|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
1.000
|
Mouse |
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
4 |
1.000
|
Human |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
1.000
|
Human Mouse |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
1.000
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
1.000
|
|
|
|
activation of innate immune response
|
GO:0002218 |
56 |
1.000
|
Mouse |
|
|
nik nf kappab signaling
|
GO:0038061 |
14 |
1.000
|
Human |
|
|
ripoptosome assembly involved in necroptotic process
|
GO:1901026 |
6 |
1.000
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.999
|
Human Mouse |
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.999
|
Mouse |
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.999
|
Mouse |
|
|
jnk cascade
|
GO:0007254 |
72 |
0.999
|
Human Mouse Rat |
|
|
cytokine production involved in immune response
|
GO:0002367 |
34 |
0.999
|
Human |
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.999
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.999
|
Human Mouse |
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
15 |
0.999
|
Mouse |
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.999
|
Human Mouse |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.999
|
Human Mouse Rat |
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.998
|
Mouse |
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.998
|
Human |
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.998
|
Mouse |
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.998
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
26 |
0.998
|
Human |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.997
|
Human |
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
30 |
0.997
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.996
|
Mouse |
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
68 |
0.995
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.993
|
Human |
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
30 |
0.992
|
Human |
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.991
|
Human Mouse |
|
|
regulation of toll like receptor signaling pathway
|
GO:0034121 |
20 |
0.990
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.990
|
Human Mouse |
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.989
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.988
|
Human |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.986
|
Human |
|
|
interleukin 13 secretion
|
GO:0072611 |
2 |
0.984
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.984
|
Human |
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.984
|
Human Mouse Rat |
|
|
toll like receptor 4 signaling pathway
|
GO:0034142 |
9 |
0.984
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.982
|
Human |
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.980
|
Human |
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.978
|
Human Mouse |
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.978
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.978
|
Human Mouse Rat |
|
|
immune effector process
|
GO:0002252 |
321 |
0.975
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.975
|
Human |
|
|
lipid transport
|
GO:0006869 |
98 |
0.970
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.969
|
Human |
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
40 |
0.963
|
Mouse |
|
|
cytokine production
|
GO:0001816 |
319 |
0.963
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.963
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.962
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.960
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.960
|
Human |
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.958
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
48 |
0.957
|
Human |
|
|
regulation of interleukin 6 production
|
GO:0032675 |
55 |
0.956
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.954
|
Mouse |
|
|
interleukin 1 mediated signaling pathway
|
GO:0070498 |
4 |
0.951
|
|
|
|
negative regulation of innate immune response
|
GO:0045824 |
17 |
0.950
|
|
|
|
interleukin 5 secretion
|
GO:0072603 |
2 |
0.946
|
|
|
|
interleukin 6 production
|
GO:0032635 |
58 |
0.945
|
|
|
|
cholesterol transport
|
GO:0030301 |
38 |
0.943
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.939
|
|
|
|
tolerance induction
|
GO:0002507 |
14 |
0.938
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.937
|
Mouse |
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.935
|
Human |
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.931
|
Human |
|
|
positive regulation of tolerance induction
|
GO:0002645 |
8 |
0.929
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.927
|
|
|
|
negative regulation of toll like receptor signaling pathway
|
GO:0034122 |
14 |
0.926
|
|
|
|
negative regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902443 |
3 |
0.923
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.921
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.921
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.918
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
61 |
0.915
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.913
|
Mouse |
|
|
interleukin 12 production
|
GO:0032615 |
32 |
0.913
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
33 |
0.909
|
|
|
|
