|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
14 |
1.000
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.993
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.992
|
|
|
|
gtp metabolic process
|
GO:0046039 |
144 |
0.991
|
|
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.990
|
|
|
|
synaptic vesicle localization
|
GO:0097479 |
59 |
0.990
|
Fly |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.989
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
122 |
0.989
|
Fly |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.986
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
122 |
0.985
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
58 |
0.976
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
65 |
0.976
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.971
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.970
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
199 |
0.969
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.969
|
|
|
|
vesicle localization
|
GO:0051648 |
86 |
0.966
|
Fly |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
205 |
0.965
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.965
|
|
|
|
clathrin coat assembly
|
GO:0048268 |
2 |
0.963
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.962
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.955
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.954
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.954
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
41 |
0.952
|
|
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.950
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.937
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.931
|
|
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.931
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.930
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.930
|
|
|
|
synaptic vesicle transport
|
GO:0048489 |
57 |
0.926
|
Fly |
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.923
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.915
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.911
|
|
|
|
establishment of synaptic vesicle localization
|
GO:0097480 |
57 |
0.911
|
Fly |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.908
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.906
|
|
|
|
synaptic vesicle recycling
|
GO:0036465 |
19 |
0.906
|
Fly |
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.906
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.894
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.892
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.891
|
Yeast Fly |
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.887
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.882
|
|
|
|
synaptic transmission
|
GO:0007268 |
329 |
0.881
|
Fly |
|
|
establishment of vesicle localization
|
GO:0051650 |
81 |
0.873
|
Fly |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.868
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.867
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.865
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.862
|
|
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.853
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.851
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.842
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
85 |
0.842
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.836
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.833
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.830
|
|
|
|
organelle localization
|
GO:0051640 |
179 |
0.825
|
Fly |
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.817
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.813
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.802
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.800
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.790
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.788
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.774
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.769
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.751
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.743
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.718
|
|
|
|
phagosome maturation
|
GO:0090382 |
4 |
0.714
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.714
|
|
|
|
olfactory learning
|
GO:0008355 |
2 |
0.708
|
|
|
|
behavioral response to nutrient
|
GO:0051780 |
1 |
0.687
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
71 |
0.685
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.681
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.678
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.655
|
|
|
|
clathrin mediated endocytosis
|
GO:0072583 |
7 |
0.649
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.645
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.619
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.619
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.618
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
139 |
0.588
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.586
|
|
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
1 |
0.579
|
|
|
|
golgi to endosome transport
|
GO:0006895 |
3 |
0.558
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
69 |
0.548
|
|
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.531
|
|
|
|
rab protein signal transduction
|
GO:0032482 |
1 |
0.523
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.514
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.501
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.496
|
Fly |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.492
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.465
|
|
|
|
synaptic vesicle endocytosis
|
GO:0048488 |
19 |
0.463
|
Fly |
|
|
regulation of clathrin mediated endocytosis
|
GO:2000369 |
4 |
0.438
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.431
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.405
|
|
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
32 |
0.379
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.372
|
|
|
|
synaptic vesicle membrane organization
|
GO:0048499 |
