Mus musculus

168 known processes

Il18

interleukin 18

(Aliases: Igif,Il-18)

Il18 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of necroptotic process GO:0060546 9 0.772
negative regulation of necrotic cell death GO:0060547 11 0.683
cellular component disassembly involved in execution phase of apoptosis GO:0006921 9 0.662
circadian sleep wake cycle non rem sleep GO:0042748 2 0.620
regulation of interleukin 1 alpha production GO:0032650 4 0.617
interleukin 1 alpha secretion GO:0050703 3 0.583
glial cell apoptotic process GO:0034349 3 0.570
regulation of defense response to bacterium GO:1900424 3 0.492
positive regulation of interleukin 1 alpha secretion GO:0050717 3 0.437
male gamete generation GO:0048232 285 0.427
regulation of apoptotic dna fragmentation GO:1902510 5 0.403
positive regulation of interleukin 1 alpha production GO:0032730 4 0.400
dna catabolic process endonucleolytic GO:0000737 15 0.360
pyroptosis GO:0070269 8 0.356
cellular macromolecule catabolic process GO:0044265 206 0.336
positive regulation of defense response to bacterium GO:1900426 1 0.335
antibacterial humoral response GO:0019731 8 0.331
response to atp GO:0033198 8 0.302
dna metabolic process GO:0006259 303 0.294
activation of cysteine type endopeptidase activity GO:0097202 27 0.288
apoptotic dna fragmentation GO:0006309 7 0.283
negative regulation of b cell activation GO:0050869 27 0.278
spermatogenesis GO:0007283 284 0.272
peptide metabolic process GO:0006518 46 0.272
cellular lipid metabolic process GO:0044255 323 0.270
organic cyclic compound catabolic process GO:1901361 295 0.269
sperm individualization GO:0007291 1 0.261
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.250
protein autoprocessing GO:0016540 2 0.233
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.232
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.231
angiogenesis GO:0001525 201 0.226
regulation of defense response GO:0031347 233 0.225
regulation of transferase activity GO:0051338 263 0.224
mitochondrial depolarization GO:0051882 6 0.223
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.223
regulation of protein kinase activity GO:0045859 232 0.219
negative regulation of t cell proliferation GO:0042130 38 0.217
regulation of necroptotic process GO:0060544 10 0.215
sensory perception GO:0007600 245 0.214
regulation of mitochondrial membrane potential GO:0051881 17 0.210
cellular response to lipid GO:0071396 145 0.210
antibacterial peptide biosynthetic process GO:0002780 2 0.209
cellular response to molecule of bacterial origin GO:0071219 83 0.208
antibacterial peptide production GO:0002778 2 0.204
apoptotic nuclear changes GO:0030262 9 0.203
regulation of antibacterial peptide production GO:0002786 1 0.193
myeloid cell differentiation GO:0030099 233 0.189
aromatic compound catabolic process GO:0019439 286 0.189
engulfment of apoptotic cell GO:0043652 3 0.188
response to lipopolysaccharide GO:0032496 128 0.181
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.176
regulation of kinase activity GO:0043549 249 0.174
release of cytochrome c from mitochondria GO:0001836 23 0.174
response to topologically incorrect protein GO:0035966 25 0.173
organic hydroxy compound metabolic process GO:1901615 203 0.173
macromolecule catabolic process GO:0009057 281 0.172
antimicrobial peptide biosynthetic process GO:0002777 2 0.171
regulation of cytokine production GO:0001817 266 0.169
macrophage differentiation GO:0030225 20 0.168
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.166
regulation of membrane potential GO:0042391 192 0.166
keratinocyte differentiation GO:0030216 48 0.164
antimicrobial peptide production GO:0002775 2 0.163
membrane depolarization GO:0051899 64 0.162
negative regulation of cell activation GO:0050866 111 0.161
compound eye development GO:0048749 1 0.161
regulation of antimicrobial humoral response GO:0002759 3 0.160