regulation of tolerance induction
|
GO:0002643 |
10 |
0.902
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.891
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.891
|
Human |
|
|
interleukin 10 secretion
|
GO:0072608 |
4 |
0.888
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
10 |
0.876
|
|
|
|
regulation of interleukin 12 production
|
GO:0032655 |
30 |
0.875
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.875
|
|
|
|
cholesterol efflux
|
GO:0033344 |
24 |
0.874
|
|
|
|
myeloid dendritic cell activation
|
GO:0001773 |
25 |
0.872
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
40 |
0.871
|
Human |
|
|
myd88 independent toll like receptor signaling pathway
|
GO:0002756 |
3 |
0.870
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.864
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.861
|
Mouse |
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.848
|
|
|
|
regulation of lipid transport
|
GO:0032368 |
36 |
0.835
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.835
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
55 |
0.834
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.833
|
Human |
|
|
negative regulation of cytokine production
|
GO:0001818 |
84 |
0.832
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.831
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.828
|
Human |
|
|
negative regulation of sterol transport
|
GO:0032372 |
4 |
0.827
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.827
|
Human |
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.818
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
51 |
0.813
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.809
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.807
|
|
|
|
regulation of interleukin 5 secretion
|
GO:2000662 |
2 |
0.801
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.799
|
|
|
|
regulation of interleukin 13 secretion
|
GO:2000665 |
2 |
0.792
|
|
|
|
negative regulation of interleukin 6 production
|
GO:0032715 |
17 |
0.790
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
10 |
0.790
|
Human |
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.788
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.786
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.781
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.779
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.779
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
50 |
0.771
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
6 |
0.764
|
|
|
|
cellular response to interleukin 1
|
GO:0071347 |
8 |
0.764
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.756
|
Human |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.742
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.738
|
|
|
|
response to dsrna
|
GO:0043331 |
30 |
0.737
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.732
|
|
|
|
histone modification
|
GO:0016570 |
159 |
0.727
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.721
|
|
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
7 |
0.721
|
Human |
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.717
|
|
|
|
positive regulation of interleukin 12 production
|
GO:0032735 |
21 |
0.712
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
40 |
0.712
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.708
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.701
|
|
|
|
alpha beta t cell proliferation
|
GO:0046633 |
21 |
0.700
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.699
|
|
|
|
response to interleukin 12
|
GO:0070671 |
2 |
0.688
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.688
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.686
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.684
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.673
|
|
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
53 |
0.670
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
49 |
0.656
|
|
|
|
regulation of protein complex disassembly
|
GO:0043244 |
28 |
0.656
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.652
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
13 |
0.646
|
Mouse |
|
|
t helper cell differentiation
|
GO:0042093 |
28 |
0.641
|
|
|
|
negative regulation of necroptotic process
|
GO:0060546 |
9 |
0.637
|
|
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
28 |
0.637
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
84 |
0.631
|
Human |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.628
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.624
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.609
|
|
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
6 |
0.607
|
|
|
|
negative regulation of interleukin 10 secretion
|
GO:2001180 |
2 |
0.607
|
|
|
|
necroptotic process
|
GO:0070266 |
21 |
0.604
|
|
|
|
regulation of sterol transport
|
GO:0032371 |
17 |
0.597
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
61 |
0.595
|
Human |
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.593
|
|
|
|
regulation of necroptotic process
|
GO:0060544 |
10 |
0.590
|
|
|
|
alpha beta t cell differentiation involved in immune response
|
GO:0002293 |
30 |
0.588
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
21 |
0.583
|
Mouse |
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
5 |
0.576
|
Human |
|
|
negative regulation of cytokine production involved in immune response