1 |
0.362
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.316
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.314
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.311
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
122 |
0.309
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.305
|
|
|
|
phagocytosis
|
GO:0006909 |
66 |
0.288
|
|
|
|
negative regulation of nervous system development
|
GO:0051961 |
156 |
0.283
|
|
|
|
jak stat cascade
|
GO:0007259 |
42 |
0.277
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.272
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.254
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.250
|
Fly |
|
|
cellularization
|
GO:0007349 |
1 |
0.248
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.242
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.228
|
Fly |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.227
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.223
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
122 |
0.204
|
|
|
|
phosphatidylinositol biosynthetic process
|
GO:0006661 |
15 |
0.202
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.202
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.200
|
|
|
|
organelle assembly
|
GO:0070925 |
177 |
0.195
|
|
|
|
positive regulation of rab gtpase activity
|
GO:0032851 |
7 |
0.181
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
266 |
0.178
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.174
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.173
|
Fly |
|
|
coagulation
|
GO:0050817 |
78 |
0.172
|
|
|
|
male gamete generation
|
GO:0048232 |
285 |
0.172
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.170
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
92 |
0.170
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.167
|
|
|
|
membrane organization
|
GO:0061024 |
245 |
0.166
|
|
|
|
endomembrane system organization
|
GO:0010256 |
147 |
0.162
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.162
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.162
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.160
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
207 |
0.159
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.159
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.156
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.156
|
|
|
|
lipid localization
|
GO:0010876 |
126 |
0.156
|
|
|
|
vesicle organization
|
GO:0016050 |
60 |
0.155
|
|
|
|
negative regulation of b cell activation
|
GO:0050869 |
27 |
0.145
|
|
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.140
|
|
|
|
genetic imprinting
|
GO:0071514 |
27 |
0.138
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
230 |
0.137
|
|
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
45 |
0.137
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
179 |
0.134
|
|
|
|
cell division
|
GO:0051301 |
120 |
0.133
|
Yeast |
|
|
actin filament organization
|
GO:0007015 |
113 |
0.128
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.127
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.126
|
|
|
|
negative regulation of protein tyrosine kinase activity
|
GO:0061099 |
3 |
0.123
|
|
|
|
negative regulation of neuron projection development
|
GO:0010977 |
50 |
0.123
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.123
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.122
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.121
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.119
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.119
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
78 |
0.118
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.118
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.117
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.115
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.113
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.111
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.111
|
|
|
|
membrane invagination
|
GO:0010324 |
17 |
0.110
|
|
|
|
skeletal system morphogenesis
|
GO:0048705 |
203 |
0.107
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.107
|
Fly |
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.106
|
|
|
|
regulation of lymphocyte anergy
|
GO:0002911 |
4 |
0.104
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.103
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
62 |
0.103
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.100
|
|
|
|
chemotaxis
|
GO:0006935 |
247 |
0.100
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.099
|
|
|
|
myotube differentiation
|
GO:0014902 |
105 |
0.099
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.099
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.098
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.097
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.097
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
114 |
0.096
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
50 |
0.096
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.095
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.095
|
|
|
|
b cell differentiation
|
GO:0030183 |
78 |
0.094
|
|
|
|
membrane budding
|
GO:0006900 |
6 |
0.093
|
|
|
|
conditioned taste aversion
|
GO:0001661 |
4 |
0.090
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.090
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.089
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.089
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.089
|
|
|
|
regulation of t cell anergy
|
GO:0002667 |
4 |
0.089
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
87 |
0.088
|
|
|
|
regulation of actin filament length
|
GO:0030832 |
45 |
0.088
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.087
|
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
71 |
0.087
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.087
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.087
|
|
|
|
molting cycle
|
GO:0042303 |
90 |
0.086
|
|
|
|
platelet activation
|
GO:0030168 |
40 |
0.086
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.084
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.084
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.083