oxidation reduction process GO:0055114 342 0.158
response to molecule of bacterial origin GO:0002237 143 0.157
positive regulation of antimicrobial peptide production GO:0002225 1 0.156
membrane hyperpolarization GO:0060081 21 0.155
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.152
toxin transport GO:1901998 38 0.151
blood vessel morphogenesis GO:0048514 285 0.151
heterocycle catabolic process GO:0046700 280 0.149
negative regulation of lymphocyte activation GO:0051250 91 0.148
lymphocyte homeostasis GO:0002260 64 0.146
negative regulation of cell proliferation GO:0008285 296 0.145
regulation of protein serine threonine kinase activity GO:0071900 157 0.145
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.144
cellular nitrogen compound catabolic process GO:0044270 280 0.142
positive regulation of apoptotic signaling pathway GO:2001235 95 0.142
cellular amine metabolic process GO:0044106 44 0.142
regulation of cell cycle GO:0051726 281 0.141
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.141
response to oxidative stress GO:0006979 123 0.140
cellularization GO:0007349 1 0.140
microglial cell activation GO:0001774 3 0.140
response to decreased oxygen levels GO:0036293 59 0.137
negative regulation of cell cycle GO:0045786 123 0.135
cellular response to biotic stimulus GO:0071216 92 0.135
cellular response to lipopolysaccharide GO:0071222 77 0.134
cellular response to oxidative stress GO:0034599 76 0.133
spermatid differentiation GO:0048515 115 0.131
positive regulation of interleukin 1 secretion GO:0050716 14 0.130
myeloid leukocyte differentiation GO:0002573 119 0.129
response to organonitrogen compound GO:0010243 246 0.129
negative regulation of phosphorylation GO:0042326 166 0.127
lipid biosynthetic process GO:0008610 179 0.126
sensory perception of sound GO:0007605 97 0.125
regulation of execution phase of apoptosis GO:1900117 9 0.125
monocarboxylic acid metabolic process GO:0032787 191 0.125
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.124
organonitrogen compound biosynthetic process GO:1901566 192 0.124
positive regulation of antimicrobial humoral response GO:0002760 2 0.124
regulation of cellular catabolic process GO:0031329 242 0.124
t cell activation GO:0042110 289 0.123
cytokine production GO:0001816 319 0.122
response to endoplasmic reticulum stress GO:0034976 53 0.122
epidermis development GO:0008544 187 0.120
response to oxygen levels GO:0070482 62 0.120
negative regulation of phosphorus metabolic process GO:0010563 184 0.119
protein catabolic process GO:0030163 221 0.119
negative regulation of t cell activation GO:0050868 65 0.119
pigment metabolic process GO:0042440 32 0.118
regulation of b cell activation GO:0050864 81 0.118
negative regulation of kinase activity GO:0033673 81 0.118
morphogenesis of embryonic epithelium GO:0016331 159 0.117
neural tube development GO:0021915 160 0.117
negative regulation of transferase activity GO:0051348 85 0.117
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.117
mitochondrion organization GO:0007005 134 0.117
cellular response to topologically incorrect protein GO:0035967 25 0.115
negative regulation of protein modification process GO:0031400 163 0.115
membrane organization GO:0061024 245 0.114
lung development GO:0030324 164 0.114
negative regulation of cellular protein metabolic process GO:0032269 247 0.113
humoral immune response GO:0006959 57 0.111
positive regulation of apoptotic process GO:0043065 217 0.111
regulation of response to wounding GO:1903034 189 0.110
negative regulation of protein phosphorylation GO:0001933 126 0.109
spermatid development GO:0007286 108 0.109
epithelial tube formation GO:0072175 130 0.107
regulation of apoptotic signaling pathway GO:2001233 197 0.107
regulation of cellular ketone metabolic process GO:0010565 66 0.107
regulation of hydrolase activity GO:0051336 246 0.106
regulation of necrotic cell death GO:0010939 13 0.105
