Mus musculus

51 known processes

Akr1a4

aldo-keto reductase family 1, member A4 (aldehyde reductase)

(Aliases: Akr1a1,2610201A18Rik)

Akr1a4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.270
cytoplasmic transport GO:0016482 234 0.263
apoptotic signaling pathway GO:0097190 306 0.194
cellular divalent inorganic cation homeostasis GO:0072503 127 0.188
extrinsic apoptotic signaling pathway GO:0097191 126 0.139
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.119
regulation of apoptotic signaling pathway GO:2001233 197 0.116
cation transport GO:0006812 399 0.112
ion transmembrane transport GO:0034220 361 0.110
cation homeostasis GO:0055080 212 0.107
male gamete generation GO:0048232 285 0.106
regulation of cellular amino acid metabolic process GO:0006521 5 0.091
cellular metal ion homeostasis GO:0006875 151 0.084
positive regulation of programmed cell death GO:0043068 218 0.080
macromolecule catabolic process GO:0009057 281 0.078
cellular homeostasis GO:0019725 240 0.076
sulfur compound metabolic process GO:0006790 100 0.076
regulation of binding GO:0051098 111 0.075
cellular ketone metabolic process GO:0042180 84 0.072
Mouse
cellular ion homeostasis GO:0006873 165 0.071
regulation of cellular ketone metabolic process GO:0010565 66 0.068
regulation of intracellular transport GO:0032386 159 0.068
positive regulation of cell death GO:0010942 224 0.068
regulation of ion transport GO:0043269 215 0.068
cellular modified amino acid metabolic process GO:0006575 63 0.068
positive regulation of secretion GO:0051047 130 0.065
regulation of cell activation GO:0050865 289 0.065
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.064
metal ion homeostasis GO:0055065 189 0.063
membrane organization GO:0061024 245 0.062
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.061
meiotic nuclear division GO:0007126 115 0.060
negative regulation of protein metabolic process GO:0051248 282 0.059
gonad development GO:0008406 141 0.058
carbohydrate derivative catabolic process GO:1901136 231 0.058
vesicle organization GO:0016050 60 0.057
oxidation reduction process GO:0055114 342 0.057
maintenance of location GO:0051235 89 0.056
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.056
positive regulation of necrotic cell death GO:0010940 1 0.056
regulation of leukocyte differentiation GO:1902105 159 0.054
protein localization to nucleus GO:0034504 121 0.053
protein maturation GO:0051604 176 0.052
endocytosis GO:0006897 168 0.051
response to amino acid GO:0043200 37 0.050
regulation of lymphocyte activation GO:0051249 240 0.050
negative regulation of cellular protein metabolic process GO:0032269 247 0.050
homeostasis of number of cells GO:0048872 210 0.050
positive regulation of apoptotic process GO:0043065 217 0.050
amine metabolic process GO:0009308 45 0.049
calcium ion homeostasis GO:0055074 127 0.048
development of primary sexual characteristics GO:0045137 143 0.048
protein import into nucleus GO:0006606 95 0.048
cellular amine metabolic process GO:0044106 44 0.048
regulation of establishment of protein localization GO:0070201 181 0.046
response to inorganic substance GO:0010035 96 0.046
protein catabolic process GO:0030163 221 0.046
lymphocyte differentiation GO:0030098 242 0.046
spermatogenesis GO:0007283 284 0.046
positive regulation of secretion by cell GO:1903532 114 0.045
calcium ion transport GO:0006816 159 0.044
positive regulation of exocytosis GO:0045921 20 0.044
signal transduction in absence of ligand GO:0038034 55 0.044
positive regulation of mapk cascade GO:0043410 170 0.044
establishment of protein localization to organelle GO:0072594 118 0.043
regulation of secretion by cell GO:1903530 249 0.043
intracellular protein transport GO:0006886 204 0.043
regulation of hydrolase activity GO:0051336 246 0.043
regulation of secretion GO:0051046 274 0.042
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.041
ameboidal type cell migration GO:0001667 128 0.040
negative regulation of cell proliferation GO:0008285 296 0.040
leukocyte mediated cytotoxicity GO:0001909 62 0.040
golgi vesicle transport GO:0048193 30 0.040
engulfment of apoptotic cell GO:0043652 3 0.039
positive regulation of cellular amine metabolic process GO:0033240 5 0.038
regulation of protein localization GO:0032880 231 0.038
