Mus musculus

0 known processes

Icos

inducible T-cell co-stimulator

(Aliases: H4,CCLP,AILIM,CRP-1,Ly115)

Icos biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
natural killer cell inhibitory signaling pathway GO:0002769 2 1.000
positive regulation of defense response GO:0031349 124 0.999
Mouse
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.997
Mouse
leukocyte mediated immunity GO:0002443 174 0.997
Mouse
regulation of interleukin 2 biosynthetic process GO:0045076 13 0.996
Mouse
positive regulation of t cell activation GO:0050870 101 0.994
Mouse
immune effector process GO:0002252 321 0.993
Mouse
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.991
Mouse
regulation of interleukin 2 production GO:0032663 28 0.989
Mouse
natural killer cell activation GO:0030101 44 0.989
positive regulation of leukocyte proliferation GO:0070665 73 0.987
Mouse
immune response activating signal transduction GO:0002757 116 0.986
Mouse
leukocyte proliferation GO:0070661 172 0.985
Mouse
lymphocyte differentiation GO:0030098 242 0.985
Mouse
interleukin 2 production GO:0032623 33 0.980
Mouse
regulation of lymphocyte activation GO:0051249 240 0.979
Mouse
positive regulation of cytokine production GO:0001819 174 0.979
Mouse
t cell activation GO:0042110 289 0.979
Mouse
regulation of t cell activation GO:0050863 170 0.979
Mouse
regulation of cytokine biosynthetic process GO:0042035 59 0.978
Mouse
lymphocyte mediated immunity GO:0002449 139 0.977
Mouse
adaptive immune response GO:0002250 155 0.977
Mouse
t cell differentiation GO:0030217 174 0.976
Mouse
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.974
Mouse
regulation of cell activation GO:0050865 289 0.972
Mouse
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.972
positive regulation of immune effector process GO:0002699 107 0.959
Mouse
t cell costimulation GO:0031295 14 0.959
Mouse
immune response regulating signaling pathway GO:0002764 125 0.958
Mouse
regulation of cytokine production GO:0001817 266 0.955
Mouse
positive regulation of innate immune response GO:0045089 80 0.955
cytokine production GO:0001816 319 0.954
Mouse
activation of immune response GO:0002253 138 0.949
Mouse
regulation of adaptive immune response GO:0002819 90 0.943
Mouse
antigen receptor mediated signaling pathway GO:0050851 64 0.942
Mouse
positive regulation of cytokine biosynthetic process GO:0042108 40 0.931
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.927
Mouse
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.927
Mouse
leukocyte differentiation GO:0002521 342 0.926
Mouse
defense response to other organism GO:0098542 197 0.925
regulation of leukocyte proliferation GO:0070663 121 0.921
Mouse
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.921
Mouse
regulation of leukocyte mediated immunity GO:0002703 104 0.921
Mouse
regulation of innate immune response GO:0045088 91 0.918
b cell activation GO:0042113 161 0.912
Mouse
positive regulation of interleukin 2 biosynthetic process GO:0045086 8 0.906
Mouse
positive regulation of lymphocyte proliferation GO:0050671 70 0.896
Mouse
regulation of dendritic cell chemotaxis GO:2000508 1 0.893
cellular response to cytokine stimulus GO:0071345 189 0.892
positive regulation of leukocyte mediated immunity GO:0002705 70 0.891
Mouse
apoptotic signaling pathway GO:0097190 306 0.888
Mouse
regulation of interleukin 4 biosynthetic process GO:0045402 3 0.875
positive regulation of interleukin 2 production GO:0032743 19 0.875
Mouse
regulation of lymphocyte mediated immunity GO:0002706 84 0.870
Mouse
alpha beta t cell proliferation GO:0046633 21 0.855
Mouse
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.851
positive regulation of cellular amine metabolic process GO:0033240 5 0.845
t cell proliferation GO:0042098 120 0.839
Mouse
innate immune response GO:0045087 157 0.839
positive regulation of inflammatory response GO:0050729 47 0.839
Mouse
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.836
Mouse
humoral immune response GO:0006959 57 0.833
regulation of t cell differentiation GO:0045580 83 0.832
t helper 2 cell cytokine production GO:0035745 4 0.820
interferon gamma production GO:0032609 67 0.813