positive regulation of programmed cell death GO:0043068 218 0.102
positive regulation of cellular catabolic process GO:0031331 148 0.102
cellular response to organic cyclic compound GO:0071407 87 0.102
epithelial tube morphogenesis GO:0060562 303 0.101
cellular response to hormone stimulus GO:0032870 150 0.100
positive regulation of cell death GO:0010942 224 0.100
germ cell development GO:0007281 185 0.100
positive regulation of hydrolase activity GO:0051345 148 0.099
cell fate commitment GO:0045165 210 0.098
interleukin 8 production GO:0032637 4 0.097
regulation of cellular amino acid metabolic process GO:0006521 5 0.095
extrinsic apoptotic signaling pathway GO:0097191 126 0.095
negative regulation of molecular function GO:0044092 258 0.095
respiratory tube development GO:0030323 167 0.094
developmental maturation GO:0021700 193 0.094
regulation of proteolysis GO:0030162 164 0.094
protein maturation GO:0051604 176 0.093
regulation of t cell proliferation GO:0042129 92 0.092
response to light stimulus GO:0009416 135 0.092
leukocyte differentiation GO:0002521 342 0.091
embryonic epithelial tube formation GO:0001838 130 0.091
response to radiation GO:0009314 165 0.091
positive regulation of endopeptidase activity GO:0010950 43 0.091
amine metabolic process GO:0009308 45 0.090
regulation of intracellular transport GO:0032386 159 0.090
fatty acid metabolic process GO:0006631 121 0.090
cytoplasmic transport GO:0016482 234 0.089
activation of immune response GO:0002253 138 0.089
apoptotic mitochondrial changes GO:0008637 48 0.088
negative regulation of activated t cell proliferation GO:0046007 7 0.088
response to hypoxia GO:0001666 58 0.088
negative regulation of phosphate metabolic process GO:0045936 184 0.088
skin development GO:0043588 220 0.088
b cell proliferation GO:0042100 53 0.086
regulation of leukocyte proliferation GO:0070663 121 0.086
purine nucleoside metabolic process GO:0042278 241 0.086
tube formation GO:0035148 140 0.085
protein processing GO:0016485 163 0.085
apoptotic signaling pathway GO:0097190 306 0.084
positive regulation of proteolysis GO:0045862 85 0.084
regulation of cell activation GO:0050865 289 0.084
defense response to other organism GO:0098542 197 0.083
sensory perception of mechanical stimulus GO:0050954 107 0.083
b cell activation GO:0042113 161 0.083
rho protein signal transduction GO:0007266 32 0.083
cellular response to steroid hormone stimulus GO:0071383 33 0.082
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.081
positive regulation of cellular amine metabolic process GO:0033240 5 0.081
regulation of inflammatory response GO:0050727 147 0.081
positive regulation of interleukin 1 beta production GO:0032731 16 0.080
regulation of t cell activation GO:0050863 170 0.080
cellular ketone metabolic process GO:0042180 84 0.079
cellular response to glucocorticoid stimulus GO:0071385 13 0.079
cognition GO:0050890 149 0.078
cellular amide metabolic process GO:0043603 58 0.078
interleukin 1 alpha production GO:0032610 5 0.077
cytokine secretion GO:0050663 72 0.077
regulation of reactive oxygen species metabolic process GO:2000377 40 0.077
response to unfolded protein GO:0006986 21 0.077
regulation of lymphocyte activation GO:0051249 240 0.077
regulation of neuron apoptotic process GO:0043523 122 0.076
regulation of peptidase activity GO:0052547 96 0.075
execution phase of apoptosis GO:0097194 19 0.075
lymphocyte proliferation GO:0046651 164 0.074
regulation of interleukin 1 secretion GO:0050704 15 0.074
regulation of secretion by cell GO:1903530 249 0.073
response to organic cyclic compound GO:0014070 198 0.073
cellular response to dna damage stimulus GO:0006974 207 0.073
dna catabolic process GO:0006308 19 0.072
cellular response to external stimulus GO:0071496 88 0.072
cellular amino acid metabolic process GO:0006520 103 0.072
negative regulation of leukocyte proliferation GO:0070664 46 0.072