|
GO:0002719 |
5 |
0.574
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.571
|
Human |
|
|
lipid localization
|
GO:0010876 |
126 |
0.568
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.567
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.566
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
65 |
0.559
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.555
|
Zebrafish Mouse |
|
|
glial cell apoptotic process
|
GO:0034349 |
3 |
0.552
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
50 |
0.550
|
|
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.545
|
Mouse |
|
|
sterol transport
|
GO:0015918 |
38 |
0.543
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.541
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.541
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.537
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.524
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
36 |
0.524
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.518
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.509
|
|
|
|
response to peptidoglycan
|
GO:0032494 |
9 |
0.504
|
|
|
|
regulation of cholesterol transport
|
GO:0032374 |
17 |
0.501
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
41 |
0.493
|
|
|
|
negative regulation of necrotic cell death
|
GO:0060547 |
11 |
0.493
|
|
|
|
myeloid dendritic cell differentiation
|
GO:0043011 |
16 |
0.486
|
|
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
24 |
0.477
|
Human |
|
|
lymphocyte apoptotic process
|
GO:0070227 |
54 |
0.466
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.456
|
|
|
|
negative regulation of cholesterol transport
|
GO:0032375 |
4 |
0.453
|
|
|
|
positive regulation of antibacterial peptide biosynthetic process
|
GO:0006963 |
1 |
0.451
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.445
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.443
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.431
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.430
|
|
|
|
ripoptosome assembly
|
GO:0097343 |
6 |
0.429
|
|
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.428
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
45 |
0.427
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.426
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.424
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
18 |
0.424
|
Mouse |
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.421
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.419
|
|
|
|
regulation of antibacterial peptide biosynthetic process
|
GO:0002808 |
1 |
0.416
|
|
|
|
interleukin 12 biosynthetic process
|
GO:0042090 |
8 |
0.415
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
77 |
0.414
|
|
|
|
negative regulation of interleukin 13 secretion
|
GO:2000666 |
1 |
0.413
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.413
|
Human |
|
|
ossification
|
GO:0001503 |
216 |
0.407
|
|
|
|
internal protein amino acid acetylation
|
GO:0006475 |
42 |
0.404
|
|
|
|
regulation of cholesterol efflux
|
GO:0010874 |
13 |
0.402
|
|
|
|
circadian regulation of gene expression
|
GO:0032922 |
48 |
0.402
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.402
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.401
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.397
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.389
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.389
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.387
|
|
|
|
negative regulation of b cell activation
|
GO:0050869 |
27 |
0.385
|
|
|
|
neural tube formation
|
GO:0001841 |
108 |
0.385
|
|
|
|
macromolecular complex disassembly
|
GO:0032984 |
43 |
0.378
|
|
|
|
immunoglobulin secretion
|
GO:0048305 |
17 |
0.376
|
|
|
|
regulation of alpha beta t cell proliferation
|
GO:0046640 |
18 |
0.375
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.372
|
|
|
|
primary neural tube formation
|
GO:0014020 |
95 |
0.371
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
61 |
0.369
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.367
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.364
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.361
|
|
|
|
nucleotide binding oligomerization domain containing 1 signaling pathway
|
GO:0070427 |
5 |
0.361
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
34 |
0.356
|
Human |
|
|
neuronal action potential
|
GO:0019228 |
54 |
0.355
|
|
|
|
antibacterial peptide production
|
GO:0002778 |
2 |
0.354
|
|
|
|
regulation of t cell anergy
|
GO:0002667 |
4 |
0.354
|
|
|
|
positive regulation of response to cytokine stimulus
|
GO:0060760 |
11 |
0.354
|
|
|
|
epithelial tube formation
|
GO:0072175 |
130 |
0.352
|
|
|
|
t cell anergy
|
GO:0002870 |
4 |
0.351
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.349
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.349
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.348
|
|
|
|
negative regulation of interleukin 5 secretion
|
GO:2000663 |
1 |
0.344
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
130 |
0.338
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.337
|
|
|
|
positive regulation of cytokine production involved in immune response
|
GO:0002720 |
19 |
0.334
|
Human |
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.333
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.326