regulation of defense response GO:0031347 233 0.811
Mouse
positive regulation of cell activation GO:0050867 158 0.809
Mouse
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.798
regulation of b cell proliferation GO:0030888 39 0.797
regulation of t cell proliferation GO:0042129 92 0.794
Mouse
positive regulation of t cell proliferation GO:0042102 52 0.792
Mouse
t cell receptor signaling pathway GO:0050852 46 0.778
Mouse
positive regulation of interferon gamma production GO:0032729 39 0.776
positive regulation of lymphocyte activation GO:0051251 140 0.770
Mouse
b cell receptor signaling pathway GO:0050853 20 0.767
regulation of alpha beta t cell proliferation GO:0046640 18 0.759
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.757
regulation of interferon gamma production GO:0032649 57 0.729
regulation of alpha beta t cell activation GO:0046634 53 0.728
Mouse
regulation of inflammatory response GO:0050727 147 0.724
Mouse
interleukin 10 secretion GO:0072608 4 0.713
lymphocyte costimulation GO:0031294 15 0.712
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.700
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.699
Mouse
positive regulation of t cell costimulation GO:2000525 2 0.697
cell killing GO:0001906 67 0.697
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.696
innate immune response activating signal transduction GO:0002758 50 0.695
inflammatory response to antigenic stimulus GO:0002437 30 0.691
Mouse
negative regulation of immune system process GO:0002683 209 0.689
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.681
alpha beta t cell activation GO:0046631 91 0.658
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.649
regulation of lymphocyte proliferation GO:0050670 117 0.618
Mouse
regulation of natural killer cell activation GO:0032814 22 0.617
i kappab kinase nf kappab signaling GO:0007249 85 0.613
cytokine mediated signaling pathway GO:0019221 115 0.610
regulation of response to wounding GO:1903034 189 0.598
Mouse
positive regulation of alpha beta t cell activation GO:0046635 39 0.596
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.593
cytokine metabolic process GO:0042107 71 0.588
Mouse
negative thymic t cell selection GO:0045060 12 0.587
Mouse
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.560
regulation of cellular amine metabolic process GO:0033238 20 0.560
negative regulation of t cell activation GO:0050868 65 0.550
regulation of cellular amino acid metabolic process GO:0006521 5 0.545
regulation of regulatory t cell differentiation GO:0045589 7 0.539
regulation of cytokine secretion GO:0050707 61 0.526
b cell proliferation GO:0042100 53 0.524
cellular amino acid metabolic process GO:0006520 103 0.522
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.521
peptidyl tyrosine modification GO:0018212 145 0.512
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.506
cellular ketone metabolic process GO:0042180 84 0.498
negative regulation of regulatory t cell differentiation GO:0045590 2 0.488
membrane fusion GO:0061025 38 0.486
regulation of establishment of protein localization GO:0070201 181 0.483
negative regulation of innate immune response GO:0045824 17 0.483
negative regulation of leukocyte mediated immunity GO:0002704 29 0.476
positive regulation of lymphocyte anergy GO:0002913 4 0.468
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.467
positive regulation of adaptive immune response GO:0002821 61 0.465
Mouse
cytokine secretion GO:0050663 72 0.461
amine metabolic process GO:0009308 45 0.442
negative regulation of cytokine production GO:0001818 84 0.439
lymphocyte proliferation GO:0046651 164 0.435
Mouse
hematopoietic stem cell migration GO:0035701 1 0.431
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.426
cell chemotaxis GO:0060326 81 0.418
negative regulation of phosphorus metabolic process GO:0010563 184 0.417
myeloid leukocyte activation GO:0002274 83 0.416
negative regulation of immune effector process GO:0002698 55 0.414
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.409
Mouse
regulation of b cell mediated immunity GO:0002712 37 0.400
Mouse
b cell mediated immunity GO:0019724 71 0.389
Mouse
