Mus musculus

0 known processes

Bace2

beta-site APP-cleaving enzyme 2

(Aliases: ASP21,DRAP,BAE2,1110059C24Rik,AI850424,CEAP1,AEPLC,CDA13,ARP1,ALP56)

Bace2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amine metabolic process GO:0044106 44 0.095
cellular amino acid metabolic process GO:0006520 103 0.081
regulation of cellular ketone metabolic process GO:0010565 66 0.080
cellular ketone metabolic process GO:0042180 84 0.078
amine metabolic process GO:0009308 45 0.078
regulation of cellular amino acid metabolic process GO:0006521 5 0.072
regulation of cellular amine metabolic process GO:0033238 20 0.071
positive regulation of cellular amine metabolic process GO:0033240 5 0.070
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.069
regulation of defense response GO:0031347 233 0.060
cytokine production GO:0001816 319 0.055
immune effector process GO:0002252 321 0.054
male gamete generation GO:0048232 285 0.046
protein maturation GO:0051604 176 0.044
negative regulation of cell proliferation GO:0008285 296 0.042
negative regulation of phosphate metabolic process GO:0045936 184 0.042
negative regulation of protein metabolic process GO:0051248 282 0.040
Human
spermatogenesis GO:0007283 284 0.040
peptidyl amino acid modification GO:0018193 336 0.038
cellular lipid metabolic process GO:0044255 323 0.038
regulation of protein localization GO:0032880 231 0.036
cation transport GO:0006812 399 0.035
regulation of hormone levels GO:0010817 211 0.034
negative regulation of molecular function GO:0044092 258 0.034
heterocycle catabolic process GO:0046700 280 0.033
organic cyclic compound catabolic process GO:1901361 295 0.033
regulation of cytokine production GO:0001817 266 0.033
cell adhesion GO:0007155 329 0.032
glycoprotein metabolic process GO:0009100 116 0.032
Human
regulation of secretion GO:0051046 274 0.031
negative regulation of cellular protein metabolic process GO:0032269 247 0.031
purine containing compound metabolic process GO:0072521 311 0.031
apoptotic signaling pathway GO:0097190 306 0.030
positive regulation of protein modification process GO:0031401 299 0.029
negative regulation of phosphorylation GO:0042326 166 0.029
protein processing GO:0016485 163 0.029
oxidation reduction process GO:0055114 342 0.029
ras protein signal transduction GO:0007265 77 0.029
aromatic compound catabolic process GO:0019439 286 0.028
small gtpase mediated signal transduction GO:0007264 97 0.028
nucleoside phosphate metabolic process GO:0006753 338 0.028
cell recognition GO:0008037 83 0.027
regulation of hydrolase activity GO:0051336 246 0.026
regulation of secretion by cell GO:1903530 249 0.026
mapk cascade GO:0000165 281 0.026
response to molecule of bacterial origin GO:0002237 143 0.026
negative regulation of phosphorus metabolic process GO:0010563 184 0.025
rho protein signal transduction GO:0007266 32 0.025
response to organonitrogen compound GO:0010243 246 0.025
negative regulation of lymphocyte activation GO:0051250 91 0.024
extracellular structure organization GO:0043062 148 0.024
lipid biosynthetic process GO:0008610 179 0.024
carbohydrate metabolic process GO:0005975 230 0.024
intracellular protein transport GO:0006886 204 0.024
nucleoside catabolic process GO:0009164 206 0.024
lymphocyte mediated immunity GO:0002449 139 0.024
nitrogen compound transport GO:0071705 271 0.023
carbohydrate derivative biosynthetic process GO:1901137 183 0.023
Human
regulation of cell activation GO:0050865 289 0.023
regulation of multi organism process GO:0043900 111 0.023
cell type specific apoptotic process GO:0097285 268 0.023
regulation of t cell activation GO:0050863 170 0.023
positive regulation of nervous system development GO:0051962 221 0.023
regulation of mapk cascade GO:0043408 248 0.023
developmental maturation GO:0021700 193 0.022
blood circulation GO:0008015 195 0.022
regulation of protein maturation GO:1903317 96 0.022
cellular nitrogen compound catabolic process GO:0044270 280 0.022
respiratory system development GO:0060541 190 0.022
skeletal system development GO:0001501 356 0.021
organonitrogen compound biosynthetic process GO:1901566 192 0.021
renal system development GO:0072001 225 0.021
regulation of cell motility GO:2000145 236 0.021
ribose phosphate metabolic process GO:0019693 291 0.021
nucleobase containing small molecule metabolic process GO:0055086 352 0.021
positive regulation of secretion GO:0051047 130 0.021
purine nucleotide metabolic process GO:0006163 302 0.021
purine nucleotide catabolic process GO:0006195 211 0.021
peptide secretion GO:0002790 114 0.021
negative regulation of immune system process GO:0002683 209 0.021
nucleoside triphosphate metabolic process GO:0009141 230 0.021
positive regulation of protein phosphorylation GO:0001934 242 0.021
nucleotide metabolic process GO:0009117 332 0.021
response to organic cyclic compound GO:0014070 198 0.021