|
|
|
|
cd4 positive alpha beta t cell activation
|
GO:0035710 |
45 |
0.325
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.315
|
|
|
|
positive regulation of fever generation by positive regulation of prostaglandin secretion
|
GO:0071812 |
2 |
0.314
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
43 |
0.311
|
|
|
|
regulation of lymphocyte anergy
|
GO:0002911 |
4 |
0.308
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.307
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
30 |
0.306
|
|
|
|
muscle cell proliferation
|
GO:0033002 |
52 |
0.305
|
Rat |
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.304
|
Mouse |
|
|
positive regulation of lipopolysaccharide mediated signaling pathway
|
GO:0031666 |
5 |
0.303
|
|
|
|
negative regulation of interleukin 5 production
|
GO:0032714 |
4 |
0.298
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.298
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.297
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
6 |
0.297
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.296
|
|
|
|
hair follicle development
|
GO:0001942 |
85 |
0.294
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.289
|
Human |
|
|
odontogenesis of dentin containing tooth
|
GO:0042475 |
66 |
0.289
|
|
|
|
activation of jnkk activity
|
GO:0007256 |
3 |
0.289
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.289
|
Human |
|
|
circadian rhythm
|
GO:0007623 |
114 |
0.287
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
163 |
0.286
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.286
|
|
|
|
regulation of cytokine secretion involved in immune response
|
GO:0002739 |
4 |
0.286
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.285
|
|
|
|
regulation of antibacterial peptide production
|
GO:0002786 |
1 |
0.285
|
|
|
|
respiratory system development
|
GO:0060541 |
190 |
0.281
|
|
|
|
action potential
|
GO:0001508 |
78 |
0.279
|
|
|
|
tube formation
|
GO:0035148 |
140 |
0.278
|
|
|
|
macrophage cytokine production
|
GO:0010934 |
9 |
0.278
|
|
|
|
negative regulation of odontogenesis of dentin containing tooth
|
GO:0042489 |
1 |
0.278
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.277
|
|
|
|
photoreceptor cell development
|
GO:0042461 |
40 |
0.274
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.273
|
|
|
|
neural tube development
|
GO:0021915 |
160 |
0.272
|
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.272
|
|
|
|
myeloid leukocyte cytokine production
|
GO:0061082 |
12 |
0.271
|
|
|
|
negative regulation of odontogenesis
|
GO:0042483 |
3 |
0.270
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.270
|
|
|
|
negative regulation of interleukin 13 production
|
GO:0032696 |
2 |
0.268
|
|
|
|
interferon beta production
|
GO:0032608 |
16 |
0.265
|
Mouse |
|
|
negative regulation of inflammatory response
|
GO:0050728 |
61 |
0.265
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.264
|
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.260
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
116 |
0.257
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.257
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.256
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.251
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
76 |
0.251
|
|
|
|
protein complex disassembly
|
GO:0043241 |
40 |
0.250
|
|
|
|
negative regulation of t cell proliferation
|
GO:0042130 |
38 |
0.248
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
38 |
0.248
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.247
|
|
|
|
interleukin 2 production
|
GO:0032623 |
33 |
0.246
|
Human |
|
|
regulation of gliogenesis
|
GO:0014013 |
50 |
0.245
|
|
|
|
negative regulation of interleukin 12 production
|
GO:0032695 |
10 |
0.245
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
18 |
0.245
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
21 |
0.244
|
|
|
|
lymphocyte anergy
|
GO:0002249 |
4 |
0.243
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.242
|
|
|
|
positive regulation of t cell anergy
|
GO:0002669 |
4 |
0.239
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
19 |
0.239
|
Human |
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.235
|
|
|
|
hepaticobiliary system development
|
GO:0061008 |
67 |
0.234
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.233
|
|
|
|
cytokine production involved in inflammatory response
|
GO:0002534 |
9 |
0.229
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.229
|
|
|
|
circadian temperature homeostasis
|
GO:0060086 |
2 |
0.225
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
142 |
0.224
|
|
|
|
positive regulation of antimicrobial humoral response
|
GO:0002760 |
2 |
0.224
|
|
|
|
regulation of macrophage cytokine production
|
GO:0010935 |
8 |
0.223
|
|
|
|
protein deubiquitination
|
GO:0016579 |
19 |
0.221
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.221
|
Human |
|
|
positive regulation of hormone secretion
|
GO:0046887 |
38 |
0.221
|
|
|
|
response to interleukin 1
|
GO:0070555 |
11 |
0.218
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.218
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.217
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.212
|
|
|
|
negative regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903556 |
17 |
0.211
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