myeloid cell differentiation GO:0030099 233 0.038
regulation of t cell activation GO:0050863 170 0.038
wound healing GO:0042060 157 0.038
dna metabolic process GO:0006259 303 0.038
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.037
tissue homeostasis GO:0001894 115 0.037
nucleobase containing small molecule metabolic process GO:0055086 352 0.037
lymphocyte proliferation GO:0046651 164 0.037
regulation of protein kinase activity GO:0045859 232 0.037
t cell activation GO:0042110 289 0.036
protein localization to organelle GO:0033365 185 0.036
regulation of protein stability GO:0031647 52 0.036
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.035
regulation of cellular amine metabolic process GO:0033238 20 0.034
sequestering of metal ion GO:0051238 19 0.033
innate immune response GO:0045087 157 0.033
regulation of cellular response to stress GO:0080135 159 0.033
negative regulation of molecular function GO:0044092 258 0.033
regulation of cytoplasmic transport GO:1903649 112 0.033
actin cytoskeleton organization GO:0030036 220 0.033
regulation of intracellular protein transport GO:0033157 82 0.032
cellular chemical homeostasis GO:0055082 215 0.032
peptidyl amino acid modification GO:0018193 336 0.032
cation transmembrane transport GO:0098655 266 0.032
organonitrogen compound catabolic process GO:1901565 264 0.032
maternal placenta development GO:0001893 20 0.031
regulation of response to wounding GO:1903034 189 0.031
arp2 3 complex mediated actin nucleation GO:0034314 3 0.031
cellular protein catabolic process GO:0044257 155 0.031
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.031
response to oxidative stress GO:0006979 123 0.031
Yeast
multicellular organismal homeostasis GO:0048871 164 0.030
modification dependent macromolecule catabolic process GO:0043632 133 0.030
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.030
extracellular structure organization GO:0043062 148 0.030
regulation of membrane potential GO:0042391 192 0.030
necrotic cell death GO:0070265 30 0.030
positive regulation of peptidase activity GO:0010952 49 0.030
regulation of mapk cascade GO:0043408 248 0.030
response to organonitrogen compound GO:0010243 246 0.029
posttranscriptional regulation of gene expression GO:0010608 155 0.029
cellular macromolecule catabolic process GO:0044265 206 0.029
cell killing GO:0001906 67 0.029
nuclear division GO:0000280 158 0.028
immune effector process GO:0002252 321 0.028
purine ribonucleotide metabolic process GO:0009150 290 0.028
leukocyte mediated immunity GO:0002443 174 0.028
regulation of map kinase activity GO:0043405 120 0.028
positive regulation of cell activation GO:0050867 158 0.028
transmembrane transport GO:0055085 412 0.028
epidermis development GO:0008544 187 0.027
nuclear import GO:0051170 95 0.027
cellular calcium ion homeostasis GO:0006874 119 0.027
cytosolic calcium ion homeostasis GO:0051480 70 0.027
renal system development GO:0072001 225 0.027
nucleotide metabolic process GO:0009117 332 0.027
reactive oxygen species metabolic process GO:0072593 84 0.026
regulation of defense response GO:0031347 233 0.026
skin development GO:0043588 220 0.026
inorganic ion transmembrane transport GO:0098660 234 0.026
cell type specific apoptotic process GO:0097285 268 0.026
purine ribonucleotide catabolic process GO:0009154 208 0.026
t cell differentiation GO:0030217 174 0.025
cellular response to dna damage stimulus GO:0006974 207 0.025
mapk cascade GO:0000165 281 0.025
regulation of peptidase activity GO:0052547 96 0.025
divalent inorganic cation homeostasis GO:0072507 138 0.025
regulation of protein transport GO:0051223 163 0.025
heterocycle catabolic process GO:0046700 280 0.025
mesonephros development GO:0001823 97 0.025
purine nucleotide catabolic process GO:0006195 211 0.025
regulation of nucleocytoplasmic transport GO:0046822 73 0.025
epithelial tube morphogenesis GO:0060562 303 0.025
regulation of proteolysis GO:0030162 164 0.025
nucleocytoplasmic transport GO:0006913 139 0.025
modification dependent protein catabolic process GO:0019941 133 0.025
nuclear transport GO:0051169 139 0.025
purine containing compound metabolic process GO:0072521 311 0.025
divalent metal ion transport GO:0070838 172 0.024
kidney development GO:0001822 213 0.024
anatomical structure homeostasis GO:0060249 145 0.024