regulation of eosinophil degranulation GO:0043309 1 0.389
cell activation involved in immune response GO:0002263 126 0.387
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.386
response to lipopolysaccharide GO:0032496 128 0.386
peptidyl tyrosine phosphorylation GO:0018108 143 0.384
t cell selection GO:0045058 34 0.380
Mouse
negative t cell selection GO:0043383 13 0.377
Mouse
helper t cell chemotaxis GO:0035704 1 0.376
positive regulation of acute inflammatory response GO:0002675 16 0.366
t helper 17 cell chemotaxis GO:0035705 1 0.364
positive regulation of b cell mediated immunity GO:0002714 26 0.363
Mouse
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.363
Mouse
vesicle fusion GO:0006906 16 0.353
negative regulation of phosphate metabolic process GO:0045936 184 0.350
regulation of vesicle fusion GO:0031338 6 0.344
regulation of natural killer cell mediated immunity GO:0002715 19 0.339
leukocyte activation involved in immune response GO:0002366 126 0.338
Mouse
regulation of type iia hypersensitivity GO:0001796 4 0.338
positive regulation of response to wounding GO:1903036 66 0.336
Mouse
inflammatory response GO:0006954 244 0.334
Mouse
activation of innate immune response GO:0002218 56 0.334
negative regulation of interferon gamma production GO:0032689 18 0.328
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.327
natural killer cell mediated cytotoxicity GO:0042267 29 0.325
pattern recognition receptor signaling pathway GO:0002221 47 0.323
tumor necrosis factor biosynthetic process GO:0042533 10 0.323
regulation of protein transport GO:0051223 163 0.322
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.320
positive regulation of cell killing GO:0031343 33 0.318
alpha beta t cell differentiation GO:0046632 69 0.317
protein kinase b signaling GO:0043491 74 0.316
Mouse
immune response inhibiting cell surface receptor signaling pathway GO:0002767 3 0.312
interleukin 12 secretion GO:0072610 3 0.311
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.308
regulation of regulated secretory pathway GO:1903305 20 0.306
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.298
stress activated protein kinase signaling cascade GO:0031098 81 0.297
t helper cell differentiation GO:0042093 28 0.296
defense response to gram positive bacterium GO:0050830 50 0.295
mapk cascade GO:0000165 281 0.294
regulation of monocyte extravasation GO:2000437 2 0.293
cellular amine metabolic process GO:0044106 44 0.292
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.289
immune response inhibiting signal transduction GO:0002765 4 0.285
regulation of cell killing GO:0031341 40 0.280
metal ion homeostasis GO:0055065 189 0.279
regulation of secretion by cell GO:1903530 249 0.277
defense response to bacterium GO:0042742 119 0.276
t cell differentiation involved in immune response GO:0002292 30 0.275
mature dendritic cell differentiation GO:0097029 3 0.274
regulation of t cell costimulation GO:2000523 2 0.272
divalent inorganic cation homeostasis GO:0072507 138 0.272
regulation of vesicle mediated transport GO:0060627 139 0.271
lymph node development GO:0048535 18 0.270
negative regulation of phosphorylation GO:0042326 166 0.262
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.261
Mouse
alpha beta t cell activation involved in immune response GO:0002287 31 0.260
eosinophil activation GO:0043307 1 0.258
regulation of monocyte chemotaxis GO:0090025 3 0.253
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.253
production of molecular mediator of immune response GO:0002440 103 0.251
Mouse
immune complex clearance GO:0002434 2 0.250
positive regulation of b cell activation GO:0050871 49 0.246
Mouse
reactive oxygen species metabolic process GO:0072593 84 0.245
regulation of lymphocyte differentiation GO:0045619 107 0.244
negative regulation of eosinophil degranulation GO:0043310 1 0.243
positive regulation of protein kinase b signaling GO:0051897 32 0.240
Mouse
negative regulation of leukocyte differentiation GO:1902106 51 0.239
granulocyte chemotaxis GO:0071621 39 0.239
defense response to virus GO:0051607 68 0.235
regulation of ion transport GO:0043269 215 0.230