striated muscle tissue development GO:0014706 293 0.020
cellular response to lipid GO:0071396 145 0.020
leukocyte mediated immunity GO:0002443 174 0.020
regulation of intracellular transport GO:0032386 159 0.020
regulation of establishment of protein localization GO:0070201 181 0.020
cellular homeostasis GO:0019725 240 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.019
organelle fission GO:0048285 170 0.019
glycosyl compound metabolic process GO:1901657 246 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
inflammatory response GO:0006954 244 0.019
cellular response to hormone stimulus GO:0032870 150 0.019
response to growth factor GO:0070848 198 0.019
organonitrogen compound catabolic process GO:1901565 264 0.019
nucleoside phosphate catabolic process GO:1901292 222 0.019
macromolecule catabolic process GO:0009057 281 0.019
epithelial tube morphogenesis GO:0060562 303 0.019
negative regulation of multi organism process GO:0043901 68 0.019
endocytosis GO:0006897 168 0.019
regulation of protein transport GO:0051223 163 0.019
hematopoietic progenitor cell differentiation GO:0002244 143 0.019
regulation of membrane potential GO:0042391 192 0.019
regulation of organelle organization GO:0033043 289 0.018
purine ribonucleoside metabolic process GO:0046128 241 0.018
regulation of lymphocyte activation GO:0051249 240 0.018
regulation of kinase activity GO:0043549 249 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
sulfur compound metabolic process GO:0006790 100 0.018
amide transport GO:0042886 138 0.018
ribonucleoside metabolic process GO:0009119 245 0.018
regulation of transferase activity GO:0051338 263 0.018
purine ribonucleoside catabolic process GO:0046130 205 0.018
regulation of cell migration GO:0030334 219 0.018
angiogenesis GO:0001525 201 0.018
protein localization to organelle GO:0033365 185 0.017
g protein coupled receptor signaling pathway GO:0007186 243 0.017
regulation of response to wounding GO:1903034 189 0.017
defense response to bacterium GO:0042742 119 0.017
cellular response to organonitrogen compound GO:0071417 145 0.017
rhythmic process GO:0048511 174 0.017
respiratory tube development GO:0030323 167 0.017
peptidyl tyrosine phosphorylation GO:0018108 143 0.017
glucose homeostasis GO:0042593 128 0.017
nucleotide catabolic process GO:0009166 217 0.017
t cell activation GO:0042110 289 0.017
organophosphate catabolic process GO:0046434 232 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
ribonucleotide metabolic process GO:0009259 291 0.016
negative regulation of cellular amine metabolic process GO:0033239 1 0.016
response to inorganic substance GO:0010035 96 0.016
cytoplasmic transport GO:0016482 234 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
response to acid chemical GO:0001101 111 0.016
regulation of protein processing GO:0070613 96 0.016
lung development GO:0030324 164 0.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.016
transmembrane transport GO:0055085 412 0.016
regulation of proteolysis GO:0030162 164 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
cellular response to biotic stimulus GO:0071216 92 0.016
leukocyte differentiation GO:0002521 342 0.016
negative regulation of cell activation GO:0050866 111 0.016
ribonucleoside triphosphate metabolic process GO:0009199 220 0.016
purine nucleoside catabolic process GO:0006152 205 0.016
ossification GO:0001503 216 0.016
chemotaxis GO:0006935 247 0.016
production of molecular mediator of immune response GO:0002440 103 0.016
extracellular matrix organization GO:0030198 147 0.016
response to lipopolysaccharide GO:0032496 128 0.016
muscle system process GO:0003012 141 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
cell maturation GO:0048469 127 0.016
circadian rhythm GO:0007623 114 0.015
cytokine secretion GO:0050663 72 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
defense response to other organism GO:0098542 197 0.015
positive regulation of cell death GO:0010942 224 0.015
carbohydrate derivative catabolic process GO:1901136 231 0.015
activation of immune response GO:0002253 138 0.015
ribonucleoside catabolic process GO:0042454 206 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.015
skin development GO:0043588 220 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
bone development GO:0060348 120 0.015
midgut development GO:0007494 4 0.015
purine ribonucleotide metabolic process GO:0009150 290 0.015
wound healing GO:0042060 157 0.015
regulation of cell projection organization GO:0031344 206 0.015
adaptive immune response GO:0002250 155 0.015
innate immune response GO:0045087 157 0.015
development of primary sexual characteristics GO:0045137 143 0.015
ribonucleoside triphosphate catabolic process GO:0009203 199 0.015
morphogenesis of a branching structure GO:0001763 203 0.015
mitotic cell cycle GO:0000278 195 0.015