negative regulation of immune system process GO:0002683 209 0.071
cellular response to corticosteroid stimulus GO:0071384 13 0.071
interleukin 1 beta production GO:0032611 30 0.071
cellular response to cytokine stimulus GO:0071345 189 0.070
er nucleus signaling pathway GO:0006984 27 0.069
negative regulation of cytokine production GO:0001818 84 0.069
response to dexamethasone GO:0071548 8 0.069
cellular response to abiotic stimulus GO:0071214 56 0.068
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.068
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.068
t cell homeostasis GO:0043029 35 0.068
purine containing compound metabolic process GO:0072521 311 0.067
response to organophosphorus GO:0046683 22 0.067
t cell apoptotic process GO:0070231 39 0.067
regulation of interleukin 1 production GO:0032652 26 0.067
negative regulation of lymphocyte proliferation GO:0050672 45 0.066
midgut development GO:0007494 4 0.066
zymogen activation GO:0031638 41 0.066
cation transport GO:0006812 399 0.065
neural tube formation GO:0001841 108 0.065
neuron death GO:0070997 154 0.065
positive regulation of peptidase activity GO:0010952 49 0.065
regulation of response to biotic stimulus GO:0002831 38 0.065
interleukin 1 beta secretion GO:0050702 16 0.065
cell type specific apoptotic process GO:0097285 268 0.064
positive regulation of secretion GO:0051047 130 0.064
neuron apoptotic process GO:0051402 142 0.063
signal transduction in absence of ligand GO:0038034 55 0.063
regulation of cell migration GO:0030334 219 0.063
regulation of protein transport GO:0051223 163 0.062
b cell homeostasis GO:0001782 34 0.062
muscle cell differentiation GO:0042692 261 0.061
positive regulation of neuron death GO:1901216 28 0.061
respiratory system development GO:0060541 190 0.061
negative regulation of b cell proliferation GO:0030889 13 0.061
protein heterooligomerization GO:0051291 14 0.060
endoplasmic reticulum unfolded protein response GO:0030968 19 0.060
negative regulation of nik nf kappab signaling GO:1901223 2 0.060
positive regulation of protein phosphorylation GO:0001934 242 0.060
lymphocyte apoptotic process GO:0070227 54 0.059
necroptotic process GO:0070266 21 0.059
response to steroid hormone GO:0048545 56 0.059
homeostasis of number of cells GO:0048872 210 0.059
myeloid leukocyte activation GO:0002274 83 0.058
regulation of adaptive immune response GO:0002819 90 0.058
regulation of hormone levels GO:0010817 211 0.057
regulation of dna catabolic process GO:1903624 5 0.057
autophagy GO:0006914 45 0.057
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.057
i kappab kinase nf kappab signaling GO:0007249 85 0.056
regulation of b cell proliferation GO:0030888 39 0.056
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.056
negative regulation of protein metabolic process GO:0051248 282 0.055
rhythmic process GO:0048511 174 0.055
ectopic germ cell programmed cell death GO:0035234 9 0.055
regulation of endopeptidase activity GO:0052548 89 0.055
positive regulation of cytokine production GO:0001819 174 0.055
positive regulation of protein modification process GO:0031401 299 0.054
t cell proliferation GO:0042098 120 0.054
dendrite development GO:0016358 115 0.054
regulation of body fluid levels GO:0050878 162 0.054
female gamete generation GO:0007292 74 0.053
interleukin 1 production GO:0032612 31 0.053
interleukin 1 secretion GO:0050701 16 0.053
regulation of intracellular protein transport GO:0033157 82 0.052
response to uv GO:0009411 44 0.052
purine nucleoside triphosphate metabolic process GO:0009144 226 0.051
carbohydrate derivative biosynthetic process GO:1901137 183 0.051
single organism nuclear import GO:1902593 95 0.051
small molecule biosynthetic process GO:0044283 132 0.051
regulation of lymphocyte proliferation GO:0050670 117 0.051
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.050