regulation of t cell extravasation GO:2000407 3 0.230
positive regulation of alpha beta t cell proliferation GO:0046641 12 0.229
Mouse
regulation of corticotropin releasing hormone secretion GO:0043397 2 0.226
regulation of kinase activity GO:0043549 249 0.225
b cell activation involved in immune response GO:0002312 50 0.221
Mouse
positive regulation of monocyte extravasation GO:2000439 1 0.218
positive regulation of cell death GO:0010942 224 0.216
eosinophil activation involved in immune response GO:0002278 1 0.216
dna recombination GO:0006310 92 0.214
Mouse
toll like receptor signaling pathway GO:0002224 38 0.214
regulation of organelle organization GO:0033043 289 0.212
lymphocyte apoptotic process GO:0070227 54 0.210
positive regulation of protein phosphorylation GO:0001934 242 0.210
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.209
negative regulation of defense response GO:0031348 77 0.209
inositol lipid mediated signaling GO:0048017 41 0.208
Mouse
endocytosis GO:0006897 168 0.206
regulation of protein kinase activity GO:0045859 232 0.199
negative regulation of protein phosphorylation GO:0001933 126 0.198
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.197
t cell mediated immunity GO:0002456 50 0.196
cellular response to molecule of fungal origin GO:0071226 2 0.195
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.195
Mouse
natural killer cell mediated immunity GO:0002228 29 0.195
regulation of interleukin 1 beta secretion GO:0050706 15 0.194
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.194
regulation of protein secretion GO:0050708 82 0.190
immunoglobulin mediated immune response GO:0016064 69 0.190
Mouse
regulation of immunological synapse formation GO:2000520 2 0.190
cytokine biosynthetic process GO:0042089 68 0.187
Mouse
myeloid cell differentiation GO:0030099 233 0.187
regulation of t helper 2 cell cytokine production GO:2000551 3 0.186
t cell activation involved in immune response GO:0002286 43 0.185
protein secretion GO:0009306 111 0.185
cellular response to molecule of bacterial origin GO:0071219 83 0.184
glycoprotein biosynthetic process GO:0009101 89 0.183
positive regulation of leukocyte differentiation GO:1902107 86 0.183
regulatory t cell differentiation GO:0045066 10 0.180
regulation of mapk cascade GO:0043408 248 0.180
microglial cell activation involved in immune response GO:0002282 1 0.179
g protein coupled receptor signaling pathway GO:0007186 243 0.178
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.178
regulation of acute inflammatory response GO:0002673 27 0.177
regulation of b cell activation GO:0050864 81 0.174
Mouse
t cell extravasation GO:0072683 4 0.172
interleukin 12 production GO:0032615 32 0.172
somatic cell dna recombination GO:0016444 51 0.168
Mouse
positive regulation of intracellular transport GO:0032388 70 0.166
negative regulation of protein modification process GO:0031400 163 0.165
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.161
negative regulation of growth GO:0045926 99 0.161
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.159
cellular response to lipid GO:0071396 145 0.159
regulation of apoptotic signaling pathway GO:2001233 197 0.154
peptidyl amino acid modification GO:0018193 336 0.154
regulation of peptidase activity GO:0052547 96 0.153
interleukin 4 production GO:0032633 24 0.153
glycoprotein metabolic process GO:0009100 116 0.151
positive regulation of monocyte chemotaxis GO:0090026 2 0.149
t helper 2 cell differentiation GO:0045064 12 0.149
regulation of interleukin 10 secretion GO:2001179 4 0.145
negative regulation of cell activation GO:0050866 111 0.145
regulation of protein localization GO:0032880 231 0.143
release of sequestered calcium ion into cytosol GO:0051209 42 0.142
negative regulation of intracellular signal transduction GO:1902532 167 0.141
dendritic cell differentiation GO:0097028 26 0.140
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.139
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.139
negative regulation of multi organism process GO:0043901 68 0.138
cdc42 protein signal transduction GO:0032488 0 0.138
positive regulation of protein secretion GO:0050714 52 0.136