positive regulation of protein modification process GO:0031401 299 0.024
regulation of vesicle mediated transport GO:0060627 139 0.024
ribonucleoside metabolic process GO:0009119 245 0.024
hydrogen ion transmembrane transport GO:1902600 25 0.024
actin polymerization or depolymerization GO:0008154 54 0.023
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.023
endomembrane system organization GO:0010256 147 0.023
ribose phosphate metabolic process GO:0019693 291 0.023
cell fate commitment GO:0045165 210 0.023
monosaccharide metabolic process GO:0005996 106 0.023
meiotic cell cycle GO:0051321 122 0.023
ketone catabolic process GO:0042182 3 0.022
Mouse
central nervous system morphogenesis GO:0021551 2 0.022
regulation of protein localization to nucleus GO:1900180 60 0.022
cellular response to oxidative stress GO:0034599 76 0.022
Yeast
hemostasis GO:0007599 78 0.022
organophosphate catabolic process GO:0046434 232 0.022
nucleoside catabolic process GO:0009164 206 0.022
sequestering of calcium ion GO:0051208 18 0.022
leukocyte differentiation GO:0002521 342 0.022
embryonic organ morphogenesis GO:0048562 276 0.022
lymphocyte activation involved in immune response GO:0002285 93 0.021
nucleotide catabolic process GO:0009166 217 0.021
actin filament branching GO:0090135 1 0.021
positive regulation of apoptotic signaling pathway GO:2001235 95 0.021
inter male aggressive behavior GO:0002121 3 0.021
proteasomal protein catabolic process GO:0010498 98 0.020
meiotic cell cycle process GO:1903046 77 0.020
gland development GO:0048732 330 0.020
multi multicellular organism process GO:0044706 109 0.020
Mouse
response to organic cyclic compound GO:0014070 198 0.020
asymmetric stem cell division GO:0098722 3 0.020
inorganic cation transmembrane transport GO:0098662 207 0.020
calcium ion transmembrane transport GO:0070588 85 0.020
purine containing compound catabolic process GO:0072523 213 0.020
nitrogen compound transport GO:0071705 271 0.020
positive regulation of wnt signaling pathway GO:0030177 45 0.020
regulation of body fluid levels GO:0050878 162 0.020
blood coagulation GO:0007596 76 0.020
negative regulation of protein modification process GO:0031400 163 0.019
cytosolic calcium ion transport GO:0060401 48 0.019
sensory organ morphogenesis GO:0090596 242 0.019
positive regulation of lymphocyte activation GO:0051251 140 0.019
regulation of protein import into nucleus GO:0042306 52 0.019
camera type eye development GO:0043010 266 0.019
heart morphogenesis GO:0003007 178 0.019
positive regulation of actin nucleation GO:0051127 3 0.019
superoxide metabolic process GO:0006801 27 0.019
ribonucleotide metabolic process GO:0009259 291 0.019
regulation of anatomical structure size GO:0090066 178 0.018
inflammatory response GO:0006954 244 0.018
divalent inorganic cation transport GO:0072511 178 0.018
ubiquitin dependent protein catabolic process GO:0006511 129 0.018
protein processing GO:0016485 163 0.018
extracellular matrix organization GO:0030198 147 0.018
regulation of transferase activity GO:0051338 263 0.018
regulation of protein targeting GO:1903533 61 0.018
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.018
nucleoside phosphate metabolic process GO:0006753 338 0.018
aromatic compound catabolic process GO:0019439 286 0.018
organic cyclic compound catabolic process GO:1901361 295 0.018
Mouse
response to metal ion GO:0010038 47 0.018
positive regulation of cellular component biogenesis GO:0044089 94 0.018
cellular response to thyroid hormone stimulus GO:0097067 1 0.018
natural killer cell activation involved in immune response GO:0002323 10 0.017
regulation of transcription regulatory region dna binding GO:2000677 9 0.017
negative regulation of lymphocyte activation GO:0051250 91 0.017
er to golgi vesicle mediated transport GO:0006888 11 0.017
actin filament polymerization GO:0030041 44 0.017
positive regulation of lamellipodium assembly GO:0010592 2 0.017
purine ribonucleoside metabolic process GO:0046128 241 0.017
nucleoside triphosphate metabolic process GO:0009141 230 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
sensory perception GO:0007600 245 0.017
response to reactive oxygen species GO:0000302 56 0.017
regulation of protein serine threonine kinase activity GO:0071900 157 0.017