alcohol metabolic process GO:0006066 116 0.050
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.050
thymocyte apoptotic process GO:0070242 19 0.050
epithelial cell proliferation GO:0050673 174 0.049
regulation of secretion GO:0051046 274 0.049
innate immune response GO:0045087 157 0.049
leukocyte activation involved in immune response GO:0002366 126 0.049
endocytosis GO:0006897 168 0.049
regulation of system process GO:0044057 200 0.048
defense response to virus GO:0051607 68 0.048
positive regulation of interleukin 1 beta secretion GO:0050718 14 0.048
regulation of establishment of protein localization GO:0070201 181 0.048
positive regulation of innate immune response GO:0045089 80 0.048
regulation of circadian sleep wake cycle GO:0042749 3 0.047
regulation of protein localization GO:0032880 231 0.047
positive regulation of secretion by cell GO:1903532 114 0.047
syncytium formation GO:0006949 43 0.047
regulation of neuron death GO:1901214 134 0.047
myotube differentiation GO:0014902 105 0.047
cellular response to dexamethasone stimulus GO:0071549 8 0.047
positive regulation of kinase activity GO:0033674 155 0.046
regulation of interleukin 1 beta production GO:0032651 25 0.046
transmembrane transport GO:0055085 412 0.046
regulation of nucleotide metabolic process GO:0006140 169 0.046
purine nucleoside catabolic process GO:0006152 205 0.046
secondary metabolic process GO:0019748 18 0.046
reactive oxygen species metabolic process GO:0072593 84 0.046
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.045
cellular response to organonitrogen compound GO:0071417 145 0.045
macrophage activation GO:0042116 27 0.045
cellular chemical homeostasis GO:0055082 215 0.044
anion transport GO:0006820 177 0.044
lipid catabolic process GO:0016042 69 0.044
positive regulation of immune effector process GO:0002699 107 0.044
small gtpase mediated signal transduction GO:0007264 97 0.044
positive regulation of jnk cascade GO:0046330 46 0.043
regulation of lymphocyte apoptotic process GO:0070228 41 0.043
jnk cascade GO:0007254 72 0.043
positive regulation of behavior GO:0048520 40 0.043
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.043
muscle system process GO:0003012 141 0.043
memory GO:0007613 58 0.043
wound healing GO:0042060 157 0.043
positive regulation of neuron apoptotic process GO:0043525 25 0.043
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.042
regulation of leukocyte apoptotic process GO:2000106 56 0.042
circadian rhythm GO:0007623 114 0.042
protein oligomerization GO:0051259 67 0.041
nucleoside phosphate metabolic process GO:0006753 338 0.041
peptidyl amino acid modification GO:0018193 336 0.041
mapk cascade GO:0000165 281 0.041
regulation of mapk cascade GO:0043408 248 0.041
protein modification by small protein conjugation or removal GO:0070647 207 0.041
positive regulation of defense response GO:0031349 124 0.040
response to glucocorticoid GO:0051384 20 0.040
hemostasis GO:0007599 78 0.040
regulation of thymocyte apoptotic process GO:0070243 14 0.040
positive regulation of protein transport GO:0051222 93 0.039
positive regulation of lymphocyte activation GO:0051251 140 0.039
carboxylic acid biosynthetic process GO:0046394 86 0.039
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.039
steroid metabolic process GO:0008202 119 0.039
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.039
gtp metabolic process GO:0046039 144 0.039
regulation of nucleoside metabolic process GO:0009118 130 0.038
intrinsic apoptotic signaling pathway GO:0097193 132 0.038
glycosyl compound catabolic process GO:1901658 206 0.038
skeletal system development GO:0001501 356 0.038
purine ribonucleotide catabolic process GO:0009154 208 0.038
regulation of circadian sleep wake cycle non rem sleep GO:0045188 1 0.038
positive regulation of transferase activity GO:0051347 167 0.038
nucleobase containing small molecule metabolic process GO:0055086 352 0.038