eosinophil mediated immunity GO:0002447 1 0.135
sequestering of calcium ion GO:0051208 18 0.135
interleukin 2 biosynthetic process GO:0042094 15 0.133
Mouse
positive regulation of cell development GO:0010720 237 0.133
positive regulation of homeostatic process GO:0032846 64 0.133
membrane organization GO:0061024 245 0.133
positive regulation of cytokine secretion GO:0050715 41 0.132
negative regulation of cellular protein metabolic process GO:0032269 247 0.132
regulation of immunoglobulin mediated immune response GO:0002889 37 0.130
Mouse
gliogenesis GO:0042063 141 0.129
myeloid leukocyte mediated immunity GO:0002444 42 0.128
regulation of map kinase activity GO:0043405 120 0.128
ensheathment of neurons GO:0007272 76 0.128
sequestering of metal ion GO:0051238 19 0.127
regulation of interleukin 4 production GO:0032673 18 0.126
regulation of calcium ion transport into cytosol GO:0010522 31 0.125
positive regulation of hydrolase activity GO:0051345 148 0.125
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.123
lymphocyte migration GO:0072676 26 0.123
response to molecule of bacterial origin GO:0002237 143 0.121
regulation of lipid transport GO:0032368 36 0.120
positive regulation of interleukin 13 production GO:0032736 4 0.120
positive regulation of lymphocyte differentiation GO:0045621 61 0.120
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.117
neuronal action potential GO:0019228 54 0.116
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.116
negative regulation of b cell activation GO:0050869 27 0.116
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.115
monocyte extravasation GO:0035696 2 0.115
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.115
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.114
cation transport GO:0006812 399 0.114
positive regulation of secretion by cell GO:1903532 114 0.114
myeloid cell activation involved in immune response GO:0002275 34 0.114
ribonucleotide metabolic process GO:0009259 291 0.113
regulation of interleukin 1 beta production GO:0032651 25 0.112
necrotic cell death GO:0070265 30 0.110
vesicle organization GO:0016050 60 0.110
positive regulation of t cell migration GO:2000406 10 0.109
regulation of type 2 immune response GO:0002828 18 0.108
leukocyte mediated cytotoxicity GO:0001909 62 0.107
positive regulation of lymphocyte migration GO:2000403 11 0.107
transmission of nerve impulse GO:0019226 76 0.107
antigen processing and presentation GO:0019882 47 0.107
regulation of stress activated mapk cascade GO:0032872 69 0.106
positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 2 0.106
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.105
phosphatidylinositol mediated signaling GO:0048015 41 0.104
Mouse
positive regulation of mapk cascade GO:0043410 170 0.104
negative regulation of cell proliferation GO:0008285 296 0.104
organonitrogen compound catabolic process GO:1901565 264 0.104
rho protein signal transduction GO:0007266 32 0.103
positive regulation of t cell extravasation GO:2000409 2 0.103
somatic diversification of immunoglobulins GO:0016445 43 0.102
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.101
regulation of cysteine type endopeptidase activity GO:2000116 65 0.101
mast cell activation GO:0045576 27 0.101
cellular response to lipopolysaccharide GO:0071222 77 0.100
response to organic cyclic compound GO:0014070 198 0.099
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.099
regulation of lymphocyte apoptotic process GO:0070228 41 0.098
cellular calcium ion homeostasis GO:0006874 119 0.098
myeloid leukocyte differentiation GO:0002573 119 0.098
response to drug GO:0042493 75 0.097
activation of jun kinase activity GO:0007257 15 0.097
positive regulation of chemotaxis GO:0050921 38 0.097
positive regulation of acute inflammatory response to antigenic stimulus GO:0002866 7 0.096
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.094
nucleobase containing small molecule metabolic process GO:0055086 352 0.093
second messenger mediated signaling GO:0019932 73 0.093
positive regulation of immunological synapse formation GO:2000522 1 0.092
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.092
Mouse