t cell mediated immunity GO:0002456 50 0.015
divalent metal ion transport GO:0070838 172 0.015
single organism cell adhesion GO:0098602 156 0.014
regulation of cell adhesion GO:0030155 154 0.014
gland development GO:0048732 330 0.014
alpha beta t cell activation GO:0046631 91 0.014
alcohol metabolic process GO:0006066 116 0.014
ribonucleotide catabolic process GO:0009261 208 0.014
regionalization GO:0003002 337 0.014
fatty acid metabolic process GO:0006631 121 0.014
hormone metabolic process GO:0042445 86 0.014
protein modification by small protein conjugation or removal GO:0070647 207 0.014
regulation of cell cycle GO:0051726 281 0.014
regulation of protein secretion GO:0050708 82 0.014
macromolecule glycosylation GO:0043413 55 0.014
regulation of epithelial cell proliferation GO:0050678 141 0.014
germ cell development GO:0007281 185 0.014
regulation of anatomical structure size GO:0090066 178 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
detection of stimulus GO:0051606 84 0.014
regulation of system process GO:0044057 200 0.014
hormone secretion GO:0046879 128 0.014
negative regulation of protein phosphorylation GO:0001933 126 0.014
antimicrobial peptide biosynthetic process GO:0002777 2 0.014
regulation of lipid metabolic process GO:0019216 118 0.014
nucleoside metabolic process GO:0009116 246 0.014
branching morphogenesis of an epithelial tube GO:0048754 159 0.014
carbohydrate homeostasis GO:0033500 128 0.014
ion transmembrane transport GO:0034220 361 0.014
connective tissue development GO:0061448 179 0.014
cell substrate adhesion GO:0031589 130 0.014
immune response regulating signaling pathway GO:0002764 125 0.014
cellular response to growth factor stimulus GO:0071363 197 0.013
extrinsic apoptotic signaling pathway GO:0097191 126 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.013
regulation of cytoplasmic transport GO:1903649 112 0.013
negative regulation of hydrolase activity GO:0051346 71 0.013
purine nucleoside triphosphate catabolic process GO:0009146 203 0.013
divalent inorganic cation transport GO:0072511 178 0.013
purine ribonucleotide catabolic process GO:0009154 208 0.013
circulatory system process GO:0003013 197 0.013
peptidyl tyrosine modification GO:0018212 145 0.013
glycoprotein biosynthetic process GO:0009101 89 0.013
Human
lymphocyte proliferation GO:0046651 164 0.013
positive regulation of intracellular transport GO:0032388 70 0.013
negative regulation of protein processing GO:0010955 79 0.013
positive regulation of secretion by cell GO:1903532 114 0.013
organ growth GO:0035265 117 0.013
protein secretion GO:0009306 111 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
carboxylic acid biosynthetic process GO:0046394 86 0.013
wnt signaling pathway GO:0016055 188 0.013
epithelial cell proliferation GO:0050673 174 0.013
peptidyl serine modification GO:0018209 83 0.013
organelle localization GO:0051640 179 0.013
lymphocyte differentiation GO:0030098 242 0.013
organic acid biosynthetic process GO:0016053 86 0.013
nucleoside triphosphate catabolic process GO:0009143 205 0.013
glycosylation GO:0070085 62 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
regulation of t cell proliferation GO:0042129 92 0.013
nuclear division GO:0000280 158 0.013
negative regulation of protein maturation GO:1903318 79 0.013
meiotic cell cycle GO:0051321 122 0.013
positive regulation of protein transport GO:0051222 93 0.013
cation transmembrane transport GO:0098655 266 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
gonad development GO:0008406 141 0.012
muscle tissue development GO:0060537 308 0.012
establishment of blood nerve barrier GO:0008065 3 0.012
compound eye development GO:0048749 1 0.012
regulation of neuron differentiation GO:0045664 281 0.012
protein glycosylation GO:0006486 55 0.012
regulation of leukocyte proliferation GO:0070663 121 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
meiotic cell cycle process GO:1903046 77 0.012
muscle cell differentiation GO:0042692 261 0.012
regulation of protein serine threonine kinase activity GO:0071900 157 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
microtubule based process GO:0007017 236 0.012
peptide transport GO:0015833 133 0.012
cellular response to lipopolysaccharide GO:0071222 77 0.012
protein ubiquitination GO:0016567 171 0.012
blood vessel morphogenesis GO:0048514 285 0.012
cellular macromolecule catabolic process GO:0044265 206 0.012
fertilization GO:0009566 127 0.012
protein modification by small protein conjugation GO:0032446 187 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
cell killing GO:0001906 67 0.012
striated muscle myosin thick filament assembly GO:0071688 1 0.012
interleukin 8 production GO:0032637 4 0.012
regulation of vasculature development GO:1901342 88 0.012
regulation of peptidase activity GO:0052547 96 0.012