|
|
|
|
b cell homeostasis
|
GO:0001782 |
34 |
0.082
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.082
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
45 |
0.082
|
|
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.082
|
|
|
|
cellular response to peptide
|
GO:1901653 |
92 |
0.081
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
34 |
0.081
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.081
|
|
|
|
cell cell adhesion
|
GO:0098609 |
41 |
0.081
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.081
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
3 |
0.081
|
|
|
|
positive regulation of non canonical wnt signaling pathway
|
GO:2000052 |
6 |
0.080
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.080
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.079
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.078
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.078
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.078
|
|
|
|
morphogenesis of a polarized epithelium
|
GO:0001738 |
37 |
0.076
|
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.075
|
|
|
|
positive regulation of lymphocyte anergy
|
GO:0002913 |
4 |
0.075
|
|
|
|
lateral inhibition
|
GO:0046331 |
1 |
0.075
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.075
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.074
|
|
|
|
maintenance of location
|
GO:0051235 |
89 |
0.074
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.074
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
45 |
0.074
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.073
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.073
|
|
|
|
methylation
|
GO:0032259 |
134 |
0.073
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
157 |
0.073
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.072
|
|
|
|
positive regulation of t cell anergy
|
GO:0002669 |
4 |
0.071
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.071
|
|
|
|
t cell anergy
|
GO:0002870 |
4 |
0.071
|
|
|
|
cell junction maintenance
|
GO:0034331 |
4 |
0.071
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.070
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.069
|
|
|
|
regulation of neurotrophin trk receptor signaling pathway
|
GO:0051386 |
4 |
0.068
|
|
|
|
sensory perception
|
GO:0007600 |
245 |
0.067
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.067
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
130 |
0.067
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.065
|
|
|
|
positive regulation of notch signaling pathway
|
GO:0045747 |
18 |
0.065
|
|
|
|
associative learning
|
GO:0008306 |
61 |
0.065
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
82 |
0.064
|
|
|
|
regulation of necrotic cell death
|
GO:0010939 |
13 |
0.063
|
|
|
|
response to peptide hormone
|
GO:0043434 |
127 |
0.063
|
|
|
|
glucose metabolic process
|
GO:0006006 |
92 |
0.063
|
|
|
|
apoptotic cell clearance
|
GO:0043277 |
17 |
0.062
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.062
|
|
|
|
notch signaling pathway
|
GO:0007219 |
71 |
0.062
|
Fly |
|
|
salivary gland development
|
GO:0007431 |
37 |
0.062
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.062
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.061
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
25 |
0.061
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.061
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.060
|
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.060
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.060
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.060
|
|
|
|
spermatogenesis
|
GO:0007283 |
284 |
0.059
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.059
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.058
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.058
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.057
|
Fly |
|
|
negative regulation of leukocyte proliferation
|
GO:0070664 |
46 |
0.057
|
|
|
|
lipid storage
|
GO:0019915 |
36 |
0.056
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
56 |
0.056
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.056
|
Fly |
|
|
extracellular structure organization
|
GO:0043062 |
148 |
0.055
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.055
|
|
|
|
protein secretion
|
GO:0009306 |
111 |
0.055
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.053
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.053
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.053
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.053
|
|
|
|
regulation of epidermal growth factor activated receptor activity
|
GO:0007176 |
7 |
0.053
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
54 |
0.052
|
|
|
|
pallium development
|
GO:0021543 |
120 |
0.052
|
|
|
|
cerebellar granule cell precursor tangential migration
|
GO:0021935 |
1 |
0.052
|
|
|
|
regulation of rab protein signal transduction
|
GO:0032483 |
8 |
0.052
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.051
|
|
|
|
locomotory behavior
|
GO:0007626 |
195 |
0.050
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
92 |
0.050
|
Yeast |
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.050
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.050
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.049
|
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.049
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.048
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
127 |
0.047
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.047
|
|
|
|
actin filament polymerization
|
GO:0030041 |
44 |
0.047
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.047
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.046
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.046
|
|
|
|
exocrine system development
|
GO:0035272 |
45 |
0.046
|
|
|
|
dna alkylation
|
GO:0006305 |
43 |
0.045
|
|
|
|
glycerophospholipid biosynthetic process
|
GO:0046474 |
32 |
0.045
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
45 |
0.045
|
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
36 |
0.045
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.045
|
|
|
|
cognition
|
GO:0050890 |
149 |