t helper 17 cell lineage commitment GO:0072540 4 0.092
t cell differentiation in thymus GO:0033077 77 0.091
Mouse
regulation of intracellular transport GO:0032386 159 0.091
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.091
regulation of myeloid cell differentiation GO:0045637 96 0.091
cytosolic calcium ion transport GO:0060401 48 0.090
dendritic cell chemotaxis GO:0002407 7 0.090
positive regulation of translational initiation by iron GO:0045994 2 0.090
positive regulation of oligodendrocyte differentiation GO:0048714 9 0.090
acute inflammatory response to antigenic stimulus GO:0002438 12 0.089
positive regulation of phospholipase c activity GO:0010863 2 0.089
protein maturation GO:0051604 176 0.089
jnk cascade GO:0007254 72 0.088
regulation of protein targeting GO:1903533 61 0.088
cellular homeostasis GO:0019725 240 0.088
negative regulation of secretion GO:0051048 61 0.088
carbohydrate derivative biosynthetic process GO:1901137 183 0.088
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.087
regulation of secretion GO:0051046 274 0.087
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.087
nitrogen compound transport GO:0071705 271 0.086
multicellular organismal signaling GO:0035637 91 0.086
cytokine production involved in immune response GO:0002367 34 0.086
methylation GO:0032259 134 0.085
type 2 immune response GO:0042092 23 0.085
phagocytosis GO:0006909 66 0.084
negative regulation of interleukin 2 biosynthetic process GO:0045085 3 0.084
cellular response to biotic stimulus GO:0071216 92 0.084
regulation of t cell receptor signaling pathway GO:0050856 21 0.084
positive regulation of secretion GO:0051047 130 0.084
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.084
leukocyte degranulation GO:0043299 27 0.084
negative regulation of leukocyte proliferation GO:0070664 46 0.084
interleukin 13 secretion GO:0072611 2 0.084
interleukin 2 mediated signaling pathway GO:0038110 2 0.084
isotype switching GO:0045190 36 0.084
Mouse
positive regulation of endocytosis GO:0045807 42 0.083
macrophage activation GO:0042116 27 0.083
dna metabolic process GO:0006259 303 0.082
Mouse
granulocyte activation GO:0036230 10 0.082
positive regulation of interferon alpha production GO:0032727 4 0.081
positive regulation of t cell anergy GO:0002669 4 0.081
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.081
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.081
negative regulation of t cell proliferation GO:0042130 38 0.081
glucose metabolic process GO:0006006 92 0.080
purine containing compound metabolic process GO:0072521 311 0.080
regulation of reactive oxygen species metabolic process GO:2000377 40 0.079
immunoglobulin secretion GO:0048305 17 0.079
regulation of interleukin 13 secretion GO:2000665 2 0.079
corticotropin releasing hormone secretion GO:0043396 2 0.079
regulation of hydrolase activity GO:0051336 246 0.078
t cell chemotaxis GO:0010818 6 0.078
protein localization to organelle GO:0033365 185 0.078
positive regulation of lipid transport GO:0032370 22 0.077
growth of symbiont in host GO:0044117 23 0.077
negative regulation of b cell proliferation GO:0030889 13 0.077
fever generation GO:0001660 7 0.077
interleukin 5 secretion GO:0072603 2 0.077
regulation of chemokine production GO:0032642 30 0.076
regulation of lymphocyte anergy GO:0002911 4 0.076
regulation of tumor necrosis factor production GO:0032680 49 0.075
cellular metal ion homeostasis GO:0006875 151 0.075
positive regulation of t cell differentiation GO:0045582 52 0.074
osteoclast differentiation GO:0030316 62 0.074
cellular response to interleukin 15 GO:0071350 2 0.074
action potential GO:0001508 78 0.074
cellular ion homeostasis GO:0006873 165 0.074
negative regulation of lymphocyte activation GO:0051250 91 0.073
growth involved in symbiotic interaction GO:0044110 23 0.073
divalent metal ion transport GO:0070838 172 0.073
b cell differentiation GO:0030183 78 0.072
regulation of endopeptidase activity GO:0052548 89 0.072
positive regulation of protein modification process GO:0031401 299 0.070
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.070
negative regulation of lymphocyte proliferation GO:0050672 45 0.070