purine containing compound catabolic process GO:0072523 213 0.012
positive regulation of transferase activity GO:0051347 167 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.012
sensory perception GO:0007600 245 0.012
regulation of interleukin 8 production GO:0032677 3 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.012
negative regulation of proteolysis GO:0045861 74 0.012
chromatin modification GO:0016568 187 0.012
cellular protein complex assembly GO:0043623 116 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
mitochondrion organization GO:0007005 134 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
neuron death GO:0070997 154 0.012
leukocyte mediated cytotoxicity GO:0001909 62 0.012
negative regulation of protein modification process GO:0031400 163 0.012
regulation of gtp catabolic process GO:0033124 113 0.011
positive regulation of cell development GO:0010720 237 0.011
cellular chemical homeostasis GO:0055082 215 0.011
regulation of cellular component size GO:0032535 121 0.011
histone modification GO:0016570 159 0.011
regulation of angiotensin metabolic process GO:0060177 4 0.011
dna metabolic process GO:0006259 303 0.011
positive regulation of immune effector process GO:0002699 107 0.011
membrane organization GO:0061024 245 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
regulation of endopeptidase activity GO:0052548 89 0.011
meiotic nuclear division GO:0007126 115 0.011
homeostasis of number of cells GO:0048872 210 0.011
skeletal system morphogenesis GO:0048705 203 0.011
actin cytoskeleton organization GO:0030036 220 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
negative regulation of t cell activation GO:0050868 65 0.011
leukocyte proliferation GO:0070661 172 0.011
regulation of cellular catabolic process GO:0031329 242 0.011
single organismal cell cell adhesion GO:0016337 131 0.011
positive regulation of cytokine production GO:0001819 174 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
multicellular organism growth GO:0035264 161 0.011
regulation of angiogenesis GO:0045765 81 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
camera type eye development GO:0043010 266 0.011
biomineral tissue development GO:0031214 64 0.011
protein catabolic process GO:0030163 221 0.011
nuclear transport GO:0051169 139 0.011
regulation of apoptotic signaling pathway GO:2001233 197 0.011
embryonic organ morphogenesis GO:0048562 276 0.011
transmission of nerve impulse GO:0019226 76 0.011
positive regulation of apoptotic signaling pathway GO:2001235 95 0.011
defecation GO:0030421 1 0.011
response to peptide hormone GO:0043434 127 0.011
anatomical structure homeostasis GO:0060249 145 0.011
mitotic cytokinesis GO:0000281 4 0.011
inorganic ion transmembrane transport GO:0098660 234 0.011
cellular response to molecule of bacterial origin GO:0071219 83 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
negative regulation of cell cycle GO:0045786 123 0.011
covalent chromatin modification GO:0016569 163 0.011
regulation of binding GO:0051098 111 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
cellular response to dna damage stimulus GO:0006974 207 0.010
cellular metal ion homeostasis GO:0006875 151 0.010
cellular response to insulin stimulus GO:0032869 78 0.010
response to oxygen levels GO:0070482 62 0.010
synapse organization GO:0050808 125 0.010
neuronal action potential GO:0019228 54 0.010
positive regulation of kinase activity GO:0033674 155 0.010
negative regulation of peptidase activity GO:0010466 46 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.010
heart morphogenesis GO:0003007 178 0.010
interspecies interaction between organisms GO:0044419 83 0.010
forebrain development GO:0030900 302 0.010
regulation of protein kinase activity GO:0045859 232 0.010
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.010
spermatid differentiation GO:0048515 115 0.010
regulation of organ morphogenesis GO:2000027 144 0.010
cation homeostasis GO:0055080 212 0.010
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.010
regulation of inflammatory response GO:0050727 147 0.010
nephron development GO:0072006 109 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.010
regulation of cytoskeleton organization GO:0051493 122 0.010
action potential GO:0001508 78 0.010
telencephalon development GO:0021537 186 0.010
bmp signaling pathway GO:0030509 93 0.010
tissue homeostasis GO:0001894 115 0.010
t cell proliferation GO:0042098 120 0.010

Bace2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.030
disease of metabolism DOID:0014667 0 0.018
sensory system disease DOID:0050155 0 0.016
retinal disease DOID:5679 0 0.013
eye disease DOID:5614 0 0.013
retinal degeneration DOID:8466 0 0.013
eye and adnexa disease DOID:1492 0 0.013
central nervous system disease DOID:331 0 0.012
musculoskeletal system disease DOID:17 0 0.011
inherited metabolic disorder DOID:655 0 0.011