0.044
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
50 |
0.044
|
|
|
|
negative regulation of fibroblast apoptotic process
|
GO:2000270 |
6 |
0.044
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.043
|
|
|
|
central nervous system neuron differentiation
|
GO:0021953 |
162 |
0.043
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
128 |
0.043
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
119 |
0.042
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.042
|
|
|
|
hindbrain radial glia guided cell migration
|
GO:0021932 |
12 |
0.042
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.042
|
|
|
|
negative regulation of b cell proliferation
|
GO:0030889 |
13 |
0.041
|
|
|
|
tissue homeostasis
|
GO:0001894 |
115 |
0.041
|
|
|
|
cell cell adhesion via plasma membrane adhesion molecules
|
GO:0098742 |
40 |
0.041
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.041
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.041
|
|
|
|
sensory perception of sound
|
GO:0007605 |
97 |
0.041
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
145 |
0.041
|
|
|
|
platelet derived growth factor receptor signaling pathway
|
GO:0048008 |
32 |
0.041
|
|
|
|
regulation of zinc ion transport
|
GO:0071579 |
2 |
0.041
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
21 |
0.040
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.040
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.040
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
20 |
0.039
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.039
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.039
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.039
|
|
|
|
cell fate specification
|
GO:0001708 |
72 |
0.038
|
|
|
|
substrate adhesion dependent cell spreading
|
GO:0034446 |
30 |
0.038
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.038
|
|
|
|
regulation of cell substrate adhesion
|
GO:0010810 |
73 |
0.038
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.038
|
|
|
|
sperm individualization
|
GO:0007291 |
1 |
0.038
|
|
|
|
cerebellum morphogenesis
|
GO:0021587 |
42 |
0.037
|
|
|
|
hindbrain morphogenesis
|
GO:0021575 |
46 |
0.037
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.037
|
|
|
|
extracellular matrix organization
|
GO:0030198 |
147 |
0.037
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.037
|
|
|
|
negative regulation of receptor activity
|
GO:2000272 |
5 |
0.037
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.037
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
60 |
0.036
|
|
|
|
negative regulation of neuron death
|
GO:1901215 |
98 |
0.036
|
|
|
|
cell junction organization
|
GO:0034330 |
77 |
0.036
|
|
|
|
adherens junction maintenance
|
GO:0034334 |
1 |
0.036
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.035
|
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.035
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.035
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
106 |
0.035
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
58 |
0.035
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.035
|
|
|
|
sensory perception of mechanical stimulus
|
GO:0050954 |
107 |
0.034
|
|
|
|
cellular response to epidermal growth factor stimulus
|
GO:0071364 |
4 |
0.034
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.034
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
76 |
0.033
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
234 |
0.033
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.033
|
|
|
|
lymphocyte anergy
|
GO:0002249 |
4 |
0.033
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.032
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.032
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.032
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.032
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.032
|
|
|
|
regulation of b cell activation
|
GO:0050864 |
81 |
0.032
|
|
|
|
exocytosis
|
GO:0006887 |
121 |
0.032
|
|
|
|
positive regulation of wnt signaling pathway planar cell polarity pathway
|
GO:2000096 |
5 |
0.031
|
|
|
|
membrane tubulation
|
GO:0097320 |
4 |
0.031
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
84 |
0.031
|
|
|
|
negative regulation of purine nucleotide catabolic process
|
GO:0033122 |
9 |
0.031
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.031
|
|
|
|
endosome organization
|
GO:0007032 |
9 |
0.031
|
|
|
|
gliogenesis
|
GO:0042063 |
141 |
0.031
|
|
|
|
response to insulin
|
GO:0032868 |
100 |
0.031
|
|
|
|
kidney epithelium development
|
GO:0072073 |
121 |
0.031
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
51 |
0.031
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.031
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
64 |
0.030
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.030
|
|
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.030
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
45 |
0.030
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.030
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
203 |
0.030
|
|
|
|
negative regulation of t cell proliferation
|
GO:0042130 |
38 |
0.030
|
|
|
|
translation
|
GO:0006412 |
93 |
0.029
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.029
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.029
|
|
|
|
spermatid development
|
GO:0007286 |
108 |
0.029
|
|
|
|
cardiac cell fate specification
|
GO:0060912 |
2 |
0.029
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
160 |
0.029
|
Yeast |
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
64 |
0.029
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
40 |
0.029
|
|
|
|
negative regulation of hormone biosynthetic process
|
GO:0032353 |
4 |
0.029
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.029
|
Fly |
|
|
action potential
|
GO:0001508 |
78 |
0.029
|
|
|
|
blood coagulation
|
GO:0007596 |
76 |
0.029
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.028
|
|
|
|
mesenchyme development
|
GO:0060485 |
152 |
0.028
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.028
|
|
|
|
regulation of phagocytosis
|
GO:0050764 |
33 |
0.028
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.028
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