chemotaxis GO:0006935 247 0.037
fat soluble vitamin biosynthetic process GO:0042362 4 0.037
positive regulation of stress activated mapk cascade GO:0032874 48 0.037
regulation of protein processing GO:0070613 96 0.037
cellular homeostasis GO:0019725 240 0.037
regulation of cell motility GO:2000145 236 0.037
immune effector process GO:0002252 321 0.037
protein secretion GO:0009306 111 0.037
organonitrogen compound catabolic process GO:1901565 264 0.036
cellular lipid catabolic process GO:0044242 52 0.036
cell maturation GO:0048469 127 0.036
nitrogen compound transport GO:0071705 271 0.036
response to alcohol GO:0097305 48 0.036
purinergic nucleotide receptor signaling pathway GO:0035590 3 0.036
phospholipid metabolic process GO:0006644 87 0.036
organic hydroxy compound biosynthetic process GO:1901617 77 0.036
response to corticosteroid GO:0031960 20 0.036
establishment of protein localization to organelle GO:0072594 118 0.036
digestive system development GO:0055123 200 0.036
purine containing compound catabolic process GO:0072523 213 0.036
defense response to bacterium GO:0042742 119 0.035
organophosphate catabolic process GO:0046434 232 0.035
ion transmembrane transport GO:0034220 361 0.035
regulation of interleukin 8 secretion GO:2000482 2 0.035
regulation of circadian rhythm GO:0042752 58 0.035
regulation of activated t cell proliferation GO:0046006 16 0.035
inflammatory response GO:0006954 244 0.035
phenol containing compound metabolic process GO:0018958 60 0.035
regulation of stress activated mapk cascade GO:0032872 69 0.035
regulation of interleukin 1 beta secretion GO:0050706 15 0.034
kidney development GO:0001822 213 0.034
purine nucleoside triphosphate catabolic process GO:0009146 203 0.034
immunoglobulin production GO:0002377 73 0.034
adaptive immune response GO:0002250 155 0.034
reactive nitrogen species metabolic process GO:2001057 0 0.034
regulation of t cell apoptotic process GO:0070232 28 0.033
positive regulation of cytokine secretion GO:0050715 41 0.033
response to drug GO:0042493 75 0.033
blood coagulation GO:0007596 76 0.033
positive regulation of antibacterial peptide production GO:0002803 1 0.033
leukocyte proliferation GO:0070661 172 0.033
interleukin 18 production GO:0032621 4 0.033
g protein coupled receptor signaling pathway GO:0007186 243 0.033
learning or memory GO:0007611 148 0.032
cellular response to alcohol GO:0097306 23 0.032
phagocytosis GO:0006909 66 0.032
exocytosis GO:0006887 121 0.032
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.032
nucleoside triphosphate catabolic process GO:0009143 205 0.032
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.031
regulation of protein targeting GO:1903533 61 0.031
programmed necrotic cell death GO:0097300 28 0.031
ras protein signal transduction GO:0007265 77 0.031
apoptotic process involved in development GO:1902742 28 0.031
purine ribonucleotide metabolic process GO:0009150 290 0.031
developmental programmed cell death GO:0010623 41 0.031
negative regulation of intracellular signal transduction GO:1902532 167 0.031
regulation of autophagy GO:0010506 30 0.031
ribonucleoside triphosphate metabolic process GO:0009199 220 0.031
positive regulation of mapk cascade GO:0043410 170 0.030
negative regulation of response to wounding GO:1903035 77 0.030
regulation of protein maturation GO:1903317 96 0.030
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.030
hormone secretion GO:0046879 128 0.030
digestive tract development GO:0048565 190 0.030
positive regulation of protein secretion GO:0050714 52 0.030
nucleoside metabolic process GO:0009116 246 0.030
defense response to gram positive bacterium GO:0050830 50 0.029
leukocyte apoptotic process GO:0071887 71 0.029
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.029
regulation of protein catabolic process GO:0042176 108 0.029
activation of mapk activity involved in innate immune response GO:0035419 2 0.028