natural killer cell degranulation GO:0043320 3 0.017
cellular response to lipid GO:0071396 145 0.017
rho protein signal transduction GO:0007266 32 0.017
protein import GO:0017038 101 0.017
neuronal action potential GO:0019228 54 0.017
negative regulation of cell activation GO:0050866 111 0.017
muscle cell differentiation GO:0042692 261 0.017
negative regulation of t cell activation GO:0050868 65 0.016
skeletal system development GO:0001501 356 0.016
regulation of homeostatic process GO:0032844 182 0.016
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.016
purine nucleoside metabolic process GO:0042278 241 0.016
male gonad development GO:0008584 88 0.016
ear morphogenesis GO:0042471 118 0.016
positive regulation of ossification GO:0045778 47 0.016
positive regulation of lamellipodium organization GO:1902745 3 0.016
positive regulation of map kinase activity GO:0043406 84 0.016
protein targeting GO:0006605 143 0.016
microtubule based transport GO:0010970 50 0.016
regulation of actin nucleation GO:0051125 4 0.016
protein stabilization GO:0050821 25 0.015
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.015
positive regulation of growth GO:0045927 104 0.015
regulation of multi organism process GO:0043900 111 0.015
regulation of cellular component biogenesis GO:0044087 181 0.015
positive regulation of organelle organization GO:0010638 128 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
negative regulation of proteolysis GO:0045861 74 0.015
regulation of ossification GO:0030278 112 0.015
peptide transport GO:0015833 133 0.014
cellular response to molecule of bacterial origin GO:0071219 83 0.014
leukocyte proliferation GO:0070661 172 0.014
negative regulation of vesicle fusion GO:0031339 1 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.014
intrinsic apoptotic signaling pathway GO:0097193 132 0.014
cellular response to lipopolysaccharide GO:0071222 77 0.014
regulation of kinase activity GO:0043549 249 0.014
mitotic cell cycle GO:0000278 195 0.014
regulation of lymphocyte differentiation GO:0045619 107 0.014
regulation of cell motility GO:2000145 236 0.014
urogenital system development GO:0001655 261 0.014
mitotic cytokinesis GO:0000281 4 0.014
positive regulation of mitochondrial calcium ion concentration GO:0051561 3 0.014
sensory system development GO:0048880 3 0.014
regulation of leukocyte proliferation GO:0070663 121 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
multicellular organismal signaling GO:0035637 91 0.014
regulation of transmembrane transport GO:0034762 128 0.014
cellular response to glucose stimulus GO:0071333 45 0.014
protein ubiquitination GO:0016567 171 0.014
male sex differentiation GO:0046661 109 0.013
t cell proliferation GO:0042098 120 0.013
nucleoside phosphate catabolic process GO:1901292 222 0.013
positive regulation of synaptic plasticity GO:0031915 4 0.013
lipid localization GO:0010876 126 0.013
regulation of cell shape GO:0008360 39 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
multicellular organism growth GO:0035264 161 0.013
regulation of ion transmembrane transport GO:0034765 119 0.013
ossification GO:0001503 216 0.013
proton transport GO:0015992 35 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
regulation of metal ion transport GO:0010959 106 0.013
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
regulation of lymphocyte proliferation GO:0050670 117 0.013
removal of superoxide radicals GO:0019430 12 0.013
protein secretion GO:0009306 111 0.013
negative regulation of neuron death GO:1901215 98 0.013
molting cycle GO:0042303 90 0.013
second messenger mediated signaling GO:0019932 73 0.013
mechanoreceptor differentiation GO:0042490 67 0.013
purine ribonucleoside catabolic process GO:0046130 205 0.013
calcium mediated signaling using intracellular calcium source GO:0035584 3 0.013
blood vessel morphogenesis GO:0048514 285 0.013
regulation of ion homeostasis GO:2000021 64 0.013
negative regulation of immune system process GO:0002683 209 0.013
rna interference GO:0016246 2 0.012
adult locomotory behavior GO:0008344 91 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
response to acid chemical GO:0001101 111 0.012
protein oligomerization GO:0051259 67 0.012
bone development GO:0060348 120 0.012