regulation of growth of symbiont in host GO:0044126 19 0.069
thymic t cell selection GO:0045061 22 0.069
Mouse
positive regulation of interferon gamma biosynthetic process GO:0045078 4 0.069
lymphocyte activation involved in immune response GO:0002285 93 0.069
Mouse
positive regulation of immunoglobulin production GO:0002639 28 0.069
Mouse
regulation of hormone levels GO:0010817 211 0.068
activation of mapk activity GO:0000187 59 0.068
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.068
nucleotide metabolic process GO:0009117 332 0.067
inflammatory cell apoptotic process GO:0006925 11 0.066
cytoplasmic transport GO:0016482 234 0.066
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.066
detection of yeast GO:0001879 2 0.066
cell type specific apoptotic process GO:0097285 268 0.066
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.066
positive regulation of interleukin 12 production GO:0032735 21 0.066
t cell migration GO:0072678 19 0.066
regulation of protein maturation GO:1903317 96 0.065
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.064
positive regulation of immune complex clearance by monocytes and macrophages GO:0090265 2 0.064
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.064
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.064
establishment of protein localization to organelle GO:0072594 118 0.064
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.063
regulation of transferase activity GO:0051338 263 0.063
positive regulation of stress activated mapk cascade GO:0032874 48 0.063
maintenance of location GO:0051235 89 0.062
t cell lineage commitment GO:0002360 13 0.062
protein homotrimerization GO:0070207 4 0.062
negative regulation of interleukin 10 secretion GO:2001180 2 0.062
programmed necrotic cell death GO:0097300 28 0.061
anatomical structure homeostasis GO:0060249 145 0.060
regulation of protein serine threonine kinase activity GO:0071900 157 0.060
positive t cell selection GO:0043368 23 0.060
regulation of phagocytosis GO:0050764 33 0.060
positive regulation of organelle organization GO:0010638 128 0.060
positive regulation of type ii hypersensitivity GO:0002894 4 0.060
negative regulation of secretion by cell GO:1903531 54 0.059
response to peptide GO:1901652 136 0.059
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.059
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.059
Mouse
positive regulation of jnk cascade GO:0046330 46 0.058
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.058
negative regulation of macrophage apoptotic process GO:2000110 3 0.058
t cell apoptotic process GO:0070231 39 0.058
negative regulation of growth of symbiont in host GO:0044130 19 0.058
tissue remodeling GO:0048771 102 0.058
glial cell apoptotic process GO:0034349 3 0.056
positive regulation of intracellular protein transport GO:0090316 42 0.056
response to molecule of fungal origin GO:0002238 4 0.056
axon ensheathment GO:0008366 76 0.056
aromatic compound catabolic process GO:0019439 286 0.056
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.056
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.056
lymphocyte anergy GO:0002249 4 0.056
positive regulation of myoblast differentiation GO:0045663 8 0.056
signal transduction in absence of ligand GO:0038034 55 0.056
positive regulation of phagocytosis GO:0050766 26 0.055
anion transport GO:0006820 177 0.055
bone resorption GO:0045453 38 0.055
regulation of alpha beta t cell differentiation GO:0046637 35 0.054
sensitization GO:0046960 2 0.054
regulation of peptide transport GO:0090087 91 0.054
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.054
single organism cell adhesion GO:0098602 156 0.054
homeostasis of number of cells GO:0048872 210 0.054
purine ribonucleoside metabolic process GO:0046128 241 0.053
dephosphorylation GO:0016311 129 0.053
positive regulation of epithelial cell proliferation GO:0050679 68 0.053

Icos disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.116
hypersensitivity reaction disease DOID:0060056 0 0.116
disease of anatomical entity DOID:7 0 0.116
primary immunodeficiency disease DOID:612 0 0.074
b cell deficiency DOID:2115 0 0.074