negative regulation of mapk cascade GO:0043409 65 0.028
nucleoside triphosphate metabolic process GO:0009141 230 0.028
regulation of tumor necrosis factor production GO:0032680 49 0.028
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.028
peripheral nervous system development GO:0007422 53 0.028
peptidyl tyrosine phosphorylation GO:0018108 143 0.028
renal system development GO:0072001 225 0.028
insulin secretion GO:0030073 89 0.027
ribonucleotide catabolic process GO:0009261 208 0.027
negative regulation of macrophage apoptotic process GO:2000110 3 0.027
regulation of cellular amine metabolic process GO:0033238 20 0.027
ribose phosphate metabolic process GO:0019693 291 0.027
organophosphate biosynthetic process GO:0090407 122 0.027
regulation of interleukin 18 production GO:0032661 3 0.027
organic acid transport GO:0015849 101 0.027
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.027
cellular protein catabolic process GO:0044257 155 0.027
positive regulation of protein kinase activity GO:0045860 144 0.027
anatomical structure homeostasis GO:0060249 145 0.027
positive regulation of interleukin 8 secretion GO:2000484 1 0.027
regulation of cysteine type endopeptidase activity GO:2000116 65 0.027
nucleotide metabolic process GO:0009117 332 0.027
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.027
nucleocytoplasmic transport GO:0006913 139 0.027
purine nucleotide metabolic process GO:0006163 302 0.027
placenta development GO:0001890 140 0.027
regulation of defense response to virus by host GO:0050691 8 0.026
stem cell differentiation GO:0048863 268 0.026
heart morphogenesis GO:0003007 178 0.026
positive regulation of inflammatory response GO:0050729 47 0.026
actin filament organization GO:0007015 113 0.026
response to thyroid hormone GO:0097066 2 0.026
regulation of ion transport GO:0043269 215 0.026
carbohydrate homeostasis GO:0033500 128 0.026
response to peptide GO:1901652 136 0.026
reactive oxygen species biosynthetic process GO:1903409 8 0.026
tissue homeostasis GO:0001894 115 0.026
glycerolipid metabolic process GO:0046486 122 0.026
regulation of multi organism process GO:0043900 111 0.026
lipid modification GO:0030258 65 0.025
response to purine containing compound GO:0014074 28 0.025
necrotic cell death GO:0070265 30 0.025
regulation of antimicrobial peptide production GO:0002784 1 0.025
peptide transport GO:0015833 133 0.025
cell death in response to oxidative stress GO:0036473 24 0.025
divalent inorganic cation transport GO:0072511 178 0.025
glucose homeostasis GO:0042593 128 0.025
hematopoietic progenitor cell differentiation GO:0002244 143 0.025
regulation of production of molecular mediator of immune response GO:0002700 65 0.024
cellular response to peptide hormone stimulus GO:0071375 92 0.024
organic acid biosynthetic process GO:0016053 86 0.024
regulation of humoral immune response GO:0002920 22 0.024
neuron maturation GO:0042551 29 0.024
ribonucleoside triphosphate catabolic process GO:0009203 199 0.024
immunoglobulin mediated immune response GO:0016064 69 0.024
actin cytoskeleton organization GO:0030036 220 0.024
regulation of hormone secretion GO:0046883 88 0.024
negative regulation of cellular amine metabolic process GO:0033239 1 0.024
sequestering of metal ion GO:0051238 19 0.024
nucleoside phosphate catabolic process GO:1901292 222 0.024
negative regulation of cellular component organization GO:0051129 194 0.023

Il18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.086
nervous system disease DOID:863 0 0.086
sensory system disease DOID:0050155 0 0.054
eye and adnexa disease DOID:1492 0 0.054
eye disease DOID:5614 0 0.054
retinal disease DOID:5679 0 0.052
retinal degeneration DOID:8466 0 0.052
cancer DOID:162 0 0.046
disease of cellular proliferation DOID:14566 0 0.046
organ system cancer DOID:0050686 0 0.046
disease of metabolism DOID:0014667 0 0.024