50 |
0.206
|
Human |
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
30 |
0.206
|
|
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
23 |
0.202
|
|
|
|
b cell apoptotic process
|
GO:0001783 |
19 |
0.201
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
26 |
0.200
|
Mouse |
|
|
type i interferon production
|
GO:0032606 |
29 |
0.199
|
Mouse |
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.198
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.198
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.197
|
|
|
|
negative regulation of macrophage cytokine production
|
GO:0010936 |
1 |
0.195
|
|
|
|
alpha beta t cell differentiation
|
GO:0046632 |
69 |
0.195
|
|
|
|
germinal center formation
|
GO:0002467 |
16 |
0.193
|
|
|
|
regulation of defense response to bacterium
|
GO:1900424 |
3 |
0.193
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.192
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.190
|
|
|
|
positive regulation of lymphocyte anergy
|
GO:0002913 |
4 |
0.188
|
|
|
|
odontogenesis
|
GO:0042476 |
78 |
0.187
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
82 |
0.187
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.187
|
|
|
|
synapse organization
|
GO:0050808 |
125 |
0.187
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.187
|
|
|
|
amide transport
|
GO:0042886 |
138 |
0.184
|
|
|
|
hormone secretion
|
GO:0046879 |
128 |
0.184
|
|
|
|
neural tube closure
|
GO:0001843 |
90 |
0.181
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.180
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.180
|
|
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
14 |
0.178
|
|
|
|
respiratory tube development
|
GO:0030323 |
167 |
0.177
|
Mouse |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.175
|
|
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.174
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.171
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.170
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.167
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.162
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.161
|
|
|
|
positive regulation of peptide hormone secretion
|
GO:0090277 |
31 |
0.160
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
69 |
0.160
|
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.159
|
|
|
|
spleen development
|
GO:0048536 |
39 |
0.159
|
|
|
|
protein oligomerization
|
GO:0051259 |
67 |
0.157
|
|
|
|
negative regulation of tumor necrosis factor production
|
GO:0032720 |
17 |
0.157
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.157
|
|
|
|
positive regulation of immature t cell proliferation
|
GO:0033091 |
4 |
0.156
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
6 |
0.156
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
70 |
0.155
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.153
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
91 |
0.153
|
|
|
|
regulation of steroid biosynthetic process
|
GO:0050810 |
26 |
0.151
|
|
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
30 |
0.150
|
|
|
|
regulation of hepatocyte proliferation
|
GO:2000345 |
6 |
0.148
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.146
|
|
|
|
t cell differentiation involved in immune response
|
GO:0002292 |
30 |
0.146
|
|
|
|
i kappab phosphorylation
|
GO:0007252 |
6 |
0.145
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.144
|
|
|
|
cytokine secretion involved in immune response
|
GO:0002374 |
6 |
0.144
|
|
|
|
autophagy
|
GO:0006914 |
45 |
0.141
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
25 |
0.140
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.139
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.139
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.138
|
|
|
|
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway
|
GO:0043162 |
3 |
0.138
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
62 |
0.138
|
Human |
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.137
|
|
|
|
positive regulation of defense response to bacterium
|
GO:1900426 |
1 |
0.137
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.136
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.135
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.134
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
60 |
0.134
|
|
|
|
molting cycle
|
GO:0042303 |
90 |
0.133
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.131
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.130
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.130
|
|
|
|
skeletal system development
|
GO:0001501 |
356 |
0.129
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.128
|
|
|
|
response to exogenous dsrna
|
GO:0043330 |
22 |
0.127
|
|
|
|
positive regulation of peptide secretion
|
GO:0002793 |
33 |
0.127
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.127
|
Human |
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.127
|
|
|
|
liver development
|
GO:0001889 |
66 |
0.126
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
83 |
0.126
|
|
|
|
mesoderm development
|
GO:0007498 |
100 |
0.126
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.125
|
|
|
|
antimicrobial peptide production
|
GO:0002775 |
2 |
0.124
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
31 |
0.123
|
|
|
|
regulation of interferon gamma production
|
