid transport
|
GO:0015718 |
44 |
0.020
|
|
|
|
response to dsrna
|
GO:0043331 |
30 |
0.020
|
|
|
|
negative regulation of cytokine secretion
|
GO:0050710 |
15 |
0.020
|
|
|
|
regulation of fever generation by regulation of prostaglandin secretion
|
GO:0071810 |
2 |
0.020
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.020
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.020
|
|
|
|
positive regulation of b cell mediated immunity
|
GO:0002714 |
26 |
0.020
|
|
|
|
regulation of ligase activity
|
GO:0051340 |
10 |
0.020
|
|
|
|
glucose homeostasis
|
GO:0042593 |
128 |
0.020
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.020
|
|
|
|
fever generation
|
GO:0001660 |
7 |
0.020
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
70 |
0.019
|
|
|
|
t helper 2 cell cytokine production
|
GO:0035745 |
4 |
0.019
|
|
|
|
positive regulation of antimicrobial humoral response
|
GO:0002760 |
2 |
0.019
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.019
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
5 |
0.019
|
Human |
|
|
positive regulation of organic acid transport
|
GO:0032892 |
11 |
0.019
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
30 |
0.019
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.019
|
|