30 |
0.028
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.028
|
|
|
|
neural tube closure
|
GO:0001843 |
90 |
0.027
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
123 |
0.027
|
|
|
|
post golgi vesicle mediated transport
|
GO:0006892 |
13 |
0.027
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
221 |
0.027
|
Fly |
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.027
|
|
|
|
multi multicellular organism process
|
GO:0044706 |
109 |
0.027
|
|
|
|
hemostasis
|
GO:0007599 |
78 |
0.027
|
|
|
|
neuron migration
|
GO:0001764 |
122 |
0.027
|
|
|
|
regulation of neurotransmitter transport
|
GO:0051588 |
35 |
0.027
|
|
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.027
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
93 |
0.027
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.027
|
|
|
|
response to drug
|
GO:0042493 |
75 |
0.027
|
|
|
|
activation of mapk activity
|
GO:0000187 |
59 |
0.026
|
|
|
|
adult behavior
|
GO:0030534 |
135 |
0.026
|
|
|
|
regulation of bmp signaling pathway
|
GO:0030510 |
60 |
0.026
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.026
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.026
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.026
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.026
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.026
|
|
|
|
regulation of protein binding
|
GO:0043393 |
60 |
0.026
|
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
29 |
0.026
|
|
|
|
mitotic cytokinesis
|
GO:0000281 |
4 |
0.026
|
|
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
2 |
0.026
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
41 |
0.026
|
|
|
|
negative regulation of cell projection organization
|
GO:0031345 |
56 |
0.026
|
|
|
|
telencephalon development
|
GO:0021537 |
186 |
0.025
|
|
|
|
regulation of b cell differentiation
|
GO:0045577 |
23 |
0.025
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.025
|
|
|
|
lipid modification
|
GO:0030258 |
65 |
0.025
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.025
|
|
|
|
spinal cord development
|
GO:0021510 |
81 |
0.025
|
|
|
|
protein polymerization
|
GO:0051258 |
57 |
0.025
|
|
|
|
ruffle organization
|
GO:0031529 |
16 |
0.025
|
|
|
|
regulation of non canonical wnt signaling pathway
|
GO:2000050 |
12 |
0.024
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
43 |
0.024
|
|
|
|
golgi localization
|
GO:0051645 |
4 |
0.024
|
|
|
|
plasma membrane organization
|
GO:0007009 |
90 |
0.024
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.024
|
|
|
|
actin cytoskeleton reorganization
|
GO:0031532 |
21 |
0.024
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.024
|
|
|
|
positive regulation of phagocytosis engulfment
|
GO:0060100 |
3 |
0.024
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
49 |
0.024
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
65 |
0.024
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.024
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
121 |
0.024
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.024
|
|
|
|
regulation of antigen receptor mediated signaling pathway
|
GO:0050854 |
29 |
0.024
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.024
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.023
|
|
|
|
appendage morphogenesis
|
GO:0035107 |
149 |
0.023
|
|
|
|
macromolecule methylation
|
GO:0043414 |
120 |
0.023
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.023
|
|
|
|
hormone metabolic process
|
GO:0042445 |
86 |
0.023
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
142 |
0.023
|
|
|
|
inositol phosphate catabolic process
|
GO:0071545 |
4 |
0.023
|
|
|
|
negative regulation of cell morphogenesis involved in differentiation
|
GO:0010771 |
48 |
0.023
|
|
|
|
cellular response to amino acid stimulus
|
GO:0071230 |
29 |
0.023
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.022
|
|
|
|
branching morphogenesis of an epithelial tube
|
GO:0048754 |
159 |
0.022
|
|
|
|
negative regulation of hormone metabolic process
|
GO:0032351 |
4 |
0.022
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.022
|
|
|
|
positive regulation of phospholipase c activity
|
GO:0010863 |
2 |
0.022
|
|
|
|
protein localization to membrane
|
GO:0072657 |
108 |
0.022
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.022
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
36 |
0.022
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.022
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
79 |
0.021
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.021
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
61 |
0.021
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.021
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
95 |
0.021
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.021
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.021
|
|
|
|
cytokinetic process
|
GO:0032506 |
2 |
0.021
|
|
|
|
negative regulation of ras gtpase activity
|
GO:0034261 |
3 |
0.021
|
|
|
|
phagocytosis engulfment
|
GO:0006911 |
16 |
0.021
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
26 |
0.021
|
|
|
|
calcium ion transport
|
GO:0006816 |
159 |
0.021
|
|
|
|
negative regulation of gliogenesis
|
GO:0014014 |
23 |
0.021
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.021
|
|
|
|
positive regulation of phagocytosis
|
GO:0050766 |
26 |
0.021
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
78 |
0.021
|
|
|
|
negative regulation of antigen receptor mediated signaling pathway
|
GO:0050858 |
16 |
0.020
|
|
|
|
positive regulation of dna templated transcription elongation
|
GO:0032786 |
2 |
0.020
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
80 |
0.020
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.020
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.020
|
|
|
|
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
|
GO:1901030 |
6 |
0.020
|
|
|
|
neural tube formation
|
GO:0001841 |
108 |
0.020
|
|
|
|
muscle fiber development
|
GO:0048747 |
76 |
0.020
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.020
|
|
|
|
signal transduction in absence of ligand
|
GO:0038034 |
55 |
0.020
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.020
|
|