GO:0032649 |
57 |
0.122
|
|
|
|
b 1 b cell homeostasis
|
GO:0001922 |
4 |
0.122
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.122
|
Human |
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
45 |
0.121
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.119
|
|
|
|
protein secretion
|
GO:0009306 |
111 |
0.118
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.118
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.117
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.116
|
Mouse |
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.116
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.116
|
Human |
|
|
response to muramyl dipeptide
|
GO:0032495 |
9 |
0.116
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.115
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.115
|
|
|
|
regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902442 |
3 |
0.115
|
|
|
|
organic acid biosynthetic process
|
GO:0016053 |
86 |
0.114
|
|
|
|
regulation of cd8 positive alpha beta t cell extravasation
|
GO:2000449 |
3 |
0.114
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.114
|
|
|
|
myelination
|
GO:0042552 |
74 |
0.113
|
|
|
|
regulation of tight junction assembly
|
GO:2000810 |
2 |
0.111
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.111
|
|
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
3 |
0.109
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.109
|
|
|
|
negative regulation of lipid transport
|
GO:0032369 |
8 |
0.109
|
|
|
|
mitochondrion organization
|
GO:0007005 |
134 |
0.109
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
10 |
0.108
|
|
|
|
mesoderm formation
|
GO:0001707 |
62 |
0.108
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
55 |
0.107
|
|
|
|
antibacterial peptide biosynthetic process
|
GO:0002780 |
2 |
0.107
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
98 |
0.107
|
|
|
|
mammary gland epithelium development
|
GO:0061180 |
65 |
0.106
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
93 |
0.106
|
|
|
|
organic anion transport
|
GO:0015711 |
137 |
0.106
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.106
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.105
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.105
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.104
|
|
|
|
organic hydroxy compound biosynthetic process
|
GO:1901617 |
77 |
0.104
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
42 |
0.104
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.103
|
|
|
|
regulation of glial cell differentiation
|
GO:0045685 |
41 |
0.103
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.103
|
|
|
|
negative regulation of osteoblast differentiation
|
GO:0045668 |
30 |
0.102
|
|
|
|
lung development
|
GO:0030324 |
164 |
0.102
|
|
|
|
regulation of chromatin modification
|
GO:1903308 |
57 |
0.101
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
93 |
0.100
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.100
|
|
|
|
positive regulation of inflammatory response
|
GO:0050729 |
47 |
0.099
|
|
|
|
negative regulation of protein complex disassembly
|
GO:0043242 |
22 |
0.098
|
|
|
|
negative regulation of ossification
|
GO:0030279 |
49 |
0.098
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
31 |
0.098
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.097
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
39 |
0.096
|
|
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
26 |
0.096
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.096
|
|
|
|
positive regulation of antimicrobial peptide production
|
GO:0002225 |
1 |
0.096
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.095
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.095
|
|
|
|
regulation of immunoglobulin production
|
GO:0002637 |
42 |
0.095
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
159 |
0.094
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.093
|
|
|
|
positive regulation of cytokine secretion involved in immune response
|
GO:0002741 |
2 |
0.093
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
104 |
0.093
|
Human |
|
|
leukocyte apoptotic process
|
GO:0071887 |
71 |
0.091
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.091
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
34 |
0.091
|
|
|
|
mammary gland lobule development
|
GO:0061377 |
22 |
0.090
|
|
|
|
regulation of protein binding
|
GO:0043393 |
60 |
0.090
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
70 |
0.089
|
Human |
|
|
regulation of protein ubiquitination
|
GO:0031396 |
52 |
0.089
|
|
|
|
dendritic cell differentiation
|
GO:0097028 |
26 |
0.089
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
52 |
0.089
|
|
|
|
t cell cytokine production
|
GO:0002369 |
10 |
0.089
|
Human |
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
57 |
0.089
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
62 |
0.088
|
|
|
|
blood circulation
|
GO:0008015 |
195 |
0.088
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
34 |
0.088
|
|
|
|
negative regulation of leukocyte proliferation
|
GO:0070664 |
46 |
0.087
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
82 |
0.087
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.086
|
|
|
|
trachea gland development
|
GO:0061153 |
3 |
0.086
|
|
|
|
negative regulation of cytokine biosynthetic process
|
GO:0042036 |
13 |
0.086
|
|