receptor mediated endocytosis GO:0006898 51 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
regulation of neuron death GO:1901214 134 0.012
regulation of calcium ion transport into cytosol GO:0010522 31 0.012
ceramide biosynthetic process GO:0046513 20 0.012
circulatory system process GO:0003013 197 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
placenta development GO:0001890 140 0.012
amide transport GO:0042886 138 0.012
regulation of neuron differentiation GO:0045664 281 0.012
posttranscriptional gene silencing by rna GO:0035194 10 0.012
lateral line system development GO:0048925 1 0.012
purine nucleotide metabolic process GO:0006163 302 0.012
response to lipopolysaccharide GO:0032496 128 0.012
wnt signaling pathway GO:0016055 188 0.012
cellular response to oxygen radical GO:0071450 14 0.012
lateral inhibition GO:0046331 1 0.012
connective tissue development GO:0061448 179 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
organophosphate biosynthetic process GO:0090407 122 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
positive regulation of cell development GO:0010720 237 0.012
membrane fusion GO:0061025 38 0.012
myeloid leukocyte differentiation GO:0002573 119 0.012
fucose metabolic process GO:0006004 1 0.011
leukocyte homeostasis GO:0001776 79 0.011
positive regulation of response to wounding GO:1903036 66 0.011
regulation of voltage gated calcium channel activity GO:1901385 4 0.011
calcium ion transport into cytosol GO:0060402 48 0.011
transcription factor import into nucleus GO:0042991 26 0.011
single organism nuclear import GO:1902593 95 0.011
diol metabolic process GO:0034311 5 0.011
tissue remodeling GO:0048771 102 0.011
regulation of transporter activity GO:0032409 57 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.011
microtubule based process GO:0007017 236 0.011
plasma cell differentiation GO:0002317 3 0.011
regulation of cell migration GO:0030334 219 0.011
axon ensheathment GO:0008366 76 0.011
nucleoside metabolic process GO:0009116 246 0.011
lipid storage GO:0019915 36 0.011
ras protein signal transduction GO:0007265 77 0.011
regulation of actin cytoskeleton organization GO:0032956 84 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
regulation of calcium ion transport GO:0051924 69 0.011
cellular protein complex assembly GO:0043623 116 0.011
epithelial cell development GO:0002064 159 0.011
retina development in camera type eye GO:0060041 119 0.011
positive regulation of cell cycle process GO:0090068 61 0.011
development of primary male sexual characteristics GO:0046546 88 0.010
ribonucleotide catabolic process GO:0009261 208 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.010
notochord cell development GO:0060035 1 0.010
regulation of dna binding GO:0051101 39 0.010
muscle cell fate specification GO:0042694 1 0.010
regulation of epithelial cell proliferation GO:0050678 141 0.010
morphogenesis of embryonic epithelium GO:0016331 159 0.010
plasma membrane organization GO:0007009 90 0.010
protein polymerization GO:0051258 57 0.010
cellular component assembly involved in morphogenesis GO:0010927 139 0.010
bundle of his development GO:0003166 4 0.010
regulation of leukocyte mediated immunity GO:0002703 104 0.010
regulation of coagulation GO:0050818 31 0.010
regulation of transcription factor import into nucleus GO:0042990 24 0.010
regulation of neuron apoptotic process GO:0043523 122 0.010
hexose metabolic process GO:0019318 98 0.010
Yeast
maternal process involved in female pregnancy GO:0060135 32 0.010

Akr1a4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.052
central nervous system disease DOID:331 0 0.037
disease of anatomical entity DOID:7 0 0.037
nervous system disease DOID:863 0 0.037
bone development disease DOID:0080006 0 0.034
bone disease DOID:0080001 0 0.034
musculoskeletal system disease DOID:17 0 0.034
connective tissue disease DOID:65 0 0.034
immune system disease DOID:2914 0 0.019
osteochondrodysplasia DOID:2256 0 0.018
inherited metabolic disorder DOID:655 0 0.018
sensory system disease DOID:0050155 0 0.015
lipid storage disease DOID:9455 0 0.015
lysosomal storage disease DOID:3211 0 0.015
sphingolipidosis DOID:1927 0 0.015
neurodegenerative disease DOID:1289 0 0.013
brain disease DOID:936 0 0.012
epilepsy syndrome DOID:1826 0 0.011
electroclinical syndrome DOID:0050701 0 0.011